{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:54:55Z","timestamp":1792587295808,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007956","name":"Nanjing University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973769"],"award-info":[{"award-number":["81973769"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.intimp.2021.108107","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T02:37:07Z","timestamp":1630636627000},"page":"108107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Tetrahydropalmatine attenuates MSU crystal-induced gouty arthritis by inhibiting ROS-mediated NLRP3 inflammasome activation"],"prefix":"10.1016","volume":"100","author":[{"given":"Yifan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuzhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2021.108107_b0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41584-018-0004-x","article-title":"An update on the genetics of hyperuricaemia and gout","volume":"14","author":"Major","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7","key":"10.1016\/j.intimp.2021.108107_b0010","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108107_b0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/annrheumdis-2019-215315","article-title":"2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout","volume":"79","author":"Richette","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2021.108107_b0020","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrrheum.2017.155","article-title":"Inflammation in gout: mechanisms and therapeutic targets","volume":"13","author":"So","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2021.108107_b0025","doi-asserted-by":"crossref","first-page":"100889","DOI":"10.1016\/j.mam.2020.100889","article-title":"The NLRP3 inflammasome: Mechanism of action, role in disease and therapies","volume":"76","author":"Wang","year":"2020","journal-title":"Mol. Aspects Med."},{"issue":"1","key":"10.1016\/j.intimp.2021.108107_b0030","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/imr.12833","article-title":"Urate-induced immune programming: Consequences for gouty arthritis and hyperuricemia","volume":"294","author":"Cab\u0103u","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2021.108107_b0035","doi-asserted-by":"crossref","unstructured":"Py B, Kim M, Vakifahmetoglu-Norberg H, Yuan J. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Molecular cell. 2013;49:331-8.","DOI":"10.1016\/j.molcel.2012.11.009"},{"issue":"12","key":"10.1016\/j.intimp.2021.108107_b0040","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and Regulation of NLRP3 Inflammasome Activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2021.108107_b0045","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-0849-y","article-title":"Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression","volume":"14","author":"Liu","year":"2017","journal-title":"Journal of neuroinflammation."},{"issue":"9","key":"10.1016\/j.intimp.2021.108107_b0050","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1111\/bph.14967","article-title":"Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis","volume":"177","author":"Yin","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2021.108107_b0055","first-page":"20","article-title":"[Study on material base of corydalis rhizoma]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi =","volume":"39","author":"Yang","year":"2014","journal-title":"China journal of Chinese materia medica."},{"key":"10.1016\/j.intimp.2021.108107_b0060","doi-asserted-by":"crossref","unstructured":"Wang L, Zhang Y, Wang Z, Gong N, Kweon T, Vo B, et al. The Antinociceptive Properties of the Corydalis yanhusuo Extract. PloS one. 2016;11:e0162875.","DOI":"10.1371\/journal.pone.0162875"},{"key":"10.1016\/j.intimp.2021.108107_b0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pbb.2016.01.010","article-title":"Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement","volume":"144","author":"Gong","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.intimp.2021.108107_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2012.03.014","article-title":"The dopamine receptor antagonist levo-tetrahydropalmatine attenuates heroin self-administration and heroin-induced reinstatement in rats","volume":"102","author":"Yue","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.intimp.2021.108107_b0075","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/jcmm.14790","article-title":"l-tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK-TRAF6 interactions and inhibiting NF-\u03baB and MAPK pathways","volume":"24","author":"Zhi","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"6","key":"10.1016\/j.intimp.2021.108107_b0080","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/10715762.2016.1154549","article-title":"Tetrahydropalmatine protects rat pulmonary endothelial cells from irradiation-induced apoptosis by inhibiting oxidative stress and the calcium sensing receptor\/phospholipase C-\u03b31 pathway","volume":"50","author":"Yu","year":"2016","journal-title":"Free Radical Res."},{"key":"10.1016\/j.intimp.2021.108107_b0085","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.7150\/thno.40650","article-title":"in vivoA mouse model of MSU-induced acute inflammation suggests imiquimod-dependent targeting of as relevant therapy for gout patients","volume":"10","author":"Mariotte","year":"2020","journal-title":"Theranostics."},{"issue":"2","key":"10.1016\/j.intimp.2021.108107_b0090","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00125-019-05043-0","article-title":"Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes","volume":"63","author":"Fan","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.intimp.2021.108107_b0095","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejphar.2015.12.035","article-title":"Effect of levetiracetam versus gabapentin on peripheral neuropathy and sciatic degeneration in streptozotocin-diabetic mice: Influence on spinal microglia and astrocytes","volume":"771","author":"Reda","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2021.108107_b0100","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3748\/wjg.v11.i12.1825","article-title":"Modulation of liver oxidant-antioxidant system by ischemic preconditioning during ischemia\/reperfusion injury in rats","volume":"11","author":"Yuan","year":"2005","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.intimp.2021.108107_b0105","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ni.3333","article-title":"NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component","volume":"17","author":"Shi","year":"2016","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108107_b0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ana.25122","article-title":"Inadequate brain glycogen or sleep increases spreading depression susceptibility","volume":"83","author":"Kilic","year":"2018","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108107_b0115","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.freeradbiomed.2009.06.013","article-title":"In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012","volume":"47","author":"Kielland","year":"2009","journal-title":"Free Radical Biol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2021.108107_b0120","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/art.33355","article-title":"NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout","volume":"64","author":"Amaral","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"10","key":"10.1016\/j.intimp.2021.108107_b0125","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1002\/art.27635","article-title":"Interleukin-1 antagonism in acute gout: is targeting a single cytokine the answer?","volume":"62","author":"Neogi","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2021.108107_b0130","doi-asserted-by":"crossref","first-page":"105242","DOI":"10.1016\/j.phrs.2020.105242","article-title":"Tetrahydropalmatine triggers angiogenesis via regulation of arginine biosynthesis","volume":"163","author":"Cui","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.intimp.2021.108107_b0135","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/jcmm.16267","article-title":"PPAR\u03b3\/NF-\u03baB and TGF-\u03b21\/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis","volume":"25","author":"Yu","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2021.108107_b0140","first-page":"6873","article-title":"Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2021.108107_b0145","doi-asserted-by":"crossref","first-page":"6564","DOI":"10.12659\/MSM.910578","article-title":"Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus)","volume":"24","author":"Sun","year":"2018","journal-title":"Medical science monitor : international medical journal of experimental and clinical research."},{"key":"10.1016\/j.intimp.2021.108107_b0150","first-page":"457","article-title":"Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis","volume":"56","author":"Chang","year":"2017","journal-title":"Rheumatology (Oxford, England)."},{"key":"10.1016\/j.intimp.2021.108107_b0155","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fphys.2014.00352","article-title":"Reactive oxygen species at the crossroads of inflammasome and inflammation","volume":"5","author":"Harijith","year":"2014","journal-title":"Front. Physiol."},{"issue":"26","key":"10.1016\/j.intimp.2021.108107_b0160","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1073\/pnas.0803933105","article-title":"The Nalp3 inflammasome is essential for the development of silicosis","volume":"105","author":"Cassel","year":"2008","journal-title":"PNAS"},{"issue":"7","key":"10.1016\/j.intimp.2021.108107_b0165","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5876","key":"10.1016\/j.intimp.2021.108107_b0170","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science (New York, NY)."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921007438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921007438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:35:32Z","timestamp":1761586532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921007438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":34,"alternative-id":["S1567576921007438"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108107","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tetrahydropalmatine attenuates MSU crystal-induced gouty arthritis by inhibiting ROS-mediated NLRP3 inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108107","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108107"}}