{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:21:41Z","timestamp":1793042501249,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771768"],"award-info":[{"award-number":["81771768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.intimp.2021.107392","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T07:29:33Z","timestamp":1611991773000},"page":"107392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":182,"special_numbering":"C","title":["Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes"],"prefix":"10.1016","volume":"93","author":[{"given":"Zewen","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gailian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107392_b0005","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nrrheum.2013.8","article-title":"The problem of choice: current biologic agents and future prospects in RA","volume":"9","author":"Choy","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2021.107392_b0010","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2016-000256","article-title":"From patients with arthralgia, pre-RA and recently diagnosed RA: what is the current status of understanding RA pathogenesis?","volume":"4","author":"Molendijk","year":"2018","journal-title":"RMD Open."},{"key":"10.1016\/j.intimp.2021.107392_b0015","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1002\/art.23794","article-title":"Questionnaires in Standard Monitoring of Patients With Rheumatoid Arthritis Group, Remission and rheumatoid arthritis: data on patients receiving usual care in twenty-four countries","volume":"58","author":"Sokka","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.107392_b0020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41584-018-0070-0","article-title":"Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction","volume":"14","author":"Holers","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2021.107392_b0025","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/ard.62.4.303","article-title":"Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints","volume":"62","author":"Smith","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2021.107392_b0030","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2021.107392_b0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ar.1091320402","article-title":"Histological, histochemical and electron microscopic observations on synovial membrane","volume":"132","author":"Lever","year":"1958","journal-title":"Anat. Rec."},{"key":"10.1016\/j.intimp.2021.107392_b0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1083\/jcb.14.2.207","article-title":"Electron microscopy of the human synovial membrane","volume":"14","author":"Barland","year":"1962","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.intimp.2021.107392_b0045","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41584-019-0295-6","article-title":"Synovial macrophages shield the joints","volume":"15","author":"Collison","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2021.107392_b0050","first-page":"1345","article-title":"Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts","volume":"23","author":"Matsumoto","year":"1996","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.intimp.2021.107392_b0055","first-page":"1607","article-title":"Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice","volume":"149","author":"M\u00fcller-Ladner","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2021.107392_b0060","doi-asserted-by":"crossref","first-page":"833","DOI":"10.4049\/jimmunol.143.3.833","article-title":"Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription","volume":"143","author":"Kumkumian","year":"1989","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2021.107392_b0065","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13287-019-1359-x","article-title":"Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells","volume":"10","author":"Li","year":"2019","journal-title":"Stem Cell Res Ther."},{"key":"10.1016\/j.intimp.2021.107392_b0070","first-page":"6406","article-title":"Differential expression of cell surface antigens and glial fibrillary acidic protein in human astrocytoma subsets","volume":"46","author":"Rettig","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2021.107392_b0075","first-page":"5702","article-title":"A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells","volume":"54","author":"Monsky","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2021.107392_b0080","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1158\/2326-6066.CIR-13-0150","article-title":"Tumoral immune suppression by macrophages expressing fibroblast activation protein-\u03b1 and heme oxygenase-1","volume":"2","author":"Arnold","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.intimp.2021.107392_b0085","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1182\/blood-2005-08-3452","article-title":"Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein","volume":"107","author":"Lee","year":"2006","journal-title":"Blood."},{"key":"10.1016\/j.intimp.2021.107392_b0090","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/hep.510290631","article-title":"Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis","volume":"29","author":"Levy","year":"1999","journal-title":"Hepatology."