{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:31:50Z","timestamp":1784817110035,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010784","name":"Banco Santander","doi-asserted-by":"publisher","award":["PR26\/16-20243"],"award-info":[{"award-number":["PR26\/16-20243"]}],"id":[{"id":"10.13039\/100010784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.intimp.2020.107241","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T11:58:17Z","timestamp":1607860697000},"page":"107241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Modulation by Anisakis simplex antigen of inflammatory response generated in experimental autoimmune encephalomyelitis"],"prefix":"10.1016","volume":"90","author":[{"given":"Marta","family":"Rodero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Cu\u00e9llar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.107241_b0005","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20031579","article-title":"Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis","volume":"199","author":"Viglietta","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2020.107241_b0010","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1212\/01.wnl.0000247663.40297.2d","article-title":"Multiple sclerosis and the hygiene hypothesis","volume":"67","author":"Fleming","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2020.107241_b0015","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/IAI.71.9.4996-5004.2003","article-title":"Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis","volume":"71","author":"La Flamme","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.intimp.2020.107241_b0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jneuroim.2007.12.001","article-title":"Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response","volume":"194","author":"Zheng","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2020.107241_b0025","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4049\/jimmunol.0803803","article-title":"Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses","volume":"183","author":"Walsh","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0030","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/eji.200939721","article-title":"Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation","volume":"40","author":"Wilson","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cellimm.2010.11.006","article-title":"Taenia crassiceps infection abrogates experimental autoimmune encephalomyelitis","volume":"267","author":"Reyes","year":"2011","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0040","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.imbio.2019.08.004","article-title":"Effects of intestinal nematode treatment on CD11b activation state in an EAE mouse model of multiple sclerosis","volume":"224","author":"Donskow-\u0141ysoniewska","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.intimp.2020.107241_b0045","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/00365549850161179","article-title":"Effects of Anisakis simplex on nitric oxide production in J774 macrophages","volume":"30","author":"Cu\u00e9llar","year":"1998","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.intimp.2020.107241_b0050","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1046\/j.1365-3083.2001.00905.x","article-title":"Presence of IL-4-like molecules in larval excretory-secretory products and crude extracts from Anisakis simplex","volume":"53","author":"Cu\u00e9llar","year":"2001","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0055","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.4049\/jimmunol.0803533","article-title":"Macrophage migration inhibitory factor homologs of Anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment","volume":"182","author":"Park","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0060","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-3024.2010.01276.x","article-title":"Amelioration of intestinal colitis by macrophage migration inhibitory factor isolated from intestinal parasites through toll-like receptor 2","volume":"33","author":"Cho","year":"2011","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0065","doi-asserted-by":"crossref","first-page":"e12616","DOI":"10.1111\/pim.12616","article-title":"Induction of tolerogenic properties by Anisakis larval antigens on murine dendritic cells","volume":"41","author":"Zamora","year":"2019","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0070","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-3024.2011.01282.x","article-title":"Different serum cytokine levels in chronic vs. acute Anisakis simplex sensitization-associated urticaria","volume":"33","author":"Daschner","year":"2011","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0075","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2332\/allergolint.12-OA-0504","article-title":"Different fish-eating habits and cytokine production in chronic urticaria with and without sensitization against the fish-parasite Anisakis simplex","volume":"62","author":"Daschner","year":"2013","journal-title":"Allergol. Int."},{"key":"10.1016\/j.intimp.2020.107241_b0080","doi-asserted-by":"crossref","first-page":"e89188","DOI":"10.1371\/journal.pone.0089188","article-title":"Molecular genotyping of Anisakis larvae in Middle Eastern Japan and endoscopic evidence for preferential penetration of normal over atrophic mucosa","volume":"9","author":"Arai","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2020.107241_b0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1474-4422(03)00308-9","article-title":"Multiple sclerosis in the Japanese population","volume":"2","author":"Kira","year":"2003","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.intimp.2020.107241_b0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0020-7519(95)00111-5","article-title":"In vitro study on the effect of larval excretory\/secretory products and crude extracts from Anisakis simplex on blood coagulation","volume":"26","author":"Perteguer","year":"1996","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.intimp.2020.107241_b0095","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/08916939809003872","article-title":"Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein","volume":"28","author":"Slavin","year":"1998","journal-title":"Autoimmunity"},{"key":"10.1016\/j.intimp.2020.107241_b0100","doi-asserted-by":"crossref","first-page":"e108791","DOI":"10.1371\/journal.pone.0108791","article-title":"Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice","volume":"9","author":"Montarolo","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2020.107241_b0105","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fcimb.2012.00112","article-title":"Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients?","volume":"2","author":"Correale","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2020.107241_b0110","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1439-0450.1998.tb00833.x","article-title":"Isotype-specific