{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:42:40Z","timestamp":1789389760916,"version":"build-2803163510"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["18DZ1160200"],"award-info":[{"award-number":["18DZ1160200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871103"],"award-info":[{"award-number":["81871103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672243"],"award-info":[{"award-number":["81672243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.intimp.2021.107422","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T19:58:10Z","timestamp":1612555090000},"page":"107422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis"],"prefix":"10.1016","volume":"93","author":[{"given":"Yaling","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107422_b0005","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O'Brien","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2021.107422_b0010","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1042\/CS20160727","article-title":"Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia","volume":"131","author":"Duncombe","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.intimp.2021.107422_b0015","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/jcbfm.2015.55","article-title":"Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment","volume":"35","author":"Jing","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.intimp.2021.107422_b0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0197-4580(00)00136-6","article-title":"Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia","volume":"21","author":"Meyer","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.intimp.2021.107422_b0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbr.2017.11.029","article-title":"Cognitive, neurohistological and mortality outcomes following the four-vessel occlusion\/internal carotid artery model of chronic cerebral hypoperfusion: The impact of diabetes and aging","volume":"339","author":"Nunes Santiago","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.intimp.2021.107422_b0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.intimp.2021.107422_b0035","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S1474-4422(05)70284-2","article-title":"Risk of dementia in diabetes mellitus: a systematic review","volume":"5","author":"Biessels","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.intimp.2021.107422_b0040","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41574-018-0048-7","article-title":"Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications","volume":"14","author":"Biessels","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.intimp.2021.107422_b0045","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/jnr.23777","article-title":"Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease","volume":"95","author":"Daulatzai","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.intimp.2021.107422_b0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nbd.2014.08.034","article-title":"Diabetes augments cognitive dysfunction in chronic cerebral hypoperfusion by increasing neuronal cell death: implication of cilostazol for diabetes mellitus-induced dementia","volume":"73","author":"Kwon","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.intimp.2021.107422_b0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12974-019-1688-9","article-title":"Fu J.TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus","volume":"17","author":"Zhang","year":"2020","journal-title":"J Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107422_b0060","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fncel.2019.00310","article-title":"Comprehensive evaluation of white matter damage and neuron death and whole-transcriptome analysis of rats with chronic cerebral hypoperfusion","volume":"13","author":"Li","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2021.107422_b0065","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1007\/s12035-016-9915-1","article-title":"Molecular mechanisms of vascular dementia: what can be learned from animal models of chronic cerebral hypoperfusion?","volume":"54","author":"Du","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2021.107422_b0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jneuroim.2018.04.004","article-title":"The involvement of neuroinflammation and necroptosis in the hippocampus during vascular dementia","volume":"320","author":"Belkhelfa","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2021.107422_b0075","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.nbd.2019.01.007","article-title":"Cuzzocrea S.N-Palmitoylethanolamine-oxazoline (PEA-OXA): A new therapeutic strategy to reduce neuroinflammation, oxidative stress associated to vascular dementia in an experimental model of repeated bilateral common carotid arteries occlusion","volume":"125","author":"Impellizzeri","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.intimp.2021.107422_b0080","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.aag2590","article-title":"How neuroinflammation contributes to neurodegeneration","volume":"353","author":"Ransohoff","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.intimp.2021.107422_b0085","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.intimp.2021.107422_b0090","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuroscience.2018.08.022","article-title":"Etidronate-zinc complex ameliorated cognitive and synaptic plasticity impairments in 2-vessel occlusion model rats by reducing neuroinflammation","volume":"390","author":"Feng","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2021.107422_b0095","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/jnc.13667","article-title":"Targeting innate immunity for neurodegenerative disorders of the central nervous system","volume":"138","author":"Andreasson","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2021.107422_b0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molimm.2019.09.020","article-title":"Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2\/ TLR4\/ NF-\u03baB pathways in BV2 cells","volume":"116","author":"Zhang","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2021.107422_b0105","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/jnc.13904","article-title":"Etidronate rescues cognitive deficits through improving synaptic transmission and suppressing apoptosis in 2-vessel occlusion model rats","volume":"140","author":"Li","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2021.107422_b0110","doi-asserted-by":"crossref","first-page":"109492","DOI":"10.1016\/j.biopha.2019.109492","article-title":"Rehmannioside