{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:27:55Z","timestamp":1785162475287,"version":"3.55.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.intimp.2020.107356","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T13:56:46Z","timestamp":1610459806000},"page":"107356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Sesamin alleviates diabetes-associated behavioral deficits in rats: The role of inflammatory and neurotrophic factors"],"prefix":"10.1016","volume":"92","author":[{"given":"Shahab","family":"Ghaderi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masome","family":"Rashno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Nesari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Esmaeil","family":"Khoshnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Sarkaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layasadat","family":"Khorsandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaghoob","family":"Farbood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khodabakhsh","family":"Rashidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2020.107356_b0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"Guariguata","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.intimp.2020.107356_b0010","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jep.2013.09.003","article-title":"Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat","volume":"150","author":"Liu","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2020.107356_b0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neulet.2013.06.002","article-title":"Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat","volume":"549","author":"Liu","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2020.107356_b0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2019.03.078","article-title":"Ellagic acid protects against diabetes-associated behavioral deficits in rats: possible involved mechanisms","volume":"225","author":"Farbood","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2020.107356_b0025","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/1753-0407.12193","article-title":"Type 1 diabetes-associated cognitive decline: a meta-analysis and update of the current literature 1","volume":"6","author":"Tonoli","year":"2014","journal-title":"J. Diabetes."},{"key":"10.1016\/j.intimp.2020.107356_b0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.biopha.2017.09.146","article-title":"Aloe vera gel improves behavioral deficits and oxidative status in streptozotocin-induced diabetic rats","volume":"96","author":"Tabatabaei","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2020.107356_b0035","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/17512433.2017.1293521","article-title":"Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications","volume":"10","author":"Hamed","year":"2017","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"10.1016\/j.intimp.2020.107356_b0040","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.lfs.2019.05.071","article-title":"Sesamin: a promising protective agent against diabetes-associated cognitive decline in rats","volume":"230","author":"Farbood","year":"2019","journal-title":"Life. Sci."},{"key":"10.1016\/j.intimp.2020.107356_b0045","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jneuroim.2017.11.006","article-title":"Pinocembrin alleviates cognition deficits by inhibiting inflammation in diabetic mice","volume":"314","author":"Pei","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2020.107356_b0050","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.neuroscience.2017.05.001","article-title":"Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocininduced diabetic mice","volume":"355","author":"Fang","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2020.107356_b0055","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/s11064-018-2503-1","article-title":"Chrysophanol relieves cognition deficits and neuronal loss through inhibition of inflammation in diabetic mice","volume":"43","author":"Chu","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2020.107356_b0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fendo.2019.00025","article-title":"Role of hippocampal lipocalin-2 in experimental diabetic encephalopathy","volume":"10","author":"Bhusal","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.intimp.2020.107356_b0065","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.phymed.2016.04.008","article-title":"Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde","volume":"23","author":"Jawale","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2020.107356_b0070","series-title":"Neurotrophic Factors, Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-7571-6_1","article-title":"Neurotrophic factors: an overview","author":"Skaper","year":"2018"},{"key":"10.1016\/j.intimp.2020.107356_b0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.intimp.2020.107356_b0080","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s11745-999-0408-2","article-title":"The metabolism and distribution of sesame lignans (sesamin and episesamin) in rats","volume":"34","author":"Umeda-Sawada","year":"1999","journal-title":"Lipids"},{"key":"10.1016\/j.intimp.2020.107356_b0085","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/bdd.1862","article-title":"Pharmacokinetics and safety of the sesame lignans, sesamin and episesamin, in healthy subjects","volume":"34","author":"Tomimori","year":"2013","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.intimp.2020.107356_b0090","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cbi.2009.10.003","article-title":"Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats","volume":"183","author":"Khan","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.intimp.2020.107356_b0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1742-2094-8-57","article-title":"Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation","volume":"8","author":"Hsieh","year":"2011","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.intimp.2020.107356_b0100","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopha.2017.01.123","article-title":"Sesamin