{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T04:15:19Z","timestamp":1784952919190,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.intimp.2020.106983","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T09:17:19Z","timestamp":1600075039000},"page":"106983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["The potential protective effect of modafinil in intestinal ischemic reperfusion-induced in rats"],"prefix":"10.1016","volume":"88","author":[{"given":"MahaYehia","family":"Kamel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabreen Mahmoud","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WalaaYehia","family":"Abdelzaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.106983_b0005","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2119\/2007-00032.Guneli","article-title":"Erythropoietin protects the intestine against ischemia\/reperfusion injury in rats","volume":"13","author":"Guneli","year":"2007","journal-title":"Mol. Med."},{"key":"10.1016\/j.intimp.2020.106983_b0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fmolb.2018.00089","article-title":"Analysis of the effect of intestinal ischemia and reperfusion on the rat neutrophils proteome","volume":"5","author":"Tahir","year":"2018","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.intimp.2020.106983_b0015","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.3389\/fimmu.2019.01461","article-title":"Tissue dependent role of PTX3 during ischemia-reperfusion injury","volume":"10","author":"de Oliveira","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2020.106983_b0020","article-title":"Murine model of intestinal ischemia-reperfusion injury","volume":"111","author":"Gubernatorova","year":"2016","journal-title":"J. Vis. Exp."},{"issue":"6","key":"10.1016\/j.intimp.2020.106983_b0025","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1007\/s10620-017-4468-3","article-title":"Tumor necrosis factor \u03b1-dependent neutrophil priming prevents intestinal ischemia\/reperfusion-induced bacterial translocation","volume":"62","author":"Lu","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.intimp.2020.106983_b0030","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.3389\/fimmu.2019.02014","article-title":"Interleukin-1 family cytokines: keystones in liver inflammatory diseases","volume":"10","author":"Barbier","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2020.106983_b0035","doi-asserted-by":"crossref","unstructured":"A. Zager ,W.N. Brand\u00e3o ,R.O. Margatho ,D.S. G. Cruz ,J. P. Peron ,S. Tufik ,Monica L. Andersen ,M. Moresco ,F.Pizza ,G. Plazzi ,B.R. Kornum ,J. Palermo-Neto, Increased interferon-mediated immunity following in vitro and in vivo modafinil treatment on peripheral immune cells. Prog. Neuropsychopharmacol. Biol. Psychiatry 81 (2018 Feb 2) 297-305. doi: 10.1016\/j.pnpbp.2017.09.009. Epub 2017 Sep 15.","DOI":"10.1016\/j.pnpbp.2017.09.009"},{"key":"10.1016\/j.intimp.2020.106983_b0040","doi-asserted-by":"crossref","unstructured":"K.C. Schmitt, M.E. Reith, The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors, PloS One 6(10) (2011 October 17) e25790. 10.1371\/journal.pone.0025790.","DOI":"10.1371\/journal.pone.0025790"},{"issue":"8","key":"10.1016\/j.intimp.2020.106983_b0045","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1445-5994.2008.01710.x","article-title":"Modafinil-induced psychosis","volume":"38","author":"Wu","year":"2008","journal-title":"Int. Med. J."},{"issue":"9","key":"10.1016\/j.intimp.2020.106983_b0050","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2165\/11315280-000000000-00000","article-title":"A rmodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives","volume":"29","author":"Darwish","year":"2009","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.intimp.2020.106983_b0055","doi-asserted-by":"crossref","unstructured":"S. Wood, J.R. Sage, T. Shuman, S.G. Anagnostaras, Psychostimulants and cognition: a continuum of behavioral and cognitive activation. Pharmacol. Rev. 66(1) (2014. January 1) 193\u2013221.","DOI":"10.1124\/pr.112.007054"},{"key":"10.1016\/j.intimp.2020.106983_b0060","doi-asserted-by":"crossref","unstructured":"M. J. Minzenberg, CS. Carter, Modafinil: A review of neurochemical actions and effects on cognition. Neuropsychopharmacol 33(7) (2008) 1477-10.","DOI":"10.1038\/sj.npp.1301534"},{"key":"10.1016\/j.intimp.2020.106983_b0065","doi-asserted-by":"crossref","unstructured":"T. Ishizuka, T. Murotani, A. Yamatodani, Modanifil activates the histaminergic system through the orexinergic neurons. Neurosci. Lett. 483(3) (2010) 193\u2013196.","DOI":"10.1016\/j.neulet.2010.08.005"},{"issue":"1","key":"10.1016\/j.intimp.2020.106983_b0070","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/21556660.2020.1745209","article-title":"A review on modafinil: the characteristics, function, and use in critical care","volume":"9","author":"Hashemian","year":"2020","journal-title":"J. Drug Assess."