{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T12:59:45Z","timestamp":1765976385201,"version":"build-2065373602"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.intimp.2020.106893","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T13:24:09Z","timestamp":1599139449000},"page":"106893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Anti-inflammatory and antinociceptive activity profile of a new lead compound \u2013 LQFM219"],"prefix":"10.1016","volume":"88","author":[{"given":"Gustavo M.","family":"Galv\u00e3o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iziara F.","family":"Florentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boniek G.","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano M.","family":"Li\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 R.","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina S.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiany P.B.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elson A.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia L.P.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur C.G.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marize C.","family":"Valadares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline A.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"de S. Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Menegatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.106893_b0005","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.immuni.2014.02.009","article-title":"Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation","volume":"40","author":"Buckley","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2020.106893_b0010","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bpa.2003.12.002","article-title":"Mechanisms of the inflammatory response","volume":"18","author":"Sherwood","year":"2004","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"10.1016\/j.intimp.2020.106893_b0015","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri915","article-title":"Anti-inflammatory lipid mediators and insights into the resolution of inflammation","volume":"2","author":"Lawrence","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2020.106893_b0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.2042-7158.2012.01582.x","article-title":"Anti-inflammatory effect of (E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol","volume":"65","author":"Lino","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0025","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.2337\/dc12-0614","article-title":"Myeloperoxidase Is an Early Biomarker of Inflammation and Cardiovascular Risk in Prepubertal Obese Children","volume":"35","author":"Olza","year":"2012","journal-title":"Diab. Care"},{"key":"10.1016\/j.intimp.2020.106893_b0030","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.4155\/fmc-2016-0031","article-title":"Characterization of chemical features of potent myeloperoxidase inhibitors","volume":"8","author":"Soubhye","year":"2016","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.intimp.2020.106893_b0035","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of inflammation: the beginning programs the end","volume":"6","author":"Serhan","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2020.106893_b0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.immunol.25.022106.141647","article-title":"Resolution Phase of Inflammation: Novel Endogenous Anti-Inflammatory and Proresolving Lipid Mediators and Pathways","volume":"25","author":"Serhan","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2020.106893_b0045","unstructured":"E.A. Roth, P. Shekelle, J.J. Ofman, C.H. Maclean, W.L. Straus, S.C. Morton, M.L. Berger, A metaanalysis of severe upper gastrointestinal complications of nonsteroidal, 2002. http:\/\/www.jrheum.org\/content\/29\/4\/804http:\/\/www.jrheum.org\/alerts1.SignupforTOCsandotheralertshttp:\/\/jrheum.com\/faqwww.jrheum.orgwww.jrheum.orgDownloadedfrom."},{"key":"10.1016\/j.intimp.2020.106893_b0050","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1134\/S1070428014030105","article-title":"Synthesis of unsymmetrical hydroxybenzylphenols containing isobornyl fragments","volume":"50","author":"Buravlev","year":"2014","journal-title":"Russ. J. Org. Chem."},{"key":"10.1016\/j.intimp.2020.106893_b0055","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S1600576714022985","article-title":"Comparison of silver and molybdenum microfocus X-ray sources for single-crystal structure determination","volume":"48","author":"Krause","year":"2015","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.intimp.2020.106893_b0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053229614024218","article-title":"Crystal structure refinement with SHELXL","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. Sect. C Struct. Chem."},{"key":"10.1016\/j.intimp.2020.106893_b0065","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1107\/S0021889812029111","article-title":"WinGX and ORTEP for Windows: an update","volume":"45","author":"Farrugia","year":"2012","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.intimp.2020.106893_b0070","unstructured":"ICCVAM TEST METHOD EVALUATION REPORT IN VITRO CYTOTOXICITY TEST METHODS FOR ESTIMATING STARTING DOSES FOR ACUTE ORAL SYSTEMIC TOXICITY TESTING Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) National Toxicology Program, 2006. http:\/\/iccvam.niehs.nih.gov\/methods\/invitro.htm."},{"key":"10.1016\/j.intimp.2020.106893_b0075","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.etp.2010.03.012","article-title":"In vitro basal cytotoxicity assay applied to estimate acute oral systemic toxicity of grandisin and its major metabolite","volume":"63","author":"Vieira","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.intimp.2020.106893_b0080","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10787-017-0390-8","article-title":"Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone","volume":"26","author":"Batista","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2020.106893_b0085","first-page":"412","article-title":"Acetic acid for analgesic screening","volume":"18","author":"Koster","year":"1959","journal-title":"Fed. Proc. J."