},{"key":"10.1016\/j.intimp.2021.107392_b0095","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.humpath.2005.11.020","article-title":"Fibroblast activation protein: a serine protease expressed at the remodeling interface in idiopathic pulmonary fibrosis","volume":"37","author":"Acharya","year":"2006","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.intimp.2021.107392_b0100","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.yjmcc.2015.08.016","article-title":"Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction","volume":"87","author":"Tillmanns","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.intimp.2021.107392_b0105","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/art.27395","article-title":"Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts","volume":"62","author":"Ospelt","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.107392_b0110","doi-asserted-by":"crossref","first-page":"R171","DOI":"10.1186\/ar2080","article-title":"Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes","volume":"8","author":"Bauer","year":"2006","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.intimp.2021.107392_b0115","doi-asserted-by":"crossref","first-page":"27221","DOI":"10.1074\/jbc.271.44.27221","article-title":"A mechanism for regulation of melanoma invasion. Ligation of alpha6beta1 integrin by laminin G peptides","volume":"271","author":"Nakahara","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2021.107392_b0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2121-15-16","article-title":"FAP-\u03b1 (Fibroblast activation protein-\u03b1) is involved in the control of human breast cancer cell line growth and motility via the FAK pathway","volume":"15","author":"Jia","year":"2014","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.intimp.2021.107392_b0125","first-page":"275","article-title":"Fibroblast activation protein-\u03b1 promotes the growth and migration of lung cancer cells via the PI3K and sonic hedgehog pathways","volume":"41","author":"Jia","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2021.107392_b0130","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.122","article-title":"Downregulation of FAP suppresses cell proliferation and metastasis through PTEN\/PI3K\/AKT and Ras-ERK signaling in oral squamous cell carcinoma","volume":"5","author":"Wang","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2021.107392_b0135","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92232","article-title":"Fibroblast activation protein augments progression and metastasis of pancreatic ductal adenocarcinoma","volume":"2","author":"Lo","year":"2017","journal-title":"JCI Insight."},{"key":"10.1016\/j.intimp.2021.107392_b0140","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1093\/abbs\/gmt095","article-title":"Over-expression of fibroblast activation protein alpha increases tumor growth in xenografts of ovarian cancer cells","volume":"45","author":"Yang","year":"2013","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.intimp.2021.107392_b0145","unstructured":"Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts - PubMed, (n.d.). https:\/\/pubmed.ncbi.nlm.nih.gov\/20155839\/ (accessed September 5, 2020)."},{"key":"10.1016\/j.intimp.2021.107392_b0150","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0002-9440(10)62266-3","article-title":"Circulating CD26 is negatively associated with inflammation in human and experimental arthritis","volume":"166","author":"Busso","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2021.107392_b0155","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/bs.ircmb.2015.01.009","article-title":"New insights into the role of podoplanin in epithelial-mesenchymal transition","volume":"317","author":"Renart","year":"2015","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.intimp.2021.107392_b0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jdermsci.2017.03.012","article-title":"Podoplanin expression in peritumoral keratinocytes predicts aggressive behavior in extramammary Paget\u2019s disease","volume":"87","author":"Cho","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.intimp.2021.107392_b0165","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/cas.13580","article-title":"Podoplanin: An emerging cancer biomarker and therapeutic target","volume":"109","author":"Krishnan","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.intimp.2021.107392_b0170","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/ijc.25795","article-title":"Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx","volume":"129","author":"Huber","year":"2011","journal-title":"Int. J. Cancer."},{"key":"10.1016\/j.intimp.2021.107392_b0175","doi-asserted-by":"crossref","first-page":"8407","DOI":"10.1007\/s13277-014-2266-5","article-title":"Podoplanin\u2013a novel marker in oral carcinogenesis","volume":"35","author":"Swain","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.intimp.2021.107392_b0180","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/cup.12322","article-title":"Podoplanin expression in cancer-associated fibroblasts predicts aggressive behavior in melanoma","volume":"41","author":"Kan","year":"2014","journal-title":"J. Cutan. Pathol."},{"key":"10.1016\/j.intimp.2021.107392_b0185","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1091\/mbc.e10-06-0489","article-title":"Podoplanin associates with CD44 to promote directional cell migration","volume":"21","author":"Mart\u00edn-Villar","year":"2010","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.intimp.2021.107392_b0190","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1186\/ar3274","article-title":"The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis","volume":"13","author":"Ekwall","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2021.107392_b0195","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s13075-016-1156-1","article-title":"Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage","volume":"18","author":"Croft","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2021.107392_b0200","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-019-1263-7","article-title":"Distinct fibroblast subsets drive inflammation and damage in arthritis","volume":"570","author":"Croft","year":"2019","journal-title":"Nature."