{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T20:49:31Z","timestamp":1774212571690,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.intimp.2020.107200","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T09:57:31Z","timestamp":1606211851000},"page":"107200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears"],"prefix":"10.1016","volume":"90","author":[{"family":"Jun-Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Fang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Cun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.intimp.2020.107200_b0005","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1524-4725.1999.98257.x","article-title":"Keloids and hypertrophic scars","volume":"25","author":"English","year":"1999","journal-title":"Dermatol. Surg."},{"issue":"1","key":"10.1016\/j.intimp.2020.107200_b0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jocd.13192","article-title":"A new approach in the treatment of pediatric hypertrophic burn scars: Tixel-associated topical triamcinolone acetonide and 5-fluorouracil delivery","volume":"19","author":"Artzi","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2020.107200_b0015","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s12079-013-0195-5","article-title":"The molecular mechanism of hypertrophic scar","volume":"7","author":"Zhu","year":"2013","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.intimp.2020.107200_b0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.canlet.2019.10.015","article-title":"Targeting USP9x\/SOX2 axis contributes to the anti-osteosarcoma effect of neogambogic acid","volume":"469","author":"Chen","year":"2020","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.intimp.2020.107200_b0025","first-page":"1700","article-title":"Gambogenic acid inhibits the proliferation of smallcell lung cancer cells by arresting the cell cycle and inducing apoptosis","volume":"41","author":"Huang","year":"2019","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2020.107200_b0030","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/abbs\/gmw021","article-title":"Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-kappaB and MAPK in macrophages","volume":"48","author":"Yu","year":"2016","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"issue":"21","key":"10.1016\/j.intimp.2020.107200_b0035","first-page":"4311","article-title":"Mechanism of gambogenic acid in resisting angiogenesis of lung cancer in vitro","volume":"43","author":"Cheng","year":"2018","journal-title":"Zhongguo Zhong Yao Za Zhi."},{"issue":"2","key":"10.1016\/j.intimp.2020.107200_b0040","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbrc.2016.09.159","article-title":"Lumican alleviates hypertrophic scarring by suppressing integrin-FAK signaling","volume":"480","author":"Zhao","year":"2016","journal-title":"Biochem. Biophys. Res.. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2020.107200_b0045","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00006534-199709000-00021","article-title":"Acute and chronic animal models for excessive dermal scarring quantitative studies","volume":"100","author":"Morris","year":"1997","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.intimp.2020.107200_b0050","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ejphar.2016.09.034","article-title":"Inhibitory effect of recombinant human endostatin on the proliferation of hypertrophic scar fibroblasts in a rabbit ear model","volume":"791","author":"Gong","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2020.107200_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","article-title":"Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma","volume":"324","author":"Weidner","year":"1991","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.intimp.2020.107200_b0060","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/bmc.3311","article-title":"Simultaneous determination and pharmacokinetic study of gambogic acid and gambogenic acid in rat plasma after oral administration of Garcinia hanburyi extracts by LC-MS\/MS","volume":"29","author":"Hua","year":"2015","journal-title":"Biomed. Chromatogr."},{"issue":"6","key":"10.1016\/j.intimp.2020.107200_b0065","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1089\/jop.2012.0208","article-title":"Subconjunctival triamcinolone acetonide in the management of ocular inflammatory disease","volume":"29","author":"Athanasiadis","year":"2013","journal-title":"J. Ocul. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2020.107200_b0070","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/bjd.13954","article-title":"Cellular and molecular mechanisms of repair in acute and chronic wound healing","volume":"173","author":"Martin","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2020.107200_b0075","doi-asserted-by":"crossref","first-page":"tkz003","DOI":"10.1093\/burnst\/tkz003","article-title":"Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence","volume":"8","author":"Shirakami","year":"2020","journal-title":"Burns Trauma"},{"issue":"2","key":"10.1016\/j.intimp.2020.107200_b0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1468-3083.2011.04200.x","article-title":"Extracellular matrix molecules implicated in hypertrophic and keloid scarring","volume":"26","author":"Sidgwick","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"3","key":"10.1016\/j.intimp.2020.107200_b0085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/bioengineering6030056","article-title":"Sources of collagen for biomaterials in skin wound healing","volume":"6","author":"Davison-Kotler","year":"2019","journal-title":"Bioengineering (Basel)"},{"issue":"4","key":"10.1016\/j.intimp.2020.107200_b0090","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.smim.2014.04.007","article-title":"Inflammation and wound repair","volume":"26","author":"LeBert","year":"2014","journal-title":"Semin. