{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:57:32Z","timestamp":1793825852340,"version":"4.6.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.intimp.2021.107896","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T08:34:43Z","timestamp":1625646883000},"page":"107896","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Pseudoginsenoside-F11 promotes functional recovery after transient cerebral ischemia by regulating the microglia\/macrophage polarization in rats"],"prefix":"10.1016","volume":"99","author":[{"given":"Ying","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107896_b0005","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.1109766","article-title":"Inflammatory mechanisms in ischemic stroke: role of inflammatory cells","volume":"87","author":"Jin","year":"2010","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.intimp.2021.107896_b0010","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2021.107896_b0015","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/jcbfm.2013.146","article-title":"Microglia\/macrophage polarization dynamics in white matter after traumatic brain injury","volume":"33","author":"Wang","year":"2013","journal-title":"J. Cereb. Blood Flow Metabol. Off. J. Int. Soc. Cerebral Blood Flow Metabol."},{"key":"10.1016\/j.intimp.2021.107896_b0020","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","article-title":"Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia","volume":"43","author":"Hu","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2021.107896_b0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.mcn.2005.10.006","article-title":"Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem\/progenitor cells","volume":"31","author":"Butovsky","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2021.107896_b0030","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/glia.21266","article-title":"Identification of a microglia phenotype supportive of remyelination","volume":"60","author":"Olah","year":"2012","journal-title":"Glia."},{"key":"10.1016\/j.intimp.2021.107896_b0035","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00109-014-1182-x","article-title":"Histone demethylase Jumonji D3 (JMJD3\/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process","volume":"92","author":"Salminen","year":"2014","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.intimp.2021.107896_b0040","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/mp.2017.167","article-title":"DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1\/2-CREB-Jmjd3 pathway","volume":"23","author":"Alexaki","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.intimp.2021.107896_b0045","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2013.159","article-title":"Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson's disease","volume":"21","author":"Tang","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2021.107896_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2011.08.002","article-title":"Ginseng derivative ocotillol enhances neuronal activity through increased glutamate release: a possible mechanism underlying increased spontaneous locomotor activity of mice","volume":"195","author":"Wang","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2021.107896_b0055","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/cns.12702","article-title":"Pseudoginsenoside-F11 attenuates cerebral ischemic injury by alleviating autophagic\/lysosomal defects","volume":"23","author":"Liu","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2021.107896_b0060","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neuroscience.2019.05.030","article-title":"Pseudoginsenoside-F11 Protects against Transient Cerebral Ischemia Injury in Rats Involving Repressing Calcium Overload","volume":"411","author":"Zhang","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2021.107896_b0065","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.neuropharm.2014.01.022","article-title":"Pseudoginsenoside-F11 (PF11) exerts anti-neuroinflammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1\/IKK\/NF-kappaB, MAPKs and Akt signaling pathways","volume":"79","author":"Wang","year":"2014","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.intimp.2021.107896_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106564","article-title":"Pseudoginsenoside-F11 ameliorates ischemic neuron injury by regulating the polarization of neutrophils and macrophages in vitro","volume":"85","author":"Hou","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2021.107896_b0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.expneurol.2014.07.007","article-title":"Yonkenafil: a novel phosphodiesterase type 5 inhibitor induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke","volume":"261","author":"Chen","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2021.107896_b0080","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.phrs.2018.10.024","article-title":"Pseudoginsenoside-F11 alleviates cognitive deficits and Alzheimer's disease-type pathologies in SAMP8 mice","volume":"139","author":"Zhang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2021.107896_b0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2011.10.026","article-title":"Repeated administration of exendin-4 reduces focal cerebral ischemia-induced infarction in rats","volume":"1427","author":"Briyal","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2021.107896_b0090","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/brain\/awt319","article-title":"Progesterone in experimental permanent stroke: a dose-response and therapeutic time-window study","volume":"137","author":"Wali","year":"2014","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.intimp.2021.107896_b0095","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainres.2010.01.024","article-title":"Effects of chronic Clozapine administration on apolipoprotein D levels and on functional recovery following experimental stroke","volume":"1321","author":"Ruscher","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2021.107896_b0100","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/15548627.2018.1531196","article-title":"Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia","volume":"15","author":"Liu","year":"2019","journal-title":"Autophagy."},{"key":"10.1016\/j.intimp.2021.107896_b0105","first-page":"257","article-title":"Neuropeptide release influences brain edema formation after diffuse traumatic brain injury","volume":"86","author":"Vink","year":"2003","journal-title":"Acta neurochirurgica Supp."},{"key":"10.1016\/j.intimp.2021.107896_b0110","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/jcbfm.2014.101","article-title":"Role of spleen-derived monocytes\/macrophages in acute ischemic brain injury","volume":"34","author":"Kim","year":"2014","journal-title":"J. Cereb. Blood Flow Metabol. Off. J. Int. Soc. Cereb. Blood Flow Metabol."