{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:12:40Z","timestamp":1773850360506,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.intimp.2020.106644","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T10:15:00Z","timestamp":1590660900000},"page":"106644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A novel bispecific antibody alleviates bleomycin-induced systemic sclerosis injury"],"prefix":"10.1016","volume":"85","author":[{"given":"Qi","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelei","family":"Pi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiechao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.106644_b0005","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41467-017-01168-1","article-title":"PTP4A1 promotes TGF\u03b2 signaling and fibrosis in systemic sclerosis","volume":"8","author":"Sacchetti","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2020.106644_b0010","first-page":"705","article-title":"Systemic sclerosis-dermatological aspects. Part 1: Pathogenesis, epidemiology, clinical findings","volume":"10","author":"Sticherling","year":"2012","journal-title":"J. der Deutschen Dermatologischen Gesellschaft"},{"key":"10.1016\/j.intimp.2020.106644_b0015","doi-asserted-by":"crossref","first-page":"i33","DOI":"10.1093\/rheumatology\/kel280","article-title":"Pathophysiology and clinical consequences of Raynaud's phenomenon related to systemic sclerosis","volume":"45","author":"Sunderk\u00f6tter","year":"2006","journal-title":"Rheumatology"},{"key":"10.1016\/j.intimp.2020.106644_b0020","first-page":"270938","article-title":"Vascular changes in bleomycin-induced scleroderma","author":"Yamamoto","year":"2011","journal-title":"Int. J. Rheumatol."},{"key":"10.1016\/j.intimp.2020.106644_b0025","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1002\/art.30568","article-title":"The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis","volume":"63","author":"Artlett","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2020.106644_b0030","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/exd.13366","article-title":"Transforming growth factor \u03b2 inhibitor Repsox down-regulates collagen expression of scleroderma dermal fibroblasts and prevents bleomycin-induced mice skin fibrosis","volume":"26","author":"Ide","year":"2017","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.intimp.2020.106644_b0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.0959-9673.2004.00377.x","article-title":"Smad3 as a mediator of the fibrotic response","volume":"85","author":"Flanders","year":"2004","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.intimp.2020.106644_b0040","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1002\/art.22927","article-title":"Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis","volume":"56","author":"Parel","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2020.106644_b0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cytogfr.2015.12.002","article-title":"New insights into CD4+ T cell abnormalities in systemic sclerosis","volume":"28","author":"Liu","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.intimp.2020.106644_b0050","doi-asserted-by":"crossref","first-page":"762","DOI":"10.2307\/3579368","article-title":"Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation","volume":"145","author":"Johnston","year":"1996","journal-title":"Radiat. Res."},{"key":"10.1016\/j.intimp.2020.106644_b0055","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI12568","article-title":"Transient expression of IL-1\u03b2 induces acute lung injury and chronic repair leading to pulmonary fibrosis","volume":"107","author":"Kolb","year":"2001","journal-title":"J. Clin. Investigat."},{"key":"10.1016\/j.intimp.2020.106644_b0060","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20092121","article-title":"Bleomycin and IL-1\u03b2-mediated pulmonary fibrosis is IL-17A dependent","volume":"207","author":"Wilson","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2020.106644_b0065","doi-asserted-by":"crossref","first-page":"01611","DOI":"10.3389\/fimmu.2018.01611","article-title":"IL-1-IL-17 signaling axis contributes to fibrosis and inflammation in two different murine models of systemic sclerosis","volume":"9","author":"Min-Jung","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2020.106644_b0070","doi-asserted-by":"crossref","first-page":"e23185","DOI":"10.1371\/journal.pone.0023185","article-title":"IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis","volume":"6","author":"Pam\u00e9la","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2020.106644_b0075","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 induce innate IL-17 production from \u03b3\u03b4 T Cells, amplifying Th17 responses and autoimmunity","volume":"31","author":"Sutton","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2020.106644_b0080","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/978-3-319-31407-5_43","article-title":"Drug development and regulatory considerations for SSc therapies","author":"Wright","year":"2017","journal-title":"Scleroderma"},{"key":"10.1016\/j.intimp.2020.106644_b0085","doi-asserted-by":"crossref","unstructured":"Massimo, Sabbatini, Domenico, et al., EC-MPS permits lower gastrointestinal symptom burden despite higher MPA exposure in patients with severe MMF-related gastrointestinal side-effects, Fundam. Clin. Pharmacol. 