imparts neuroprotection against intrastriatal 6-hydroxydopamine toxicity by inhibition of astroglial activation, apoptosis, and oxidative stress","volume":"88","author":"Baluchnejadmojarad","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2020.107356_b0105","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/aps.2017.103","article-title":"Sesamin alleviates blood-brain barrier disruption in mice with experimental traumatic brain injury","volume":"38","author":"Liu","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2020.107356_b0110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/19390211.2016.1204404","article-title":"Effect of sesamin supplementation on glycemic status, inflammatory markers, and adiponectin levels in patients with type 2 diabetes mellitus","volume":"14","author":"Mohammad Shahi","year":"2017","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.intimp.2020.107356_b0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jneuroim.2016.04.002","article-title":"Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy","volume":"295","author":"Ahmad","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2020.107356_b0120","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neulet.2016.09.055","article-title":"Effects of (-)-sesamin on chronic stress-induced memory deficits in mice","volume":"634","author":"Zhao","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2020.107356_b0125","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s11064-016-2146-z","article-title":"Effects of (\u2212)-Sesamin on chronic stress-induced anxiety disorders in mice","volume":"42","author":"Zhao","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2020.107356_b0130","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jnutbio.2018.10.006","article-title":"(+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation","volume":"64","author":"Zhao","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.intimp.2020.107356_b0135","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.3233\/JAD-170969","article-title":"Effects of composite supplement containing astaxanthin and sesamin on cognitive functions in people with mild cognitive impairment: a randomized, double-blind, placebo-controlled trial","volume":"62","author":"Ito","year":"2018","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.intimp.2020.107356_b0140","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0091-3057(86)90552-6","article-title":"Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat","volume":"24","author":"Pellow","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.intimp.2020.107356_b0145","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","article-title":"The open-field test: a critical review","volume":"83","author":"Walsh","year":"1976","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.intimp.2020.107356_b0150","series-title":"Mood and Anxiety Related Phenotypes in Mice, Neuromethods","first-page":"1","article-title":"The open field test","author":"Gould","year":"2009"},{"key":"10.1016\/j.intimp.2020.107356_b0155","doi-asserted-by":"crossref","unstructured":"N. Naghdi A. Asadollahi Genomic and nongenomic effects of intrahippocampal microinjection of testosterone on long-term memory in male adult rats Behav. Brain Res. 153 2004 1 6.","DOI":"10.1016\/j.bbr.2003.10.027"},{"key":"10.1016\/j.intimp.2020.107356_b0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pbb.2013.10.021","article-title":"Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress\u2013PARP pathway","volume":"114","author":"Jangra","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.intimp.2020.107356_b0165","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/aps.2013.158","article-title":"Oxymatrine attenuates diabetes-associated cognitive deficits in rats","volume":"35","author":"Wang","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2020.107356_b0170","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/jsfa.5974","article-title":"Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK-Ay mice","volume":"93","author":"Hong","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.intimp.2020.107356_b0175","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.3390\/nu7064689","article-title":"Sesamin ameliorates advanced glycation end products-induced pancreatic \u03b2-cell dysfunction and apoptosis","volume":"7","author":"Kong","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2020.107356_b0180","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ejphar.2012.09.031","article-title":"The sesame lignan sesamin attenuates vascular dysfunction in streptozotocin diabetic rats: involvement of nitric oxide and oxidative stress","volume":"698","author":"Baluchnejadmojarad","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2020.107356_b0185","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.3892\/mmr.2017.6420","article-title":"Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction","volume":"15","author":"Thuy","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2020.107356_b0190","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1399-5448.2009.00618.x","article-title":"Neurocognitive functioning in preschool-age children with type 1 diabetes mellitus","volume":"11","author":"Pati\u00f1o-Fern\u00e1ndez","year":"2010","journal-title":"Pediatr. Diabetes."