},{"key":"10.1016\/j.intimp.2020.106893_b0090","first-page":"409","article-title":"A method for measurement of analgesic activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.intimp.2020.106893_b0100","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3390\/molecules21121757","article-title":"Pharmacological Properties of Riparin IV in Models of Pain and Inflammation","volume":"21","author":"Nascimento","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2020.106893_b0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jep.2006.09.032","article-title":"Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea","volume":"110","author":"Passos","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ptr.2650060102","article-title":"Action of compounds fromMandevilla velutina on croton oil-induced ear oedema in mice. A comparative study with steroidal and nonsteroidal antiinflammatory drugs","volume":"6","author":"Zanini","year":"1992","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2020.106893_b0115","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(99)00086-8","article-title":"Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan","volume":"20","author":"Silvia Fr\u00f6de Saleh","year":"1999","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.intimp.2020.106893_b0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.2042-7158.2012.01582.x","article-title":"Anti-inflammatory effect of (E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol","volume":"65","author":"Lino","year":"2013","journal-title":"J Pharm Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0125","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cyto.2000.0816","article-title":"The modulatory role played by TNF-\u03b1 and il-1\u03b2 in the inflammatory responses induced by Carrageenan in the mouse model of pleurisy","volume":"13","author":"Fr\u00f6de","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2020.106893_b0130","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.lfs.2012.12.003","article-title":"Anti-inflammatory and antinociceptive activities of LQFM002 \u2014 A 4-nerolidylcatechol derivative","volume":"92","author":"Costa","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2020.106893_b0135","article-title":"The preparation of some trinitrophenylpyrazoles","volume":"3024\u20133027","author":"Finar","year":"1957","journal-title":"J Chem Soc."},{"issue":"12","key":"10.1016\/j.intimp.2020.106893_b0140","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1080\/00397911.2012.657764","article-title":"Chemoselective and regiospecific formylation of 1-penyl-1H-pyrazoles through the duff reaction","volume":"43","author":"de Oliveira","year":"2013","journal-title":"Synth. Commun."},{"issue":"16","key":"10.1016\/j.intimp.2020.106893_b0145","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1016\/j.tet.2010.02.064","article-title":"Preparation, crystal structure, and spectroscopic, chemical, and electrochemical properties of (2E,4E)-4-[4-(dimethylamino)phenyl]-1-(3-guaiazulenyl)-1,3-butadiene compared with those of (E)-2-[4-(dimethylamino)phenyl]-1-(3-guaiazulenyl)ethylene chemistry","volume":"66","author":"Takekuma","year":"2010","journal-title":"Tetrahedron"},{"key":"10.1016\/j.intimp.2020.106893_b0150","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jep.2012.05.009","article-title":"Antinociceptive activity of aqueous extract and isolated compounds of Lithrea molleoides","volume":"142","author":"Morucci","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0155","unstructured":"Unclassified ENV\/JM\/MONO(2001)4 JOINT MEETING OF THE CHEMICALS COMMITTEE AND THE WORKING PARTY ON CHEMICALS, PESTICIDES AND BIOTECHNOLOGY OECD SERIES ON TESTING AND ASSESSMENT Number 24 GUIDANCE DOCUMENT ON ACUTE ORAL TOXICITY TESTING JT00111082 Document complet disponible sur OLIS dans son format d\u2019origine Complete document available on OLIS in its original format, 2001."},{"key":"10.1016\/j.intimp.2020.106893_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/539807","article-title":"Analgesic and Anti-Inflammatory Activities of Leaf Extract of Mallotus repandus (Willd.)","volume":"2014","author":"Hasan","year":"2014","journal-title":"Muell. Arg., BioMed. Res. Int."},{"key":"10.1016\/j.intimp.2020.106893_b0165","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1189\/jlb.0805452","article-title":"Selective local PMN recruitment by CXCL1 or CXCL2\/3 injection does not cause inflammatory pain","volume":"79","author":"Rittner","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2020.106893_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00140","article-title":"Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-\u03baB and Nrf2 Signaling","volume":"9","author":"Khalid","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0175","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1472-8206.2012.01068.x","article-title":"Pharmacological mechanisms involved in the antinociceptive effects of dexmedetomidine in mice","volume":"28","author":"Rangel","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0180","first-page":"1295","article-title":"Palliative Care Files Steroids as pain relief adjuvants","volume":"56","author":"Vyvey","year":"2010","journal-title":"Can. Fam. Phys."},{"key":"10.1016\/j.intimp.2020.106893_b0185","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.2147\/JPR.S222095","article-title":"Co-Administered Low Doses Of Ibuprofen And Dexamethasone Produce Synergistic Antinociceptive Effects On Neuropathic Mechanical Allodynia In Rats","volume":"12","author":"Park","year":"2019","journal-title":"J. Pain Res."},{"key":"10.1016\/j.intimp.2020.106893_b0190","doi-asserted-by":"crossref","unstructured":"J.C. Fehrenbacher, M.R. Vasko, D.B. Duarte, Models of Inflammation: Carrageenan- or Complete Freund\u2019s Adjuvant (CFA)-Induced Edema and Hypersensitivity in the Rat, Curr. Protoc. Pharmacol. 