23 (2009) 617\u2013624.","DOI":"10.1111\/j.1472-8206.2009.00711.x"},{"key":"10.1016\/j.intimp.2020.106644_b0090","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.3748\/wjg.15.2817","article-title":"Drug-induced liver injury: Is it somehow foreseeable?","volume":"15","author":"Tarantino","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2020.106644_b0095","doi-asserted-by":"crossref","unstructured":"J.M.V. Laar, R.W. Simms, Immunomodulatory, immunoablative, and biologic therapies, Scleroderma. (2017) 567\u2013582.","DOI":"10.1007\/978-3-319-31407-5_41"},{"key":"10.1016\/j.intimp.2020.106644_b0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.semarthrit.2009.09.003","article-title":"Is there a role for B-cell depletion as therapy for scleroderma: A case report and review of the literature","volume":"40","author":"Daoussis","year":"2011","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.intimp.2020.106644_b0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/art.22289","article-title":"Recombinant human anti-transforming growth factor \u03b21 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I\/II trial of CAT-192","volume":"56","author":"Denton","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2020.106644_b0110","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.biopha.2017.02.045","article-title":"A recombinant IgG-like bispecific antibody acting as interleukin-1\u03b2 and interleukin-17A inhibitor exhibits a promising efficacy for rheumatoid arthritis","volume":"89","author":"Wang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2020.106644_b0115","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1073\/pnas.1035999100","article-title":"IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist","volume":"100","author":"Susumu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2020.106644_b0120","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.20060285","article-title":"A crucial role for interleukin (IL) -1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis","volume":"203","author":"Sutton","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2020.106644_b0125","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1189\/jlb.1012543","article-title":"The role of inflammasome-derived IL-1 in driving IL-17 responses","volume":"93","author":"Mills","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2020.106644_b0130","first-page":"172","article-title":"Effectiveness of etanercept in bleomycin-induced experimental scleroderma","volume":"42","author":"Koca","year":"2008","journal-title":"Rheumatology"},{"key":"10.1016\/j.intimp.2020.106644_b0135","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.4049\/jimmunol.1102048","article-title":"IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation","volume":"187","author":"Rider","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2020.106644_b0140","first-page":"223","article-title":"Increased expression of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis","volume":"46","author":"Ziegenhagen","year":"1998","journal-title":"J. Investig. Med"},{"key":"10.1016\/j.intimp.2020.106644_b0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.imlet.2017.11.012","article-title":"The IL-1 family of cytokines. Do they have a role in scleroderma fibrosis?","volume":"195","author":"Artlett","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.intimp.2020.106644_b0150","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jlb.64.4.528","article-title":"TNF and IL-6 mediate MIP-1alpha expression in bleomycin-induced lung injury","volume":"64","author":"Smith","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2020.106644_b0155","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bbrc.2007.03.141","article-title":"Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling","volume":"357","author":"Muselet-Charlier","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2020.106644_b0160","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.lfs.2008.03.018","article-title":"Diallyl sulfide attenuates bleomycin-induced pulmonary fibrosis: Critical role of iNOS, NF-kB, TNF-\u03b1 and IL-1\u03b2","volume":"82","author":"Kalayarasan","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2020.106644_b0165","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1667\/RR3478.1","article-title":"Interleukin 1\u03b2 (IL1B) Signaling is a Critical Component of Radiation-Induced Skin Fibrosis","volume":"165","author":"Liu","year":"2006","journal-title":"Radiat. Res."},{"key":"10.1016\/j.intimp.2020.106644_b0170","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1002\/art.34643","article-title":"Potential roles of interleukin-17A in the development of skin fibrosis in mice","volume":"64","author":"Okamoto","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2020.106644_b0175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbi.2018.03.011","article-title":"MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis","volume":"70","author":"Zhang","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2020.106644_b0180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)63289-0","article-title":"Targeted disruption of TGF-\u03b2\/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma","volume":"165","author":"Gabriella","year":"2004","journal-title":"Am. J. of Pathol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920306275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920306275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:22:35Z","timestamp":1761585755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920306275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":36,"alternative-id":["S1567576920306275"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106644","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel bispecific antibody alleviates bleomycin-induced systemic sclerosis injury","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106644","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106644"}}