immune responses in murine experimental anisakiasis","volume":"45","author":"Perteguer","year":"1998","journal-title":"J. Vet. Med. Ser. B"},{"key":"10.1016\/j.intimp.2020.107241_b0115","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/01.nrl.0000204859.15501.6b","article-title":"Emerging monoclonal antibody therapies for multiple sclerosis","volume":"12","author":"Cree","year":"2006","journal-title":"Neurologist"},{"key":"10.1016\/j.intimp.2020.107241_b0120","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1212\/WNL.0b013e318249f6f0","article-title":"The evidence for a role of B cells in multiple sclerosis","volume":"78","author":"Disanto","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2020.107241_b0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneuroim.2010.02.008","article-title":"The antibody response to oligodendrocyte specific protein in multiple sclerosis","volume":"221","author":"Aslam","year":"2010","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2020.107241_b0130","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1373\/clinchem.2012.194423","article-title":"Antigen microarrays for the study of autoimmune diseases","volume":"59","author":"Yeste","year":"2013","journal-title":"Clin. Chem."},{"key":"10.1016\/j.intimp.2020.107241_b0135","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40263-015-0299-y","article-title":"Teriflunomide in patients with relapsing-remitting forms of multiple sclerosis","volume":"30","author":"Chan","year":"2016","journal-title":"CNS Drugs"},{"key":"10.1016\/j.intimp.2020.107241_b0145","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1056\/NEJM200011163432001","article-title":"Relapses and progression of disability in multiple sclerosis","volume":"343","author":"Confavreux","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2020.107241_b0150","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1093\/brain\/awg081","article-title":"Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process","volume":"126","author":"Confavreux","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.intimp.2020.107241_b0155","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood-brain barrier in health and chronic neurodegenerative disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2020.107241_b0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mod.2015.07.007","article-title":"Formation and maintenance of the BBB","volume":"138","author":"Blanchette","year":"2015","journal-title":"Mech. Dev."},{"key":"10.1016\/j.intimp.2020.107241_b0165","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1034\/j.1398-9995.2001.00207.x","article-title":"Serum CD23 is not altered in gastroallergic anisakiasis, but correlates with the production of specific IgE and the amount of polyclonal stimulation","volume":"56","author":"Daschner","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2020.107241_b0170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cyto.2005.07.012","article-title":"Cytokines in the induction and resolution of experimental autoimmune encephalomyelitis","volume":"32","author":"McGeachy","year":"2005","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2020.107241_b0175","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.intimp.2018.08.021","article-title":"Impacts of simultaneous exposure to arsenic (III) and copper (II) on inflammatory response, immune homeostasis, and heat shock response in chicken thymus","volume":"64","author":"Liu","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2020.107241_b0180","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1084\/jem.20012076","article-title":"Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation","volume":"195","author":"Gorelik","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2020.107241_b0185","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.4049\/jimmunol.1000288","article-title":"TGF-beta enhances effector Th1 cell activation but promotes self-regulation via IL-10","volume":"184","author":"Huss","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2020.107241_b0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2020.107241_b0195","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/1352458513498128","article-title":"Tumor necrosis factor is elevated in progressive multiple sclerosis and causes excitotoxic neurodegeneration","volume":"20","author":"Rossi","year":"2014","journal-title":"Multiple Sclerosis"},{"key":"10.1016\/j.intimp.2020.107241_b0200","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1007\/s00018-008-8059-5","article-title":"Astrocytes in multiple sclerosis: a product of their environment","volume":"65","author":"Nair","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2020.107241_b0205","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.intimp.2020.107241_b0210","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.1107","article-title":"Immune function of astrocytes","volume":"36","author":"Dong","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2020.107241_b0215","doi-asserted-by":"crossref","first-page":"327470","DOI":"10.1155\/2015\/327470","article-title":"T helper lymphocyte subsets and plasticity in autoimmunity and cancer: an overview","volume":"2015","author":"Ivanova","year":"2015","journal-title":"Biomed Res. Int."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920337085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920337085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T04:31:02Z","timestamp":1744950662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920337085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":43,"alternative-id":["S1567576920337085"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.107241","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation by Anisakis simplex antigen of inflammatory response generated in experimental autoimmune encephalomyelitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.107241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107241"}}