{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:13:06Z","timestamp":1791000786698,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.intimp.2021.107758","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T03:28:23Z","timestamp":1621826903000},"page":"107758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Gastrodia remodels intestinal microflora to suppress inflammation in mice with early atherosclerosis"],"prefix":"10.1016","volume":"96","author":[{"given":"Fei-Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo-Chuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Lin","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Si","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yuan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-9256","authenticated-orcid":false,"given":"Chen-Xi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Li","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Jing","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Shan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107758_b0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.atherosclerosis.2020.03.024","article-title":"atherosclerosis: gone with the Wnt?","volume":"301","author":"Philippe","year":"2020","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.intimp.2021.107758_b0010","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0955-2863(02)00294-2","article-title":"The degree of unsaturation of dietary fatty acids and the development of atherosclerosis (review)","volume":"14","author":"Moreno","year":"2003","journal-title":"J. Nutr. Biochem."},{"issue":"12","key":"10.1016\/j.intimp.2021.107758_b0015","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1042\/CS20180306","article-title":"Atherosclerosis and inflammation: overview and updates","volume":"132","author":"Geovanini","year":"2018","journal-title":"Clin. Sci. (Lond.)."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2021.107758_b0020","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11010-010-0484-8","article-title":"The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway","volume":"342","author":"Geng","year":"2010","journal-title":"J. Mol. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.intimp.2021.107758_b0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11883-017-0675-9","article-title":"Gut microbiota and atherosclerosis","volume":"19","author":"Li","year":"2017","journal-title":"J. Curr. Atheroscler. Rep."},{"key":"10.1016\/j.intimp.2021.107758_b0030","unstructured":"M. Schietroma, B. Pessia, F. Carlei, et al., Intestinal permeability and systemic endotoxemia in patients with acute pancreatitis. J. Annali italiani di chirurgia (2016)."},{"key":"10.1016\/j.intimp.2021.107758_b0035","article-title":"Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-\u03b1-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells","author":"Mamiko","year":"2017","journal-title":"J. Biochem. Biophys. Res. Commun."},{"issue":"20","key":"10.1016\/j.intimp.2021.107758_b0040","first-page":"3992","article-title":"Gastrodin in modulating body mass and metabolism in obese rats fed with high-fat diet","volume":"12","author":"Wang","year":"2008","journal-title":"J. Clin. Rehabilitative Tissue Eng. Res."},{"issue":"5","key":"10.1016\/j.intimp.2021.107758_b0045","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s11596-014-1331-z","article-title":"Protection of salvianolate against atherosclerosis via regulating the inflammation in rats","volume":"34","author":"Meng","year":"2014","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2021.107758_b0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-4165(03)00161-2","article-title":"Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages","volume":"1623","author":"Maeda","year":"2003","journal-title":"Biochim. Biophys. Acta."},{"issue":"1","key":"10.1016\/j.intimp.2021.107758_b0055","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12944-019-1056-x","article-title":"Identification of biomarkers in macrophages of atherosclerosis by microarray analysis","volume":"18","author":"Huang","year":"2019","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.intimp.2021.107758_b0060","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3389\/fphys.2017.00600","article-title":"Oxidative Stress-Mediated Atherosclerosis: Mechanisms and Therapies","volume":"8","author":"Yang","year":"2017","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107758_b0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1253\/circj.CJ-09-0706","article-title":"Inflammation in atherosclerosis: transition from theory to practice","volume":"74","author":"Libby","year":"2010","journal-title":"Circ. J."},{"issue":"2","key":"10.1016\/j.intimp.2021.107758_b0070","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ncpcardio0396","article-title":"The impact of progenitor cells in atherosclerosis","volume":"3","author":"Xu","year":"2006","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.intimp.2021.107758_b0075","first-page":"59","article-title":"Immunology and atherosclerosis : the possible mechanisms","volume":"14","author":"Dziekiewicz","year":"2008","journal-title":"Int. Rev. Allergol. Clin. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2021.107758_b0080","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4244\/EIJV4I3A67","article-title":"A primer on the immune system in the pathogenesis and treatment of atherosclerosis","volume":"4","author":"Segers","year":"2008","journal-title":"EuroIntervention."},{"issue":"2","key":"10.1016\/j.intimp.2021.107758_b0085","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4056\/sigs.2981345","article-title":"Veillonella, Firmicutes: Microbes disguised as Gram negatives","volume":"9","author":"Vesth","year":"2013","journal-title":"Stand Genomic Sci."},{"issue":"7122","key":"10.1016\/j.intimp.2021.107758_b0090","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2021.107758_b0095","doi-asserted-by":"crossref","first-page":"501","DOI":"10.5114\/aoms.2011.23418","article-title":"Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults","volume":"7","author":"Abdallah Ismail","year":"2011","journal-title":"Arch. Med. Sci."