{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:41:57Z","timestamp":1793457717500,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.intimp.2021.107545","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T04:26:42Z","timestamp":1616473602000},"page":"107545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: Involvement of SIRT1-mTOR\/NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"95","author":[{"given":"Xinrui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiquan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107545_b0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3233\/JAD-180314","article-title":"Morphological and pathological characteristics of brain in diabetic encephalopathy","volume":"65","author":"Chen","year":"2018","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.intimp.2021.107545_b0010","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0166-2236(00)01656-8","article-title":"Cognition and synaptic plasticity in diabetes mellitus","volume":"23","author":"Gispen","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.intimp.2021.107545_b0015","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3390\/molecules23030522","article-title":"Inhibiting the NLRP3 inflammasome activation with MCC950 ameliorates diabetic encephalopathy in db\/db mice","volume":"23","author":"Zhai","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2021.107545_b0020","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1111\/jcmm.15026","article-title":"Quercetin protects against diabetic encephalopathy via SIRT1\/NLRP3 pathway in db\/db mice","volume":"24","author":"Hu","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2021.107545_b0025","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41598-018-37215-0","article-title":"Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation","volume":"9","author":"Hsieh","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2021.107545_b0030","doi-asserted-by":"crossref","first-page":"731","DOI":"10.2174\/1567205014666170117104053","article-title":"High glucose enhances neurotoxicity and inflammatory cytokine secretion by stimulated human astrocytes","volume":"14","author":"Bahniwal","year":"2017","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.intimp.2021.107545_b0035","doi-asserted-by":"crossref","first-page":"11788","DOI":"10.1039\/C4CC00968A","article-title":"Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications","volume":"50","author":"Zhao","year":"2014","journal-title":"Chem. Commun. (Camb)."},{"key":"10.1016\/j.intimp.2021.107545_b0040","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1089\/ars.2012.4843","article-title":"In African American type 2 diabetic patients, is vitamin D deficiency associated with lower blood levels of hydrogen sulfide and cyclic adenosine monophosphate, and elevated oxidative stress?","volume":"18","author":"Jain","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2021.107545_b0045","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mad.2016.11.005","article-title":"New mechanism of lipotoxicity in diabetic cardiomyopathy: deficiency of endogenous H2S production and ER stress","volume":"162","author":"Guo","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.intimp.2021.107545_b0050","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1093\/ndt\/gfq749","article-title":"Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide","volume":"26","author":"Yuan","year":"2011","journal-title":"Nephrol. Dial Transplant."},{"key":"10.1016\/j.intimp.2021.107545_b0055","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/758358","article-title":"Cardiac H2S generation is reduced in ageing diabetic mice","volume":"2015","author":"Jin","year":"2015","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.intimp.2021.107545_b0060","doi-asserted-by":"crossref","first-page":"E190","DOI":"10.1152\/ajpendo.00196.2016","article-title":"Exogenous H2S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes","volume":"312","author":"Yang","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2021.107545_b0065","first-page":"3281","article-title":"Cystathionine beta synthase-hydrogen sulfide system in paraventricular nucleus reduced high fatty diet induced obesity and insulin resistance by brain-adipose axis","volume":"2018","author":"Zheng","year":"1864","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.intimp.2021.107545_b0070","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1021\/acschemneuro.9b00120","article-title":"Tacrine-hydrogen sulfide donor hybrid ameliorates cognitive impairment in the aluminum chloride mouse model of Alzheimer's disease","volume":"10","author":"Cheng","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.intimp.2021.107545_b0075","doi-asserted-by":"crossref","first-page":"8360738","DOI":"10.1155\/2016\/8360738","article-title":"AP39, a mitochondria-targeted hydrogen sulfide donor, supports cellular bioenergetics and protects against Alzheimer's disease by preserving mitochondrial function in APP\/PS1 mice and neurons","volume":"2016","author":"Zhao","year":"2016","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.intimp.2021.107545_b0080","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1089\/ars.2017.7195","article-title":"Sulfhydrated sirtuin-1 increasing its deacetylation activity is an essential epigenetics mechanism of anti-atherogenesis by hydrogen sulfide","volume":"30","author":"Du","year":"2019","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.intimp.2021.107545_b0085","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1096\/fj.201900393RR","article-title":"Hydrogen sulfide protects against particle-induced inflammatory response and osteolysis via SIRT1 pathway in prosthesis loosening","volume":"34","author":"Liu","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2021.107545_b0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.canlet.2019.04.031","article-title":"A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K\/AKT\/mTOR and Ras\/Raf\/MEK\/ERK signaling pathways","volume":"455","author":"Dong","year":"2019","journal-title":"Can. Lett."