{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:49:41Z","timestamp":1793774981850,"version":"4.6.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.intimp.2021.107991","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T19:30:36Z","timestamp":1629747036000},"page":"107991","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Runx1\/miR-26a\/Jagged1 signaling axis controls osteoclastogenesis and alleviates orthodontically induced inflammatory root resorption"],"prefix":"10.1016","volume":"100","author":[{"given":"Xiaoge","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2021.107991_b0005","first-page":"21","article-title":"Microbial Colonization on Elastomeric Ligatures during Orthodontic Therapeutics: An Overview","volume":"31","author":"Sawhney","year":"2018","journal-title":"Turk J Orthod"},{"issue":"1","key":"10.1016\/j.intimp.2021.107991_b0010","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1177\/0022034514555364","article-title":"Notch signaling induces root resorption via RANKL and IL-6 from hPDL cells","volume":"94","author":"Kikuta","year":"2015","journal-title":"J Dent Res"},{"issue":"5","key":"10.1016\/j.intimp.2021.107991_b0015","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1601-0825.2010.01780.x","article-title":"IL-8 and MCP-1 induced by excessive orthodontic force mediates odontoclastogenesis in periodontal tissues","volume":"17","author":"Asano","year":"2011","journal-title":"Oral Dis"},{"key":"10.1016\/j.intimp.2021.107991_b0020","doi-asserted-by":"crossref","unstructured":"Patel, S. and T.P. Ford, Is the resorption external or internal? Dent Update, 2007. 34(4): p. 218-20, 222, 224-6, 229.","DOI":"10.12968\/denu.2007.34.4.218"},{"issue":"6937","key":"10.1016\/j.intimp.2021.107991_b0025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2021.107991_b0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1601-6343.2009.01444.x","article-title":"RANK\/RANKL\/OPG during orthodontic tooth movement","volume":"12","author":"Yamaguchi","year":"2009","journal-title":"Orthod Craniofac Res"},{"issue":"4","key":"10.1016\/j.intimp.2021.107991_b0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/ejo\/cjq068","article-title":"Expressions of RANKL\/RANK and M-CSF\/c-fms in root resorption lacunae in rat molar by heavy orthodontic force","volume":"33","author":"Nakano","year":"2011","journal-title":"Eur J Orthod"},{"issue":"4","key":"10.1016\/j.intimp.2021.107991_b0040","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1601-0825.2011.01886.x","article-title":"T-helper 17 cells mediate the osteo\/odontoclastogenesis induced by excessive orthodontic forces","volume":"18","author":"Hayashi","year":"2012","journal-title":"Oral Dis"},{"issue":"8","key":"10.1016\/j.intimp.2021.107991_b0045","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/154405910608500812","article-title":"RANKL increase in compressed periodontal ligament cells from root resorption","volume":"85","author":"Yamaguchi","year":"2006","journal-title":"J Dent Res"},{"issue":"2","key":"10.1016\/j.intimp.2021.107991_b0050","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0765.2007.01008.x","article-title":"Effects of compression force on fibroblast growth factor-2 and receptor activator of nuclear factor kappa B ligand production by periodontal ligament cells in vitro","volume":"43","author":"Nakajima","year":"2008","journal-title":"J Periodontal Res"},{"issue":"6","key":"10.1016\/j.intimp.2021.107991_b0055","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4041\/kjod.2013.43.6.294","article-title":"Role of interleukin-6 in orthodontically induced inflammatory root resorption in humans","volume":"43","author":"Kunii","year":"2013","journal-title":"Korean J Orthod"},{"issue":"15","key":"10.1016\/j.intimp.2021.107991_b0060","first-page":"1759","article-title":"Knockdown of DANCR reduces osteoclastogenesis and root resorption induced by compression force via","volume":"18","author":"Zhang","year":"2019","journal-title":"Jagged1."},{"issue":"2","key":"10.1016\/j.intimp.2021.107991_b0065","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm2632","article-title":"Biogenesis of small RNAs in animals","volume":"10","author":"Kim","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"10.1016\/j.intimp.2021.107991_b0070","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1074\/jbc.M805777200","article-title":"Impaired micro-RNA pathways diminish osteoclast differentiation and function","volume":"284","author":"Sugatani","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.intimp.2021.107991_b0075","doi-asserted-by":"crossref","unstructured":"Interfering with miR-24 alleviates rotenone-induced dopaminergic neuron injury via enhancing autophagy by upregulating DJ-1. Aging Pathobiology and Therapeutics, 2019. 