{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:31:27Z","timestamp":1782423087025,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["470377\/2011\u20139"],"award-info":[{"award-number":["470377\/2011\u20139"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201326\/010.000918\/2016 APQ1"],"award-info":[{"award-number":["E\u201326\/010.000918\/2016 APQ1"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201326\/010.001631\/2019 APQ1"],"award-info":[{"award-number":["E\u201326\/010.001631\/2019 APQ1"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201326\/103.138\/2011"],"award-info":[{"award-number":["E\u201326\/103.138\/2011"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.intimp.2021.107440","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T12:45:16Z","timestamp":1613393116000},"page":"107440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["5-lipoxygenase- and Glucocorticoid-dependent eosinophilia in a novel surgical model in mice"],"prefix":"10.1016","volume":"94","author":[{"given":"Bruno Marques","family":"Vieira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Corr\u00eaa de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Masid\u2212de\u2212Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Nunes","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca S.","family":"Brum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ignez C.","family":"Gaspar\u2212Elsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Xavier\u2212Elsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2021.107440_b0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0031-6997(24)01404-2","article-title":"Pharmacology of the eosinophil","volume":"51","author":"Giembycz","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.intimp.2021.107440_b0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"Rothenberg","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2021.107440_b0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-065X.2011.01026.x","article-title":"Eosinophils: multifaceted biologic properties and roles in health and disease","volume":"242","author":"Kita","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2021.107440_b0020","doi-asserted-by":"crossref","first-page":"G890","DOI":"10.1152\/ajpgi.00015.2005","article-title":"Eosinophils alter colonic epithelial barrier function: role for major basic protein","volume":"289","author":"Ackerman","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2021.107440_b0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2222.2008.02958.x","article-title":"Eosinophils: biological properties and role in health and disease","volume":"38","author":"Hogan","year":"2008","journal-title":"Clin. Exp. Allergy"},{"issue":"2","key":"10.1016\/j.intimp.2021.107440_b0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12016-015-8525-4","article-title":"The Eosinophil in Infection","volume":"50","author":"Ravin","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.intimp.2021.107440_b0035","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.1128\/IAI.00329-06","article-title":"Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection","volume":"74","author":"Specht","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.intimp.2021.107440_b0040","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.4049\/jimmunol.165.8.4544","article-title":"Role of IL\u22125 in innate and adaptive immunity to larval Strongyloidesstercoralis in mice","volume":"165","author":"Herbert","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2021.107440_b0045","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1365-2222.2008.03037.x","article-title":"Weller PF Immunoregulatory roles of eosinophils: a new look at a familiar cell","volume":"38","author":"Akuthota","year":"2008","journal-title":"Clin. Exp. Allergy."},{"key":"10.1016\/j.intimp.2021.107440_b0050","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/icb.2009.115","article-title":"Eosinophils and Th2 immunity: contemporary insights","volume":"88","author":"Spencer","year":"2010","journal-title":"Immunol. Cell. Biol."},{"key":"10.1016\/j.intimp.2021.107440_b0055","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-2776(08)01003-1","article-title":"Biology of the eosinophil","volume":"101","author":"Blanchard","year":"2009","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.intimp.2021.107440_b0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: changing perspectives in health and disease","volume":"13","author":"Rosenberg","year":"2013","journal-title":"Nat Rev Immunol."},{"key":"10.1016\/j.intimp.2021.107440_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2019.576967","article-title":"CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis","volume":"333","author":"Shou","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"4","key":"10.1016\/j.intimp.2021.107440_b0070","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1084\/jem.183.4.1893","article-title":"Inhibition of leukotriene B4\u2212receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis","volume":"183","author":"Gladue","year":"1996","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.intimp.2021.107440_b0075","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2021.107440_b0080","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pupt.2017.05.007","article-title":"IL\u221213 and idiopathic pulmonary fibrosis: Possible links and new therapeutic strategies","volume":"45","author":"Passalacqua","year":"2017","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2021.107440_b0085","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0001-706X(98)00088-6","article-title":"Eosinophils, eosinophil cationic protein and eosinophil\u2212derived neurotoxin in serum and urine of patients with onchocerciasis coinfected with intestinal nematodes and in urinary schistosomiasis","volume":"72","author":"Tischendorf","year":"1999","journal-title":"Acta Trop."},{"key":"10.1016\/j.intimp.2021.107440_b0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40413-016-0094-3","article-title":"Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases","volume":"9","author":"Metcalfe","year":"2016","journal-title":"World Allergy Organ. J."},{"issue":"12","key":"10.1016\/j.intimp.2021.107440_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116141","article-title":"Generation of Eosinophils from Cryopreserved Murine Bone Marrow Cells","volume":"9","author":"Schollaert","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.intimp.2021.107440_b0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.intimp.2019.04.002","article-title":"Potent stimulation of eosinopoiesis in murine bone\u2212marrow by myriadenolide is mediated by cysteinyl\u2212leukotriene signaling","volume":"72","author":"Vieira","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2021.107440_b0105","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1084\/jem.172.5.1425","article-title":"Eosinophilia in transgenic mice expressing interleukin 5","volume":"172","author":"Dent","year":"1990","journal-title":"J Exp Med."