{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:40:25Z","timestamp":1776919225219,"version":"3.51.2"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871539"],"award-info":[{"award-number":["81871539"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313613"],"award-info":[{"award-number":["2018A030313613"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011481"],"award-info":[{"award-number":["2021A1515011481"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.intimp.2021.108142","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T19:29:44Z","timestamp":1632166184000},"page":"108142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury"],"prefix":"10.1016","volume":"100","author":[{"given":"Meixin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjie","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqun","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-6922","authenticated-orcid":false,"given":"Hua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.intimp.2021.108142_b0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41581-018-0052-0","article-title":"Global epidemiology and outcomes of acute kidney injury","volume":"14","author":"Hoste","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108142_b0010","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.intimp.2021.108142_b0015","doi-asserted-by":"crossref","first-page":"e13646","DOI":"10.1111\/apha.13646","article-title":"AKI and CKD","volume":"232","author":"Lichtenberger","year":"2021","journal-title":"Acta Physiol."},{"issue":"9","key":"10.1016\/j.intimp.2021.108142_b0020","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors","volume":"6","author":"Honda","year":"2006","journal-title":"Nat. Rev. Immunol."},{"issue":"44","key":"10.1016\/j.intimp.2021.108142_b0025","doi-asserted-by":"crossref","first-page":"15989","DOI":"10.1073\/pnas.0508327102","article-title":"Negative regulation of Toll-like-receptor signaling by IRF-4","volume":"102","author":"Negishi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"issue":"6","key":"10.1016\/j.intimp.2021.108142_b0030","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/HYPERTENSIONAHA.111.00614","article-title":"Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy","volume":"61","author":"Jiang","year":"2013","journal-title":"Hypertension"},{"issue":"10","key":"10.1016\/j.intimp.2021.108142_b0035","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.4049\/jimmunol.1801549","article-title":"GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation","volume":"202","author":"Lee","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2021.108142_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02162","article-title":"IFN Regulatory Factor 4 Controls Post-ischemic Inflammation and Prevents Chronic Kidney Disease","volume":"10","author":"Lorenz","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2021.108142_b0045","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1681\/ASN.2020071010","article-title":"Deletion of Myeloid Interferon Regulatory Factor 4 (Irf4) in Mouse Model Protects against Kidney Fibrosis after Ischemic Injury by Decreased Macrophage Recruitment and Activation","volume":"32","author":"Sasaki","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"issue":"5","key":"10.1016\/j.intimp.2021.108142_b0050","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"issue":"12","key":"10.1016\/j.intimp.2021.108142_b0055","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1681\/ASN.V12122721","article-title":"Increased renal angiopoietin-1 expression in folic acid-induced nephrotoxicity in mice","volume":"12","author":"Long","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108142_b0060","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2015121376","article-title":"Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI","volume":"28","author":"Martin-Sanchez","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108142_b0065","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.kint.2017.04.021","article-title":"The IL-4 receptor \u03b1 has a critical role in bone marrow-derived fibroblast activation and renal fibrosis","volume":"92","author":"Liang","year":"2017","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.intimp.2021.108142_b0070","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1681\/ASN.2016050573","article-title":"Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury","volume":"28","author":"Wang","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"10","key":"10.1016\/j.intimp.2021.108142_b0075","doi-asserted-by":"crossref","first-page":"6570","DOI":"10.4049\/jimmunol.175.10.6570","article-title":"Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages","volume":"175","author":"Lehtonen","year":"2005","journal-title":"J. Immunol."},{"issue":"29","key":"10.1016\/j.intimp.2021.108142_b0080","doi-asserted-by":"crossref","first-page":"11415","DOI":"10.1074\/jbc.RA118.002416","article-title":"Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages","volume":"293","author":"Hsu","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.intimp.2021.108142_b0085","doi-asserted-by":"crossref","first-page":"e25812","DOI":"10.1371\/journal.pone.0025812","article-title":"Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development","volume":"6","author":"Yamamoto","year":"2011","journal-title":"PLoS One."