{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:29:21Z","timestamp":1787682561305,"version":"build-2784847793"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970944"],"award-info":[{"award-number":["81970944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991502"],"award-info":[{"award-number":["81991502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.intimp.2021.107803","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T10:50:41Z","timestamp":1622717441000},"page":"107803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The emerging role of Interleukin 37 in bone homeostasis and inflammatory bone diseases"],"prefix":"10.1016","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3978-7165","authenticated-orcid":false,"given":"Peiyao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-3114","authenticated-orcid":false,"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107803_b0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.smim.2018.01.001","article-title":"Complement involvement in bone homeostasis and bone disorders","volume":"37","author":"M\u00f6dinger","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.intimp.2021.107803_b0010","doi-asserted-by":"crossref","first-page":"464","DOI":"10.2741\/4600","article-title":"Osteoimmunology: The Nexus between bone and immune system","volume":"23","author":"Dar","year":"2018","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.intimp.2021.107803_b0015","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3389\/fimmu.2019.00797","article-title":"Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing","volume":"10","author":"Bucher","year":"2019","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2021.107803_b0020","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.1944","article-title":"IL-37 is a fundamental inhibitor of innate immunity","volume":"11","author":"Nold","year":"2010","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/imr.12605","article-title":"Suppression of inflammation and acquired immunity by IL-37","volume":"281","author":"Cavalli","year":"2018","journal-title":"Immunol. Rev."},{"issue":"12","key":"10.1016\/j.intimp.2021.107803_b0030","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1161\/ATVBAHA.115.306543","article-title":"IL-37 Is a Novel Proangiogenic Factor of Developmental and Pathological Angiogenesis","volume":"35","author":"Yang","year":"2015","journal-title":"Arterioscler. Thromb.. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0035","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3390\/cells9010178","article-title":"Parsing the IL-37-Mediated Suppression of Inflammasome Function","volume":"9","author":"Rudloff","year":"2020","journal-title":"Cells"},{"issue":"15","key":"10.1016\/j.intimp.2021.107803_b0040","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.3390\/ijms20153701","article-title":"Mast Cells May Regulate The Anti-Inflammatory Activity of IL-37","volume":"20","author":"Theoharides","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cyto.2014.03.002","article-title":"Long-range DNA interactions at the IL-1\/IL-36\/IL-37 gene cluster (2q13) are induced by activation of monocytes","volume":"68","author":"Sharaf","year":"2014","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.intimp.2021.107803_b0050","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41419-018-0664-0","article-title":"IL-37 isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner","volume":"9","author":"Zhao","year":"2018","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.intimp.2021.107803_b0055","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.smim.2013.10.004","article-title":"Interleukin-37","volume":"25","author":"Dinarello","year":"2013","journal-title":"Semin. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2021.107803_b0060","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1101\/gr.4338005","article-title":"A genome-wide survey of structural variation between human and chimpanzee","volume":"15","author":"Newman","year":"2005","journal-title":"Genome Res."},{"key":"10.1016\/j.intimp.2021.107803_b0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fimmu.2013.00167","article-title":"New Insights in the Immunobiology of IL-1 Family Members","volume":"4","author":"van de Veerdonk","year":"2013","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/imr.12616","article-title":"Interleukin-18: Biological properties and role in disease pathogenesis","volume":"281","author":"Kaplanski","year":"2018","journal-title":"Immunol. Rev."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2021.107803_b0075","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jim.2012.10.017","article-title":"Analysis of nuclear localization of interleukin-1 family cytokines by flow cytometry","volume":"387","author":"Ross","year":"2013","journal-title":"J. Immunol. Methods"},{"issue":"8","key":"10.1016\/j.intimp.2021.107803_b0080","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1073\/pnas.1424626112","article-title":"Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8","volume":"112","author":"Li","year":"2015","journal-title":"Proc. National Acad. Sci. USA"},{"issue":"7678","key":"10.1016\/j.intimp.2021.107803_b0085","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature24293","article-title":"IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity","volume":"551","author":"Molgora","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2021.107803_b0090","first-page":"83","article-title":"IL-37 suppresses MyD88-mediated inflammatory responses in human aortic valve interstitial cells","volume":"23","author":"Zhan","year":"2017","journal-title":"Mol. Med. (Cambridge, Mass.)"