{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:43:20Z","timestamp":1790775800833,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.intimp.2021.107455","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T02:11:45Z","timestamp":1613009505000},"page":"107455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Effect of gingival mesenchymal stem cell-derived exosomes on inflammatory macrophages in a high-lipid microenvironment"],"prefix":"10.1016","volume":"94","author":[{"given":"Yalong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanchen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9499","key":"10.1016\/j.intimp.2021.107455_b0005","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"issue":"19","key":"10.1016\/j.intimp.2021.107455_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25194508","article-title":"Systemic manifestations of the periodontal disease: A bibliometric review","volume":"25","author":"Ahmad","year":"2020","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.intimp.2021.107455_b0015","first-page":"72","article-title":"Prevalence of periodontal disease, its association with systemic diseases and prevention","volume":"11","author":"Nazir","year":"2017","journal-title":"Int J Health Sci (Qassim)"},{"issue":"43","key":"10.1016\/j.intimp.2021.107455_b0020","first-page":"41","article-title":"Toll-like receptors and their role in periodontal health and disease","volume":"2007","author":"Mahanonda","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.intimp.2021.107455_b0025","article-title":"Classic and new mediators for in vitro modelling of human macrophages","author":"Luque-Martin","year":"2020","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107455_b0030","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"issue":"8","key":"10.1016\/j.intimp.2021.107455_b0035","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1111\/odi.13167","article-title":"M1 macrophages regulate TLR4\/AP1 via paracrine to promote alveolar bone destruction in periodontitis","volume":"25","author":"Zhu","year":"2019","journal-title":"Oral Dis."},{"issue":"10","key":"10.1016\/j.intimp.2021.107455_b0040","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat. Immunol."},{"issue":"5966","key":"10.1016\/j.intimp.2021.107455_b0045","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells","volume":"327","author":"Geissmann","year":"2010","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.intimp.2021.107455_b0050","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2337\/db17-0356","article-title":"Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and Beiging in white adipose tissue","volume":"67","author":"Zhao","year":"2018","journal-title":"Diabetes"},{"issue":"22","key":"10.1016\/j.intimp.2021.107455_b0055","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.7150\/thno.35528","article-title":"Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2021.107455_b0060","article-title":"The oral health status of patients with peripheral vascular disorders: a systematic review","volume":"1708538120963914","author":"Almoosawy","year":"2020","journal-title":"Vascular"},{"issue":"8","key":"10.1016\/j.intimp.2021.107455_b0065","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1902\/jop.2000.71.8.1375","article-title":"Pathophysiological relationships between periodontitis and systemic disease: recent concepts involving serum lipids","volume":"71","author":"Iacopino","year":"2000","journal-title":"J. Periodontol."},{"key":"10.1016\/j.intimp.2021.107455_b0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2014.12.007","article-title":"Interferon-gamma in foam cell formation and progression of atherosclerosis","volume":"441","author":"Yu","year":"2015","journal-title":"Clin. Chim. Acta"},{"issue":"19","key":"10.1016\/j.intimp.2021.107455_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197341","article-title":"Total blood exosomes in breast cancer: Potential role in crucial steps of tumorigenesis","volume":"21","author":"Konoshenko","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.intimp.2021.107455_b0080","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.1007\/s11033-020-05659-1","article-title":"Salivary exosomes: properties, medical applications, and isolation methods","volume":"47","author":"Cheshmi","year":"2020","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2021.107455_b0085","doi-asserted-by":"crossref","first-page":"107881","DOI":"10.1016\/j.celrep.2020.107881","article-title":"Macrophage exosomes resolve atherosclerosis by regulating hematopoiesis and inflammation via MicroRNA cargo","volume":"32","author":"Bouchareychas","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.intimp.2021.107455_b0090","doi-asserted-by":"crossref","DOI":"10.2174\/1574888X15666200501235201","article-title":"The use of mesenchymal stem cells and their derived extracellular vesicles in cardiovascular disease treatment","author":"Khoei","year":"2020","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.intimp.2021.107455_b0095","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jconrel.2020.07.042","article-title":"Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: strategies and significance","volume":"326","author":"Salunkhe","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.intimp.2021.107455_b0100","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107455_b0105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12964-020-00650-6","article-title":"Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages","volume":"18","author":"Asgarpour","year":"2020","journal-title":"Cell Commun Signal"},{"issue":"18","key":"10.1016\/j.intimp.2021.107455_b0110","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2217\/epi-2020-0026","article-title":"Exosomal microRNAs: novel players in cervical cancer","volume":"12","author":"Nahand","year":"2020","journal-title":"Epigenomics"},{"issue":"4","key":"10.1016\/j.intimp.2021.107455_b0115","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2217\/epi-2019-0192","article-title":"Exosomal miRNAs: novel players in viral infection","volume":"12","author":"Nahand","year":"2020","journal-title":"Epigenomics"},{"issue":"6","key":"10.1016\/j.intimp.2021.107455_b0120","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.clinthera.2014.04.019","article-title":"Exosomes as immunotheranostic nanoparticles","volume":"36","author":"Natasha","year":"2014","journal-title":"Clin. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2021.107455_b0125","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.clinthera.2014.04.018","article-title":"Potential of cancer cell-derived exosomes in clinical application: a review of recent research advances","volume":"36","author":"Sun","year":"2014","journal-title":"Clin. Ther."},{"issue":"241","key":"10.1016\/j.intimp.2021.107455_b0130","first-page":"e241","article-title":"PLK-1 silencing in bladder cancer by siRNA delivered with exosomes","volume":"91","author":"Greco","year":"2016","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.intimp.2021.107455_b0135","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12964-020-00623-9","article-title":"Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis","volume":"18","author":"Ghaemmaghami","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.intimp.2021.107455_b0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.omtn.2020.05.012","article-title":"Non-coding RNAs and exosomes: their role in the pathogenesis of sepsis","volume":"21","author":"Hashemian","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"9","key":"10.1016\/j.intimp.2021.107455_b0145","first-page":"4998","article-title":"Exosomes released by human umbilical cord mesenchymal stem cells protect against renal interstitial fibrosis through ROS-mediated P38MAPK\/ERK signaling pathway","volume":"12","author":"Liu","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"8","key":"10.1016\/j.intimp.2021.107455_b0150","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41419-020-02857-4","article-title":"MicroRNA-377-3p released by mesenchymal stem cell exosomes ameliorates lipopolysaccharide-induced acute lung injury by targeting RPTOR to induce autophagy","volume":"11","author":"Wei","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2021.107455_b0155","doi-asserted-by":"crossref","first-page":"564731","DOI":"10.3389\/fbioe.2020.564731","article-title":"A new self-healing hydrogel containing hucMSC-derived exosomes promotes bone regeneration","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"14","key":"10.1016\/j.intimp.2021.107455_b0160","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1089\/scd.2014.0316","article-title":"Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro","volume":"24","author":"Shabbir","year":"2015","journal-title":"Stem Cells Dev."},{"issue":"3","key":"10.1016\/j.intimp.2021.107455_b0165","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/stem.2298","article-title":"Comprehensive proteomic analysis of mesenchymal stem cell exosomes reveals modulation of angiogenesis via nuclear factor-KappaB signaling","volume":"34","author":"Anderson","year":"2016","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.intimp.2021.107455_b0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","article-title":"A network of macrophages supports mitochondrial homeostasis in the heart","volume":"183","author":"Nicolas-Avila","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2021.107455_b0175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.archoralbio.2018.11.007","article-title":"Gingival mesenchymal stem cells attenuate pro-inflammatory macrophages stimulated with oxidized low-density lipoprotein and modulate lipid metabolism","volume":"98","author":"Hong","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.intimp.2021.107455_b0180","doi-asserted-by":"crossref","first-page":"106030","DOI":"10.1016\/j.intimp.2019.106030","article-title":"Role of gingival mesenchymal stem cell exosomes in macrophage polarization under inflammatory conditions","volume":"81","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107455_b0185","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/s13287-020-01937-8","article-title":"Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization","volume":"11","author":"Wang","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"8","key":"10.1016\/j.intimp.2021.107455_b0190","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.7150\/thno.41580","article-title":"Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"issue":"23","key":"10.1016\/j.intimp.2021.107455_b0195","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.ehj.2003.09.016","article-title":"Risk factors for cardiovascular disease in patients with periodontitis","volume":"24","author":"Buhlin","year":"2003","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.intimp.2021.107455_b0200","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2174\/1574888X12666170316105805","article-title":"Effects of hyperlipidemia and cardiovascular diseases on proliferation, differentiation and homing of mesenchymal stem cells","volume":"12","author":"Ye","year":"2017","journal-title":"Curr. Stem Cell Res. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2021.107455_b0205","first-page":"1580","article-title":"Hyperlipidemia compromises homing efficiency of systemically transplanted BMSCs and inhibits bone regeneration","volume":"7","author":"Xu","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"6","key":"10.1016\/j.intimp.2021.107455_b0210","doi-asserted-by":"crossref","first-page":"e503","DOI":"10.11607\/jomi.te31","article-title":"The role of systemically delivered bone marrow-derived mesenchymal stem cells in the regeneration of periodontal tissues","volume":"28","author":"Yu","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implants"},{"issue":"2","key":"10.1016\/j.intimp.2021.107455_b0215","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jbmr.541","article-title":"Adverse effects of hyperlipidemia on bone regeneration and strength","volume":"27","author":"Pirih","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.intimp.2021.107455_b0220","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2174\/1574888X13666180220141114","article-title":"Updates on GMSCs treatment for autoimmune diseases","volume":"13","author":"Huang","year":"2018","journal-title":"Curr. Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2021.107455_b0225","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bbrc.2010.01.126","article-title":"Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine","volume":"393","author":"Tomar","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2021.107455_b0230","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.canlet.2018.01.029","article-title":"The therapeutic potential of human adipose-derived mesenchymal stem cells producing CXCL10 in a mouse melanoma lung metastasis model","volume":"419","author":"Mirzaei","year":"2018","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.intimp.2021.107455_b0235","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jcb.26169","article-title":"Stem cell therapy: a new therapeutic option for cardiovascular diseases","volume":"119","author":"Goradel","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.intimp.2021.107455_b0240","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/jcp.25990","article-title":"Therapeutic application of multipotent stem cells","volume":"233","author":"Mirzaei","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.intimp.2021.107455_b0245","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.stem.2012.05.015","article-title":"Mesenchymal stromal cells: new directions","volume":"10","author":"Keating","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.intimp.2021.107455_b0250","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000047856","article-title":"The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion","volume":"169","author":"Gao","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.intimp.2021.107455_b0255","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1479-5876-9-29","article-title":"Risk factors in the development of stem cell therapy","volume":"9","author":"Herberts","year":"2011","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2021.107455_b0260","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3350\/cmh.2020.0194","article-title":"The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future","volume":"27","author":"Watanabe","year":"2021","journal-title":"Clin. Mol. Hepatol."},{"issue":"4","key":"10.1016\/j.intimp.2021.107455_b0265","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/leu.2014.41","article-title":"MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease","volume":"28","author":"Kordelas","year":"2014","journal-title":"Leukemia"},{"issue":"10","key":"10.1016\/j.intimp.2021.107455_b0270","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.5966\/sctm.2015-0078","article-title":"Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression","volume":"4","author":"Doeppner","year":"2015","journal-title":"Stem Cells Transl. Med."},{"issue":"10","key":"10.1016\/j.intimp.2021.107455_b0275","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1002\/jcb.26726","article-title":"The extracellular vesicles-derived from mesenchymal stromal cells: a new therapeutic option in regenerative medicine","volume":"119","author":"Nooshabadi","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2021.107455_b0280","doi-asserted-by":"crossref","first-page":"31295","DOI":"10.3402\/jev.v5.31295","article-title":"Nanoparticle analysis sheds budding insights into genetic drivers of extracellular vesicle biogenesis","volume":"5","author":"Hurwitz","year":"2016","journal-title":"J. Extracell. Vesicles"},{"issue":"6","key":"10.1016\/j.intimp.2021.107455_b0285","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1007\/s10753-015-0194-1","article-title":"Ox-LDL upregulates IL-6 expression by enhancing NF-\u03baB in an IGF2-dependent manner in THP-1 macrophages","volume":"38","author":"Wang","year":"2015","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.intimp.2021.107455_b0290","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00041433-200310000-00006","article-title":"Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function","volume":"14","author":"Chinetti","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.intimp.2021.107455_b0295","doi-asserted-by":"crossref","DOI":"10.1111\/jgh.15025","article-title":"Regulation of lipid-induced macrophage polarization through modulating peroxisome proliferator-activated receptor-gamma activity affects hepatic lipid metabolism via a Toll-like receptor 4\/NF-kappaB signaling pathway","author":"Wu","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2021.107455_b0300","doi-asserted-by":"crossref","first-page":"3426925","DOI":"10.1155\/2020\/3426925","article-title":"Shen-Hong-Tong-Luo formula attenuates macrophage inflammation and lipid accumulation through the activation of the PPAR-gamma\/LXR-alpha\/ABCA1 pathway","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"issue":"5","key":"10.1016\/j.intimp.2021.107455_b0305","doi-asserted-by":"crossref","DOI":"10.3390\/cells8050467","article-title":"Molecular mechanisms responsible for therapeutic potential of mesenchymal stem cell-derived secretome","volume":"8","author":"Harrell","year":"2019","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.intimp.2021.107455_b0310","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0765.2005.00814.x","article-title":"Inflammatory bone destruction and osteoimmunology","volume":"40","author":"Takayanagi","year":"2005","journal-title":"J. Periodontal Res."},{"issue":"3","key":"10.1016\/j.intimp.2021.107455_b0315","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/CRD.0000000000000021","article-title":"Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy","volume":"22","author":"Hartman","year":"2014","journal-title":"Cardiol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2021.107455_b0320","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.atherosclerosis.2015.08.037","article-title":"Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis","volume":"243","author":"Lim","year":"2015","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.intimp.2021.107455_b0325","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/jth.12712","article-title":"Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions","volume":"12","author":"Srikanthan","year":"2014","journal-title":"J. Thromb. Haemost."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921000916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921000916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:29:22Z","timestamp":1761586162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921000916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":65,"alternative-id":["S1567576921000916"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107455","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of gingival mesenchymal stem cell-derived exosomes on inflammatory macrophages in a high-lipid microenvironment","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107455"}}