},{"key":"10.1016\/j.intimp.2021.107545_b0095","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jdermsci.2020.02.004","article-title":"Exogenous hydrogen sulfide inhibits human melanoma cell development via suppression of the PI3K\/AKT\/mTOR pathway","volume":"98","author":"Xiao","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.intimp.2021.107545_b0100","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cbi.2015.10.021","article-title":"Hydrogen sulfide (H2S) attenuates uranium-induced acute nephrotoxicity through oxidative stress and inflammatory response via Nrf2-NF-\u03baB pathways","volume":"242","author":"Zheng","year":"2015","journal-title":"Chem. Biol. Interact"},{"key":"10.1016\/j.intimp.2021.107545_b0105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3389\/fncel.2020.00210","article-title":"Hydrogen sulfide reduces cognitive impairment in rats after subarachnoid hemorrhage by ameliorating neuroinflammation mediated by the TLR4\/NF-\u03baB pathway in microglia","volume":"14","author":"Duan","year":"2020","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.intimp.2021.107545_b0110","doi-asserted-by":"crossref","first-page":"28827","DOI":"10.1074\/jbc.M114.596593","article-title":"Hydrogen sulfide alleviates diabetic nephropathy in a streptozotocin-induced diabetic rat model","volume":"289","author":"Zhou","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2021.107545_b0115","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.3892\/mmr.2017.7004","article-title":"Hydrogen sulfide prevents homocysteine-induced endoplasmic reticulum stress in PC12 cells by upregulating SIRT1","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2021.107545_b0120","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/ijnp\/pyx030","article-title":"Hydrogen sulfide inhibits chronic unpredictable mild stress-induced depressive-like behavior by upregulation of Sirt-1: Involvement in suppression of hippocampal endoplasmic reticulum stress","volume":"20","author":"Liu","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.intimp.2021.107545_b0125","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ceb.2011.09.003","article-title":"mTOR signaling in disease","volume":"23","author":"Dazert","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.intimp.2021.107545_b0130","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jdermsci.2017.04.013","article-title":"Sirt1 ameliorates systemic sclerosis by targeting the mTOR pathway","volume":"87","author":"Zhu","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.intimp.2021.107545_b0135","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1194\/jlr.M063537","article-title":"Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR\/S6K1 pathway in mice","volume":"57","author":"Liu","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.intimp.2021.107545_b0140","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejphar.2017.02.034","article-title":"Activation of mTOR\/I\u03baB-\u03b1\/NF-\u03baB pathway contributes to LPS-induced hypotension and inflammation in rats","volume":"802","author":"Temiz-Resitoglu","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2021.107545_b0145","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3389\/fphar.2019.01292","article-title":"Rapamycin attenuates high glucose-induced inflammation through modulation of mTOR\/NF-\u03baB pathways in macrophages","volume":"10","author":"Dai","year":"2019","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.intimp.2021.107545_b0150","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2017.11.004","article-title":"H2S protects lipopolysaccharide-induced inflammation by blocking NF-\u03baB transactivation in endothelial cells","volume":"338","author":"Bourque","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2021.107545_b0155","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural dietary supplementation of anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of Alzheimer's disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2021.107545_b0160","doi-asserted-by":"crossref","first-page":"6293","DOI":"10.1007\/s12035-019-1512-7","article-title":"Hesperetin confers neuroprotection by regulating Nrf2\/TLR4\/NF-\u03baB signaling in an A\u03b2 mouse model","volume":"56","author":"Ikram","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2021.107545_b0165","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.1039\/C9NJ00210C","article-title":"A novel near-infrared fluorescent hydrogen sulfide probe for live cell and tissue imaging","volume":"43","author":"Huang","year":"2019","journal-title":"New J. Chem."},{"key":"10.1016\/j.intimp.2021.107545_b0170","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1007\/s12035-015-9425-6","article-title":"Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: In vitro and in vivo evidences","volume":"53","author":"Liu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2021.107545_b0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12974-017-0940-4","article-title":"Endogenous hydrogen sulphide attenuates NLRP3 inflammasome-mediated neuroinflammation by suppressing the P2X7 receptor after intracerebral haemorrhage in rats","volume":"14","author":"Zhao","year":"2017","journal-title":"J. Neuroinflammation."},{"key":"10.1016\/j.intimp.2021.107545_b0180","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbrc.2014.10.033","article-title":"Activation of AMPK participates hydrogen sulfide-induced cyto-protective effect against dexamethasone in osteoblastic MC3T3-E1 cells","volume":"454","author":"Yang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2021.107545_b0185","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.freeradbiomed.2010.06.002","article-title":"Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death","volume":"49","author":"Fukui","year":"2010","journal-title":"Free Radic Biol. Med."},{"key":"10.1016\/j.intimp.2021.107545_b0190","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.1039\/c4ob00285g","article-title":"A colorimetric and ratiometric fluorescent probe for the imaging of endogenous hydrogen sulphide in living cells and sulphide determination in mouse hippocampus","volume":"12","author":"Zhang","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.intimp.2021.107545_b0195","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1007\/s10753-018-0858-8","article-title":"Chikusetsusaponin V inhibits LPS-activated inflammatory responses via SIRT1\/NF-\u03baB signaling pathway in RAW264.7 cells","volume":"41","author":"Yuan","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2021.107545_b0200","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/labinvest.2016.129","article-title":"H2S inhibits pulmonary arterial endothelial cell inflammation in rats with monocrotaline-induced pulmonary hypertension","volume":"97","author":"Feng","year":"2016","journal-title":"Lab Invest."