{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:18:46Z","timestamp":1793888326475,"version":"4.8.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.intimp.2021.108001","type":"journal-article","created":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T03:04:52Z","timestamp":1627095892000},"page":"108001","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["The natural compound puerarin alleviates inflammation and apoptosis in experimental cell and rat preeclampsia models"],"prefix":"10.1016","volume":"99","author":[{"given":"Xiaoping","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10022","key":"10.1016\/j.intimp.2021.108001_b0005","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.intimp.2021.108001_b0010","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrneph.2014.102","article-title":"Pre-eclampsia part 1: current understanding of its pathophysiology","volume":"10","author":"Chaiworapongsa","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.intimp.2021.108001_b0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bpobgyn.2019.06.005","article-title":"Immunomodulation and preeclampsia","volume":"60","author":"Rambaldi","year":"2019","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.intimp.2021.108001_b0020","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fendo.2020.00080","article-title":"Role of the NLRP3 Inflammasome in Preeclampsia","volume":"11","author":"Shirasuna","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"9","key":"10.1016\/j.intimp.2021.108001_b0025","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.4049\/jimmunol.178.9.5949","article-title":"Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles","volume":"178","author":"Germain","year":"2007","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.intimp.2021.108001_b0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000074824","article-title":"Endothelial dysfunction in preeclampsia. Increased homocysteine and decreased nitric oxide levels","volume":"56","author":"Var","year":"2003","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.intimp.2021.108001_b0035","doi-asserted-by":"crossref","unstructured":"K.P. Conrad, D.F. Benyo, Placental cytokines and the pathogenesis of preeclampsia, American journal of reproductive immunology (New York, N.Y. : 1989) 37(3) (1997) 240-9.","DOI":"10.1111\/j.1600-0897.1997.tb00222.x"},{"issue":"10","key":"10.1016\/j.intimp.2021.108001_b0040","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/hr.2016.53","article-title":"Increased neuronal seizure activity correlates with excessive systemic inflammation in a rat model of severe preeclampsia","volume":"39","author":"Liu","year":"2016","journal-title":"Hypertens Res"},{"issue":"6","key":"10.1016\/j.intimp.2021.108001_b0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tice.2014.08.004","article-title":"Oxidative stress and apoptosis in preeclampsia","volume":"46","author":"Can","year":"2014","journal-title":"Tissue Cell"},{"issue":"5","key":"10.1016\/j.intimp.2021.108001_b0050","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.2353\/ajpath.2007.061035","volume":"170","author":"Cindrova-Davies","year":"2007","journal-title":"The American journal of pathology"},{"issue":"2","key":"10.1016\/j.intimp.2021.108001_b0055","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00441-016-2466-y","article-title":"Imbalance between proliferation and apoptosis-related impaired GPR30 expression is involved in preeclampsia","volume":"366","author":"Li","year":"2016","journal-title":"Cell Tissue Res"},{"issue":"7","key":"10.1016\/j.intimp.2021.108001_b0060","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/ptr.5083","article-title":"Puerarin: a review of pharmacological effects","volume":"28","author":"Zhou","year":"2014","journal-title":"Phytother Res"},{"issue":"6","key":"10.1016\/j.intimp.2021.108001_b0065","first-page":"407","article-title":"Progress on the pharmacological research of puerarin: a review","volume":"12","author":"Wei","year":"2014","journal-title":"Chin J Nat Med"},{"issue":"2","key":"10.1016\/j.intimp.2021.108001_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171612","article-title":"Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4\/NF-\u03baB signaling pathway","volume":"12","author":"Ma","year":"2017","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.intimp.2021.108001_b0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1142\/S0192415X19500022","article-title":"Puerarin Reduces Blood Pressure in Spontaneously Hypertensive Rats by Targeting