},{"issue":"4","key":"10.1016\/j.intimp.2021.107803_b0095","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ni.3103","article-title":"IL-37 requires the receptors IL-18R\u03b1 and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction","volume":"16","author":"Nold-Petry","year":"2015","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2021.107803_b0100","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/all.12566","article-title":"IL-37 requires IL-18R\u03b1 and SIGIRR\/IL-1R8 to diminish allergic airway inflammation in mice","volume":"70","author":"Lunding","year":"2015","journal-title":"Allergy"},{"issue":"7","key":"10.1016\/j.intimp.2021.107803_b0105","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1073\/pnas.1324140111","article-title":"Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses","volume":"111","author":"Bulau","year":"2014","journal-title":"Proc. Nat. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.intimp.2021.107803_b0110","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.4049\/jimmunol.180.8.5477","article-title":"The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines","volume":"180","author":"Sharma","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2021.107803_b0115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-\u03b2\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0120","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1189\/jlb.5RU0816-341R","article-title":"A protective role of IL-37 in cancer: a new hope for cancer patients","volume":"101","author":"Abulkhir","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2021.107803_b0125","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/sji.12322","article-title":"Increased IL-37 in Atherosclerotic Disease could be Suppressed by Atorvastatin Therapy","volume":"82","author":"Shaoyuan","year":"2015","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.intimp.2021.107803_b0130","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-981-13-9367-9_10","article-title":"NF-\u03baB, I\u03baB, and IKK: Integral Components of Immune System Signaling","volume":"1172","author":"Mulero","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0135","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/imr.12550","article-title":"The interplay of IKK, NF-\u03baB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation","volume":"277","author":"Kondylis","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2021.107803_b0140","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.intimp.2017.12.010","article-title":"Interleukin-37 alleviates airway inflammation and remodeling in asthma via inhibiting the activation of NF-\u03baB and STAT3 signalings","volume":"55","author":"Huang","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2021.107803_b0145","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1177\/0022034513500306","article-title":"Advances in the regulation of osteoclasts and osteoclast functions","volume":"92","author":"Boyce","year":"2013","journal-title":"J. Dent. Res."},{"issue":"4","key":"10.1016\/j.intimp.2021.107803_b0150","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00418-018-1636-2","article-title":"Recent advances in osteoclast biology","volume":"149","author":"Ono","year":"2018","journal-title":"Histochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0155","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2174\/1568010054022015","article-title":"Osteoblasts and osteoclasts in bone remodeling and inflammation","volume":"4","author":"Tanaka","year":"2005","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"issue":"7","key":"10.1016\/j.intimp.2021.107803_b0160","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1172\/JCI94606","article-title":"The many ways of osteoclast activation","volume":"127","author":"Lorenzo","year":"2017","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0165","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/jcp.25134","article-title":"Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease","volume":"231","author":"Salamanna","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2021.107803_b0170","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12967-015-0394-3","article-title":"Interleukin-37 is increased in ankylosing spondylitis patients and associated with disease activity","volume":"13","author":"Chen","year":"2015","journal-title":"Journal of translational medicine"},{"key":"10.1016\/j.intimp.2021.107803_b0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.imlet.2016.04.004","article-title":"IL-37 inhibits lipopolysaccharide-induced osteoclast formation and bone resorption in vivo","volume":"175","author":"Saeed","year":"2016","journal-title":"Immunol. Lett."