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2020.107200_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071545","article-title":"Macrophage phenotypes regulate scar formation and chronic wound healing","volume":"18","author":"Hesketh","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2020.107200_b0100","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.1096\/fj.10-178087","article-title":"Mechanical force prolongs acute inflammation via T-cell-dependent pathways during scar formation","volume":"25","author":"Wong","year":"2011","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.intimp.2020.107200_b0105","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.3892\/mmr.2017.7209","article-title":"Naringenin attenuates fibroblast activation and inflammatory response in a mechanical stretch-induced hypertrophic scar mouse model","volume":"16","author":"Shan","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.intimp.2020.107200_b0110","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tcb.2005.09.002","article-title":"Inflammatory cells during wound repair: the good, the bad and the ugly","volume":"15","author":"Martin","year":"2005","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.intimp.2020.107200_b0115","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/sonc.2002.37264","article-title":"Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications","volume":"29","author":"Ferrara","year":"2002","journal-title":"Semin. Oncol."},{"issue":"4","key":"10.1016\/j.intimp.2020.107200_b0120","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3390\/ijms19041264","article-title":"Molecular pharmacology of VEGF-a isoforms: binding and signalling at VEGFR2","volume":"19","author":"Peach","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.intimp.2020.107200_b0125","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrm.2016.87","article-title":"Mechanisms and regulation of endothelial VEGF receptor signalling","volume":"17","author":"Simons","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2020.107200_b0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1084\/jem.172.1.245","article-title":"Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db db mice","volume":"17","author":"Tsuboi","year":"1990","journal-title":"J. Exp.. Med."},{"key":"10.1016\/j.intimp.2020.107200_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2017.12.002","article-title":"Important signals regulating coronary artery angiogenesis","volume":"117","author":"Shoeibi","year":"2018","journal-title":"Microvasc. Res."},{"issue":"3","key":"10.1016\/j.intimp.2020.107200_b0140","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/jsre.1994.1036","article-title":"Basic fibroblast growth factor in the early human burn wound","volume":"56","author":"Gibran","year":"1994","journal-title":"J. Surg. Res."},{"issue":"9","key":"10.1016\/j.intimp.2020.107200_b0145","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.3390\/ijms19092638","article-title":"Bradykinin B2 receptor contributes to inflammatory responses in human endothelial cells by the transactivation of the fibroblast growth factor receptor FGFR-1","volume":"19","author":"Terzuoli","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2020.107200_b0150","first-page":"267","article-title":"Signal transduction in angiogenesis","volume":"94","author":"Zachary","year":"2005","journal-title":"Exs"},{"key":"10.1016\/j.intimp.2020.107200_b0155","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-beta\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.intimp.2020.107200_b0160","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.burns.2011.08.013","article-title":"Effect of tetrandrine on the TGF-beta-induced smad signal transduction pathway in human hypertrophic scar fibroblasts in vitro","volume":"38","author":"Zunwen","year":"2012","journal-title":"Burns"},{"key":"10.1016\/j.intimp.2020.107200_b0165","doi-asserted-by":"crossref","unstructured":"A.S. Colwell, T.T. Phan, W. Kong, M.T. Longaker, P.H. Lorenz, Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation, Plast Reconstr Surg. 116(5) (2005) 1387-1390; discussion 1391-1392. Doi: 10.1097\/01.prs.0000182343.99694.28.","DOI":"10.1097\/01.prs.0000182343.99694.28"},{"issue":"2","key":"10.1016\/j.intimp.2020.107200_b0170","doi-asserted-by":"crossref","first-page":"192e","DOI":"10.1097\/PRS.0000000000004590","article-title":"Anti-CTGF oligonucleotide reduces severity of postsurgical hypertrophic scars in a randomized, double-blind, within-subject, placebo-controlled study","volume":"142","author":"Jensen","year":"2018","journal-title":"Plast. Reconstr. Surg."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920336675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920336675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:48:45Z","timestamp":1762552125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920336675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":34,"alternative-id":["S1567576920336675"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.107200","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.107200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107200"}}