},{"issue":"Pt 6","key":"10.1016\/j.intimp.2021.107758_b0100","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1099\/00207713-52-6-2141","article-title":"Growth requirements and fermentation products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. nov., comb. nov","volume":"52","author":"Duncan","year":"2002","journal-title":"Int. J. Syst. Evol. Microbiol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107758_b0105","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/01.mpg.0000252184.89922.5f","article-title":"Effects of oral administration of bifidobacterium breve on fecal lactic acid and short-chain fatty acids in low birth weight infants","volume":"44","author":"Wang","year":"2007","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"issue":"2","key":"10.1016\/j.intimp.2021.107758_b0110","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1078\/072320203322346029","article-title":"Reclassification of Bacteroides putredinis (Weinberg et al., 1937) in a new genus Alistipes gen. nov., as Alistipes putredinis comb. nov., and description of Alistipes finegoldii sp. nov., from human sources","volume":"26","author":"Rautio","year":"2003","journal-title":"Syst. Appl. Microbiol."},{"issue":"5","key":"10.1016\/j.intimp.2021.107758_b0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.anaerobe.2004.05.006","article-title":"Inhibition of Clostridium perfringens sporulation by Bacteroides fragilis and short-chain fatty acids","volume":"10","author":"Wrigley","year":"2004","journal-title":"Anaerobe."},{"key":"10.1016\/j.intimp.2021.107758_b0120","doi-asserted-by":"crossref","unstructured":"Qingsen, Shang, Guanrui, et al., Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice \u2013 ScienceDirect. J. Funct. Foods, 28 (2017) 138\u2013146.","DOI":"10.1016\/j.jff.2016.11.002"},{"key":"10.1016\/j.intimp.2021.107758_b0125","doi-asserted-by":"crossref","first-page":"14405","DOI":"10.1038\/srep14405","article-title":"Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.intimp.2021.107758_b0130","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1136\/gutjnl-2014-306928","article-title":"Microbiota and diabetes: an evolving relationship","volume":"63","author":"Tilg","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2021.107758_b0135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.intimp.2021.107758_b0140","doi-asserted-by":"crossref","unstructured":"A. Rivi\u00e8re, M. Selak, D. Lantin, et al., Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Front. Microbiol. 7 (2016) 979. Published 2016 Jun 28.","DOI":"10.3389\/fmicb.2016.00979"},{"issue":"3","key":"10.1016\/j.intimp.2021.107758_b0145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3177\/jnsv.51.156","article-title":"Dose-Dependent Stimulatory and Inhibitory Effects of Luminal and Serosal n-Butyric Acid on Epithelial Cell Proliferation of Pig Distal Colonic Mucosa","volume":"51","author":"Inagaki","year":"2005","journal-title":"J. Nutr. Sci. Vitaminol."},{"issue":"7\u20138","key":"10.1016\/j.intimp.2021.107758_b0150","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.nut.2013.11.018","article-title":"Effect of oral consumption of probiotic Lactobacillus planatarum P-8 on fecal microbiota, SIgA, SCFAs, and TBAs of adults of different ages","volume":"30","author":"Wang","year":"2014","journal-title":"Nutrition."},{"issue":"11","key":"10.1016\/j.intimp.2021.107758_b0155","doi-asserted-by":"crossref","first-page":"21089","DOI":"10.1002\/jcp.28711","article-title":"The effects and mechanisms of myeloid differentiation protein 2 on intestinal mucosal permeability in mice with chronic colitis","volume":"234","author":"Han","year":"2019","journal-title":"J. Cell Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107758_b0160","doi-asserted-by":"crossref","first-page":"134","DOI":"10.5713\/ajas.15.0534","article-title":"Effect of Polysaccharides from Acanthopanax senticosus on Intestinal Mucosal Barrier of Escherichia coli Lipopolysaccharide Challenged Mice","volume":"29","author":"Han","year":"2016","journal-title":"Asian-Australas J. Anim. Sci."},{"issue":"7268","key":"10.1016\/j.intimp.2021.107758_b0165","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nature08530","article-title":"Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43","volume":"461","author":"Maslowski","year":"2009","journal-title":"Nature"},{"issue":"D16","key":"10.1016\/j.intimp.2021.107758_b0170","doi-asserted-by":"crossref","first-page":"18205","DOI":"10.1029\/2000JD900663","article-title":"Climatology of dust aerosol size distribution and optical properties derived from remotely sensed data in the solar spectrum","volume":"106","author":"Tanr\u00e9","year":"2001","journal-title":"J. Geophys. Res. Atmos."},{"key":"10.1016\/j.intimp.2021.107758_b0175","unstructured":"R. Bakirova, S. Fasylov, O. Nurkenov, et al., [Research of anti-inflammatory activity of the thiosemicarbaziden-morpholinilacetic acid]. Georgian Med News, (240) (2015) 88\u201393."},{"key":"10.1016\/j.intimp.2021.107758_b0180","doi-asserted-by":"crossref","unstructured":"Mirmonsef, Paria, Makinde, et al., Short chain fatty acids induce IL-1 beta production: The role of monocarboxylate transporters (MCTs). J. Immunol., 188 (2012).","DOI":"10.4049\/jimmunol.188.Supp.117.16"},{"issue":"10","key":"10.1016\/j.intimp.2021.107758_b0185","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/nu3100858","article-title":"Regulation of inflammation by short chain fatty acids","volume":"3","author":"Vinolo","year":"2011","journal-title":"Nutrients."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921003945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921003945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T19:07:09Z","timestamp":1727291229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921003945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":37,"alternative-id":["S1567576921003945"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107758","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrodia remodels intestinal microflora to suppress inflammation in mice with early atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107758"}}