{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:03:20Z","timestamp":1793023400747,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2016shmszx130079"],"award-info":[{"award-number":["cstc2016shmszx130079"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.intimp.2020.106662","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T00:23:25Z","timestamp":1592007805000},"page":"106662","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation"],"prefix":"10.1016","volume":"85","author":[{"given":"Xue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2020.106662_b0005","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/hep.27406","article-title":"The global burden of liver disease: the major impact of China","volume":"60","author":"Wang","year":"2014","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"12","key":"10.1016\/j.intimp.2020.106662_b0010","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.cgh.2015.08.015","article-title":"Current and Future Burden of Chronic Nonmalignant Liver Disease","volume":"13","author":"Udompap","year":"2015","journal-title":"Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association"},{"issue":"1","key":"10.1016\/j.intimp.2020.106662_b0015","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1038\/s41598-019-51175-z","article-title":"Hepatospecific ablation of p38alpha MAPK governs liver regeneration through modulation of inflammatory response to CCl4-induced acute injury","volume":"9","author":"Fortier","year":"2019","journal-title":"Scientific reports"},{"key":"10.1016\/j.intimp.2020.106662_b0020","doi-asserted-by":"crossref","first-page":"3140673","DOI":"10.1155\/2017\/3140673","article-title":"Oxidative Stress and Inflammation in Hepatic Diseases: Current and Future Therapy","volume":"2017","author":"Reyes-Gordillo","year":"2017","journal-title":"Oxidative medicine and cellular longevity"},{"issue":"8","key":"10.1016\/j.intimp.2020.106662_b0025","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1053\/j.gastro.2019.02.002","article-title":"Incidence and Etiology of Drug-Induced Liver Injury in Mainland China","volume":"156","author":"Shen","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2020.106662_b0030","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.lfs.2019.05.019","article-title":"Sitagliptin ameliorates thioacetamide-induced acute liver injury via modulating TLR4\/NF-KB signaling pathway in mice","volume":"228","author":"El-Kashef","year":"2019","journal-title":"Life sciences"},{"issue":"10","key":"10.1016\/j.intimp.2020.106662_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24101964","article-title":"Zerumbone Protects against Carbon Tetrachloride (CCl4)-Induced Acute Liver Injury in Mice via Inhibiting Oxidative Stress and the Inflammatory Response: Involving the TLR4\/NF-kappaB\/COX-2 Pathway","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"6","key":"10.1016\/j.intimp.2020.106662_b0040","first-page":"1265","article-title":"[Clinical characteristics and incidence in acute non A-G hepatitis], Nihon rinsho","volume":"57","author":"Yatsuhashi","year":"1999","journal-title":"Japanese journal of clinical medicine"},{"issue":"10","key":"10.1016\/j.intimp.2020.106662_b0045","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/tox.22616","article-title":"Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice","volume":"33","author":"Ning","year":"2018","journal-title":"Environmental toxicology"},{"key":"10.1016\/j.intimp.2020.106662_b0050","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.2147\/DDDT.S162950","article-title":"Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-kappaB and TGF-beta1\/Smad3 pathways","volume":"12","author":"Feng","year":"2018","journal-title":"Drug design, development and therapy"},{"key":"10.1016\/j.intimp.2020.106662_b0055","article-title":"Salidroside attenuates dextran sulfate sodium-induced colitis in mice via SIRT1\/FoxOs signaling pathway","volume":"172591","author":"Li","year":"2019","journal-title":"European journal of pharmacology"},{"issue":"5","key":"10.1016\/j.intimp.2020.106662_b0060","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/ptr.6335","article-title":"Neuroprotective effect of salidroside against central nervous system inflammation-induced cognitive deficits: A pivotal role of sirtuin 1-dependent Nrf-2\/HO-1\/NF-kappaB pathway","volume":"33","author":"Xu","year":"2019","journal-title":"Phytotherapy research : PTR"},{"issue":"S1","key":"10.1016\/j.intimp.2020.106662_b0065","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1002\/hep.21062","article-title":"Apoptosis and necrosis in the liver: A tale of two deaths?","volume":"43","author":"Malhi","year":"2006","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.intimp.2020.106662_b0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cdd.2011.96","article-title":"Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012","volume":"19","author":"Galluzzi","year":"2012","journal-title":"Cell Death Differ"},{"issue":"13","key":"10.1016\/j.intimp.2020.106662_b0075","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxidants & redox signaling"},{"key":"10.1016\/j.intimp.2020.106662_b0080","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.intimp.2017.11.007","article-title":"Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury","volume":"54","author":"Shi","year":"2018","journal-title":"International immunopharmacology"},{"issue":"12","key":"10.1016\/j.intimp.2020.106662_b0085","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1631\/jzus.B1400104","article-title":"Therapeutic detoxification of quercetin against carbon tetrachloride-induced acute liver injury in mice and its mechanism","volume":"15","author":"Zhang","year":"2014","journal-title":"Journal of Zhejiang University. Science. B"},{"key":"10.1016\/j.intimp.2020.106662_b0090","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.ijbiomac.2019.07.044","article-title":"The ameliorations of Ganoderma applanatum residue polysaccharides against CCl4 induced liver injury","volume":"137","author":"Gao","year":"2019","journal-title":"International journal of biological macromolecules"},{"issue":"2","key":"10.1016\/j.intimp.2020.106662_b0095","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0022-3565(25)12893-0","article-title":"Molecular mechanism for alkyl sulfide-modulated carbon tetrachloride-induced hepatotoxicity: the role of cytochrome