{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:12:16Z","timestamp":1788361936115,"version":"build-2803163510"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005756","name":"Shahrekord University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.intimp.2021.107436","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T09:46:06Z","timestamp":1612604766000},"page":"107436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Auraptene exerts protective effects on maternal separation stress-induced changes in behavior, hippocampus, heart and serum of mice"],"prefix":"10.1016","volume":"93","author":[{"given":"Mehran","family":"Arabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohreh Hosseini","family":"Nasab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Lorigooini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakiba Nasiri","family":"Boroujeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Mohsen","family":"Mortazavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Anjomshoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Amini-Khoei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.intimp.2021.107436_b0005","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jpsychires.2011.03.006","article-title":"Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness","volume":"45","author":"McLean","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.intimp.2021.107436_b0010","article-title":"Economic burden of anxiety disorders: a systematic review and meta-analysis","volume":"1\u201313","author":"Konnopka","year":"2020","journal-title":"Pharmacoeconomics."},{"key":"10.1016\/j.intimp.2021.107436_b0015","series-title":"The role of early life stress in HPA axis and anxiety","first-page":"141","author":"Juruena","year":"2020"},{"issue":"12","key":"10.1016\/j.intimp.2021.107436_b0020","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.biopsych.2019.04.023","article-title":"Casting a (Perineuronal) Net: Connecting Early Life Stress to Neuropathological Changes and Enhanced Anxiety in Adults","volume":"85","author":"Fitzgerald","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2021.107436_b0025","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4813616","article-title":"Rutin via Increase in the CA3 Diameter of the Hippocampus Exerted Antidepressant-Like Effect in Mouse Model of Maternal Separation Stress: Possible Involvement of NMDA Receptors","volume":"2020","author":"Anjomshoa","year":"2020","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.intimp.2021.107436_b0030","article-title":"Diosgenin via NMDA Receptor Exerted Anxiolytic-like Effect on Maternally Separated Mice","author":"Boroujeni","year":"2020","journal-title":"Curr. Pharm. Des."},{"issue":"5","key":"10.1016\/j.intimp.2021.107436_b0035","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/acps.13026","article-title":"Oxidative and nitrosative stress markers in obsessive\u2013compulsive disorder: a systematic review and meta-analysis","volume":"139","author":"Maia","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00429-016-1218-9","article-title":"Oxidative and nitrosative stress pathways in the brain of socially isolated adult male rats demonstrating depressive-and anxiety-like symptoms","volume":"222","author":"Filipovi\u0107","year":"2017","journal-title":"Brain Struct. Funct."},{"issue":"2","key":"10.1016\/j.intimp.2021.107436_b0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2174\/1570159X11666131120223530","article-title":"Oxidative imbalance and anxiety disorders","volume":"12","author":"Krolow","year":"2014","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.intimp.2021.107436_b0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.brainres.2018.10.002","article-title":"NO-sGC-cGMP signaling influence the anxiolytic like effect of lithium in mice in light and dark box and elevated plus maze","volume":"1704","author":"Walia","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2021.107436_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.108317","article-title":"High-refined carbohydrate diet consumption induces neuroinflammation and anxiety-like behavior in mice","volume":"77","author":"Gomes","year":"2020","journal-title":"J. Nutritional Biochemistry."},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/neu.2019.44","article-title":"Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation","volume":"32","author":"Imbeault","year":"2020","journal-title":"Acta neuropsychiatrica."},{"issue":"2","key":"10.1016\/j.intimp.2021.107436_b0065","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1590\/1516-4446-2018-0005","article-title":"Anxiolytic properties of compounds that counteract oxidative stress, neuroinflammation, and glutamatergic dysfunction: a review","volume":"41","author":"Santos","year":"2019","journal-title":"Brazilian J. Psychiatry."