},{"issue":"5","key":"10.1016\/j.intimp.2021.107803_b0180","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1002\/jcp.27526","article-title":"Interleukin-37 inhibits osteoclastogenesis and alleviates inflammatory bone destruction","volume":"234","author":"Tang","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2021.107803_b0185","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2007.11.013","article-title":"Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways","volume":"580","author":"Hu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2021.107803_b0190","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/0022034519847443","article-title":"IL-37- and IL-35\/IL-37-Producing Plasma Cells in Chronic Periodontitis","volume":"98","author":"Jing","year":"2019","journal-title":"J. Dent. Res."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0195","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrrheum.2017.213","article-title":"Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity","volume":"14","author":"Walsh","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/BOR.0000000000000449","article-title":"Inflammation in bone physiology and pathology","volume":"30","author":"Adamopoulos","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"issue":"14","key":"10.1016\/j.intimp.2021.107803_b0205","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.2174\/1389450118666170104153512","article-title":"Pro-Inflammatory Cytokines: New Potential Therapeutic Targets for Obesity-Related Bone Disorders","volume":"18","author":"Wang","year":"2017","journal-title":"Curr. Drug Targets"},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0210","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/039463201202500105","article-title":"IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation","volume":"25","author":"Tete","year":"2012","journal-title":"Int.. J. Immunopathol. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0215","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s12015-011-9228-8","article-title":"Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation","volume":"7","author":"Pontikoglou","year":"2011","journal-title":"Stem Cell Rev. Reports"},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0220","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2567.2012.03567.x","article-title":"Recent progress toward understanding the physiological function of bone marrow mesenchymal stem cells","volume":"136","author":"Shi","year":"2012","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0225","first-page":"288","article-title":"Research and development of osteogenic differentiation of bone marrow mesenchymal stem cells","volume":"32","author":"Dong","year":"2019","journal-title":"Zhongguo gu shang = China J. Orthopaedics Traumatol."},{"key":"10.1016\/j.intimp.2021.107803_b0230","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.12659\/MSM.903027","article-title":"IL-17A Inhibits Osteogenic Differentiation of Bone Mesenchymal Stem Cells via Wnt Signaling Pathway","volume":"23","author":"Wang","year":"2017","journal-title":"Med. Sci. Monit.: Int. Med. J. Exp. Clin. Res."},{"issue":"9","key":"10.1016\/j.intimp.2021.107803_b0235","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1096\/fj.201701256RRR","article-title":"Concentration-dependent, dual roles of IL-10 in the osteogenesis of human BMSCs via P38\/MAPK and NF-\u03baB signaling pathways","volume":"32","author":"Chen","year":"2018","journal-title":"FASEB J.: Off. Publ. Federation Am. Soc. Exp. Biol."},{"issue":"10","key":"10.1016\/j.intimp.2021.107803_b0240","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41419-019-1904-7","article-title":"Extracellular IL-37 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via activation of the PI3K\/AKT signaling pathway","volume":"10","author":"Ye","year":"2019","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2021.107803_b0245","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s11064-014-1288-0","article-title":"Bone marrow mesenchymal stem cell-derived microvesicles protect rat pheochromocytoma PC12 cells from glutamate-induced injury via a PI3K\/Akt dependent pathway","volume":"39","author":"Lin","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.intimp.2021.107803_b0250","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.lfs.2017.09.017","article-title":"MGF E peptide pretreatment improves the proliferation and osteogenic differentiation of BMSCs via MEK-ERK1\/2 and PI3K-Akt pathway under severe hypoxia","volume":"189","author":"Sha","year":"2017","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0255","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s10753-019-00960-z","article-title":"Umbilical Cord Blood Mesenchymal Stem Cells Enhance Lipopolysaccharide-Induced IL-10 and IL-37 Production in THP-1 Cells","volume":"42","author":"Zhou","year":"2019","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cei.13188","article-title":"Immune-bone interplay in the structural damage in rheumatoid arthritis","volume":"194","author":"Komatsu","year":"2018","journal-title":"Clin. Exp. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2021.107803_b0265","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1093\/rheumatology\/kew325","article-title":"Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation","volume":"55","author":"Cavalli","year":"2016","journal-title":"Rheumatology (Oxford, England)"},{"issue":"5","key":"10.1016\/j.intimp.2021.107803_b0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095346","article-title":"Plasma levels of IL-37 and correlation with TNF-\u03b1, IL-17A, and disease activity during DMARD treatment of rheumatoid arthritis","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2021.107803_b0275","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cyto.2018.07.027","article-title":"Elevated levels of IL-37 correlate with T cell activation status in rheumatoid arthritis patients","volume":"113","author":"Ragab","year":"2019","journal-title":"Cytokine"},{"issue":"12","key":"10.1016\/j.intimp.2021.107803_b0280","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/apm.12467","article-title":"Elevated serum levels of Interleukin-37 are associated with inflammatory cytokines and disease activity in rheumatoid arthritis","volume":"123","author":"Yang","year":"2015","journal-title":"APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica"},{"issue":"6","key":"10.1016\/j.intimp.2021.107803_b0285","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/1756-185X.13539","article-title":"Elevated expression of interleukin-37 in patients with rheumatoid arthritis","volume":"22","author":"Yuan","year":"2019","journal-title":"Int. J. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0290","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cyto.2015.06.005","article-title":"Elevated serum and synovial fluid levels of interleukin-37 in patients with rheumatoid arthritis: Attenuated the production of inflammatory cytokines","volume":"76","author":"Xia","year":"2015","journal-title":"Cytokine"},{"issue":"11","key":"10.1016\/j.intimp.2021.107803_b0295","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.4049\/jimmunol.1401810","article-title":"IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17-Triggering Cytokine Production and Limiting Th17 Cell Proliferation","volume":"194","author":"Ye","year":"2015","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.intimp.2021.107803_b0300","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/263625","article-title":"Cytokine-mediated bone destruction in rheumatoid arthritis","volume":"2014","author":"Jung","year":"2014","journal-title":"J. Immunol. Res."},{"issue":"9","key":"10.1016\/j.intimp.2021.107803_b0305","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nrrheum.2017.129","article-title":"Rheumatoid arthritis: Regulating the osteoclast workforce","volume":"13","author":"Mchugh","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"9","key":"10.1016\/j.intimp.2021.107803_b0310","first-page":"1461","article-title":"What drives osteoarthritis?-synovial versus subchondral bone pathology","volume":"56","author":"H\u00fcgle","year":"2017","journal-title":"Rheumatology (Oxford, England)"},{"issue":"9","key":"10.1016\/j.intimp.2021.107803_b0315","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3390\/cells8090990","article-title":"Intraarticular Ligament Degeneration Is Interrelated with Cartilage and Bone Destruction in Osteoarthritis","volume":"8","author":"Schulze-Tanzil","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0320","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0325","doi-asserted-by":"crossref","first-page":"11601","DOI":"10.1038\/s41598-017-11397-5","article-title":"IL-37 is associated with osteoarthritis disease activity and suppresses proinflammatory cytokines production in synovial cells","volume":"7","author":"Ding","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2021.107803_b0330","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0195-5616(97)50076-3","article-title":"Osteoarthritis. Joint anatomy, physiology, and pathobiology. The Veterinary clinics of North America","volume":"27","author":"Johnston","year":"1997","journal-title":"Small Animal Pract."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0335","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0945-053X(99)00024-4","article-title":"Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes","volume":"18","author":"Flannery","year":"1999","journal-title":"Matrix Biol.: J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.intimp.2021.107803_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116786","article-title":"The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review","volume":"234","author":"Mehana","year":"2019","journal-title":"Life Sci."},{"issue":"12","key":"10.1016\/j.intimp.2021.107803_b0345","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/jcb.23298","article-title":"ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis","volume":"112","author":"Verma","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.intimp.2021.107803_b0350","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1136\/ard.2004.022434","article-title":"MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis","volume":"64","author":"Tchetverikov","year":"2005","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0355","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1172\/JCI114215","article-title":"Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage","volume":"84","author":"Dean","year":"1989","journal-title":"J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.intimp.2021.107803_b0360","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/1529-0131(200106)44:6<1455::AID-ART241>3.0.CO;2-J","article-title":"Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR\/ort