},{"key":"10.1016\/j.intimp.2020.107356_b0195","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2337\/diacare.29.02.06.dc05-1626","article-title":"Improving metabolic control leads to better working memory in adults with type 2 diabetes","volume":"29","author":"Ryan","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.intimp.2020.107356_b0200","first-page":"561","article-title":"The aqueous extract of Portulaca oleracea ameliorates neurobehavioral dysfunction and hyperglycemia related to streptozotocin-diabetes induced in ovariectomized rats","volume":"15","author":"Tabatabaei","year":"2016","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.intimp.2020.107356_b0205","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2015.01.031","article-title":"Sesamin suppresses STZ induced INS-1 cell apoptosis through inhibition of NF-\u03baB activation and regulation of Bcl-2 family protein expression","volume":"750","author":"Zheng","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2020.107356_b0210","doi-asserted-by":"crossref","first-page":"16961","DOI":"10.3390\/ijms131216961","article-title":"Effects of sesamin on streptozotocin (STZ)-induced NIT-1 pancreatic \u03b2-cell damage","volume":"13","author":"Lei","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2020.107356_b0215","first-page":"2733","article-title":"Ameliorating effect of sesamin on insulin resistance of hepatic L02 cells induced by high glucose\/high insulin","volume":"32","author":"Mengxi","year":"2019","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.intimp.2020.107356_b0220","article-title":"Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathway","volume":"173052","author":"Li","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2020.107356_b0225","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1096\/fasebj.13.10.1137","article-title":"Is NF-\u03baB the sensor of oxidative stress?","volume":"13","author":"Li","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2020.107356_b0230","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnmol.2015.00077","article-title":"NF-kappaB signaling pathways in neurological inflammation: a mini review","volume":"8","author":"Shih","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2020.107356_b0235","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2020.107356_b0240","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1158\/1541-7786.MCR-09-0565","article-title":"Sesamin manifests chemopreventive effects through the suppression of NF-\u03baB\u2013regulated cell survival, proliferation, invasion, and angiogenic gene products","volume":"8","author":"Harikumar","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.intimp.2020.107356_b0245","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuint.2015.01.003","article-title":"Effects of (-)-sesamin on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and dopaminergic neuronal cells of Parkinson's disease rat models","volume":"83","author":"Park","year":"2015","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.intimp.2020.107356_b0250","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3892\/or.2015.3888","article-title":"Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-\u03baB signaling pathways in prostate cancer cells","volume":"33","author":"Xu","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.intimp.2020.107356_b0255","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.imlet.2004.10.004","article-title":"Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-\u03baB","volume":"97","author":"Jeng","year":"2005","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.intimp.2020.107356_b0260","doi-asserted-by":"crossref","first-page":"12441","DOI":"10.1021\/acs.jafc.9b03652","article-title":"Supplementation of sesamin alleviates stress-induced behavioral and psychological disorders via reshaping the gut microbiota structure","volume":"67","author":"Wang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2020.107356_b0265","doi-asserted-by":"crossref","first-page":"10883","DOI":"10.1523\/JNEUROSCI.2594-09.2009","article-title":"NGF is essential for hippocampal plasticity and learning","volume":"29","author":"Conner","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2020.107356_b0270","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nbd.2006.11.015","article-title":"Nerve growth factor promotes survival of new neurons in the adult hippocampus","volume":"26","author":"Frielingsdorf","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.intimp.2020.107356_b0275","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuropharm.2013.07.023","article-title":"Chronic intracerebroventricular infusion of nerve growth factor improves recognition memory in the rat","volume":"75","author":"Birch","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.intimp.2020.107356_b0280","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/j.1460-2075.1985.tb03791.x","article-title":"Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation","volume":"4","author":"Korsching","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2020.107356_b0285","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1101\/lm.54603","article-title":"BDNF and activity-dependent synaptic modulation","volume":"10","author":"Lu","year":"2003","journal-title":"Learn. Mem."},{"key":"10.1016\/j.intimp.2020.107356_b0290","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/7854_2012_220","article-title":"All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis","volume":"15","author":"Vivar","year":"2013","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.intimp.2020.107356_b0295","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/dneu.20765","article-title":"Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease","volume":"70","author":"Yoshii","year":"2010","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.intimp.2020.107356_b0300","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fnins.2013.00188","article-title":"Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking","volume":"7","author":"Baj","year":"2013","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2020.107356_b0305","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/1533317519860334","article-title":"Decreased levels of serum IGF-1 and vitamin D are associated with cognitive impairment in patients With type 2 diabetes","volume":"34","author":"Rui-hua","year":"2019","journal-title":"Am. J. Alzheimer's Dis."