{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:56:18Z","timestamp":1792252578683,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872528"],"award-info":[{"award-number":["81872528"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2020-MS-262"],"award-info":[{"award-number":["2020-MS-262"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.intimp.2021.107910","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T21:32:05Z","timestamp":1624915925000},"page":"107910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The addition of topical calcipotriol to phototherapy enhance the efficacy of treatment in patients with vitiligo: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"98","author":[{"given":"Mengjie","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.107910_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100981","article-title":"Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders","volume":"57","author":"Bellei","year":"2020","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2021.107910_b0010","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jaad.2010.11.061","article-title":"Vitiligo: a comprehensive overview\u2014part I: introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up","volume":"65","author":"Alikhan","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107910_b0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijwd.2017.11.005","article-title":"Vitiligo: Patient stories, self-esteem, and the psychological burden of disease","volume":"4","author":"Grimes","year":"2018","journal-title":"Int. J. Womens Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107910_b0020","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/med.21754","article-title":"Mechanisms of melanocyte death in vitiligo","volume":"41","author":"Chen","year":"2021","journal-title":"Med. Res. Rev."},{"issue":"16","key":"10.1016\/j.intimp.2021.107910_b0025","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1001\/jama.2016.12399","article-title":"Interventions for vitiligo","volume":"316","author":"Ezzedine","year":"2016","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.intimp.2021.107910_b0030","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/jid.2014.527","article-title":"Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind, placebo-controlled study","volume":"135","author":"Cavali\u00e9","year":"2015","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2021.107910_b0035","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jaad.2010.10.043","article-title":"Vitiligo: a comprehensive overview Part II: treatment options and approach to treatment","volume":"65","author":"Felsten","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2021.107910_b0040","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1615\/JEnvironPatholToxicolOncol.2015014168","article-title":"Different advanced therapeutic approaches to treat vitiligo","volume":"34","author":"Sharma","year":"2015","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107910_b0045","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0733-8635(18)30290-0","article-title":"Calcipotriol. A new topical antipsoriatic","volume":"11","author":"Kragballe","year":"1993","journal-title":"Dermatol. Clin."},{"issue":"2","key":"10.1016\/j.intimp.2021.107910_b0050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1468-3083.2002.00407.x","article-title":"Treatment of vitiligo by topical calcipotriol","volume":"16","author":"Chiav\u00e9rini","year":"2002","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107910_b0055","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.det.2016.11.008","article-title":"Phototherapy and combination therapies for vitiligo","volume":"35","author":"Esmat","year":"2017","journal-title":"Dermatol. Clin."},{"issue":"1","key":"10.1016\/j.intimp.2021.107910_b0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/14728214.2020.1712358","article-title":"Emerging drugs for the treatment of vitiligo","volume":"25","author":"Karagaiah","year":"2020","journal-title":"Expert Opin. Emerg. Drugs."},{"issue":"5","key":"10.1016\/j.intimp.2021.107910_b0065","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/jdv.12726","article-title":"Comparison of efficacy and safety profile of topical calcipotriol ointment in combination with NB-UVB vs. NB-UVB alone in the treatment of vitiligo: a 24-week prospective right\u2013left comparative clinical trial","volume":"29","author":"Khullar","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107910_b0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-0781.2005.00139.x","article-title":"No additional effect of topical calcipotriol on narrow-band UVB phototherapy in patients with generalized vitiligo","volume":"21","author":"Ada","year":"2005","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.intimp.2021.107910_b0075","first-page":"ED000142","article-title":"Higgins J.P.,et al., Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"issue":"7414","key":"10.1016\/j.intimp.2021.107910_b0080","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.intimp.2021.107910_b0085","unstructured":"Alderson P., Green S., Higgins J.P. (Eds.) Cochrane Reviewers' Handbook 4.2.2 [updated March 2004]. In The Cochrane Library, Issue 2, 2004 Chichester, UK: John Wiley & Sons, Ltd; 2004."},{"issue":"Pt A","key":"10.1016\/j.intimp.2021.107910_b0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cct.2015.09.002","article-title":"Meta-analysis in clinical trials revisited","volume":"45","author":"DerSimonian","year":"2015","journal-title":"Control Clin. Trials."},{"issue":"10","key":"10.1016\/j.intimp.2021.107910_b0095","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1177\/0962280220910172","article-title":"Hybrid test for publication bias in meta-analysis","volume":"29","author":"Lin","year":"2020","journal-title":"Stat. Methods Med. Res."