},{"key":"10.1016\/j.intimp.2021.107436_b0070","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbi.2018.11.316","article-title":"Brain tumor necrosis factor-\u03b1 mediates anxiety-like behavior in a mouse model of severe obesity","volume":"77","author":"Fourrier","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.intimp.2021.107436_b0075","doi-asserted-by":"crossref","DOI":"10.5812\/modernc.95082","article-title":"The Effect of Inhaling the Aroma of Rosemary Essential Oil on the Pre-Hospital Emergency Personnel Stress and Anxiety: A Quasi-Experimental Study","volume":"16","author":"Rahimi","year":"2019","journal-title":"Modern Care J."},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0080","doi-asserted-by":"crossref","DOI":"10.5812\/aapm.41238","article-title":"Comparing the effect of preoperative administration of melatonin and Passiflora incarnata on postoperative cognitive disorders in adult patients undergoing elective surgery","volume":"7","author":"Rokhtabnak","year":"2017","journal-title":"Anesthesiology Pain Medicine"},{"issue":"4","key":"10.1016\/j.intimp.2021.107436_b0085","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.amjcard.2016.05.041","article-title":"Meta-analysis of anxiety as a risk factor for cardiovascular disease","volume":"118","author":"Emdin","year":"2016","journal-title":"Am. J. Cardiology."},{"key":"10.1016\/j.intimp.2021.107436_b0090","article-title":"Inflammatory Genotype Moderates the Association Between Anxiety and Systemic Inflammation in Adults at Risk for Cardiovascular Disease","author":"Key","year":"2020","journal-title":"J. Cardiovasc. Nurs."},{"issue":"2","key":"10.1016\/j.intimp.2021.107436_b0095","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/1099800419890424","article-title":"Relationship of Anxiety, Inflammation, and Telomere Length in Postpartum Women: A Pilot Study","volume":"22","author":"Groer","year":"2020","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.intimp.2021.107436_b0100","doi-asserted-by":"crossref","DOI":"10.1177\/1753944719851950","article-title":"Inflammation, depression and cardiovascular disease in women: The role of the immune system across critical reproductive events","volume":"13","author":"Mattina","year":"2019","journal-title":"Therapeutic advances in cardiovascular disease."},{"issue":"3","key":"10.1016\/j.intimp.2021.107436_b0105","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1378\/chest.105.3.897","article-title":"Basic mechanisms in congestive heart failure: recognizing the role of proinflammatory cytokines","volume":"105","author":"Mann","year":"1994","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.intimp.2021.107436_b0110","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/01.RES.0000043825.01705.1B","article-title":"Inflammatory mediators and the failing heart: past, present, and the foreseeable future","volume":"91","author":"Mann","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2021.107436_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phymed.2018.03.049","article-title":"Auraptene regulates Th1\/Th2\/TReg balances, NF-\u03baB nuclear localization and nitric oxide production in normal and Th2 provoked situations in human isolated lymphocytes","volume":"43","author":"Askari","year":"2018","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.intimp.2021.107436_b0120","doi-asserted-by":"crossref","first-page":"20230","DOI":"10.3390\/molecules201119691","article-title":"Auraptene acts as an anti-inflammatory agent in the mouse brain","volume":"20","author":"Okuyama","year":"2015","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.intimp.2021.107436_b0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0197-0186(02)00070-0","article-title":"Pentylenetetrazol-induced seizures and kindling: changes in free fatty acids, superoxide dismutase, and glutathione peroxidase activity","volume":"42","author":"Erakovi\u0107","year":"2003","journal-title":"Neurochem. Int."},{"issue":"3","key":"10.1016\/j.intimp.2021.107436_b0130","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2174\/138945011794815248","article-title":"Auraptene: a natural biologically active compound with multiple targets","volume":"12","author":"Genovese","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.intimp.2021.107436_b0135","doi-asserted-by":"crossref","unstructured":"Krishnan P, Kleiner-Hancock H. Effects of auraptene on IGF-1 stimulated cell cycle progression in the human breast cancer cell line, MCF-7. International journal of breast cancer. 2012;2012.","DOI":"10.1155\/2012\/502092"},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0140","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1139\/bcb-2017-0146","article-title":"Efficacy of hyperthermia in human colon adenocarcinoma cells is improved by auraptene","volume":"96","author":"Moussavi","year":"2018","journal-title":"Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2021.107436_b0145","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/1533034616650119","article-title":"Auraptene attenuates malignant properties of esophageal stem-like cancer cells","volume":"16","author":"Saboor-Maleki","year":"2017","journal-title":"Technol. Cancer Res. Treat."