{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:15:54Z","timestamp":1792977354787,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.intimp.2021.107660","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T12:36:29Z","timestamp":1618490189000},"page":"107660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis"],"prefix":"10.1016","volume":"96","author":[{"given":"Zhiheng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jidan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107660_b0005","doi-asserted-by":"crossref","DOI":"10.2174\/1871520620666200302112517","article-title":"Cryptotanshinone suppresses liver fibrosis by attenuating epithelial-mesenchymal transition through targeting hedgehog pathway","author":"Ren","year":"2020","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.intimp.2021.107660_b0010","doi-asserted-by":"crossref","first-page":"111044","DOI":"10.1016\/j.fct.2019.111044","article-title":"Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-kappaB and Akt","volume":"135","author":"Kim","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.intimp.2021.107660_b0015","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s10753-019-00973-8","article-title":"Umbelliferone ameliorates CCl4-induced liver fibrosis in rats by upregulating PPARgamma and attenuating oxidative stress, inflammation, and TGF-beta1\/Smad3 signaling","volume":"42","author":"Mahmoud","year":"2019","journal-title":"Inflammation"},{"issue":"6","key":"10.1016\/j.intimp.2021.107660_b0020","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1039\/D0FO00660B","article-title":"Pelargonidin ameliorates CCl4-induced liver fibrosis by suppressing the ROS-NLRP3-IL-1beta axis via activating the Nrf2 pathway","volume":"11","author":"Shi","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2021.107660_b0025","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3389\/fphar.2019.00431","article-title":"Interaction mechanisms between the NOX4\/ROS and RhoA\/ROCK1 signaling pathways as new anti- fibrosis targets of ursolic acid in hepatic stellate cells","volume":"10","author":"Huang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2021.107660_b0030","doi-asserted-by":"crossref","first-page":"114846","DOI":"10.1016\/j.taap.2019.114846","article-title":"Anti-inflammatory effects of Aureusidin in LPS-stimulated RAW264.7 macrophages via suppressing NF-kappaB and activating ROS- and MAPKs-dependent Nrf2\/HO-1 signaling pathways","volume":"387","author":"Ren","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107660_b0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13071-018-3223-8","article-title":"NLRP3 inflammasome activation from Kupffer cells is involved in liver fibrosis of Schistosoma japonicum-infected mice via NF-kappaB","volume":"12","author":"Zhang","year":"2019","journal-title":"Parasit Vect."},{"issue":"12","key":"10.1016\/j.intimp.2021.107660_b0040","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/s41374-018-0127-3","article-title":"The STAT3 inhibitor S3I\u2013201 suppresses fibrogenesis and angiogenesis in liver fibrosis","volume":"98","author":"Wang","year":"2018","journal-title":"Lab. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2021.107660_b0045","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s11033-020-05290-0","article-title":"Neovascularization is a key feature of liver fibrosis progression: anti-angiogenesis as an innovative way of liver fibrosis treatment","volume":"47","author":"Zadorozhna","year":"2020","journal-title":"Mol. Biol. Rep."},{"issue":"9","key":"10.1016\/j.intimp.2021.107660_b0050","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1111\/jcmm.14543","article-title":"Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis","volume":"23","author":"Feng","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2021.107660_b0055","article-title":"Liver fibrosis regression correlates with downregulation in liver angiogenesis in chronic hepatitis C through viral eradication","author":"Chen","year":"2020","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2021.107660_b0060","first-page":"e2000711","article-title":"Pterostilbene alleviates Abeta1-42 -induced cognitive dysfunction via inhibition of oxidative stress by activating Nrf2 signaling pathway","author":"Xu","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2021.107660_b0065","doi-asserted-by":"crossref","first-page":"112445","DOI":"10.1016\/j.jep.2019.112445","article-title":"SanWeiGanJiang San relieves liver injury via Nrf2\/Bach1","volume":"251","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2021.107660_b0070","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1039\/C9FO01984G","article-title":"Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1\/Nrf2 pathway and inhibiting the NF-kappaB and NLRP3 pathways in carrageenan-induced pleurisy","volume":"11","author":"Gao","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2021.107660_b0075","doi-asserted-by":"crossref","first-page":"2969802","DOI":"10.1155\/2019\/2969802","article-title":"Effects of ethyl pyruvate on bile duct ligation-induced liver fibrosis by regulating Nrf2 pathway and proinflammatory cytokines in rats","volume":"2019","author":"Zong","year":"2019","journal-title":"Gastroenterol. Res. Pract."},{"issue":"8","key":"10.1016\/j.intimp.2021.107660_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/cells9081808","article-title":"The NLRP3 inflammasome: metabolic regulation and contribution to inflammaging","volume":"9","author":"Meyers","year":"2020","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.intimp.2021.107660_b0085","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1096\/fj.201801749RRR","article-title":"Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy","volume":"33","author":"Chen","year":"2019","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.intimp.2021.107660_b0090","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/hep.29523","article-title":"NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice","volume":"67","author":"Wree","year":"2018","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.intimp.2021.107660_b0095","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/ddr.21649","article-title":"Oridonin ameliorates carbon tetrachloride-induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome","volume":"81","author":"Liu","year":"2020","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.intimp.2021.107660_b0100","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.micpath.2018.11.007","article-title":"Protective effects of alpinetin on lipopolysaccharide\/d-Galactosamine-induced liver injury through inhibiting inflammatory and oxidative responses","volume":"126","author":"Liu","year":"2019","journal-title":"Microb. Pathog."