},{"key":"10.1016\/j.intimp.2021.107392_b0205","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mvr.2008.07.008","article-title":"Endosialin\/TEM 1\/CD248 is a pericyte marker of embryonic and tumor neovascularization","volume":"76","author":"Bagley","year":"2008","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.intimp.2021.107392_b0210","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/wrr.12542","article-title":"Isolation of CD248-expressing stromal vascular fraction for targeted improvement of wound healing","volume":"25","author":"Brett","year":"2017","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.intimp.2021.107392_b0215","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5966\/sctm.2011-0018","article-title":"Concise review: role of mesenchymal stem cells in wound repair","volume":"1","author":"Maxson","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.intimp.2021.107392_b0220","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1016\/j.febslet.2007.06.063","article-title":"CD248\/Endosialin is dynamically expressed on a subset of stromal cells during lymphoid tissue development, splenic remodeling and repair","volume":"581","author":"Lax","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2021.107392_b0225","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1002\/art.27701","article-title":"CD248 and its cytoplasmic domain: a therapeutic target for arthritis","volume":"62","author":"Maia","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.107392_b0230","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1002\/art.34556","article-title":"The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice","volume":"64","author":"Naylor","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.107392_b0235","doi-asserted-by":"crossref","unstructured":"Identification of the complement decay-accelerating factor (DAF) on epithelium and glandular cells and in body fluids, J. Exp. Med. 165 (1987) 848\u2013864.","DOI":"10.1084\/jem.165.3.848"},{"key":"10.1016\/j.intimp.2021.107392_b0240","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.4049\/jimmunol.156.7.2528","article-title":"Localization of classical and alternative pathway regulatory activity within the decay-accelerating factor","volume":"156","author":"Brodbeck","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2021.107392_b0245","doi-asserted-by":"crossref","unstructured":"Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA\/SLE) Consortium, F. Zhang, K. Wei, K. Slowikowski, C.Y. Fonseka, D.A. Rao, S. Kelly, S.M. Goodman, D. Tabechian, L.B. Hughes, K. Salomon-Escoto, G.F.M. Watts, A.H. Jonsson, J. Rangel-Moreno, N. Meednu, C. Rozo, W. Apruzzese, T.M. Eisenhaure, D.J. Lieb, D.L. Boyle, A.M. Mandelin, B.F. Boyce, E. DiCarlo, E.M. Gravallese, P.K. Gregersen, L. Moreland, G.S. Firestein, N. Hacohen, C. Nusbaum, J.A. Lederer, H. Perlman, C. Pitzalis, A. Filer, V.M. Holers, V.P. Bykerk, L.T. Donlin, J.H. Anolik, M.B. Brenner, S. Raychaudhuri, Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry, Nat Immunol. 20 (2019) 928\u2013942. https:\/\/doi.org\/10.1038\/s41590-019-0378-1.","DOI":"10.1038\/s41590-019-0378-1"},{"key":"10.1016\/j.intimp.2021.107392_b0250","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy."},{"key":"10.1016\/j.intimp.2021.107392_b0255","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/jcb.24443","article-title":"Human adipose CD34+ CD90+ stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues","volume":"114","author":"Ferraro","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2021.107392_b0260","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jtos.2015.12.006","article-title":"Stem cells in the limbal stroma","volume":"14","author":"Funderburgh","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.intimp.2021.107392_b0265","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2021.107392_b0270","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1084\/jem.120.3.413","article-title":"The AKR Thymic antigen and its distribution in Leukemias and nervous tissues","volume":"120","author":"Reif","year":"1964","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2021.107392_b0275","doi-asserted-by":"crossref","first-page":"11611","DOI":"10.1007\/s13277-016-5112-0","article-title":"Multiple roles of CD90 in cancer","volume":"37","author":"Kumar","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.intimp.2021.107392_b0280","first-page":"277","article-title":"Expression of TGF-beta isoforms by Thy-1+ and Thy-1- pulmonary fibroblast subsets: evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6","volume":"13","author":"Silvera","year":"1994","journal-title":"Lymphokine Cytokine Res."