A attenuates cognitive deficits in rats with vascular dementia (VD) through suppressing oxidative stress, inflammation and apoptosis","volume":"120","author":"Sun","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107422_b0115","first-page":"9601","article-title":"Inflammation, apoptosis and autophagy as critical players in vascular dementia","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2021.107422_b0120","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jep.2007.10.026","article-title":"Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia","volume":"115","author":"Zhang","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2021.107422_b0125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.lfs.2016.03.005","article-title":"Stabilization of HIF-1\u03b1 modulates VEGF and Caspase-3 in the hippocampus of rats following transient global ischemia induced by asphyxial cardiac arrest","volume":"151","author":"Liu","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2021.107422_b0130","doi-asserted-by":"crossref","first-page":"117043","DOI":"10.1016\/j.lfs.2019.117043","article-title":"Amentoflavone suppresses amyloid \u03b21-42 neurotoxicity in Alzheimer's disease through the inhibition of pyroptosis","volume":"239","author":"Zhao","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2021.107422_b0135","doi-asserted-by":"crossref","first-page":"109618","DOI":"10.1016\/j.biopha.2019.109618","article-title":"Interaction between hyperphosphorylated tau and pyroptosis in forskolin and streptozotocin induced AD models","volume":"121","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107422_b0140","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2021.107422_b0145","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.intimp.2021.107422_b0150","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"Feldstein AE.NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2021.107422_b0155","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s10787-019-00607-3","article-title":"Curcumin: a modulator of inflammatory signaling pathways in the immune system","volume":"27","author":"Kahkhaie","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2021.107422_b0160","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.msec.2017.03.226","article-title":"Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives","volume":"77","author":"Hussain","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol Appl."},{"key":"10.1016\/j.intimp.2021.107422_b0165","doi-asserted-by":"crossref","first-page":"12237","DOI":"10.1002\/jcp.27965","article-title":"Curcumin as a therapeutic candidate for multiple sclerosis: Molecular mechanisms and targets","volume":"234","author":"Ghanaatian","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2021.107422_b0170","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1136\/jim-2016-000240","article-title":"Protective effects of a natural product, curcumin, against amyloid \u03b2 induced mitochondrial and synaptic toxicities in Alzheimer's disease","volume":"64","author":"Reddy","year":"2016","journal-title":"J. Invest. Med."},{"key":"10.1016\/j.intimp.2021.107422_b0175","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pnpbp.2013.05.001","article-title":"Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice","volume":"45","author":"Yu","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2021.107422_b0180","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12640-019-00030-0","article-title":"Effects of curcumin on microglial cells","volume":"36","author":"Ghasemi","year":"2019","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.intimp.2021.107422_b0185","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1248\/bpb.b16-00567","article-title":"Cinepazide maleate improves cognitive function and protects hippocampal neurons in diabetic rats with chronic cerebral hypoperfusion","volume":"40","author":"Li","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.intimp.2021.107422_b0190","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s12035-016-0351-z","article-title":"The role of autophagy in the correlation between neuron damage and cognitive impairment in rat chronic cerebral hypoperfusion","volume":"55","author":"Zou","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2021.107422_b0195","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnins.2020.00028","article-title":"Transcranial direct current stimulation ameliorates cognitive impairment via modulating oxidative stress, inflammation, and autophagy in a rat model of vascular dementia","volume":"14","author":"Guo","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2021.107422_b0200","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1089\/ars.2020.8076","article-title":"Inflammation in neurological disorders: the thin boundary between brain and periphery","volume":"33","author":"Cervellati","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2021.107422_b0205","first-page":"8253904","article-title":"Acupuncture attenuates inflammation in microglia of vascular dementia rats by inhibiting miR-93-mediated TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.intimp.2021.107422_b0210","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1007\/s11064-019-02817-1","article-title":"TREM2 attenuates A\u03b21-42-mediated neuroinflammation in BV-2 cells by downregulating TLR signaling","volume":"44","author":"Long","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2021.107422_b0215","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.expneurol.2018.01.016","article-title":"Lou H.TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease","volume":"302","author":"Ren","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2021.107422_b0220","doi-asserted-by":"crossref","first-page":"17023-","DOI":"10.1038\/sigtrans.2017.23","article-title":"Sun SC.NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther."},{"key":"10.1016\/j.intimp.2021.107422_b0225","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/iub.1704","article-title":"Ligustrazine suppresses neuron apoptosis via the Bax\/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia","volume":"70","author":"Zhao","year":"2018","journal-title":"IUBMB Life"},{"key":"10.1016\/j.intimp.2021.107422_b0230","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neuroscience.2018.03.029","article-title":"Anti-oxidative and anti-apoptotic effects of acupuncture: role of thioredoxin-1 in the hippocampus of vascular dementia rats","volume":"379","author":"Zhu","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2021.107422_b0235","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.intimp.2018.12.019","article-title":"The mechanisms of NLRP3 inflammasome\/pyroptosis activation and their role in Parkinson's disease","volume":"67","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2021.107422_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102286","article-title":"Modulation of inflammasome and pyroptosis by Olaparib, a PARP-1 inhibitor, in the R6\/2 mouse model of Huntington's disease","volume":"9","author":"Paldino","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2021.107422_b0245","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12974-019-1668-0","article-title":"Hai J.URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion","volume":"16","author":"Su","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107422_b0250","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/STROKEAHA.115.011679","article-title":"Characterization of white matter injury in a rat model of chronic cerebral hypoperfusion","volume":"47","author":"Choi","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2021.107422_b0255","doi-asserted-by":"crossref","first-page":"116566","DOI":"10.1016\/j.lfs.2019.116566","article-title":"The neuroprotection of liraglutide on diabetic cognitive deficits is associated with improved hippocampal synapses and inhibited neuronal apoptosis","volume":"231","author":"Yan","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2021.107422_b0260","doi-asserted-by":"crossref","DOI":"10.3390\/nu11112755","article-title":"Mumefural ameliorates cognitive impairment in chronic cerebral hypoperfusion via regulating the septohippocampal cholinergic system and neuroinflammation","volume":"11","author":"Bang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2021.107422_b0265","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.7150\/thno.37119","article-title":"Upregulation of neuronal PGC-1\u03b1 ameliorates cognitive impairment induced by chronic cerebral hypoperfusion","volume":"10","author":"Han","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2021.107422_b0270","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1523\/JNEUROSCI.2451-17.2018","article-title":"TRPM2 channel aggravates CNS inflammation and cognitive impairment via activation of microglia in chronic cerebral hypoperfusion","volume":"38","author":"Miyanohara","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2021.107422_b0275","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153615","article-title":"SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes","volume":"20","author":"Hern\u00e1ndez","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2021.107422_b0280","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.freeradbiomed.2019.11.002","article-title":"Increased inflammation, oxidative stress and a reduction in antioxidant defense enzymes in perivascular adipose tissue contribute to vascular dysfunction in type 2 diabetes","volume":"146","author":"Azul","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2021.107422_b0285","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/157340606776056133","article-title":"Curcumin is an inhibitor of p300 histone acetylatransferase","volume":"2","author":"Marcu","year":"2006","journal-title":"Med. Chem."},{"key":"10.1016\/j.intimp.2021.107422_b0290","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bbrc.2014.01.195","article-title":"Aberrant histone acetylation contributes to elevated interleukin-6 production in rheumatoid arthritis synovial fibroblasts","volume":"444","author":"Wada","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2021.107422_b0295","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1128\/AAC.01238-06","article-title":"Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species","volume":"51","author":"Cui","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.intimp.2021.107422_b0300","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jnutbio.2010.03.014","article-title":"Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin","volume":"22","author":"Yun","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.intimp.2021.107422_b0305","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24020367","article-title":"Effects of betaine on LPS-stimulated activation of microglial M1\/M2 phenotypes by suppressing TLR4\/NF-\u03baB pathways in N9 cells","volume":"24","author":"Shi","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2021.107422_b0310","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s11064-019-02748-x","article-title":"Imbalance of microglial TLR4\/TREM2 in LPS-treated APP\/PS1 transgenic mice: A potential link between Alzheimer\u2019s disease and systemic inflammation","volume":"44","author":"Zhou","year":"2019","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2021.107422_b0315","first-page":"3875","article-title":"Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) activation balance astrocyte polarization into a proinflammatory phenotype","volume":"55","author":"Rosciszewski","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2021.107422_b0320","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.20041611","article-title":"Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2","volume":"201","author":"Takahashi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2021.107422_b0325","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","article-title":"TREM2 maintains microglial metabolic fitness in Alzheimer's disease","volume":"170","author":"Ulland","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2021.107422_b0330","doi-asserted-by":"crossref","first-page":"243ra286","DOI":"10.1126\/scitranslmed.3009093","article-title":"TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis","volume":"6","author":"Kleinberger","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.intimp.2021.107422_b0335","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/gutjnl-2017-314107","article-title":"Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage","volume":"68","author":"Perugorria","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2021.107422_b0340","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13024-018-0262-8","article-title":"The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease","volume":"13","author":"Cheng-Hathaway","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.intimp.2021.107422_b0345","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13024-020-00402-7","article-title":"The Alzheimer's disease-associated