{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:42:17Z","timestamp":1784126537666,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81503556"],"award-info":[{"award-number":["81503556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2019JJ50469"],"award-info":[{"award-number":["2019JJ50469"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.intimp.2020.107151","type":"journal-article","created":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T17:29:02Z","timestamp":1607275742000},"page":"107151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Amygdalin inhibits TGF\u03b21-induced activation of hepatic stellate cells (HSCs) in vitro and CCl4-induced hepatic fibrosis in rats in vivo"],"prefix":"10.1016","volume":"90","author":[{"given":"Ruoyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2020.107151_b0005","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.intimp.2020.107151_b0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bpg.2011.02.005","article-title":"Mechanisms of hepatic fibrogenesis","volume":"25","author":"Lee","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"issue":"4","key":"10.1016\/j.intimp.2020.107151_b0015","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.intimp.2020.107151_b0020","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/S0016-5085(99)70413-0","article-title":"The virtuosity of hepatic stellate cells","volume":"117","author":"Friedman","year":"1999","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.intimp.2020.107151_b0025","doi-asserted-by":"crossref","first-page":"G7","DOI":"10.1152\/ajpgi.2000.279.1.G7","article-title":"Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex","volume":"279","author":"Eng","year":"2000","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"issue":"3","key":"10.1016\/j.intimp.2020.107151_b0030","first-page":"27","article-title":"Hepatic fibrosis\u2013role of hepatic stellate cell activation","volume":"4","author":"Safadi","year":"2002","journal-title":"MedGenMed"},{"issue":"2 Suppl","key":"10.1016\/j.intimp.2020.107151_b0035","first-page":"37","article-title":"Transforming growth factor-beta (TGF-beta): a key-role in liver fibrogenesis","volume":"22","author":"Bedossa","year":"1995","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.intimp.2020.107151_b0040","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/jhep.2001.28457","article-title":"Transforming growth factor beta and the liver","volume":"34","author":"Bissell","year":"2001","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.intimp.2020.107151_b0045","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2012.11.022","article-title":"miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis","volume":"58","author":"Roderburg","year":"2013","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.intimp.2020.107151_b0050","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bpg.2011.02.011","article-title":"Anti-fibrogenic strategies and the regression of fibrosis","volume":"25","author":"Kisseleva","year":"2011","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"issue":"2","key":"10.1016\/j.intimp.2020.107151_b0055","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.clnu.2012.07.001","article-title":"Garlic extract attenuating rat liver fibrosis by inhibiting TGF-beta1","volume":"32","author":"D'Argenio","year":"2013","journal-title":"Clin. Nutr."},{"issue":"3","key":"10.1016\/j.intimp.2020.107151_b0060","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1248\/bpb.28.449","article-title":"Armeniacae semen extract suppresses lipopolysaccharide-induced expressions of cyclooxygenase [correction of cycloosygenase]-2 and inducible nitric oxide synthase in mouse BV2 microglial cells","volume":"28","author":"Chang","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2020.107151_b0065","unstructured":"T. Fukuda, T. Ito H Fau - Mukainaka, H. Mukainaka T Fau - Tokuda, H. Tokuda H Fau - Nishino, T. Nishino H Fau - Yoshida, T. Yoshida, Anti-tumor promoting effect of glycosides from Prunus persica seeds, (0918-6158 (Print))."},{"issue":"5","key":"10.1016\/j.intimp.2020.107151_b0070","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.3892\/mmr.2013.1391","article-title":"Amygdalin inhibits renal fibrosis in chronic kidney disease","volume":"7","author":"Guo","year":"2013","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2020.107151_b0075","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/aps.2016.35","article-title":"Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2\/9, TIMP1\/2 and the TGF-beta\/Smad signaling pathways","volume":"37","author":"Li","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2020.107151_b0080","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jep.2018.11.027","article-title":"Chinese medicine CGA formula ameliorates liver fibrosis induced by carbon tetrachloride involving inhibition of hepatic apoptosis in rats","volume":"232","author":"Tian","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2020.107151_b0085","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1038\/s41598-017-05190-7","article-title":"ENMD-1068 inhibits liver fibrosis through attenuation of TGF-\u03b21\/Smad2\/3 signaling in mice","volume":"7","author":"Quan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2020.107151_b0090","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.biopha.2018.08.156","article-title":"Knockdown of LOXL1 inhibits TGF-beta1-induced proliferation and fibrogenesis of hepatic stellate cells by inhibition of Smad2\/3 phosphorylation","volume":"107","author":"Ma","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.intimp.2020.107151_b0095","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/hep.20452","article-title":"Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice","volume":"40","author":"Sakaida","year":"2004","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.intimp.2020.107151_b0100","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1572-0241.1999.884_m.x","article-title":"Quantitative analysis of liver fibrosis and stellate cell changes in patients with chronic hepatitis C after interferon therapy","volume":"94","author":"Sakaida","year":"1999","journal-title":"Am. J. Gastroenterol."