{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:54:53Z","timestamp":1793012093992,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473652"],"award-info":[{"award-number":["81473652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873251"],"award-info":[{"award-number":["81873251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.intimp.2021.107396","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:57:19Z","timestamp":1612270639000},"page":"107396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["UUO induces lung fibrosis with macrophage-myofibroblast transition in rats"],"prefix":"10.1016","volume":"93","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuijuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Shimosawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107396_b0005","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"The Lancet"},{"key":"10.1016\/j.intimp.2021.107396_b0010","doi-asserted-by":"crossref","unstructured":"GBD 2015 Disease and Injury Incidence and Prevalence Collaborators, Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015, The Lancet 388 (2016) 1545\u20131602, doi:10.1016\/S0140-6736(16)31678-6.","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"10.1016\/j.intimp.2021.107396_b0015","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/S0140-6736(17)30788-2","article-title":"Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy","volume":"390","author":"Levin","year":"2017","journal-title":"The Lancet"},{"key":"10.1016\/j.intimp.2021.107396_b0020","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"The Lancet"},{"key":"10.1016\/j.intimp.2021.107396_b0025","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1378\/chest.120.6.1883","article-title":"Pulmonary infectious mortality among patients with end-stage renal disease","volume":"120","author":"Sarnak","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.intimp.2021.107396_b0030","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1681\/ASN.2016050573","article-title":"Macrophage-to-myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury","volume":"28","author":"Wang","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.intimp.2021.107396_b0035","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2021.107396_b0040","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ejphar.2013.08.019","article-title":"Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models","volume":"718","author":"Lieber","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2021.107396_b0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000368267","article-title":"Mineralocorticoid and SGK1-sensitive inflammation and tissue fibrosis","volume":"128","author":"Artunc","year":"2014","journal-title":"Nephron. Physiol."},{"key":"10.1016\/j.intimp.2021.107396_b0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/eurheartj\/ehi023","article-title":"Spironolactone improves lung diffusion in chronic heart failure","volume":"26","author":"Agostoni","year":"2005","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.intimp.2021.107396_b0055","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000473702","article-title":"The Inhibitory effect of eplerenone on cell proliferation in the contralateral kidneys of rats with unilateral ureteral obstruction","volume":"136","author":"Wang","year":"2017","journal-title":"Nephron"},{"issue":"9","key":"10.1016\/j.intimp.2021.107396_b0060","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1364\/BOE.7.003519","article-title":"Characterizing fibrosis in UUO mice model using multiparametric analysis of phasor distribution from FLIM images","volume":"7","author":"Suman","year":"2016","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.intimp.2021.107396_b0065","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev-physiol-022516-034356","article-title":"Mechanisms of organ injury and repair by macrophages","volume":"79","author":"Vannella","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.intimp.2021.107396_b0070","article-title":"New therapeutic strategies for IPF: Based on the \u201cphagocytosis-secretion-immunization\u201d network regulation mechanism of pulmonary macrophages","volume":"118","author":"Guoxiu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107396_b0075","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.402","article-title":"Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis","volume":"7","author":"Meng","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2021.107396_b0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/kisup.2014.7","article-title":"Macrophages promote renal fibrosis through direct and indirect mechanisms","volume":"4","author":"Nikolic-Paterson","year":"2014","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.intimp.2021.107396_b0085","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41581-019-0110-2","article-title":"Macrophages: versatile players in renal inflammation and fibrosis","volume":"15","author":"Tang","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.intimp.2021.107396_b0090","doi-asserted-by":"crossref","unstructured":"Burman Ankita. Tanjore Harikrishna, Blackwell Timothy S. Endoplasmic reticulum stress in pulmonary fibrosis. Matrix Biol. (2018) 355\u2013365. doi:10.1016\/j.matbio. 2018.03.015.","DOI":"10.1016\/j.matbio.2018.03.015"},{"key":"10.1016\/j.intimp.2021.107396_b0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000497489","article-title":"Eplerenone ameliorates cell pyroptosis in contralateral kidneys of rats with unilateral ureteral obstruction","volume":"142","author":"Ma","year":"2019","journal-title":"Nephron"},{"key":"10.1016\/j.intimp.2021.107396_b0100","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1111\/ggi.13054","article-title":"Chronic kidney disease: a likely underestimated component of multimorbidity in older patients with chronic obstructive pulmonary disease","volume":"17","author":"Corsonello","year":"2017","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.intimp.2021.107396_b0105","article-title":"When kidneys and lungs suffer together","author":"Claudio","year":"2018","journal-title":"J. Nephrol."},{"key":"10.1016\/j.intimp.2021.107396_b0110","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biochi.2012.09.030","article-title":"The mineralocorticoid signaling pathway throughout development: expression, regulation and pathophysiological implications","volume":"95","author":"Martinerie","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.intimp.2021.107396_b0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/019021401750069384","article-title":"Modulation of transalveolar fluid absorption by endogenous aldosterone in adult rats","volume":"27","author":"Suzuki","year":"2001","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.intimp.2021.107396_b0120","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.25011\/cim.v39i1.26326","article-title":"Reduction of acute lung injury by administration of spironolactone after intestinal ischemia and reperfusion in rats","volume":"39","author":"Barut","year":"2016","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/j.intimp.2021.107396_b0125","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.ajpath.2016.01.018","article-title":"Mechanisms of lung fibrosis resolution","volume":"186","author":"Glasser","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2021.107396_b0130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0021-9150(01)00771-7","article-title":"Macrophages, myofibroblasts and neointimal hyperplasia after coronary artery injury and repair","volume":"163","author":"Bayes-Genis","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.intimp.2021.107396_b0135","doi-asserted-by":"crossref","unstructured":"Torres \u00c1ngelo, et al. Intraglomerular monocyte\/macrophage infiltration and macrophage-myofibroblast transition during diabetic nephropathy Is regulated by the a adenosine receptor. Cells 9(4), doi:10.3390\/cells9041051 (2020).","DOI":"10.3390\/cells9041051"},{"issue":"34","key":"10.1016\/j.intimp.2021.107396_b0140","doi-asserted-by":"crossref","first-page":"20741","DOI":"10.1073\/pnas.1917663117","article-title":"Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition","volume":"117","author":"Ming-Kuen","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"1","key":"10.1016\/j.intimp.2021.107396_b0145","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.kint.2017.07.026","article-title":"The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring","volume":"93","author":"Ming-Kuen","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.intimp.2021.107396_b0150","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.steroids.2014.05.001","article-title":"Mineralocorticoid receptor in adipocytes and macrophages: a promising target to fight metabolic syndrome","volume":"91","author":"Marzolla","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.intimp.2021.107396_b0155","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/HYPERTENSIONAHA.113.01803","article-title":"Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone\/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure","volume":"63","author":"Rickard","year":"2014","journal-title":"Hypertension"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921000321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921000321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:30:09Z","timestamp":1761586209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921000321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":31,"alternative-id":["S1567576921000321"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107396","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"UUO induces lung fibrosis with macrophage-myofibroblast transition in rats","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107396"}}