},{"issue":"10","key":"10.1016\/j.intimp.2021.107436_b0150","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3390\/ijms17101716","article-title":"Auraptene and other prenyloxyphenylpropanoids suppress microglial activation and dopaminergic neuronal cell death in a lipopolysaccharide-induced model of Parkinson\u2019s disease","volume":"17","author":"Okuyama","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2021.107436_b0155","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.neuroscience.2010.08.005","article-title":"Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression","volume":"170","author":"Desbonnet","year":"2010","journal-title":"Neuroscience"},{"issue":"7","key":"10.1016\/j.intimp.2021.107436_b0160","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1039\/C9FO00318E","article-title":"Hepatoprotection of auraptene from the peels of citrus fruits against 17\u03b1-ethinylestradiol-induced cholestasis in mice by activating farnesoid X receptor","volume":"10","author":"Wang","year":"2019","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2021.107436_b0165","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2016.02.041","article-title":"Auraptene induces oligodendrocyte lineage precursor cells in a cuprizone-induced animal model of demyelination","volume":"1639","author":"Nakajima","year":"2016","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0170","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbr.2004.05.018","article-title":"Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: evidence from inbred strains of mice","volume":"156","author":"Ducottet","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.intimp.2021.107436_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.niox.2020.03.001","article-title":"Blockade of nitric oxide signalling promotes resilience to the effects of social defeat stress on the conditioned rewarding properties of MDMA in mice","author":"Garc\u00eda-Pardo","year":"2020","journal-title":"Nitric Oxide"},{"issue":"6","key":"10.1016\/j.intimp.2021.107436_b0180","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s10787-019-00581-w","article-title":"Inflammatory responses bridge comorbid cardiac disorder in experimental model of IBD induced by DSS: protective effect of the trigonelline","volume":"27","author":"Omidi-Ardali","year":"2019","journal-title":"Inflammopharmacology"},{"issue":"5\u20136","key":"10.1016\/j.intimp.2021.107436_b0185","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000503728","article-title":"Trigonelline through the attenuation of oxidative stress exerts antidepressant-and anxiolytic-like effects in a mouse model of maternal separation stress","volume":"105","author":"Lorigooini","year":"2020","journal-title":"Pharmacology"},{"key":"10.1016\/j.intimp.2021.107436_b0190","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.intimp.2018.11.037","article-title":"On the role of corticosterone in behavioral disorders, microbiota composition alteration and neuroimmune response in adult male mice subjected to maternal separation stress","volume":"66","author":"Amini-Khoei","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2021.107436_b0195","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbr.2016.07.002","article-title":"The essential role of hippocampal alpha6 subunit-containing GABAA receptors in maternal separation stress-induced adolescent depressive behaviors","volume":"313","author":"Yang","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0200","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbr.2005.04.003","article-title":"Prenatal stress produces more behavioral alterations than maternal separation in the elevated plus-maze and in the elevated T-maze","volume":"163","author":"Estanislau","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.intimp.2021.107436_b0205","first-page":"89","article-title":"Effect of maternal separation stress on behavior of neonatal rd mice","volume":"27","author":"Zhang","year":"2017","journal-title":"Chinese Journal of Comparative Medicine."},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0210","doi-asserted-by":"crossref","first-page":"2","DOI":"10.12965\/jer.2040016.008","article-title":"The role of neuroinflammation on pathogenesis of affective disorders","volume":"16","author":"Rhie","year":"2020","journal-title":"Journal of Exercise Rehabilitation."},{"key":"10.1016\/j.intimp.2021.107436_b0215","doi-asserted-by":"crossref","DOI":"10.1177\/1744806919900717","article-title":"Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model","volume":"16","author":"Guan","year":"2020","journal-title":"Molecular pain."