56 (2012) 5.4.1-5.4.4. Doi: 10.1002\/0471141755.ph0504s56.","DOI":"10.1002\/0471141755.ph0504s56"},{"key":"10.1016\/j.intimp.2020.106893_b0195","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0026-895X(24)09255-1","article-title":"Protein Kinase C-\u03b1 Coordinately Regulates Cytosolic Phospholipase A 2 Activity and the Expression of Cyclooxygenase-2 through Different Mechanisms in Mouse Keratinocytes","volume":"59","author":"Wang","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0200","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.bcp.2006.01.005","article-title":"Involvement of tumor necrosis factor (TNF)-\u03b1 in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice","volume":"71","author":"Murakawa","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0205","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3109\/09637486.2014.886184","article-title":"Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice","volume":"65","author":"Luo","year":"2014","journal-title":"Int. J. Food Sci. Nutr."},{"key":"10.1016\/j.intimp.2020.106893_b0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejphar.2016.08.033","article-title":"Design, synthesis and pharmacological evaluation of new anti-inflammatory compounds","volume":"791","author":"Cidade","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0215","doi-asserted-by":"crossref","unstructured":"L.P. de Oliveira, D.P.B. da Silva, I.F. Florentino, J.O. Fajemiroye, T.S. de Oliveira, R.I. de \u00c1. Marcelino, F. Pazini, L.M. Li\u00e3o, P.C. Ghedini, S.S. de Moura, M.C. Valadares, V.V. de Carvalho, B.G. Vaz, R. Menegatti, E.A. Costa, New pyrazole derivative 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole: synthesis and assessment of some biological activities, Chem. Biol. Drug Des. 89 (2017) 124\u2013135. Doi: 10.1111\/cbdd.12838.","DOI":"10.1111\/cbdd.12838"},{"key":"10.1016\/j.intimp.2020.106893_b0220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.niox.2017.04.006","article-title":"Potential anti-inflammatory effect of LQFM-021 in carrageenan-induced inflammation: the role of nitric oxide","volume":"69","author":"Florentino","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.intimp.2020.106893_b0225","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejps.2017.06.006","article-title":"Pharmacological evaluation and molecular docking of new di-tert-butylphenol compound, LQFM-091, a new dual 5-LOX\/COX inhibitor","volume":"106","author":"Lino","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.intimp.2020.106893_b0230","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00210-013-0854-3","article-title":"Niacin inhibits carrageenan-induced neutrophil migration in mice, Naunyn-Schmiedeberg\u2019s","volume":"386","author":"Ferreira","year":"2013","journal-title":"Arch. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0235","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejphar.2015.11.034","article-title":"Nicorandil inhibits neutrophil recruitment in carrageenan-induced experimental pleurisy in mice","volume":"769","author":"Matsui","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0240","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3181\/00379727-143-37397","article-title":"Some Quantitative Temporal Characteristics of Carrageenin-Induced Pleurisy in the Rat","volume":"143","author":"Vinegar","year":"1973","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.intimp.2020.106893_b0245","first-page":"33","article-title":"Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives","volume":"6","author":"Khan","year":"2018","journal-title":"Med. Sci."},{"key":"10.1016\/j.intimp.2020.106893_b0250","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3164\/jcbn.15-104","article-title":"Neutrophil myeloperoxidase and its substrates: formation of specific markers and reactive compounds during inflammation","volume":"58","author":"Kato","year":"2016","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.intimp.2020.106893_b0255","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00004770-200303000-00009","article-title":"Proinflammatory Cytokines Induce Cyclooxygenase-2 mRNA and Protein Expression in Human Pulp Cell Cultures","volume":"29","author":"Chang","year":"2003","journal-title":"J. Endod.."},{"key":"10.1016\/j.intimp.2020.106893_b0260","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jep.2016.06.022","article-title":"Evidence for the involvement of TNF-\u03b1 and IL-1\u03b2 in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-\u03b1-bisabolol, its main compound, in mice","volume":"191","author":"Barreto","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2020.106893_b0265","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/08830189809043005","article-title":"Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist","volume":"16","author":"Dinarello","year":"1998","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.intimp.2020.106893_b0270","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive role of cytokines and chemokines: Targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2020.106893_b0275","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive Oxygen Species in Inflammation and Tissue Injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2020.106893_b0280","doi-asserted-by":"crossref","unstructured":"G.L. da Silva, C. Luft, A. Lunardelli, R.H. Amaral, D.A.D.S. Melo, M.V.F. Donadio, F.B. Nunes, M.S. de Azambuja, J.C. Santana, C.M.B. Moraes, R.O. Mello, E. Cassel, M.A.D.A. Pereira, J.R. de Oliveira, Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil, Anais Da Acad. Brasileira de Ci\u00eancias. 87 (2015) 1397\u20131408. Doi: 10.1590\/0001-3765201520150056.","DOI":"10.1590\/0001-3765201520150056"},{"key":"10.1016\/j.intimp.2020.106893_b0285","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.phymed.2013.09.001","article-title":"Antioxidant and intestinal anti-inflammatory effects of plant-derived coumarin derivatives","volume":"21","author":"Witaicenis","year":"2014","journal-title":"Phytomedicine"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920323493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920323493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:44:57Z","timestamp":1762551897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920323493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":56,"alternative-id":["S1567576920323493"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106893","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory and antinociceptive activity profile of a new lead compound \u2013 LQFM219","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106893","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106893"}}