},{"key":"10.1016\/j.intimp.2021.107896_b0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cbi.2008.04.015","article-title":"Effects of resveratrol and its derivatives on lipopolysaccharide-induced microglial activation and their structure-activity relationships","volume":"174","author":"Meng","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.intimp.2021.107896_b0120","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/cns.12575","article-title":"Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia","volume":"22","author":"Meng","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2021.107896_b0125","doi-asserted-by":"crossref","DOI":"10.1007\/s12264-019-00388-3","article-title":"Dual Functions of Microglia in Ischemic Stroke","author":"Qin","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.intimp.2021.107896_b0130","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12974-018-1124-6","article-title":"Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33\/ST2 axis-mediated microglia\/macrophage M2 polarization","volume":"15","author":"Jiang","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107896_b0135","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/STROKEAHA.115.012079","article-title":"Interleukin-4 Is Essential for Microglia\/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia","volume":"47","author":"Liu","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2021.107896_b0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12974-015-0270-3","article-title":"Malibatol A regulates microglia M1\/M2 polarization in experimental stroke in a PPARgamma-dependent manner","volume":"12","author":"Pan","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107896_b0145","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12974-018-1172-y","article-title":"URMC-099 facilitates amyloid-beta clearance in a murine model of Alzheimer's disease","volume":"15","author":"Kiyota","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107896_b0150","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nrn3053","article-title":"Repertoire of microglial and macrophage responses after spinal cord injury","volume":"12","author":"David","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.intimp.2021.107896_b0155","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat7554","article-title":"Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation","volume":"363","author":"Jordao","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.intimp.2021.107896_b0160","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41593-018-0100-x","article-title":"Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models","volume":"21","author":"Ajami","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2021.107896_b0165","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s40478-020-01010-8","article-title":"Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis","volume":"8","author":"Bottcher","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.intimp.2021.107896_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104586","article-title":"Pseudoginsenoside-F11 improves long-term neurological function and promotes neurogenesis after transient cerebral ischemia in mice","volume":"133","author":"Yuan","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.intimp.2021.107896_b0175","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/tra.12620","article-title":"Pseudoginsenoside-F11 alleviates oligomeric beta-amyloid-induced endosome-lysosome defects in microglia","volume":"20","author":"Yao","year":"2019","journal-title":"Traffic."},{"key":"10.1016\/j.intimp.2021.107896_b0180","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.immuni.2008.12.009","article-title":"Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells","volume":"30","author":"Wei","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2021.107896_b0185","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1038\/emboj.2009.271","article-title":"Jmjd3 contributes to the control of gene expression in LPS-activated macrophages","volume":"28","author":"De Santa","year":"2009","journal-title":"The EMBO journal."},{"key":"10.1016\/j.intimp.2021.107896_b0190","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2021.107896_b0195","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1182\/blood-2009-04-217620","article-title":"Epigenetic regulation of the alternatively activated macrophage phenotype","volume":"114","author":"Ishii","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2021.107896_b0200","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/jcp.25201","article-title":"Epigenetic Modulation in Periodontitis: Interaction of Adiponectin and JMJD3-IRF4 Axis in Macrophages","volume":"231","author":"Xuan","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2021.107896_b0205","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3796","article-title":"alpha-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2021.107896_b0210","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.505","article-title":"RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization","volume":"8","author":"Meng","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2021.107896_b0215","article-title":"Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression","volume":"8","author":"Wang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2021.107896_b0220","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.expneurol.2018.07.007","article-title":"Inhibiting Jumoji domain containing protein 3 (JMJD3) prevent neuronal apoptosis from stroke","volume":"308","author":"Zhang","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2021.107896_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2018.05.009","article-title":"JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing beta-MHC expression","volume":"477","author":"Guo","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.intimp.2021.107896_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105970","article-title":"N2 neutrophils may participate in spontaneous recovery after transient cerebral ischemia by inhibiting ischemic neuron injury in rats","volume":"77","author":"Hou","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2021.107896_b0235","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3109\/07853890.2013.770333","article-title":"Inhibition of the mTOR pathway: a possible protective role in coronary artery disease","volume":"45","author":"Tarantino","year":"2013","journal-title":"Ann. Med."},{"key":"10.1016\/j.intimp.2021.107896_b0240","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fnana.2015.00048","article-title":"Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K\/Akt\/mTOR pathway activation","volume":"9","author":"Li","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.intimp.2021.107896_b0245","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12974-021-02174-3","article-title":"Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating microglia\/macrophage polarization via FPR2\/ALX-dependent AMPK-mTOR pathway","volume":"18","author":"Xu","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107896_b0250","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1186\/s12974-020-01987-y","article-title":"Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia","volume":"17","author":"He","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.intimp.2021.107896_b0255","article-title":"Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921005324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921005324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T20:12:41Z","timestamp":1730837561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921005324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":51,"alternative-id":["S1567576921005324"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107896","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pseudoginsenoside-F11 promotes functional recovery after transient cerebral ischemia by regulating the microglia\/macrophage polarization in rats","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107896","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107896"}}