},{"key":"10.1016\/j.intimp.2021.107436_b0220","article-title":"Cellular mechanisms and molecular signaling pathways in stress-induced anxiety, depression, and blood\u2013brain barrier inflammation and leakage","volume":"1\u201323","author":"Welcome","year":"2020","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0225","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/13880209.2019.1702704","article-title":"Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress","volume":"58","author":"Nouri","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2021.107436_b0230","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3389\/fpsyt.2018.00776","article-title":"Brain-derived neurotrophic factor precursor in the hippocampus regulates both depressive and anxiety-like behaviors in rats","volume":"9","author":"Zhong","year":"2019","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.intimp.2021.107436_b0235","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neulet.2017.04.058","article-title":"Rutin alleviates chronic unpredictable stress-induced behavioral alterations and hippocampal damage in mice","volume":"656","author":"Parashar","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2021.107436_b0240","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuroscience.2016.03.062","article-title":"Rolipram improves cognition, reduces anxiety-and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia","volume":"326","author":"Soares","year":"2016","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.intimp.2021.107436_b0245","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neures.2010.08.007","article-title":"Oxidative stress in anxiety and comorbid disorders","volume":"68","author":"Hovatta","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.intimp.2021.107436_b0250","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.2147\/NDT.S247599","volume":"16","author":"Moradi-Kor","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"2","key":"10.1016\/j.intimp.2021.107436_b0255","article-title":"Association of serum vitamin D and total antioxidant capacity levels with stress and anxiety in young female students","volume":"11","author":"Hashemi","year":"2017","journal-title":"Iranian J. Psychiatry Behavioral Sciences."},{"key":"10.1016\/j.intimp.2021.107436_b0260","unstructured":"Namvaran A. Effects of N-Acetylcysteine on Noise Exposure induced Oxidative Stress and Depressive-and Anxiety-Like Behaviors in Adult Male Mice. Basic and Clinical Neuroscience.0-."},{"key":"10.1016\/j.intimp.2021.107436_b0265","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.euroneuro.2017.09.004","article-title":"Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour","volume":"30","author":"Gutierrez","year":"2020","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2021.107436_b0270","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.pnpbp.2009.08.012","article-title":"Involvement of NO\u2013cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice","volume":"33","author":"Gilhotra","year":"2009","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.intimp.2021.107436_b0275","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3892\/br.2017.901","article-title":"Chlorpheniramine and escitalopram: Similar antidepressant and nitric oxide lowering roles in a mouse model of anxiety","volume":"6","author":"Gammoh","year":"2017","journal-title":"Biomedical Reports."},{"issue":"6","key":"10.1016\/j.intimp.2021.107436_b0280","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s10072-018-3287-4","article-title":"High serum levels of malondialdehyde and antioxidant enzymes are associated with post-stroke anxiety","volume":"39","author":"Liu","year":"2018","journal-title":"Neurological Sciences."},{"key":"10.1016\/j.intimp.2021.107436_b0285","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.bbi.2016.03.025","article-title":"Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder","volume":"56","author":"Goldsmith","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.intimp.2021.107436_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030777","article-title":"Depression, comorbid anxiety disorders, and heart rate variability in physically healthy, unmedicated patients: implications for cardiovascular risk","volume":"7","author":"Kemp","year":"2012","journal-title":"PLoS ONE"},{"issue":"1\u20133","key":"10.1016\/j.intimp.2021.107436_b0295","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jad.2010.02.112","article-title":"Cardiovascular disease in persons with depressive and anxiety disorders","volume":"125","author":"Vogelzangs","year":"2010","journal-title":"J. Affect. Disord."},{"issue":"5","key":"10.1016\/j.intimp.2021.107436_b0300","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ypmed.2008.02.016","article-title":"Depression and anxiety associated with cardiovascular disease among persons aged 45 years and older in 38 states of the United States, 2006","volume":"46","author":"Fan","year":"2008","journal-title":"Prev. Med."},{"issue":"4","key":"10.1016\/j.intimp.2021.107436_b0305","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/01.CIR.0000153813.64165.5D","article-title":"Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women","volume":"111","author":"Albert","year":"2005","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.intimp.2021.107436_b0310","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4037\/ajcc2007.16.4.361","article-title":"\u201cThe rust of life\u201d: impact of anxiety on cardiac patients","volume":"16","author":"Moser","year":"2007","journal-title":"Am. J. Crit. Care"},{"issue":"11","key":"10.1016\/j.intimp.2021.107436_b0315","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11920-016-0739-5","article-title":"Anxiety disorders and cardiovascular disease","volume":"18","author":"Celano","year":"2016","journal-title":"Current psychiatry reports."