1(1): p. 17-24.","DOI":"10.31491\/APT.2019.12.004"},{"issue":"2","key":"10.1016\/j.intimp.2021.107991_b0080","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"7006","key":"10.1016\/j.intimp.2021.107991_b0085","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2021.107991_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2017.01.028","article-title":"MicroRNA-34c promotes osteoclast differentiation through targeting LGR4","volume":"610","author":"Cong","year":"2017","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.intimp.2021.107991_b0095","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/jcb.29401","article-title":"miR-181b\/Oncostatin m axis inhibits prostate cancer bone metastasis via modulating osteoclast differentiation","volume":"121","author":"Han","year":"2020","journal-title":"J Cell Biochem"},{"issue":"9","key":"10.1016\/j.intimp.2021.107991_b0100","doi-asserted-by":"crossref","first-page":"572","DOI":"10.5483\/BMBRep.2019.52.9.076","article-title":"miR-101-3p\/Rap1b signal pathway plays a key role in osteoclast differentiation after treatment with bisphosphonates","volume":"52","author":"Li","year":"2019","journal-title":"BMB Rep"},{"issue":"5","key":"10.1016\/j.intimp.2021.107991_b0105","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00774-019-00997-y","article-title":"miR-142-5p promotes the osteoclast differentiation of bone marrow-derived macrophages via PTEN\/PI3K\/AKT\/FoxO1 pathway","volume":"37","author":"Lou","year":"2019","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"10.1016\/j.intimp.2021.107991_b0110","doi-asserted-by":"crossref","first-page":"75","DOI":"10.14348\/molcells.2015.2241","article-title":"MicroRNA-26a regulates RANKL-induced osteoclast formation","volume":"38","author":"Kim","year":"2015","journal-title":"Mol Cells"},{"issue":"6","key":"10.1016\/j.intimp.2021.107991_b0115","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1182\/blood-2002-06-1740","article-title":"Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells","volume":"101","author":"Yamada","year":"2003","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.intimp.2021.107991_b0120","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/onc.2016.194","article-title":"MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1","volume":"36","author":"Lu","year":"2017","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.intimp.2021.107991_b0125","first-page":"172","article-title":"RUNX1: A Regulator of NF-kB Signaling in Pulmonary Diseases","volume":"19","author":"Tang","year":"2018","journal-title":"Curr Protein Pept Sci"},{"issue":"33","key":"10.1016\/j.intimp.2021.107991_b0130","doi-asserted-by":"crossref","first-page":"11669","DOI":"10.1074\/jbc.RA119.007896","article-title":"Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation","volume":"295","author":"Tang","year":"2020","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.intimp.2021.107991_b0135","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1210\/me.2013-1305","article-title":"Runx1-mediated regulation of osteoclast differentiation and function","volume":"28","author":"Soung do","year":"2014","journal-title":"Mol Endocrinol"},{"issue":"5","key":"10.1016\/j.intimp.2021.107991_b0140","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/jor.24537","article-title":"Deletion of Runx1 in osteoclasts impairs murine fracture healing through progressive woven bone loss and delayed cartilage remodeling","volume":"38","author":"Paglia","year":"2020","journal-title":"J Orthop Res"},{"issue":"4","key":"10.1016\/j.intimp.2021.107991_b0145","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1159\/000492350","article-title":"miRNA-125b Regulates Osteogenic Differentiation of Periodontal Ligament Cells Through NKIRAS2\/NF-kappaB Pathway","volume":"48","author":"Xue","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"10.1016\/j.intimp.2021.107991_b0150","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/jbmr.1845","article-title":"miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B","volume":"28","author":"Cheng","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"7515","key":"10.1016\/j.intimp.2021.107991_b0155","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13375","article-title":"miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2","volume":"512","author":"Krzeszinski","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2021.107991_b0160","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ng0797-235","article-title":"Mutations in the human Jagged1 gene are responsible for Alagille syndrome","volume":"16","author":"Oda","year":"1997","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.intimp.2021.107991_b0165","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1186\/ar3758","article-title":"Differential regulation of osteoclastogenesis by Notch2\/Delta-like 1 and Notch1\/Jagged1 axes","volume":"14","author":"Sekine","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.intimp.2021.107991_b0170","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/jre.12357","article-title":"Jagged1 inhibits osteoprotegerin expression by human periodontal ligament cells","volume":"51","author":"Manokawinchoke","year":"2016","journal-title":"J Periodontal Res"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921006275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921006275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:37:22Z","timestamp":1761586642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921006275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":34,"alternative-id":["S1567576921006275"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107991","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Runx1\/miR-26a\/Jagged1 signaling axis controls osteoclastogenesis and alleviates orthodontically induced inflammatory root resorption","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.107991","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107991"}}