},{"issue":"2","key":"10.1016\/j.intimp.2021.107910_b0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000017991","article-title":"Combination of PUVAsol and topical calcipotriol in vitiligo","volume":"197","author":"Parsad","year":"1998","journal-title":"Dermatology"},{"issue":"3","key":"10.1016\/j.intimp.2021.107910_b0105","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1468-3083.2003.00795.x","article-title":"Is the combination of calcipotriol and PUVA effective in vitiligo?","volume":"17","author":"Baysal","year":"2003","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"5","key":"10.1016\/j.intimp.2021.107910_b0110","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1346-8138.2006.00079.x","article-title":"Narrow-band ultraviolet B as monotherapy and in combination with topical calcipotriol in the treatment of vitiligo","volume":"33","author":"Arca","year":"2006","journal-title":"J. Dermatol."},{"issue":"03","key":"10.1016\/j.intimp.2021.107910_b0115","first-page":"544","article-title":"Clinical observation of 308 nm excimer laser combined with carpotriol ointment in the treatment of craniofacial vitiligo","volume":"9","author":"Lin","year":"2009","journal-title":"Chinese J. Misdiagnostics."},{"issue":"24","key":"10.1016\/j.intimp.2021.107910_b0120","first-page":"2950","article-title":"Analysis of the efficacy of calcipotriol ointment combined with narrow-band ultraviolet in the treatment of vitiligo","volume":"24","author":"Yang","year":"2012","journal-title":"Med. J. Chinese People's Health."},{"issue":"06","key":"10.1016\/j.intimp.2021.107910_b0125","first-page":"561","article-title":"Observation on the efficacy of narrow-band ultraviolet B combined with calcipotriol ointment in the treatment of stable vitiligo","volume":"33","author":"Yang","year":"2013","journal-title":"J. Nantong Univ."},{"issue":"07","key":"10.1016\/j.intimp.2021.107910_b0130","first-page":"197","article-title":"Analysis of the efficacy of calcipotriol combined with phototherapy in the treatment of vitiligo","volume":"13","author":"Ni","year":"2015","journal-title":"Contemp. Med. Forum."},{"issue":"21","key":"10.1016\/j.intimp.2021.107910_b0135","first-page":"44","article-title":"Analysis of the efficacy of narrow-band ultraviolet B combined with calcipotriol in the treatment of stable vitiligo","volume":"24","author":"Tao","year":"2015","journal-title":"Chinese J. Aesthet. Med."},{"issue":"5","key":"10.1016\/j.intimp.2021.107910_b0140","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3390\/ijms19051509","article-title":"Clinical and molecular aspects of vitiligo treatments","volume":"19","author":"Bishnoi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2021.107910_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2016.10.048","article-title":"New discoveries in the pathogenesis and classification of vitiligo","volume":"77","author":"Rodrigues","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"12","key":"10.1016\/j.intimp.2021.107910_b0150","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/jdv.12304","article-title":"New population of amelanotic spindle cells are clearly demonstrated in vitiliginous skin after ultraviolet radiation","volume":"28","author":"Awad","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.intimp.2021.107910_b0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.det.2019.08.005","article-title":"Phototherapy for vitiligo","volume":"38","author":"Zubair","year":"2020","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.intimp.2021.107910_b0160","unstructured":"Jung H.M., Jung Y.S., Lee J.H., Kim G.M., Bae J.M., Antioxidant supplements in combination with phototherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials, J. Am. Acad. Dermatol. 17 (2018) S0190\u20139622(18)32739\u20137."},{"issue":"12","key":"10.1016\/j.intimp.2021.107910_b0165","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1111\/jdv.12619","article-title":"Narrowband ultraviolet B phototherapy in combination with other therapies for vitiligo: mechanisms and efficacies","volume":"28","author":"Yazdani","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107910_b0170","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/1346-8138.15155","article-title":"Calcipotriol and betamethasone dipropionate exhibit different immunomodulatory effects on imiquimod-induced murine psoriasiform dermatitis","volume":"47","author":"Takeoka","year":"2020","journal-title":"J. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2021.107910_b0175","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdermsci.2018.08.007","article-title":"The vitamin D(3) analog, maxacalcitol, reduces psoriasiform skin inflammation by inducing regulatory T cells and downregulating IL-23 and IL-17 production","volume":"92","author":"Hau","year":"2018","journal-title":"J. Dermatol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2021.107910_b0180","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2174\/138945008783954970","article-title":"Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation","volume":"9","author":"Birlea","year":"2008","journal-title":"Curr. Drug Targets."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921005464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921005464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T11:26:30Z","timestamp":1747308390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921005464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":36,"alternative-id":["S1567576921005464"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107910","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The addition of topical calcipotriol to phototherapy enhance the efficacy of treatment in patients with vitiligo: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107910"}}