},{"issue":"2","key":"10.1016\/j.intimp.2021.107436_b0320","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.atherosclerosis.2005.06.001","article-title":"Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA study","volume":"185","author":"Pitsavos","year":"2006","journal-title":"Atherosclerosis."},{"issue":"2","key":"10.1016\/j.intimp.2021.107436_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2013.03.018","article-title":"Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis","volume":"166","author":"Everett","year":"2013","journal-title":"Am. Heart J."},{"key":"10.1016\/j.intimp.2021.107436_b0330","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1902\/jop.2013.134006","article-title":"Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases","volume":"84","author":"Schenkein","year":"2013","journal-title":"J. Periodontol."},{"key":"10.1016\/j.intimp.2021.107436_b0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2017.05.005","article-title":"Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases","volume":"100","author":"Incalza","year":"2018","journal-title":"Vascular pharmacology."},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0340","first-page":"19","article-title":"Study of levels of malondialdehyde (MDA) among pateints with acute myocardial infarction in al-Nassiriah city","volume":"7","author":"Majid","year":"2013","journal-title":"Thi-Qar Medical Journal."},{"issue":"3","key":"10.1016\/j.intimp.2021.107436_b0345","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00580-018-2652-2","article-title":"Effects of atorvastatin on myocardial oxidative and nitrosative stress in diabetic rats","volume":"27","author":"Yaribeygi","year":"2018","journal-title":"Comp. Clin. Pathol."},{"key":"10.1016\/j.intimp.2021.107436_b0350","doi-asserted-by":"crossref","unstructured":"Matos MJ, Santana L, Uriarte E, Abreu OA, Molina E, Yordi EG. Coumarins\u2014an important class of phytochemicals. Phytochemicals-Isolation, Characterisation and Role in Human Health. 2015:113-40.","DOI":"10.5772\/59982"},{"issue":"1","key":"10.1016\/j.intimp.2021.107436_b0355","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ptr.2874","article-title":"Auraptene from Ferula szowitsiana protects human peripheral lymphocytes against oxidative stress","volume":"24","author":"Soltani","year":"2010","journal-title":"Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives."},{"key":"10.1016\/j.intimp.2021.107436_b0360","first-page":"1","article-title":"Anti-oxidant and anti-inflammatory effects of auraptene on phytohemagglutinin (PHA)-induced inflammation in human lymphocytes","author":"Askari","year":"2020","journal-title":"Pharmacol. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2021.107436_b0365","first-page":"1395","article-title":"The protective effect of auraptene against oxidative stress and pentylenetetrazol-induced chemical kindling in mice","volume":"18","author":"Etemad","year":"2019","journal-title":"Iranian Journal of Pharmaceutical Research: IJPR."},{"key":"10.1016\/j.intimp.2021.107436_b0370","first-page":"43","article-title":"Auraptene Mitigates Parkinson\u2019s Disease-Like","volume":"20","author":"Jang","year":"2020","journal-title":"Natural Products and Neuroprotection."},{"key":"10.1016\/j.intimp.2021.107436_b0375","series-title":"Auraptene and its role in chronic diseases","first-page":"399","author":"Derosa","year":"2016"},{"issue":"7","key":"10.1016\/j.intimp.2021.107436_b0380","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/mnfr.201200611","article-title":"Auraptene suppresses inflammatory responses in activated RAW 264 macrophages by inhibiting p38 mitogen-activated protein kinase activation","volume":"57","author":"Lin","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"issue":"1\u20133","key":"10.1016\/j.intimp.2021.107436_b0385","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejphar.2012.11.043","article-title":"Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice","volume":"699","author":"Okuyama","year":"2013","journal-title":"Eur. J. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921000722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921000722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:29:29Z","timestamp":1761586169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921000722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":77,"alternative-id":["S1567576921000722"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107436","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Auraptene exerts protective effects on maternal separation stress-induced changes in behavior, hippocampus, heart and serum of mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107436"}}