},{"issue":"11","key":"10.1016\/j.intimp.2020.107151_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005991","article-title":"A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes","volume":"12","author":"Sulaiman","year":"2016","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.intimp.2020.107151_b0110","doi-asserted-by":"crossref","first-page":"11976","DOI":"10.1002\/jcp.27854","article-title":"Activation of TGF-beta1\/Smad3 signaling pathway inhibits the development of ovarian follicle in polycystic ovary syndrome by promoting apoptosis of granulosa cells","volume":"234","author":"Shen","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"7","key":"10.1016\/j.intimp.2020.107151_b0115","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1440-1746.1999.01928.x","article-title":"Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy","volume":"14","author":"Li","year":"1999","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.intimp.2020.107151_b0120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncpgasthep0055","article-title":"Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications","volume":"1","author":"Friedman","year":"2004","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.intimp.2020.107151_b0125","first-page":"555","article-title":"The role of thrombocytes in liver fibrogenesis: effects of platelet lysate and thrombocyte-derived growth factors on the mitogenic activity and glycosaminoglycan synthesis of cultured rat liver fat storing cells","volume":"27","author":"Bachem","year":"1989","journal-title":"J. Clin. Chem. Clin. Biochem."},{"issue":"10","key":"10.1016\/j.intimp.2020.107151_b0130","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1478-3231.2006.01342.x","article-title":"Role of Kupffer cells in host defense and liver disease","volume":"26","author":"Bilzer","year":"2006","journal-title":"Liver Int."},{"issue":"6","key":"10.1016\/j.intimp.2020.107151_b0135","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/17474124.2.6.803","article-title":"Advances in antifibrotic therapy","volume":"2","author":"Ghiassi-Nejad","year":"2008","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.intimp.2020.107151_b0140","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1582-4934.2006.tb00292.x","article-title":"Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets","volume":"10","author":"Gressner","year":"2006","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2020.107151_b0145","first-page":"210","article-title":"Effect of CKJ recipe containing serum on activation of rat primary hepatic stellate cells, TGF-beta1 and its receptors","volume":"35","author":"Chen","year":"2015","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"4","key":"10.1016\/j.intimp.2020.107151_b0150","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/j.2040-4603.2013.tb00529.x","article-title":"Hepatic stellate cells and liver fibrosis","volume":"3","author":"Puche","year":"2013","journal-title":"Compr. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2020.107151_b0155","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2020.107151_b0160","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-2001-17554","article-title":"Cytokine receptors and signaling in hepatic stellate cells","volume":"21","author":"Pinzani","year":"2001","journal-title":"Semin. Liver Dis."},{"issue":"7","key":"10.1016\/j.intimp.2020.107151_b0165","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jcyt.2014.03.001","article-title":"TEMPORARY REMOVAL: CD271 identifies functional human hepatic stellate cells, which localize in peri-sinusoidal and portal areas in liver after partial hepatectomy","volume":"16","author":"Patil","year":"2014","journal-title":"Cytotherapy"},{"issue":"4","key":"10.1016\/j.intimp.2020.107151_b0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153118","article-title":"Characterization of the MMP\/TIMP imbalance and collagen production induced by IL-1beta or TNF-alpha release from human hepatic stellate cells","volume":"11","author":"Robert","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.intimp.2020.107151_b0175","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-beta: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.intimp.2020.107151_b0180","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-beta\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.intimp.2020.107151_b0185","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jcma.2017.09.005","article-title":"Amygdalin improves microcirculatory disturbance and attenuates pancreatic fibrosis by regulating the expression of endothelin-1 and calcitonin gene-related peptide in rats","volume":"81","author":"Zhang","year":"2018","journal-title":"J. Chin. Med. Assoc."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920336183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920336183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:42:19Z","timestamp":1762551739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920336183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":37,"alternative-id":["S1567576920336183"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.107151","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amygdalin inhibits TGF\u03b21-induced activation of hepatic stellate cells (HSCs) in vitro and CCl4-induced hepatic fibrosis in rats in vivo","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.107151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107151"}}