protective Plc\u03b32-P522R variant promotes immune functions","volume":"15","author":"Takalo","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.intimp.2021.107422_b0350","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12974-019-1634-x","article-title":"The role of Toll-like receptor 4 in apoptosis of brain tissue after induction of intracerebral hemorrhage","volume":"16","author":"Fei","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107422_b0355","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2018.08.035","article-title":"Tuning apoptosis and neuroinflammation: TBK1 restrains RIPK1","volume":"174","author":"Yu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2021.107422_b0360","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tcb.2018.02.010","article-title":"Vanpouille-box C.BAX and BAK at the gates of innate immunity","volume":"28","author":"Galluzzi","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.intimp.2021.107422_b0365","first-page":"276","article-title":"Inflammation, apoptosis, and Alzheimer's disease","volume":"8","author":"Bamberger","year":"2002","journal-title":"Neuroscientist"},{"key":"10.1016\/j.intimp.2021.107422_b0370","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/15548627.2017.1390636","article-title":"Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models","volume":"14","author":"Liu","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.intimp.2021.107422_b0375","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.biopha.2016.04.050","article-title":"IRE1\u03b1-TRAF2-ASK1 pathway is involved in CSTMP-induced apoptosis and ER stress in human non-small cell lung cancer A549 cells","volume":"82","author":"Zhang","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107422_b0380","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/toxsci\/kfx030","article-title":"Editor's highlight: Periodic exposure to smartphone-mimic low-luminance blue light induces retina damage through Bcl-2\/BAX-dependent apoptosis","volume":"157","author":"Lin","year":"2017","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.intimp.2021.107422_b0385","doi-asserted-by":"crossref","first-page":"109452","DOI":"10.1016\/j.biopha.2019.109452","article-title":"Neuroprotective effects of irisin against cerebral ischemia\/reperfusion injury via Notch signaling pathway","volume":"120","author":"Jin","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107422_b0390","doi-asserted-by":"crossref","first-page":"37959","DOI":"10.1038\/srep37959","article-title":"Tu PF.TDB protects vascular endothelial cells against oxygen-glucose deprivation\/reperfusion-induced injury by targeting miR-34a to increase Bcl-2 expression","volume":"6","author":"Liao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2021.107422_b0395","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.intimp.2021.107422_b0400","first-page":"1816","article-title":"Curcumin inhibits hypoxia inducible factor-1\u03b1-induced inflammation and apoptosis in macrophages through an ERK dependent pathway","volume":"23","author":"Ouyang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2021.107422_b0405","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.taap.2018.03.020","article-title":"Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling","volume":"346","author":"Dong","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2021.107422_b0410","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.intimp.2021.107422_b0415","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/imr.12909","article-title":"The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"297","author":"Zheng","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2021.107422_b0420","doi-asserted-by":"crossref","first-page":"101192","DOI":"10.1016\/j.arr.2020.101192","article-title":"The involvement of NLRP3 inflammasome in the treatment of Alzheimer's disease","volume":"64","author":"Feng","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2021.107422_b0425","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyaa060","article-title":"Baicalein attenuates neuroinflammation by inhibiting NLRP3\/caspase-1\/GSDMD pathway in MPTP induced mice model of Parkinson's disease","author":"Rui","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.intimp.2021.107422_b0430","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3389\/fnmol.2018.00320","article-title":"Targeting NLRP3 inflammasome in the treatment of CNS diseases","volume":"11","author":"Shao","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2021.107422_b0435","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2021.107422_b0440","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.immuni.2007.10.002","article-title":"Intracellular NOD-like receptors in host defense and disease","volume":"27","author":"Kanneganti","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2021.107422_b0445","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jneuroim.2018.11.010","article-title":"Inhibitors of NF-\u03baB and P2X7\/NLRP3\/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease","volume":"326","author":"Thawkar","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2021.107422_b0450","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12974-018-1214-5","article-title":"Basu A.HSP60 critically regulates endogenous IL-1\u03b2 production in activated microglia by stimulating NLRP3 inflammasome pathway","volume":"15","author":"Swaroop","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107422_b0455","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2021.107422_b0460","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2021.107422_b0465","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2021.107422_b0470","doi-asserted-by":"crossref","first-page":"104921","DOI":"10.1016\/j.phrs.2020.104921","article-title":"Curcumin: an inflammasome silencer","volume":"159","author":"Hasanzadeh","year":"2020","journal-title":"Pharmacol. Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921000588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921000588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:54:20Z","timestamp":1778619260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921000588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":94,"alternative-id":["S1567576921000588"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107422","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-111414\/v1","asserted-by":"object"}]},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107422","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107422"}}