},{"key":"10.1016\/j.intimp.2020.107356_b0310","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fnins.2018.00073","article-title":"The role of insulin\/IGF-1\/PI3K\/Akt\/GSK3\u03b2 signaling in parkinson's disease dementia","volume":"12","author":"Yang","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2020.107356_b0315","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1134\/S1819712416010074","article-title":"Protective effect of lutein supplementation on oxidative stress and inflammatory progression in cerebral cortex of streptozotocin-induced diabetes in rats","volume":"10","author":"Fatani","year":"2016","journal-title":"Neurochem. J."},{"key":"10.1016\/j.intimp.2020.107356_b0320","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s10072-014-1628-5","article-title":"Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats","volume":"35","author":"Ola","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.intimp.2020.107356_b0325","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/9145458","article-title":"Sesamin promotes neurite outgrowth under insufficient nerve growth factor condition in PC12 cells through ERK1\/2 pathway and SIRT1 modulation","volume":"2020","author":"Udomruk","year":"2020","journal-title":"Evidence-Based Complementary Altern. Med."},{"key":"10.1016\/j.intimp.2020.107356_b0330","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1139\/cjpp-2014-0281","article-title":"Anti-depressant effect of hesperidin in diabetic rats","volume":"92","author":"El-Marasy","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.intimp.2020.107356_b0335","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1179\/1476830515Y.0000000015","article-title":"Anxiolytic effects of sesamin in mice with chronic inflammatory pain","volume":"19","author":"Guo","year":"2016","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.intimp.2020.107356_b0340","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.neuroscience.2016.10.042","article-title":"Effects of (\u2212)-sesamin on motor and memory deficits in an MPTP-lesioned mouse model of Parkinson\u2019s disease treated with l-DOPA","volume":"339","author":"Zhao","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2020.107356_b0345","first-page":"169","article-title":"Diabetes mellitus concomitantly facilitates the induction of long-term depression and inhibits that of long-term potentiation in hippocampus","volume":"22","author":"Artola","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2020.107356_b0350","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1046\/j.0022-3042.2001.00713.x","article-title":"Effects of streptozotocin-diabetes on the hippocampal NMDA receptor complex in rats","volume":"80","author":"Gardoni","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2020.107356_b0355","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.expneurol.2011.02.004","article-title":"Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications","volume":"233","author":"Reagan","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2020.107356_b0360","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1055\/s-0031-1280129","article-title":"Effects of insulin and St. John's wort treatments on anxiety, locomotory activity, depression, and active learning parameters of streptozotocin-diabetic rats","volume":"77","author":"Can","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2020.107356_b0365","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s11011-014-9540-5","article-title":"Insulin reverses anxiety-like behavior evoked by streptozotocin-induced diabetes in mice","volume":"29","author":"Gupta","year":"2014","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.intimp.2020.107356_b0370","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neulet.2012.10.045","article-title":"Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes","volume":"531","author":"Aksu","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2020.107356_b0375","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuropharm.2017.12.001","article-title":"Insulin-mediated synaptic plasticity in the CNS; anatomical, functional and temporal contexts","volume":"136","author":"Ferrario","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.intimp.2020.107356_b0380","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.physbeh.2011.09.003","article-title":"Depressive phenotypes evoked by experimental diabetes are reversed by insulin","volume":"105","author":"Ho","year":"2012","journal-title":"Physiol. Behav."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920338248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576920338248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:24:29Z","timestamp":1761585869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576920338248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":76,"alternative-id":["S1567576920338248"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2020.107356","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sesamin alleviates diabetes-associated behavioral deficits in rats: The role of inflammatory and neurotrophic factors","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2020.107356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107356"}}