{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:10:08Z","timestamp":1791342608874,"version":"4.3.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930023"],"award-info":[{"award-number":["81930023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.intimp.2021.107812","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T11:35:35Z","timestamp":1622720135000},"page":"107812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Specific sweat metabolite profile in ocular Behcet\u2019s disease"],"prefix":"10.1016","volume":"97","author":[{"given":"Xiaoxiao","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aize","family":"Kijlstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peizeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2021.107812_b0005","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ophtha.2007.04.056","article-title":"Clinical features of Chinese patients with Beh\u00e7et's disease","volume":"115","author":"Yang","year":"2008","journal-title":"Ophthalmology"},{"issue":"17","key":"10.1016\/j.intimp.2021.107812_b0010","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","article-title":"Beh\u00e7et's disease","volume":"341","author":"Sakane","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2021.107812_b0015","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3389\/fimmu.2019.00665","article-title":"Immunopathogenesis of Behcet's disease","volume":"10","author":"Tong","year":"2019","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2021.107812_b0020","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/rheumatology\/kez043","article-title":"Epigenome-wide association study identifies Beh\u00e7et's disease-associated methylation loci in Han Chinese","volume":"58","author":"Yu","year":"2019","journal-title":"Rheumatology (Oxford)"},{"issue":"12","key":"10.1016\/j.intimp.2021.107812_b0025","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/rheumatology\/kel329","article-title":"Autoimmunity vs autoinflammation in Behcet's disease: do we oversimplify a complex disorder?","volume":"45","author":"Direskeneli","year":"2006","journal-title":"Rheumatology (Oxford)"},{"issue":"10","key":"10.1016\/j.intimp.2021.107812_b0030","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1111\/jdv.13221","article-title":"Highly abundant defense proteins in human sweat as revealed by targeted proteomics and label-free quantification mass spectrometry","volume":"29","author":"Csosz","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107812_b0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jid.2017.05.040","article-title":"Proteomic profiling of sweat exosome suggests its involvement in skin immunity","volume":"138","author":"Wu","year":"2018","journal-title":"J, Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.intimp.2021.107812_b0040","doi-asserted-by":"crossref","DOI":"10.1002\/prca.201800010","article-title":"Eccrine sweat as a biofluid for profiling immune biomarkers","volume":"12","author":"Katchman","year":"2018","journal-title":"Proteomics Clin. Appl."},{"issue":"1","key":"10.1016\/j.intimp.2021.107812_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-anchem-061318-114910","article-title":"Wearable sensors for biochemical sweat analysis","volume":"12","author":"Bandodkar","year":"2019","journal-title":"Annu. Rev. Anal. Chem. (Palo Alto Calif)"},{"issue":"3","key":"10.1016\/j.intimp.2021.107812_b0050","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1601314","article-title":"Wearable\/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module","volume":"3","author":"Lee","year":"2017","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.intimp.2021.107812_b0055","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1039\/C9LC00103D","article-title":"Passive sweat collection and colorimetric analysis of biomarkers relevant to kidney disorders using a soft microfluidic system","volume":"19","author":"Zhang","year":"2019","journal-title":"Lab Chip"},{"issue":"8697","key":"10.1016\/j.intimp.2021.107812_b0060","first-page":"1078","article-title":"International Study Group for Behcet's Disease","volume":"335","author":"Criteria for diagnosis of Behcet's disease","year":"1990","journal-title":"Lancet (London, England)"},{"issue":"D1","key":"10.1016\/j.intimp.2021.107812_b0065","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: the human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.intimp.2021.107812_b0070","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.2337\/dc16-0232","article-title":"Early prediction of developing type 2 diabetes by plasma acylcarnitines: a population-based study","volume":"39","author":"Sun","year":"2016","journal-title":"Diabetes Care"},{"issue":"W1","key":"10.1016\/j.intimp.2021.107812_b0075","doi-asserted-by":"crossref","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.intimp.2021.107812_b0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s40168-018-0588-z","article-title":"Understanding the microbial basis of body odor in pre-pubescent children and teenagers","volume":"6","author":"Lam","year":"2018","journal-title":"Microbiome"},{"issue":"6","key":"10.1016\/j.intimp.2021.107812_b0085","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.autrev.2017.12.006","article-title":"Beh\u00e7et's disease: new insights into pathophysiology, clinical features and treatment options","volume":"17","author":"Greco","year":"2018","journal-title":"Autoimmun. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2021.107812_b0090","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jbspin.2017.05.019","article-title":"Potential metabolomic biomarkers for reliable diagnosis of Behcet's disease using gas chromatography\/ time-of-flight-mass spectrometry","volume":"85","author":"Ahn","year":"2018","journal-title":"Joint Bone Spine"},{"issue":"11","key":"10.1016\/j.intimp.2021.107812_b0095","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.3390\/ijms18112309","article-title":"Urinary metabolomic profiling to identify potential biomarkers for the diagnosis of Behcet's disease by gas chromatography\/time-of-flight-mass spectrometry","volume":"18","author":"Ahn","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2021.107812_b0100","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13075-018-1712-y","article-title":"Metabolomic alterations associated with Beh\u00e7et's disease","volume":"20","author":"Zheng","year":"2018","journal-title":"Arthritis. Res. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2021.107812_b0105","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"issue":"20","key":"10.1016\/j.intimp.2021.107812_b0110","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.3748\/wjg.v23.i20.3643","article-title":"Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children","volume":"23","author":"Martin","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.intimp.2021.107812_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135856","article-title":"A comparative metabolomic evaluation of Behcet's disease with arthritis and seronegative arthritis using synovial fluid","volume":"10","author":"Ahn","year":"2015","journal-title":"PLoS One"},{"issue":"6 Pt A","key":"10.1016\/j.intimp.2021.107812_b0120","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.clnu.2017.10.009","article-title":"Citrulline in health and disease. Review on human studies","volume":"36","author":"Papadia","year":"2018","journal-title":"Clin. Nutr."},{"issue":"5","key":"10.1016\/j.intimp.2021.107812_b0125","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.1346-8138.2007.00278.x","article-title":"Oxidative stress in patients with Behcet's disease: I correlation with severity and clinical parameters","volume":"34","author":"Najim","year":"2007","journal-title":"J. Dermatol."},{"issue":"6","key":"10.1016\/j.intimp.2021.107812_b0130","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1039\/b717398a","article-title":"Recent advances in urocanic acid photochemistry, photobiology and photoimmunology","volume":"7","author":"Gibbs","year":"2008","journal-title":"Photochem. Photobiol. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2021.107812_b0135","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ni.3462","article-title":"Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Immunol."},{"issue":"541","key":"10.1016\/j.intimp.2021.107812_b0140","doi-asserted-by":"crossref","first-page":"eaao4874","DOI":"10.1126\/scisignal.aao4874","article-title":"Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye","volume":"11","author":"Sakurai","year":"2018","journal-title":"Sci. Signal"},{"issue":"1","key":"10.1016\/j.intimp.2021.107812_b0145","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1271\/bbb.100723","article-title":"Fluorometric determination of 2-oxoadipic acid, a common metabolite of tryptophan and lysine, by high-performance liquid chromatography with pre-chemical derivatization","volume":"75","author":"Shibata","year":"2011","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"4","key":"10.1016\/j.intimp.2021.107812_b0150","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1046\/j.1440-1711.2003.t01-1-01177.x","article-title":"Tryptophan and the immune response","volume":"81","author":"Moffett","year":"2003","journal-title":"Immunol. Cell Biol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921004483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921004483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:32:54Z","timestamp":1761586374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921004483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":30,"alternative-id":["S1567576921004483"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107812","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Specific sweat metabolite profile in ocular Behcet\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107812","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107812"}}