},{"issue":"15","key":"10.1016\/j.intimp.2021.107660_b0105","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.1111\/jcmm.15371","article-title":"Alpinetin inhibits breast cancer growth by ROS\/NF-kappaB\/HIF-1alpha axis","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2021.107660_b0110","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3389\/fphar.2020.00474","article-title":"Activation of PXR by alpinetin contributes to abrogate chemically induced inflammatory bowel disease","volume":"11","author":"Yu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2021.107660_b0115","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.biopha.2017.10.035","article-title":"Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism","volume":"97","author":"Zhou","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107660_b0120","doi-asserted-by":"crossref","first-page":"117175","DOI":"10.1016\/j.lfs.2019.117175","article-title":"Ursodeoxycholic acid alleviates experimental liver fibrosis involving inhibition of autophagy","volume":"242","author":"Ye","year":"2020","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.intimp.2021.107660_b0125","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/hep4.1178","article-title":"Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model","volume":"2","author":"Saijou","year":"2018","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.intimp.2021.107660_b0130","first-page":"107206","article-title":"Physcion 8-O-beta-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-kappaB P65 nuclear expression","author":"Chen","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2021.107660_b0135","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1039\/D0FO00548G","article-title":"Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice","volume":"11","author":"Zhou","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2021.107660_b0140","doi-asserted-by":"crossref","first-page":"108923","DOI":"10.1016\/j.biopha.2019.108923","article-title":"Plumbagin ameliorates liver fibrosis via a ROS-mediated NF-small ka, CyrillicB signaling pathway in vitro and in vivo","volume":"116","author":"Chen","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107660_b0145","doi-asserted-by":"crossref","first-page":"108945","DOI":"10.1016\/j.cbi.2020.108945","article-title":"Benzoquinone derivatives with antioxidant activity inhibit activated hepatic stellate cells and attenuate liver fibrosis in TAA-induced mice","volume":"317","author":"Miao","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.intimp.2021.107660_b0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.actatropica.2019.01.017","article-title":"Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis","volume":"192","author":"Perina","year":"2019","journal-title":"Acta Trop."},{"issue":"1","key":"10.1016\/j.intimp.2021.107660_b0155","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s10620-018-5311-1","article-title":"Dabigatran reduces liver fibrosis in thioacetamide-injured rats","volume":"64","author":"Lee","year":"2019","journal-title":"Dig. Dis. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2021.107660_b0160","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10456-018-9634-5","article-title":"PDGF-BB regulates splitting angiogenesis in skeletal muscle by limiting VEGF-induced endothelial proliferation","volume":"21","author":"Gianni-Barrera","year":"2018","journal-title":"Angiogenesis"},{"key":"10.1016\/j.intimp.2021.107660_b0165","doi-asserted-by":"crossref","first-page":"108628","DOI":"10.1016\/j.foodres.2019.108628","article-title":"Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation","volume":"127","author":"Wang","year":"2020","journal-title":"Food Res. Int."},{"issue":"5","key":"10.1016\/j.intimp.2021.107660_b0170","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2021.107660_b0175","doi-asserted-by":"crossref","first-page":"4703253","DOI":"10.1155\/2019\/4703253","article-title":"Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2","volume":"2019","author":"Wang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.intimp.2021.107660_b0180","doi-asserted-by":"crossref","first-page":"18719","DOI":"10.1038\/s41598-019-54663-4","article-title":"Fuzhenghuayu Decoction ameliorates hepatic fibrosis by attenuating experimental sinusoidal capillarization and liver angiogenesis","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2021.107660_b0185","doi-asserted-by":"crossref","first-page":"557170","DOI":"10.3389\/fnins.2020.557170","article-title":"Neuroprotective effect of oridonin on traumatic brain injury via inhibiting NLRP3 inflammasome in experimental mice","volume":"14","author":"Yan","year":"2020","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.intimp.2021.107660_b0190","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/hep.30252","article-title":"NLR family pyrin domain-containing 3 inflammasome activation in hepatic stellate cells induces liver fibrosis in mice","volume":"69","author":"Inzaugarat","year":"2019","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.intimp.2021.107660_b0195","doi-asserted-by":"crossref","first-page":"168","DOI":"10.21037\/atm.2020.02.21","article-title":"Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-kappaB signal pathway in hepatic stellate cells","volume":"8","author":"Dong","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2021.107660_b0200","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s13046-019-1255-3","article-title":"Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1\/NQO-1 signaling pathway","volume":"38","author":"Lou","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.intimp.2021.107660_b0205","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1021\/acs.jafc.5b05897","article-title":"Liver fibrosis can be induced by high salt intake through excess reactive oxygen species (ROS) production","volume":"64","author":"Wang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2021.107660_b0210","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36158","article-title":"Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation","volume":"7","author":"Lian","year":"2018","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.intimp.2021.107660_b0215","doi-asserted-by":"crossref","first-page":"e201900201","DOI":"10.1590\/s0102-8650201900201","article-title":"Ginsenoside Rb1 attenuates diabetic retinopathy in streptozotocin-induced diabetic rats1","volume":"34","author":"Dong","year":"2019","journal-title":"Acta Cir. Bras."