mice","volume":"44","author":"Chambers","year":"2001","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0365","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI119526","article-title":"Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints","volume":"100","author":"Lark","year":"1997","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0370","first-page":"351","article-title":"IL37 dampens the IL1\u03b2-induced catabolic status of human OA chondrocytes","volume":"56","author":"van Geffen","year":"2017","journal-title":"Rheumatology (Oxford, England)"},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0375","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.joca.2018.08.016","article-title":"IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3","volume":"27","author":"van Geffen","year":"2019","journal-title":"Osteoarthrit. Cartilage"},{"issue":"5","key":"10.1016\/j.intimp.2021.107803_b0380","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1177\/0022034515574770","article-title":"Current understanding of pathogenesis and treatment of TMJ osteoarthritis","volume":"94","author":"Wang","year":"2015","journal-title":"J. Dent. Res."},{"issue":"6","key":"10.1016\/j.intimp.2021.107803_b0385","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12692","article-title":"IL-37b alleviates inflammation in the temporomandibular joint cartilage via IL-1R8 pathway","volume":"52","author":"Luo","year":"2019","journal-title":"Cell Prolif."},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0390","first-page":"811","article-title":"Changes in bone mineral density and bone metabolic indexes in ankylosing spondylitis mouse model complicated with osteoporosis","volume":"16","author":"Hu","year":"2018","journal-title":"Exp. Therap. Med."},{"key":"10.1016\/j.intimp.2021.107803_b0395","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13075-015-0805-0","article-title":"Inflammation-driven bone formation in a mouse model of ankylosing spondylitis: sequential not parallel processes","volume":"18","author":"Tseng","year":"2016","journal-title":"Arthrit. Res. Therapy"},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0400","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1177\/0300060517708693","article-title":"Association of adipokines, interleukin-6, and tumor necrosis factor-\u03b1 concentrations with clinical characteristics and presence of spinal syndesmophytes in patients with ankylosing spondylitis: A cross-sectional study","volume":"45","author":"Gonzalez-Lopez","year":"2017","journal-title":"J. Int. Med. Res."},{"issue":"4","key":"10.1016\/j.intimp.2021.107803_b0405","doi-asserted-by":"crossref","first-page":"433","DOI":"10.5114\/ceji.2019.92805","article-title":"Biological and genetic evaluation of IL-23\/IL-17 pathway in ankylosing spondylitis patients","volume":"44","author":"Deveci","year":"2019","journal-title":"Central-European J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0410","first-page":"19","article-title":"Serum Level of Interleukin-37 and Expression of Its mRNA in Ankylosing Spondylitis Patients: Possible Role in Osteoporosis","volume":"23","author":"Fawzy","year":"2016","journal-title":"Egypt. J. Immunol."},{"issue":"15","key":"10.1016\/j.intimp.2021.107803_b0415","first-page":"2740","article-title":"Prevalence of osteoporosis and vertebral fractures and related factors in patients with ankylosing spondylitis","volume":"127","author":"Ulu","year":"2014","journal-title":"Chin. Med. J."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0420","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00296-009-0975-7","article-title":"The relation between osteoporosis and vitamin D levels and disease activity in ankylosing spondylitis","volume":"30","author":"Mermerci Ba\u015fkan","year":"2010","journal-title":"Rheumatol. Int."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0425","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: facts, fallacies and the future","volume":"75","author":"Slots","year":"2000","journal-title":"Periodontology"},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0430","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0435","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1038\/s41467-018-05940-9","article-title":"GWAS for Interleukin-1\u03b2 levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation","volume":"9","author":"Offenbacher","year":"2018","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0440","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1590\/1678-775720140259","article-title":"Host response mechanisms in periodontal diseases","volume":"23","author":"Silva","year":"2015","journal-title":"J. Appl. Oral Sci.: Revista FOB"},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0445","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0765.1992.tb01814.x","article-title":"Activated lymphocyte subsets in adult periodontitis","volume":"27","author":"Afar","year":"1992","journal-title":"J. Periodontal Res."