},{"key":"10.1016\/j.intimp.2021.107545_b0205","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fendo.2019.00025","article-title":"Role of hippocampal lipocalin-2 in experimental diabetic encephalopathy","volume":"10","author":"Bhusal","year":"2019","journal-title":"Front Endocrinol. (Lausanne)."},{"key":"10.1016\/j.intimp.2021.107545_b0210","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s00592-010-0218-0","article-title":"Encephalopathies: the emerging diabetic complications","volume":"47","author":"Sima","year":"2010","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.intimp.2021.107545_b0215","doi-asserted-by":"crossref","first-page":"611","DOI":"10.14336\/AD.2018.0707","article-title":"BDNF alleviates neuroinflammation in the hippocampus of type 1 diabetic mice via blocking the aberrant HMGB1\/RAGE\/NF-\u03baB pathway","volume":"10","author":"Han","year":"2019","journal-title":"Aging Dis."},{"key":"10.1016\/j.intimp.2021.107545_b0220","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12035-015-9667-3","article-title":"Hyperglycemia-induced oxidative-nitrosative stress induces inflammation and neurodegeneration via augmented tuberous sclerosis complex-2 (TSC-2) activation in neuronal cells","volume":"54","author":"Kumar","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2021.107545_b0225","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2021.107545_b0230","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical biology of H2S signaling through persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.intimp.2021.107545_b0235","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fncel.2019.00349","article-title":"Exogenous hydrogen sulfide offers neuroprotection on intracerebral hemorrhage injury through modulating endogenous H2S metabolism in mice","volume":"13","author":"Shan","year":"2019","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.intimp.2021.107545_b0240","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0006-291X(02)00422-9","article-title":"Brain hydrogen sulfide is severely decreased in Alzheimer's disease","volume":"293","author":"Eto","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2021.107545_b0245","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neurobiolaging.2013.09.033","article-title":"Alzheimers dis neuroimaging initiative, impaired glycemia increases disease progression in mild cognitive impairment","volume":"35","author":"Morris","year":"2014","journal-title":"Neurobiol Aging."},{"key":"10.1016\/j.intimp.2021.107545_b0250","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.molimm.2016.07.018","article-title":"SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells","volume":"77","author":"Li","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2021.107545_b0255","doi-asserted-by":"crossref","first-page":"9856","DOI":"10.1074\/jbc.M110.196790","article-title":"NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance","volume":"286","author":"Liu","year":"2011","journal-title":"J. Chem. Biol."},{"key":"10.1016\/j.intimp.2021.107545_b0260","doi-asserted-by":"crossref","first-page":"25758","DOI":"10.1074\/jbc.M112.362343","article-title":"NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response","volume":"287","author":"Liu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2021.107545_b0265","doi-asserted-by":"crossref","first-page":"8167273","DOI":"10.1155\/2016\/8167273","article-title":"Sirtuins link inflammation and metabolism","volume":"2016","author":"Vachharajani","year":"2016","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.intimp.2021.107545_b0270","doi-asserted-by":"crossref","first-page":"100396","DOI":"10.18632\/oncotarget.22237","article-title":"Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of Sirt1 in hippocampus","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget."},{"key":"10.1016\/j.intimp.2021.107545_b0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009199","article-title":"SIRT1 negatively regulates the mammalian target of rapamycin","volume":"5","author":"Ghosh","year":"2010","journal-title":"PLoS One."},{"key":"10.1016\/j.intimp.2021.107545_b0280","doi-asserted-by":"crossref","first-page":"1600338","DOI":"10.1002\/mnfr.201600338","article-title":"1,25(OH)2D\u20133 improves cardiac dysfunction, hypertrophy, and fibrosis through PARP1\/SIRT1\/mTOR-related mechanisms in type 1 diabetes","volume":"61","author":"Qu","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2021.107545_b0285","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11010-013-1946-6","article-title":"GYY4137, a novel hydrogen sulfide-releasing molecule, likely protects against high glucose-induced cytotoxicity by activation of the AMPK\/mTOR signal pathway in H9c2 cells","volume":"389","author":"Wei","year":"2014","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.intimp.2021.107545_b0290","article-title":"Inflammatory stress increases hepatic CD36 translational efficiency via activation of the mTOR signaling pathway","volume":"9","author":"Wang","year":"2014","journal-title":"Plos One."},{"key":"10.1016\/j.intimp.2021.107545_b0295","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12974-018-1141-5","article-title":"Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice","volume":"15","author":"Liu","year":"2018","journal-title":". Neuroinflammation."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921001818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921001818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:31:09Z","timestamp":1761586269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921001818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":59,"alternative-id":["S1567576921001818"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107545","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: Involvement of SIRT1-mTOR\/NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107545"}}