},{"issue":"1","key":"10.1016\/j.intimp.2021.107660_b0220","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/ars.2015.6615","article-title":"Nuclear factor E2-related factor-2 negatively regulates NLRP3 inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming","volume":"26","author":"Liu","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2021.107660_b0225","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3389\/fimmu.2019.01511","article-title":"Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1\/Nrf2 pathway","volume":"10","author":"Arioz","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2021.107660_b0230","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.fct.2018.07.048","article-title":"Anthocyanins isolated from blueberry ameliorates CCl4 induced liver fibrosis by modulation of oxidative stress, inflammation and stellate cell activation in mice","volume":"120","author":"Sun","year":"2018","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107660_b0235","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22017","article-title":"Nootkatone confers hepatoprotective and anti-fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis","volume":"32","author":"Kurdi","year":"2018","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107660_b0240","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: Pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.intimp.2021.107660_b0245","doi-asserted-by":"crossref","first-page":"986075","DOI":"10.1155\/2015\/986075","article-title":"Elevation of HO-1 expression mitigates intestinal ischemia-reperfusion injury and restores tight junction function in a rat liver transplantation model","volume":"2015","author":"Chi","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2021.107660_b0250","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1038\/ncomms11624","article-title":"Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.intimp.2021.107660_b0255","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1002\/ijc.22943","article-title":"Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment","volume":"121","author":"Osburn","year":"2007","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.intimp.2021.107660_b0260","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.freeradbiomed.2020.02.015","article-title":"Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses","volume":"150","author":"Lyu","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2021.107660_b0265","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/wrr.12708","article-title":"Roxadustat promotes angiogenesis through HIF-1alpha\/VEGF\/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats","volume":"27","author":"Zhu","year":"2019","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.intimp.2021.107660_b0270","doi-asserted-by":"crossref","first-page":"153300","DOI":"10.1016\/j.phymed.2020.153300","article-title":"Catalpol protects vascular structure and promotes angiogenesis in cerebral ischemic rats by targeting HIF-1alpha\/VEGF","volume":"78","author":"Wang","year":"2020","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.intimp.2021.107660_b0275","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4254\/wjh.v7.i3.377","article-title":"Angiogenesis and liver fibrosis","volume":"7","author":"Elpek","year":"2015","journal-title":"World J. Hepatol."},{"issue":"9","key":"10.1016\/j.intimp.2021.107660_b0280","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1177\/1535370217701005","article-title":"Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway","volume":"242","author":"Zhao","year":"2017","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"50","key":"10.1016\/j.intimp.2021.107660_b0285","doi-asserted-by":"crossref","first-page":"E6927","DOI":"10.1073\/pnas.1512683112","article-title":"Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A","volume":"112","author":"Wei","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.intimp.2021.107660_b0290","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1167\/iovs.18-25745","article-title":"Nrf2 activator RS9 suppresses pathological ocular angiogenesis and hyperpermeability","volume":"60","author":"Nakamura","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2021.107660_b0295","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3892\/ijmm.2020.4833","article-title":"ASK1\/p38mediated NLRP3 inflammasome signaling pathway contributes to aberrant retinal angiogenesis in diabetic retinopathy","volume":"47","author":"Zou","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2021.107660_b0300","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.2147\/DMSO.S264215","article-title":"NLRP3 blockade suppresses pro-inflammatory and pro-angiogenic cytokine secretion in diabetic retinopathy","volume":"13","author":"Chai","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921002964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921002964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T19:05:40Z","timestamp":1727291140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921002964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":60,"alternative-id":["S1567576921002964"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107660","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107660"}}