},{"issue":"45","key":"10.1016\/j.intimp.2021.107803_b0450","first-page":"51","article-title":"B cells in periodontitis: friends or enemies?","volume":"2007","author":"Berglundh","year":"2000","journal-title":"Periodontology"},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0455","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/cyto.2002.0873","article-title":"Interleukin-1F7B (IL-1H4\/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production","volume":"18","author":"Kumar","year":"2002","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.intimp.2021.107803_b0460","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/jre.12241","article-title":"Levels of interleukin-37 in gingival crevicular fluid, saliva, or plasma in periodontal disease","volume":"50","author":"Sa\u011flam","year":"2015","journal-title":"J. Periodontal Res."},{"key":"10.1016\/j.intimp.2021.107803_b0465","doi-asserted-by":"crossref","first-page":"2780794","DOI":"10.1155\/2019\/2780794","article-title":"Effects of Er, Cr:YSGG and Diode Lasers on Clinical Parameters and Gingival Crevicular Fluid IL-1\u03b2 and IL-37 Levels in Generalized Aggressive Periodontitis","volume":"2019","author":"Talmac","year":"2019","journal-title":"Mediators Inflamm."},{"issue":"18","key":"10.1016\/j.intimp.2021.107803_b0470","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.3390\/ijms20184541","article-title":"Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological Interactions","volume":"20","author":"de Molon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2021.107803_b0475","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/BOR.0000000000000638","article-title":"Porphyromonas gingivalis and rheumatoid arthritis","volume":"31","author":"Perricone","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"issue":"7","key":"10.1016\/j.intimp.2021.107803_b0480","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/00016357.2020.1747635","article-title":"Relationship between periodontitis and rheumatoid arthritis in Vietnamese patients","volume":"78","author":"Nguyen","year":"2020","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.intimp.2021.107803_b0485","doi-asserted-by":"crossref","first-page":"6034546","DOI":"10.1155\/2019\/6034546","article-title":"Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?","volume":"2019","author":"Ceccarelli","year":"2019","journal-title":"Mediators Inflamm."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0490","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41368-019-0064-z","article-title":"The cytokine network involved in the host immune response to periodontitis","volume":"11","author":"Pan","year":"2019","journal-title":"Int. J. Oral Sci."},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0495","doi-asserted-by":"crossref","first-page":"758","DOI":"10.4049\/jimmunol.156.2.758","article-title":"IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts","volume":"156","author":"Onoe","year":"1996","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107803_b0500","doi-asserted-by":"crossref","first-page":"917","DOI":"10.4049\/jimmunol.175.2.917","article-title":"IL-4 inhibits bone-resorbing activity of mature osteoclasts by affecting NF-kappa B and Ca2+ signaling","volume":"175","author":"Mangashetti","year":"2005","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0505","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/art.1780390318","article-title":"Interleukin-10 inhibition of the progression of established collagen-induced arthritis","volume":"39","author":"Walmsley","year":"1996","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.intimp.2021.107803_b0510","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s13075-014-0419-y","article-title":"Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction","volume":"16","author":"Greenhill","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"10.1016\/j.intimp.2021.107803_b0515","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1089\/jir.2014.0212","article-title":"The Protective Effect of Interleukin-37 on Vascular Calcification and Atherosclerosis in Apolipoprotein E-Deficient Mice with Diabetes","volume":"35","author":"Chai","year":"2015","journal-title":"J. Interferon Cytokine Res."},{"issue":"1","key":"10.1016\/j.intimp.2021.107803_b0520","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12931-017-0675-x","article-title":"The potential of interleukin-37 as an effective therapeutic agent in asthma","volume":"18","author":"Zhang","year":"2017","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.intimp.2021.107803_b0525","first-page":"165","article-title":"Role of Interleukin-37 in Inflammatory and Autoimmune Diseases","volume":"15","author":"Wang","year":"2018","journal-title":"Iranian J. Immunol.: IJI"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921004392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921004392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T11:24:30Z","timestamp":1747308270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921004392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":105,"alternative-id":["S1567576921004392"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107803","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The emerging role of Interleukin 37 in bone homeostasis and inflammatory bone diseases","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107803","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107803"}}