},{"issue":"3","key":"10.1016\/j.intimp.2020.106983_b0075","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s11011-018-0378-0","article-title":"Neuroprotective effect of ethanol and Modafinil on focal cerebral ischemia in rats","volume":"34","author":"Abbasi","year":"2019","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.intimp.2020.106983_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2019.104305","article-title":"Protective effects of modafinil administration on testicular torsion\/detorsion damage in rats","volume":"111","author":"Yousefi-Manesh","year":"2019","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.intimp.2020.106983_b0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s43440-019-00054-5","article-title":"Biochemical and histopathological evidence for the beneficial effects of modafinil on the rat model of inflammatory bowel disease: involvement of nitric oxide pathway","volume":"72","author":"Dejban","year":"2020","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.intimp.2020.106983_b0090","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1080\/08923973.2019.1669045","article-title":"Therapeutic effects of modafinil in ischemic stroke; possible role of NF-\u03baB downregulation","volume":"41","author":"Yousefi Manesh","year":"2019","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.intimp.2020.106983_b0095","doi-asserted-by":"crossref","unstructured":"J. Han ,D. Chen ,D.i Liu ,Y. Zhu, Modafinil attenuates inflammation via inhibiting Akt\/NF-\u03baB pathway in apoE-deficient mouse model of atherosclerosis, Inflammopharmacology 26(2) (2018) 385\u2013393. doi: 10.1007\/s10787-017-0387-3. Epub 2017 Aug 21.","DOI":"10.1007\/s10787-017-0387-3"},{"issue":"1","key":"10.1016\/j.intimp.2020.106983_b0100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/0269881117722997","article-title":"R Lara distinct sensitivity to caffeine-induced insomnia related to age","volume":"32","author":"Frozi Hu","year":"2018","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.intimp.2020.106983_b0105","doi-asserted-by":"crossref","unstructured":"A. Zager, Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders, Brain, Behavior, Immunity. Available online 18 April 2020.","DOI":"10.1016\/j.bbi.2020.04.038"},{"key":"10.1016\/j.intimp.2020.106983_b0110","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.jpedsurg.2014.01.057","article-title":"The effect of colchicine and low-dose methotrexate on intestinal ischemia\/reperfusion injury in an experimental model","volume":"49","author":"Boybeyi","year":"2014","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.intimp.2020.106983_b0115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Ann. Biochem."},{"key":"10.1016\/j.intimp.2020.106983_b0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/abio.2002.5676","article-title":"Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy","volume":"306","author":"Sastry","year":"2002","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.intimp.2020.106983_b0125","series-title":"Theory and practice of histological techniques","author":"Bancroft","year":"2008"},{"key":"10.1016\/j.intimp.2020.106983_b0130","series-title":"Bancroft's Theory and Practice of Histological Techniques: Expert Consult: Online and Print, 7e: Hardcover ISBN: 9780702042263","author":"Suvarna","year":"2012"},{"issue":"2","key":"10.1016\/j.intimp.2020.106983_b0135","doi-asserted-by":"crossref","first-page":"192","DOI":"10.21608\/EJH.2018.13841","article-title":"Royal jelly protects agains experimentally-induced ulcerative colitis in adult male albino rats: A histological study","volume":"41","author":"Ismail","year":"2018","journal-title":"Egypt. J. Histol."},{"issue":"2","key":"10.1016\/j.intimp.2020.106983_b0140","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/2045-9912.208515","article-title":"Protective effects of hydrogen rich water on the intestinal ischemia\/reperfusion injury due to intestinal intussusception in a rat model","volume":"7","author":"Wu","year":"2017","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.intimp.2020.106983_b0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/bmc.3361","article-title":"Quantification of malondialdehyde by HPLC-FL-application to various biological samples","volume":"29","author":"Domijan","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.intimp.2020.106983_b0150","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/792016","article-title":"Prophylactic Ozone Administration Reduces Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in the Rat","author":"Onal","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.intimp.2020.106983_b0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/08941930903469375","article-title":"Protective effects of Nigella sativa on intestinal ischemia-reperfusion injury in rats","volume":"23","author":"Terzi","year":"2010","journal-title":"J. Invest. Surg."