eNOS","volume":"47","author":"Shi","year":"2019","journal-title":"Am J Chin Med"},{"issue":"2","key":"10.1016\/j.intimp.2021.108001_b0080","first-page":"118","article-title":"Therapeutic effect of puerarin on rats with pre-eclampsia","volume":"41","author":"Wang","year":"2006","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"Pt B","key":"10.1016\/j.intimp.2021.108001_b0085","article-title":"Puerarin alleviates vincristine-induced neuropathic pain and neuroinflammation via inhibition of nuclear factor-\u03baB and activation of the TGF-\u03b2\/Smad pathway in rats","volume":"89","author":"Xie","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108001_b0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1095\/biolreprod.116.141630","article-title":"Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1\/2 and SAPK\/JNK MAPK Signaling Pathways","volume":"95","author":"Lim","year":"2016","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.intimp.2021.108001_b0095","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.3892\/mmr.2016.5569","article-title":"Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation","volume":"14","author":"Xuan","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2021.108001_b0100","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/fsn3.1342","article-title":"Gastrodin improves preeclampsia-induced cell apoptosis by regulation of TLR4\/NF-\u03baB in rats","volume":"8","author":"Mei","year":"2020","journal-title":"Food science & nutrition"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2021.108001_b0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jri.2005.10.007","article-title":"Cytokine mapping of sera from women with preeclampsia and normal pregnancies","volume":"70","author":"Jonsson","year":"2006","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2021.108001_b0110","doi-asserted-by":"crossref","unstructured":"K.P. Conrad, T.M. Miles, D.F. Benyo, Circulating levels of immunoreactive cytokines in women with preeclampsia, American journal of reproductive immunology (New York, N.Y. : 1989) 40(2) (1998) 102-11.","DOI":"10.1111\/j.1600-0897.1998.tb00398.x"},{"key":"10.1016\/j.intimp.2021.108001_b0115","doi-asserted-by":"crossref","unstructured":"F. Amraoui, L. Spijkers, H. Hassani Lahsinoui, L. Vogt, J. van der Post, S. Peters, G. Afink, C. Ris-Stalpers, B.J. van den Born, SFlt-1 elevates blood pressure by augmenting endothelin-1-mediated vasoconstriction in mice, PloS one 9(3) (2014) e91897.","DOI":"10.1371\/journal.pone.0091897"},{"issue":"10","key":"10.1016\/j.intimp.2021.108001_b0120","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1177\/0300060519860979","article-title":"Abnormal expression and clinical significance of 25-hydroxyvitamin D and sFlt-1 in patients with preeclampsia","volume":"47","author":"Chen","year":"2019","journal-title":"The Journal of international medical research"},{"key":"10.1016\/j.intimp.2021.108001_b0125","doi-asserted-by":"crossref","unstructured":"F. Li, M. Kakoki, M. Smid, K. Boggess, J. Wilder, S. Hiller, C. Bounajim, S.E. Parnell, K.K. Sulik, O. Smithies, N. Maeda-Smithies, Causative Effects of Genetically Determined High Maternal\/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice, Hypertension (Dallas, Tex. : 1979) 71(5) (2018) 894-903.","DOI":"10.1161\/HYPERTENSIONAHA.117.10849"},{"issue":"3","key":"10.1016\/j.intimp.2021.108001_b0130","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1373\/clinchem.2006.081372","article-title":"Cell-free mRNA concentrations of plasminogen activator inhibitor-1 and tissue-type plasminogen activator are increased in the plasma of pregnant women with preeclampsia","volume":"53","author":"Purwosunu","year":"2007","journal-title":"Clin. Chem."},{"key":"10.1016\/j.intimp.2021.108001_b0135","doi-asserted-by":"crossref","unstructured":"L. Xu, X. Li, E. Zhang, H. Liang, W. Li, S. Wang, S. Song, A. Ji, The effect of leech extracts on endothelial cell coagulation-related factors and endothelial dysfuction-related molecules, Clinical and experimental hypertension (New York, N.Y. : 1993) 41(3) (2019) 220-230.","DOI":"10.1080\/10641963.2018.1465076"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2021.108001_b0140","first-page":"39","article-title":"Markers of endothelial activation in preeclampsia","volume":"61","author":"Prochazka","year":"2015","journal-title":"Clinical laboratory"},{"issue":"2","key":"10.1016\/j.intimp.2021.108001_b0145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.thromres.2008.02.007","article-title":"Relationship between maternal and cord blood hemostatic disturbances in preeclamptic pregnancies","volume":"123","author":"Catarino","year":"2008","journal-title":"Thromb. Res."