{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:14:24Z","timestamp":1788880464802,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.intimp.2021.107903","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T11:15:12Z","timestamp":1624792512000},"page":"107903","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Blocking HOTAIR protects human chondrocytes against IL-1\u03b2-induced cell apoptosis, ECM degradation, inflammatory response and oxidative stress via regulating miR-222-3p\/ADAM10 axis"],"prefix":"10.1016","volume":"98","author":[{"given":"Jinliang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107903_b0005","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nrrheum.2016.148","article-title":"Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk","volume":"12","author":"Goldring","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2021.107903_b0010","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2021.107903_b0015","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/14789450.2019.1571918","article-title":"Understanding the role of chondrocytes in osteoarthritis: utilizing proteomics","volume":"16","author":"Trachana","year":"2019","journal-title":"Expert Rev. Proteomics."},{"key":"10.1016\/j.intimp.2021.107903_b0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2741\/1817","article-title":"Matrix metalloproteinases: role in arthritis","volume":"11","author":"Burrage","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.intimp.2021.107903_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110452","article-title":"Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols","volume":"129","author":"Ansari","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107903_b0030","first-page":"CD010643","article-title":"Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle","author":"Witteveen","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"Suppl 120","key":"10.1016\/j.intimp.2021.107903_b0035","first-page":"112","article-title":"Physical therapy for patients with knee and hip osteoarthritis: supervised, active treatment is current best practice","volume":"37","author":"Skou","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.intimp.2021.107903_b0040","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s13287-019-1458-8","article-title":"lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration","volume":"10","author":"Zhu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.intimp.2021.107903_b0045","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.1002\/jcb.27750","article-title":"Identification of differentially expressed long noncoding RNAs in human knee osteoarthritis","volume":"120","author":"Xiao","year":"2019","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.intimp.2021.107903_b0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jbmr.3662","article-title":"Role of Epigenomics in Bone and Cartilage Disease","volume":"34","author":"van Meurs","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2021.107903_b0055","doi-asserted-by":"crossref","first-page":"12309","DOI":"10.1002\/jcp.28020","article-title":"Epigenetics in osteoarthritis: Novel spotlight","volume":"234","author":"Fathollahi","year":"2019","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.intimp.2021.107903_b0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1302\/2046-3758.93.BJR-2019-0140.R2","article-title":"An integrated analysis of the competing endogenous RNA network and co-expression network revealed seven hub long non-coding RNAs in osteoarthritis","volume":"9","author":"Chen","year":"2020","journal-title":"Bone Joint Res."},{"key":"10.1016\/j.intimp.2021.107903_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104407","article-title":"The role and function of long non-coding RNAs in osteoarthritis","volume":"114","author":"Abbasifard","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.intimp.2021.107903_b0070","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1566523219666190716092203","article-title":"The Therapeutic Potential and Role of miRNA, lncRNA, and circRNA in Osteoarthritis","volume":"19","author":"Wu","year":"2019","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.intimp.2021.107903_b0075","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121630","article-title":"The complex landscape of microRNAs in articular cartilage: biology, pathology, and therapeutic targets","volume":"3","author":"Endisha","year":"2018","journal-title":"JCI Insight."},{"key":"10.1016\/j.intimp.2021.107903_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110642","article-title":"The emerging role of lncRNAs in chondrocytes from osteoarthritis patients","volume":"131","author":"Tu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2021.107903_b0085","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/kez102","article-title":"MicroRNA-21-5p as a novel therapeutic target for osteoarthritis","author":"Wang","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2021.107903_b0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12860-020-00299-6","article-title":"A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway","volume":"21","author":"Yang","year":"2020","journal-title":"BMC Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2021.107903_b0095","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.gene.2016.04.016","article-title":"Upregulation of lncRNA HOTAIR contributes to IL-1beta-induced MMP overexpression and chondrocytes apoptosis in temporomandibular joint osteoarthritis","volume":"586","author":"Zhang","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2021.107903_b0100","article-title":"Regulation of microRNA-221, -222, -21 and -27 in articular cartilage subjected to abnormal compressive forces","author":"Stadnik","year":"2020","journal-title":"J Physiol."},{"key":"10.1016\/j.intimp.2021.107903_b0105","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1002\/art.24678","article-title":"Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction","volume":"60","author":"Dunn","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.107903_b0110","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.joca.2017.02.791","article-title":"ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'","volume":"25","author":"Yang","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.intimp.2021.107903_b0115","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1177\/002215540104900910","article-title":"ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage","volume":"49","author":"Chubinskaya","year":"2001","journal-title":"J. Histochem Cytochem."},{"key":"10.1016\/j.intimp.2021.107903_b0120","first-page":"16","article-title":"Emerging roles of long noncoding RNA in chondrogenesis, osteogenesis, and osteoarthritis","volume":"11","author":"Sun","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.intimp.2021.107903_b0125","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/cbin.11253","article-title":"HOTAIR-induced apoptosis is mediated by sponging miR-130a-3p to repress chondrocyte autophagy in knee osteoarthritis","volume":"44","author":"He","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.intimp.2021.107903_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117685","article-title":"Long-chain non-coding RNA HOTAIR promotes the progression of osteoarthritis via sponging miR-20b\/PTEN axis","volume":"253","author":"Chen","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2021.107903_b0135","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejvs.2017.06.010","article-title":"Long Non-coding RNA-mRNA Correlation Analysis Reveals the Potential Role of HOTAIR in Pathogenesis of Sporadic Thoracic Aortic Aneurysm","volume":"54","author":"Guo","year":"2017","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.intimp.2021.107903_b0140","doi-asserted-by":"crossref","DOI":"10.1111\/wrr.12908","article-title":"LncRNA HOTAIR modulates chondrocyte apoptosis and inflammation in osteoarthritis via regulating miR-1277-5p\/SGTB axis","author":"Wang","year":"2021","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.intimp.2021.107903_b0145","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41419-018-0746-z","article-title":"Long non-coding RNA HOTAIR promotes osteoarthritis progression via miR-17-5p\/FUT2\/beta-catenin axis","volume":"9","author":"Hu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2021.107903_b0150","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20190404","article-title":"LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression","volume":"39","author":"Jiang","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.intimp.2021.107903_b0155","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/art.39520","article-title":"Long Intergenic Noncoding RNAs Mediate the Human Chondrocyte Inflammatory Response and Are Differentially Expressed in Osteoarthritis Cartilage","volume":"68","author":"Pearson","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.intimp.2021.107903_b0160","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2021.107903_b0165","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2174\/156652309788921044","article-title":"Interleukin-10 and articular cartilage: experimental therapeutical approaches in cartilage disorders","volume":"9","author":"Schulze-Tanzil","year":"2009","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.intimp.2021.107903_b0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bbacli.2014.11.009","article-title":"MicroRNA-222 regulates MMP-13 via targeting HDAC-4 during osteoarthritis pathogenesis","volume":"3","author":"Song","year":"2015","journal-title":"BBA Clin."},{"key":"10.1016\/j.intimp.2021.107903_b0175","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/tox.22923","article-title":"MiR-20a inhibits the progression of human arthritis fibroblast-like synoviocytes and inflammatory factor expression by targeting ADAM10","volume":"35","author":"Xie","year":"2020","journal-title":"Environ. Toxicol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921005397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921005397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:50:50Z","timestamp":1778820650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921005397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":35,"alternative-id":["S1567576921005397"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107903","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blocking HOTAIR protects human chondrocytes against IL-1\u03b2-induced cell apoptosis, ECM degradation, inflammatory response and oxidative stress via regulating miR-222-3p\/ADAM10 axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107903","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107903"}}