{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T22:41:56Z","timestamp":1781995316246,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004605","name":"Zhengzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.intimp.2020.106653","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T17:19:13Z","timestamp":1591723153000},"page":"106653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1\/NLRP3\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"85","author":[{"given":"Yongjin","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueliang","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.106653_b0005","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/01.CIR.94.6.1276","article-title":"Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus","volume":"94","author":"Makimattila","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2020.106653_b0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.intimp.2020.106653_b0015","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications - a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.intimp.2020.106653_b0020","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2020.106653_b0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/1472-6882-14-277","article-title":"Anti-hepatotoxic activities of hibiscus sabdariffa l. In animal model of streptozotocin diabetes-induced liver damage","volume":"14","author":"Adeyemi","year":"2014","journal-title":"BMC complementary and alternative medicine"},{"key":"10.1016\/j.intimp.2020.106653_b0030","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1093\/jn\/135.10.2299","article-title":"Quercetin decreases oxidative stress, nf-kappab activation, and inos overexpression in liver of streptozotocin-induced diabetic rats","volume":"135","author":"Dias","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.intimp.2020.106653_b0035","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00210-008-0363-y","article-title":"A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia","volume":"379","author":"Matafome","year":"2009","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106653_b0040","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI25102","article-title":"Inflammation, stress, and diabetes","volume":"115","author":"Wellen","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2020.106653_b0045","doi-asserted-by":"crossref","DOI":"10.1186\/cc6935","article-title":"Association of hmgb1 polymorphisms with outcome in patients with systemic inflammatory response syndrome","volume":"12","author":"Kornblit","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.intimp.2020.106653_b0050","doi-asserted-by":"crossref","first-page":"78764","DOI":"10.18632\/oncotarget.12853","article-title":"an inhibitor of rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure","volume":"7","author":"Xueyang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.intimp.2020.106653_b0055","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/bcp.12196","article-title":"Rho kinase inhibition in diabetic kidney disease","volume":"76","author":"Komers","year":"2013","journal-title":"Brit J Clin Pharmaco"},{"issue":"12","key":"10.1016\/j.intimp.2020.106653_b0060","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/ijo.2014.36","article-title":"Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in \u03b2-cell","volume":"38","author":"Guzm\u00e1n-Ruiz","year":"2014","journal-title":"International journal of obesity"},{"issue":"10","key":"10.1016\/j.intimp.2020.106653_b0065","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.4049\/jimmunol.1301490","article-title":"Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation","volume":"191","author":"Heid","year":"2013","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2020.106653_b0070","first-page":"S43","article-title":"Abrogation of Toll-like receptor 4 (TLR4) mitigates obesity induced insulin resistance and glucose intolerance through reducing mitochondrial ROS in visceral fat","volume":"120","author":"Hung-Yu","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"6","key":"10.1016\/j.intimp.2020.106653_b0075","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3892\/etm.2012.732","article-title":"Atorvastatin reduces serum HMGB1 levels in patients with hyperlipidemia","volume":"4","author":"Jin","year":"2012","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"9","key":"10.1016\/j.intimp.2020.106653_b0080","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/nm.3265","article-title":"Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes","volume":"19","author":"Jourdan","year":"2013","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2020.106653_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015977","article-title":"Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes","volume":"6","author":"Lee","year":"2011","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.intimp.2020.106653_b0090","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2337\/db12-0420","article-title":"Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes","volume":"62","author":"Lee","year":"2013","journal-title":"Diabetes"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2020.106653_b0095","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11010-015-2396-0","article-title":"HMGB1 binding to receptor for advanced glycation end products enhances inflammatory responses of human bronchial epithelial cell by activating p38 MAPK and ERK1\/2","volume":"405","author":"Liang","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.intimp.2020.106653_b0100","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1007\/s10753-017-0593-6","article-title":"Salidroside Attenuates LPS-Induced Acute Lung Injury in Rats","volume":"40","author":"Liu","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2020.106653_b0105","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biopha.2016.12.032","article-title":"Salidroside alleviates cigarette smoke-induced COPD in mice","volume":"86","author":"Luo","year":"2017","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/j.intimp.2020.106653_b0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.dld.2016.12.028","article-title":"Which treatment for type 2 diabetes associated with non-alcoholic fatty liver disease?","volume":"49","author":"Mazzotti","year":"2017","journal-title":"Digestive and liver disease"},{"issue":"7\u20138","key":"10.1016\/j.intimp.2020.106653_b0115","doi-asserted-by":"crossref","first-page":"840","DOI":"10.2119\/molmed.2010.00108","article-title":"Adipose and liver expression of interleukin (IL)\u22121 family members in morbid obesity and effects of weight loss","volume":"17","author":"Moschen","year":"2011","journal-title":"Mol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2020.106653_b0120","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pharmthera.2013.11.001","article-title":"An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies","volume":"141","author":"Musumeci","year":"2014","journal-title":"Pharmacology and Terapeutics"},{"issue":"8","key":"10.1016\/j.intimp.2020.106653_b0125","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1517\/14728222.2011.575360","article-title":"HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation","volume":"15","author":"Nogueira-Machado","year":"2011","journal-title":"Expert opinion on therapeutic targets"},{"key":"10.1016\/j.intimp.2020.106653_b0130","doi-asserted-by":"crossref","unstructured":"Parente DB, Netso JAO, Brasil PEAA, Paiva FF, Ravani JPR, Gomes MB, et al (2017). Preperitoneal fat as a noninvsasive marker of increased risk of severe non-alcoholic fatty liver disease in patients with type 2 diabetes. Journal of gastroenterology and hepatology 2017 Jul 20.","DOI":"10.1111\/jgh.13903"},{"issue":"2","key":"10.1016\/j.intimp.2020.106653_b0135","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2009.12.052","article-title":"Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression","volume":"140","author":"Park","year":"2010","journal-title":"Cell"},{"issue":"5963","key":"10.1016\/j.intimp.2020.106653_b0140","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.1184003","article-title":"The NLRP3 inflammasome: a sensor for metabolic danger?","volume":"327","author":"Schroder","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.intimp.2020.106653_b0145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"5","key":"10.1016\/j.intimp.2020.106653_b0150","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/aji.12506","article-title":"AGEs and 28.HMGB1 Increase Inflammatory Cytokine Production from Human Placental Cell, Resulting in an Enhancement of Monocyte Migration","volume":"75","author":"Shirasuna","year":"2016","journal-title":"Am. J. Reprod. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920303908?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920303908?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:19:00Z","timestamp":1761585540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920303908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":30,"alternative-id":["S1567576920303908"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106653","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1\/NLRP3\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106653","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106653"}}