},{"issue":"3","key":"10.1016\/j.intimp.2021.108142_b0090","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.4049\/jimmunol.0904207","article-title":"Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure","volume":"185","author":"Lassen","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2021.108142_b0095","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jep.2018.12.016","article-title":"Anthriscus sylvestris root extract reduces allergic lung inflammation by regulating interferon regulatory factor 4-mediated Th2 cell activation","volume":"232","author":"Kim","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2021.108142_b0100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejphar.2017.06.031","article-title":"Interleukin-33 signaling contributes to renal fibrosis following ischemia reperfusion","volume":"812","author":"Liang","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2021.108142_b0105","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-981-13-8871-2_12","article-title":"Myofibroblast in Kidney Fibrosis: Origin, Activation, and Regulation","volume":"1165","author":"Yuan","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2021.108142_b0110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ki.2013.153","article-title":"Raising awareness of acute kidney injury: a global perspective of a silent killer","volume":"84","author":"Lewington","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.intimp.2021.108142_b0115","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury","volume":"9","author":"Zeisberg","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2021.108142_b0120","doi-asserted-by":"crossref","first-page":"28715","DOI":"10.1038\/srep28715","article-title":"CXCL16 Deficiency Attenuates Renal Injury and Fibrosis in Salt-Sensitive Hypertension","volume":"6","author":"Liang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2021.108142_b0125","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.biopha.2018.07.031","article-title":"Inhibition of IL-18 reduces renal fibrosis after ischemia-reperfusion","volume":"106","author":"Liang","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"14","key":"10.1016\/j.intimp.2021.108142_b0130","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.7150\/thno.32352","article-title":"Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.intimp.2021.108142_b0135","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s13238-018-0527-6","article-title":"Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrow-derived macrophage","volume":"10","author":"Jiang","year":"2019","journal-title":"Protein Cell."},{"issue":"12","key":"10.1016\/j.intimp.2021.108142_b0140","doi-asserted-by":"crossref","first-page":"e2495","DOI":"10.1038\/cddis.2016.402","article-title":"Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis","volume":"7","author":"Meng","year":"2016","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.intimp.2021.108142_b0145","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41581-019-0110-2","article-title":"Macrophages: versatile players in renal inflammation and fibrosis","volume":"15","author":"Tang","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108142_b0150","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of Renal Fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"issue":"3","key":"10.1016\/j.intimp.2021.108142_b0155","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1074\/jbc.M111.289728","article-title":"IRF-4 suppresses BCR\/ABL transformation of myeloid cells in a DNA binding-independent manner","volume":"287","author":"Jo","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.intimp.2021.108142_b0160","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.intimp.2021.108142_b0165","first-page":"2415","article-title":"The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6","volume":"118","author":"Mudter","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2021.108142_b0170","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1073\/pnas.1914742117","article-title":"Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes","volume":"117","author":"Al Mamun","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"issue":"8","key":"10.1016\/j.intimp.2021.108142_b0175","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm.3218","article-title":"Origin and function of myofibroblasts in kidney fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.intimp.2021.108142_b0180","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1681\/ASN.2010080881","article-title":"CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis","volume":"22","author":"Chen","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"issue":"12","key":"10.1016\/j.intimp.2021.108142_b0185","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1681\/ASN.2014070717","article-title":"JAK3\/STAT6 Stimulates Bone Marrow-Derived Fibroblast Activation in Renal Fibrosis","volume":"26","author":"Yan","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.intimp.2021.108142_b0190","doi-asserted-by":"crossref","first-page":"174097","DOI":"10.1016\/j.ejphar.2021.174097","article-title":"Pharmacological inhibition of SETD7 by PFI-2 attenuates renal fibrosis following folic acid and obstruction injury","volume":"901","author":"Liu","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"34","key":"10.1016\/j.intimp.2021.108142_b0195","doi-asserted-by":"crossref","first-page":"20741","DOI":"10.1073\/pnas.1917663117","article-title":"Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition","volume":"117","author":"Tang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.intimp.2021.108142_b0200","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108142_b0205","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/kisup.2014.7","article-title":"Macrophages promote renal fibrosis through direct and indirect mechanisms","volume":"4","author":"Nikolic-Paterson","year":"2014","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.intimp.2021.108142_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.566535","article-title":"Inhibition of Fatty Acid-Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition","volume":"11","author":"Feng","year":"2020","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2021.108142_b0215","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921007785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921007785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:32:54Z","timestamp":1761586374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921007785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":43,"alternative-id":["S1567576921007785"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108142","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IRF-4 deficiency reduces inflammation and kidney fibrosis after folic acid-induced acute kidney injury","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108142"}}