},{"key":"10.1016\/j.intimp.2020.106983_b0160","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-079X.2004.00148.x","article-title":"Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage","volume":"37","author":"Ates","year":"2004","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.intimp.2020.106983_b0165","doi-asserted-by":"crossref","unstructured":"S. Yamamoto, M. Tanabe, G. Wakabayashi, M. Shimazu, K. Matsumoto, M. Kitajima, The role of tumor necrosis factor-alpha and interleukin-1beta in ischemia-reperfusion injury of the rat small intestine, Am. J. Vet. Res. 63 (2002) 1680\u20131686. [PubMed] [Google Scholar].","DOI":"10.2460\/ajvr.2002.63.1680"},{"issue":"2","key":"10.1016\/j.intimp.2020.106983_b0170","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/01.shk.0000238068.84826.52","article-title":"Lymphatic thoracic duct ligation modulates the serum levels of IL-1beta and IL-10 after intestinal ischemia\/reperfusion in rats with the involvement of tumor necrosis factor alpha and nitric oxide","volume":"27","author":"Cavriani","year":"2007","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.intimp.2020.106983_b0175","first-page":"134","article-title":"Kinetics of endotoxin concentration and tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 activities in the systemic and portal circulation during small intestinal ischemia and reperfusion in","volume":"99","author":"Nezu","year":"2001","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.intimp.2020.106983_b0180","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s10495-012-0706-5","article-title":"Amplification activation loop between caspase-8 and -9 dominates artemisinin-induced apoptosis of ASTC-a-1 cells","volume":"17","author":"Xiao","year":"2012","journal-title":"Apoptosis"},{"key":"10.1016\/j.intimp.2020.106983_b0185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jss.2007.12.781","article-title":"Taurine attenuates multiple organ injury induced by intestinal ischemia reperfusion in rats","volume":"149","author":"Zhang","year":"2008","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.intimp.2020.106983_b0190","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s00268-002-4056-2","article-title":"Role of nitric oxide and peroxynitrite in gut barrier failure","volume":"26","author":"Potoka","year":"2002","journal-title":"World J. Surg."},{"issue":"2","key":"10.1016\/j.intimp.2020.106983_b0195","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3892\/etm.2015.2561","article-title":"Protective effects of dexmedetomidine on intestinal ischemia-reperfusion injury","volume":"10","author":"Sun","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2020.106983_b0200","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1248\/yakushi.131.453","article-title":"Alteration of P-gp expression after intestinal ischemia-reperfusion following 16-h fasting in","volume":"3","author":"Ogura","year":"2011","journal-title":"Pharm. Soc. Jpn."},{"issue":"2","key":"10.1016\/j.intimp.2020.106983_b0205","doi-asserted-by":"crossref","first-page":"266","DOI":"10.18433\/J3JG7D","article-title":"Intestinal P-glycoprotein expression is multimodally regulated by intestinal ischemia-reperfusion","volume":"17","author":"Terada","year":"2014","journal-title":"J. Pharm. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2020.106983_b0210","doi-asserted-by":"crossref","first-page":"17788","DOI":"10.1038\/s41598-018-36198-2","article-title":"DNase-1 treatment exerts protective effects in a rat model of intestinal ischemia-reperfusion injury","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2020.106983_b0215","doi-asserted-by":"crossref","unstructured":"F.J. Guzm\u00e1n-De La Garza, C.R. C\u00e1mara-Lemarroy, R.G. Ballesteros-Elizondo, G. Alarc\u00f3n-Galv\u00e1n, P. Cordero-P\u00e9rez, N.E. Fern\u00e1ndez-Garza, Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia\/reperfusion in rats, Surg. Today 40(11) (2010) 1055\u20131062. doi: 10.1007\/s00595-009-4177-4. Epub 2010 Nov 3. PMID: 21046505.","DOI":"10.1007\/s00595-009-4177-4"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920308213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920308213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T22:02:25Z","timestamp":1744495345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920308213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":43,"alternative-id":["S1567576920308213"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106983","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential protective effect of modafinil in intestinal ischemic reperfusion-induced in rats","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.106983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106983"}}