},{"key":"10.1016\/j.intimp.2021.107392_b0285","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0002-9440(10)63330-5","article-title":"Thy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli","volume":"165","author":"Zhou","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2021.107392_b0290","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0002-9440(10)62982-3","article-title":"Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis","volume":"167","author":"Hagood","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2021.107392_b0295","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/cei.13149","article-title":"Stroma: the forgotten cells of innate immune memory","volume":"193","author":"Crowley","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2021.107392_b0300","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/1529-0131(200005)43:5<1115::AID-ANR22>3.0.CO;2-A","article-title":"Regulation of synovial B cell survival in rheumatoid arthritis by vascular cell adhesion molecule 1 (CD106) expressed on fibroblast-like synoviocytes","volume":"43","author":"Reparon-Schuijt","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.107392_b0305","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/art.22573","article-title":"Presentation of arthritogenic peptide to antigen-specific T cells by fibroblast-like synoviocytes","volume":"56","author":"Tran","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.107392_b0310","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.molmed.2010.07.004","article-title":"Rheumatoid arthritis progression mediated by activated synovial fibroblasts","volume":"16","author":"Neumann","year":"2010","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.intimp.2021.107392_b0315","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/art.37853","article-title":"Tumor necrosis factor \u03b1 induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts","volume":"65","author":"Lee","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.107392_b0320","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/350209","article-title":"Notch signaling mediates TNF-\u03b1-induced IL-6 production in cultured fibroblast-like synoviocytes from rheumatoid arthritis","volume":"2012","author":"Jiao","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.intimp.2021.107392_b0325","doi-asserted-by":"crossref","first-page":"3161750","DOI":"10.1155\/2019\/3161750","article-title":"Low-dose irradiation differentially impacts macrophage phenotype in dependence of fibroblast-like synoviocytes and radiation dose","volume":"2019","author":"Deloch","year":"2019","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.intimp.2021.107392_b0330","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/art.38871","article-title":"Prolonged tumor necrosis factor \u03b1 primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin","volume":"67","author":"Sohn","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.intimp.2021.107392_b0335","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jaut.2017.07.001","article-title":"The epigenetic architecture at gene promoters determines cell type-specific LPS tolerance","volume":"83","author":"Klein","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.intimp.2021.107392_b0340","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2967\/jnumed.119.227967","article-title":"68Ga-FAPI PET\/CT: Tracer Uptake in 28 Different Kinds of Cancer","volume":"60","author":"Kratochwil","year":"2019","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.intimp.2021.107392_b0345","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2967\/jnumed.118.210435","article-title":"A tumor-imaging method targeting cancer-associated fibroblasts","volume":"59","author":"Loktev","year":"2018","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.intimp.2021.107392_b0350","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.lungcan.2019.08.003","article-title":"Correlation between maximum standardized uptake values on FDG-PET and microenvironmental factors in patients with clinical stage IA radiologic pure-solid lung adenocarcinoma","volume":"136","author":"Ichikawa","year":"2019","journal-title":"Lung Cancer."},{"key":"10.1016\/j.intimp.2021.107392_b0355","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1137306","article-title":"Cadherin-11 in synovial lining formation and pathology in arthritis","volume":"315","author":"Lee","year":"2007","journal-title":"Science."},{"key":"10.1016\/j.intimp.2021.107392_b0360","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13075-015-0647-9","article-title":"Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism","volume":"17","author":"Noss","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2021.107392_b0365","doi-asserted-by":"crossref","unstructured":"R. Finch, A. Sostelly, K. Sue-Ling, A. Blaeuer, G. Duchateau-Nguyen, L. Ukarma, C. Petry, P. Ravva, P. Villiger, U. Junker, OP0224 results of a phase 2 study of RG6125, an anti-Cadherin-11 monoclonal antibody, in rheumatoid arthritis patients with an inadequate response to anti-tnfalpha therapy, in: Oral Presentations, BMJ Publishing Group Ltd and European League Against Rheumatism, 2019: p. 189.1-189. https:\/\/doi.org\/10.1136\/annrheumdis-2019-eular.3028.","DOI":"10.1136\/annrheumdis-2019-eular.3028"},{"key":"10.1016\/j.intimp.2021.107392_b0370","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.bbrc.2010.04.092","article-title":"Anomalous expression of Thy1 (CD90) in B-cell lymphoma cells and proliferation inhibition by anti-Thy1 antibody treatment","volume":"396","author":"Ishiura","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2021.107392_b0375","first-page":"4767","article-title":"Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model","volume":"62","author":"Cheng","year":"2002","journal-title":"Cancer Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692100028X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692100028X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:31:38Z","timestamp":1761586298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692100028X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":75,"alternative-id":["S156757692100028X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107392","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblast-like synoviocytes in rheumatoid arthritis: Surface markers and phenotypes","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107392"}}