{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:30:37Z","timestamp":1775496637083,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Commission of Health and Family Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015787","name":"Jiangsu Province Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012224","name":"Xuzhou Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.intimp.2021.107503","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T14:03:28Z","timestamp":1614348208000},"page":"107503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Caspase-1 inhibition ameliorates murine acute graft versus host disease by modulating the Th1\/Th17\/Treg balance"],"prefix":"10.1016","volume":"94","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GuiZhen","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Bhansali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"QingLing","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KunMing","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShengYun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LingYu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZhenYu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KaiLin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2021.107503_b0005","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/bjh.16190","article-title":"Advances in understanding the pathogenesis of graft-versus-host disease","volume":"187","author":"Zeiser","year":"2019","journal-title":"Brit. J. Haematol."},{"issue":"309","key":"10.1016\/j.intimp.2021.107503_b0010","article-title":"Achievement of tolerance induction to prevent acute graft-vs.-host disease","volume":"10","author":"Thangavelu","year":"2019","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2021.107503_b0015","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/j.bbmt.2019.07.017","article-title":"Outcomes and predictors of response in steroid-refractory acute graft-versus-host disease","volume":"25","author":"Rashidi","year":"2019","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"1","key":"10.1016\/j.intimp.2021.107503_b0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2021.107503_b0025","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1084\/jem.20130084","article-title":"The Nlrp3 inflammasome regulates acute graft-versus-host disease","volume":"210","author":"Jankovic","year":"2013","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.intimp.2021.107503_b0030","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.bbmt.2018.07.026","article-title":"Loss of NLRP3 function alleviates murine hepatic graft-versus-host disease","volume":"24","author":"Zhu","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.intimp.2021.107503_b0035","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1038\/ncomms4209","article-title":"Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation","volume":"5","author":"Van Opdenbosch","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2021.107503_b0040","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.clim.2015.11.012","article-title":"Blockage of caspase-1 activation ameliorates bone marrow inflammation in mice after hematopoietic stem cell transplantation","volume":"162","author":"Qiao","year":"2016","journal-title":"Clin. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2021.107503_b0045","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1182\/blood.V88.8.3230.bloodjournal8883230","article-title":"An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin","volume":"88","author":"Cooke","year":"1996","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.intimp.2021.107503_b0050","first-page":"9","article-title":"CXCR4-transduced mesenchymal stem cells protect mice against graft-versus-host disease","volume":"43","author":"Chen","year":"2012","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.intimp.2021.107503_b0055","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cyto.2014.04.002","article-title":"Deviated balance between Th1 and Th17 cells exacerbates acute graft-versus-host disease in mice","volume":"68","author":"Pan","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2021.107503_b0060","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.3389\/fimmu.2018.02092","article-title":"Esculetin ameliorates psoriasis-like skin disease in mice by inducing CD4(+)Foxp3(+) regulatory T cells","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Immunol."},{"issue":"101","key":"10.1016\/j.intimp.2021.107503_b0065","article-title":"Innate immune activation by tissue injury and cell death in the setting of hematopoietic stem cell transplantation","volume":"6","author":"Brennan","year":"2015","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2021.107503_b0070","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00109-011-0767-x","article-title":"Danger signals activating innate immunity in graft-versus-host disease","volume":"89","author":"Zeiser","year":"2011","journal-title":"J. Mole. Med. (Berlin, Germany)"},{"key":"10.1016\/j.intimp.2021.107503_b0075","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cellimm.2016.07.014","article-title":"The impact of P2X7 receptor antagonist, brilliant blue G on graft-versus-host disease in mice after allogeneic hematopoietic stem cell transplantation","volume":"310","author":"Zhong","year":"2016","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.intimp.2021.107503_b0080","doi-asserted-by":"crossref","first-page":"105771","DOI":"10.1016\/j.intimp.2019.105771","article-title":"Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats","volume":"75","author":"Liang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2021.107503_b0085","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12974-015-0334-4","article-title":"Caspase-1 inhibitor ameliorates experimental autoimmune myasthenia gravis by innate dendric cell IL-1-IL-17 pathway","volume":"12","author":"Wang","year":"2015","journal-title":"J. Neuroinflammat."},{"issue":"19","key":"10.1016\/j.intimp.2021.107503_b0090","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.4103\/0366-6999.166039","article-title":"Inhibition of alveolar macrophage pyroptosis reduces lipopolysaccharide-induced acute lung injury in mice","volume":"128","author":"Wu","year":"2015","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"4","key":"10.1016\/j.intimp.2021.107503_b0095","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3892\/or.2015.4176","article-title":"Protective effect of neutralizing anti-IL-18alpha monoclonal antibody on a mouse model of acute graft-versus-host disease","volume":"34","author":"Li","year":"2015","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2021.107503_b0100","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1172\/JCI6896","article-title":"Differential roles of IL-1 and TNF-\u03b1 on graft-versus-host disease and graft versus leukemia","volume":"104","author":"Hill","year":"1999","journal-title":"J. Clin. Investig."},{"issue":"2","key":"10.1016\/j.intimp.2021.107503_b0105","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbmt.2009.10.002","article-title":"Association of HMGB1 polymorphisms with outcome after allogeneic hematopoietic cell transplantation","volume":"16","author":"Kornblit","year":"2010","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"2","key":"10.1016\/j.intimp.2021.107503_b0110","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clim.2015.08.012","article-title":"Role of HMGB1 in regulation of STAT3 expression in CD4(+) T cells from patients with aGVHD after allogeneic hematopoietic stem cell transplantation","volume":"161","author":"Xu","year":"2015","journal-title":"Clin. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2021.107503_b0115","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.4049\/jimmunol.1402609","article-title":"The free radical scavenger necroX-7 attenuates acute graft-versus-host disease via reciprocal regulation of Th1\/regulatory T cells and inhibition of HMGB1 release","volume":"194","author":"Im","year":"2015","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2021.107503_b0120","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1182\/blood-2008-08-172155","article-title":"IL-17 contributes to CD4-mediated graft-versus-host disease","volume":"113","author":"Kappel","year":"2009","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.intimp.2021.107503_b0125","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1182\/blood-2007-12-126987","article-title":"Absence of donor Th17 leads to augmented Th1 differentiation and exacerbated acute graft-versus-host disease","volume":"112","author":"Yi","year":"2008","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.intimp.2021.107503_b0130","doi-asserted-by":"crossref","first-page":"e2666","DOI":"10.1038\/cddis.2017.95","article-title":"IL-27 triggers IL-10 production in Th17 cells via a c-Maf\/RORgammat\/Blimp-1 signal to promote the progression of endometriosis","volume":"8","author":"Chang","year":"2017","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.intimp.2021.107503_b0135","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nbt.1903","article-title":"Therapeutic targeting of the IL-12\/23 pathways: generation and characterization of ustekinumab","volume":"29","author":"Benson","year":"2011","journal-title":"Nat. Biotechnol."},{"issue":"7583","key":"10.1016\/j.intimp.2021.107503_b0140","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nature16460","article-title":"Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration","volume":"528","author":"Lindemans","year":"2015","journal-title":"Nature"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921001399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921001399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:27:43Z","timestamp":1761586063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921001399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":28,"alternative-id":["S1567576921001399"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107503","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caspase-1 inhibition ameliorates murine acute graft versus host disease by modulating the Th1\/Th17\/Treg balance","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107503","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107503"}}