},{"issue":"4","key":"10.1016\/j.intimp.2021.108001_b0150","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22834","article-title":"Association of pro- and anti-inflammatory cytokines in preeclampsia","volume":"33","author":"Aggarwal","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"issue":"2","key":"10.1016\/j.intimp.2021.108001_b0155","doi-asserted-by":"crossref","first-page":"220","DOI":"10.12891\/ceog2077.2016","article-title":"Correlation of the system of cytokines in moderate and severe preeclampsia","volume":"43","author":"Daneva","year":"2016","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"10.1016\/j.intimp.2021.108001_b0160","doi-asserted-by":"crossref","unstructured":"P. Chatterjee, S.E. Kopriva, V.L. Chiasson, K.J. Young, R.P. Tobin, K. Newell-Rogers, B.M. Mitchell, Interleukin-4 deficiency induces mild preeclampsia in mice, Journal of hypertension 31(7) (2013) 1414-23; discussion 1423.","DOI":"10.1097\/HJH.0b013e328360ae6c"},{"key":"10.1016\/j.intimp.2021.108001_b0165","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.lfs.2018.05.029","article-title":"Maternal one carbon metabolism through increased oxidative stress and disturbed angiogenesis can influence placental apoptosis in preeclampsia","volume":"206","author":"Kasture","year":"2018","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.intimp.2021.108001_b0170","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1177\/1933719108322438","article-title":"Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia","volume":"15","author":"Heazell","year":"2008","journal-title":"Reproductive sciences (Thousand Oaks, Calif.)"},{"issue":"1","key":"10.1016\/j.intimp.2021.108001_b0175","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0002-9440(10)65123-1","article-title":"Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall","volume":"155","author":"DiFederico","year":"1999","journal-title":"The American journal of pathology"},{"issue":"2","key":"10.1016\/j.intimp.2021.108001_b0180","first-page":"271","article-title":"Placental apoptosis in preeclampsia","volume":"96","author":"Allaire","year":"2000","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.intimp.2021.108001_b0185","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1507\/endocrj.47.317","article-title":"Changes in proliferative potential, apoptosis and Bcl-2 protein expression in cytotrophoblasts and syncytiotrophoblast in human placenta over the course of pregnancy","volume":"47","author":"Ishihara","year":"2000","journal-title":"Endocr. J."},{"issue":"4","key":"10.1016\/j.intimp.2021.108001_b0190","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1568-1637(03)00026-6","article-title":"Caspases, apoptosis and aging","volume":"2","author":"Zhang","year":"2003","journal-title":"Ageing research reviews"},{"issue":"2","key":"10.1016\/j.intimp.2021.108001_b0195","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3892\/etm.2015.2910","article-title":"Puerarin attenuates the inflammatory response and apoptosis in LPS-stimulated cardiomyocytes","volume":"11","author":"Yuan","year":"2016","journal-title":"Experimental and therapeutic medicine"},{"issue":"3","key":"10.1016\/j.intimp.2021.108001_b0200","first-page":"957","article-title":"Protective role of puerarin on LPS\/D-Gal induced acute liver injury via restoring autophagy","volume":"10","author":"Li","year":"2018","journal-title":"American journal of translational research"},{"issue":"4","key":"10.1016\/j.intimp.2021.108001_b0205","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3109\/01480545.2015.1126842","article-title":"Apoptotic effects on maturation of mouse oocytes, fertilization and fetal development by puerarin","volume":"39","author":"Huang","year":"2016","journal-title":"Drug Chem. Toxicol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921006378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921006378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T20:14:29Z","timestamp":1730837669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921006378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":41,"alternative-id":["S1567576921006378"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108001","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The natural compound puerarin alleviates inflammation and apoptosis in experimental cell and rat preeclampsia models","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108001"}}