P450 2E1, P450 2B and glutathione S-transferase expression","volume":"277","author":"Kim","year":"1996","journal-title":"The Journal of pharmacology and experimental therapeutics"},{"issue":"4","key":"10.1016\/j.intimp.2020.106662_b0100","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1007\/s13277-013-1486-4","article-title":"Liver cancer-related gene CYP2E1 expression in HBV transgenic mice with acute liver injury","volume":"35","author":"Zhang","year":"2014","journal-title":"Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"key":"10.1016\/j.intimp.2020.106662_b0105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2019.04.019","article-title":"Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration","volume":"227","author":"Dong","year":"2019","journal-title":"Life sciences"},{"issue":"2","key":"10.1016\/j.intimp.2020.106662_b0110","first-page":"724","article-title":"Oxidative and reductive metabolism by cytochrome P450 2E1, FASEB journal : official publication of the Federation of American Societies for","volume":"6","author":"Koop","year":"1992","journal-title":"Experimental Biology"},{"issue":"2","key":"10.1016\/j.intimp.2020.106662_b0115","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0168-8278(01)00142-8","article-title":"Oxidative stress-related molecules and liver fibrosis","volume":"35","author":"Parola","year":"2001","journal-title":"Journal of hepatology"},{"issue":"4","key":"10.1016\/j.intimp.2020.106662_b0120","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/10715760601118361","article-title":"S-allyl cysteine prevents CCl(4)-induced acute liver injury in rats","volume":"41","author":"Kodai","year":"2007","journal-title":"Free radical research"},{"issue":"7","key":"10.1016\/j.intimp.2020.106662_b0125","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Archives of toxicology"},{"issue":"10","key":"10.1016\/j.intimp.2020.106662_b0130","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.lfs.2003.08.010","article-title":"Hyaluronic acid and chondroitin-4-sulphate treatment reduces damage in carbon tetrachloride-induced acute rat liver injury","volume":"74","author":"Campo","year":"2004","journal-title":"Life sciences"},{"key":"10.1016\/j.intimp.2020.106662_b0135","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41420-019-0198-y","article-title":"Hyperglycemia exacerbates acetaminophen-induced acute liver injury by promoting liver-resident macrophage proinflammatory response via AMPK\/PI3K\/AKT-mediated oxidative stress","volume":"5","author":"Wang","year":"2019","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.intimp.2020.106662_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.05.039","article-title":"In vitro\/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-alpha-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury","volume":"131","author":"Sun","year":"2019","journal-title":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.intimp.2020.106662_b0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fct.2013.11.017","article-title":"Hepatoprotective properties of sesamin against CCl4 induced oxidative stress-mediated apoptosis in mice via JNK pathway","volume":"64","author":"Ma","year":"2014","journal-title":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association"},{"issue":"14","key":"10.1016\/j.intimp.2020.106662_b0150","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1111\/febs.13775","article-title":"Cell death and inflammation: the case for IL-1 family cytokines as the canonical DAMPs of the immune system","volume":"283","author":"Martin","year":"2016","journal-title":"The FEBS journal"},{"key":"10.1016\/j.intimp.2020.106662_b0155","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2019.04.012","article-title":"Circulating Peroxiredoxin-1 is a novel damage-associated molecular pattern and aggravates acute liver injury via promoting inflammation","volume":"137","author":"He","year":"2019","journal-title":"Free radical biology & medicine"},{"key":"10.1016\/j.intimp.2020.106662_b0160","article-title":"Hepatoprotective effects of a traditional Chinese medicine formula against carbon tetrachloride-induced hepatotoxicity in vivo and in vitro","volume":"117","author":"Ren","year":"2019","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"6","key":"10.1016\/j.intimp.2020.106662_b0165","first-page":"7939","article-title":"Saikosaponind alleviates carbontetrachloride induced acute hepatocellular injury by inhibiting oxidative stress and NLRP3 inflammasome activation in the HL7702 cell line","volume":"17","author":"Lin","year":"2018","journal-title":"Molecular medicine reports"},{"issue":"12","key":"10.1016\/j.intimp.2020.106662_b0170","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and Regulation of NLRP3 Inflammasome Activation","volume":"41","author":"He","year":"2016","journal-title":"Trends in biochemical sciences"},{"issue":"7381","key":"10.1016\/j.intimp.2020.106662_b0175","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.intimp.2020.106662_b0180","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1521-6918(03)00053-2","article-title":"Advances in alcoholic liver disease","volume":"17","author":"Arteel","year":"2003","journal-title":"Best practice & research. Clinical gastroenterology"},{"issue":"10","key":"10.1016\/j.intimp.2020.106662_b0185","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1172\/JCI60777","article-title":"IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice","volume":"122","author":"Petrasek","year":"2012","journal-title":"The Journal of clinical investigation"},{"issue":"1","key":"10.1016\/j.intimp.2020.106662_b0190","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2014.10.005","article-title":"Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort","volume":"148","author":"Setiawan","year":"2015","journal-title":"Gastroenterology"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920305567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920305567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:16:42Z","timestamp":1761585402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920305567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":38,"alternative-id":["S1567576920305567"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106662","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106662","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106662"}}