},{"issue":"4","key":"10.1016\/j.intimp.2021.107440_b0110","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1165\/ajrcmb.17.4.2691","article-title":"Rapid increase in bone\u2212 marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge","volume":"17","author":"Gaspar Elsas","year":"1997","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2021.107440_b0115","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1164\/rccm.200905-0800OC","article-title":"Inducible nitric oxide synthase\/CD95L\u2212 dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine","volume":"181","author":"Queto","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.intimp.2021.107440_b0120","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.lfs.2013.11.006","article-title":"Essential roles of endogenous glucocorticoids and TNF\/TNFR1 in promoting bone\u2212marrow eosinopoiesis in ovalbumin\u2212 sensitized, airway\u2212challenged mice","volume":"94","author":"Masid\u2212de\u2212Brito","year":"2014","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.intimp.2021.107440_b0125","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/sj.bjp.0705943","article-title":"Induction of bone\u2212marrow eosinophilia in mice submitted to surgery is dependent on stress\u2212induced secretion of glucocorticoids","volume":"143","author":"Xavier\u2212Elsas","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2021.107440_b0130","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/sj.bjp.0703145","article-title":"Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone\u2212marrow from normal and allergic mice","volume":"129","author":"Gaspar Elsas","year":"2000","journal-title":"Br J Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2021.107440_b0135","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1365-2222.2009.03289.x","article-title":"Evidence for a regulatory role of alpha 4\u2212integrins in the maturation of eosinophils generated from the bone marrow in the presence of dexamethasone","volume":"39","author":"Gaspar\u2212Elsas","year":"2009","journal-title":"Clin Exp Allergy."},{"key":"10.1016\/j.intimp.2021.107440_b0140","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/1874306400802010060","article-title":"In vitro effects of budesonide on eosinophil\u2212basophil lineage commitment","volume":"2","author":"Cyr","year":"2008","journal-title":"Open Respir. Med. J."},{"key":"10.1016\/j.intimp.2021.107440_b0145","first-page":"403970","article-title":"Roles of 5\u2212 lipoxygenase and cysteinyl\u2212leukotriene type 1 receptors in the hematological response to allergen challenge and its prevention by diethylcarbamazine in a murine model of asthma","volume":"2014","author":"Masid\u2212de\u2212Brito","year":"2014","journal-title":"Mediators Inflamm."},{"issue":"3","key":"10.1016\/j.intimp.2021.107440_b0150","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/08923973.2020.1733598","article-title":"Allergen challenge\u2212induced changes in bone\u2212marrow responses to leukotriene D4, nonsteroidal anti\u2212inflammatory drugs and cytokines","volume":"42","author":"Masid\u2212de\u2212Brito","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.intimp.2021.107440_b0155","first-page":"102160","article-title":"5\u2212lipoxygenase\u2212dependent recruitment of neutrophils and macrophages by eotaxin-1\u2212stimulated murine eosinophils","volume":"2014","author":"Luz","year":"2014","journal-title":"MediatorsInflamm."},{"key":"10.1016\/j.intimp.2021.107440_b0160","first-page":"474132","article-title":"Modulation of the effects of lung immune response on bone\u2212marrow by oral antigen exposure","volume":"2013","author":"Xavier\u2212Elsas","year":"2013","journal-title":"Biomed. Res. Int."},{"issue":"2","key":"10.1016\/j.intimp.2021.107440_b0165","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jlb.60.2.285","article-title":"Cloning of the murine eosinophil peroxidase gene (mEPO): characterization of a conserved subgroup of mammalian hematopoietic peroxidases","volume":"60","author":"Horton","year":"1996","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2021.107440_b0170","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1189\/jlb.0310184","article-title":"Technical advance: autofluorescence as a tool for myeloid cell analysis","volume":"88","author":"Mitchell","year":"2010","journal-title":"J. Leukoc. Biol."},{"issue":"10","key":"10.1016\/j.intimp.2021.107440_b0175","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/eji.1830031011","article-title":"A rapid method for the isolation of functional thymus\u2212derived murine lymphocytes","volume":"3","author":"Julius","year":"1973","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2021.107440_b0180","unstructured":"Aryeh MA, Michael HP, Steven BA \u2212 Inflammation and its mediators, Editor(s): Marc C. Hochberg, Alan J. Silman, Josef S. Smolen, Michael E. Weinblatt, Michael H. Weisman, Rheumatology (Sixth Edition), 2015,.Pages 169\u2212182, ISBN 9780323091381."},{"issue":"5","key":"10.1016\/j.intimp.2021.107440_b0185","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1398-9995.1986.tb00314.x","article-title":"Chemotactic activity of LTB4 in man","volume":"41","author":"Bisgaard","year":"1986","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2021.107440_b0190","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1136\/thorax.55.suppl_2.S28","article-title":"Variant LTC(4) synthase allele modifies cysteinyl\u2212leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast","volume":"55","author":"Sampson","year":"2000","journal-title":"Thorax"},{"issue":"9","key":"10.1016\/j.intimp.2021.107440_b0195","doi-asserted-by":"crossref","first-page":"922","DOI":"10.3109\/02770903.2013.823447","article-title":"A review on leukotrienes and their receptors with reference to asthma","volume":"50","author":"Singh","year":"2013","journal-title":"J. Asthma."},{"issue":"3","key":"10.1016\/j.intimp.2021.107440_b0200","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1158\/2326-6066.CIR-18-0494","article-title":"Activated Eosinophils Exert Antitumorigenic Activities in Colorectal Cancer","volume":"7","author":"Reichman","year":"2019","journal-title":"Cancer Immunol. Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692100076X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692100076X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:32:18Z","timestamp":1761586338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692100076X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":40,"alternative-id":["S156757692100076X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107440","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-lipoxygenase- and Glucocorticoid-dependent eosinophilia in a novel surgical model in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107440"}}