{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:33:46Z","timestamp":1775187226905,"version":"3.50.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600602"],"award-info":[{"award-number":["81600602"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.intimp.2021.108156","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T07:54:36Z","timestamp":1633506876000},"page":"108156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"PA","title":["Development and validation of a ferroptosis-related prognostic model for the prediction of progression-free survival and immune microenvironment in patients with papillary thyroid carcinoma"],"prefix":"10.1016","volume":"101","author":[{"given":"Yinde","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingchen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Lun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4448-0774","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.108156_b0005","doi-asserted-by":"crossref","first-page":"965212","DOI":"10.1155\/2013\/965212","article-title":"Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors","volume":"2013","author":"Pellegriti","year":"2013","journal-title":"J. Cancer Epidemiol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108156_b0010","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1507\/endocrj.EJ18-0537","article-title":"The roles and role-players in thyroid cancer angiogenesis","volume":"66","author":"Rajabi","year":"2019","journal-title":"Endocr. J."},{"issue":"6","key":"10.1016\/j.intimp.2021.108156_b0015","first-page":"374","article-title":"New developments in the diagnosis and treatment of thyroid cancer","volume":"63","author":"Schneider","year":"2013","journal-title":"CA Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.intimp.2021.108156_b0020","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1056\/NEJMra1501993","article-title":"Biologic and Clinical Perspectives on Thyroid Cancer","volume":"375","author":"Fagin","year":"2016","journal-title":"New England J. Med."},{"issue":"3","key":"10.1016\/j.intimp.2021.108156_b0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nrc3431","article-title":"Molecular pathogenesis and mechanisms of thyroid cancer","volume":"13","author":"Xing","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.intimp.2021.108156_b0030","doi-asserted-by":"crossref","unstructured":"L. Davies, L.G. Morris, M. Haymart, A.Y. Chen, D. Goldenberg, J. Morris, J.B. Ogilvie, D.J. Terris, J. Netterville, R.J. Wong, G. Randolph, AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY DISEASE STATE CLINICAL REVIEW: THE INCREASING INCIDENCE OF THYROID CANCER, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 21(6) (2015) 686-96.","DOI":"10.4158\/EP14466.DSCR"},{"key":"10.1016\/j.intimp.2021.108156_b0035","doi-asserted-by":"crossref","first-page":"86","DOI":"10.12688\/f1000research.12811.1","article-title":"Recent advances in managing differentiated thyroid cancer","volume":"7","author":"Lamartina","year":"2018","journal-title":"F1000Research"},{"issue":"20","key":"10.1016\/j.intimp.2021.108156_b0040","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.1158\/1078-0432.CCR-16-0484","article-title":"Thyroid Cancer: Risk-Stratified Management and Individualized Therapy","volume":"22","author":"Raue","year":"2016","journal-title":"Clin Cancer Res."},{"issue":"5","key":"10.1016\/j.intimp.2021.108156_b0045","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.intimp.2021.108156_b0050","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"51","key":"10.1016\/j.intimp.2021.108156_b0055","doi-asserted-by":"crossref","first-page":"e1904197","DOI":"10.1002\/adma.201904197","article-title":"Recent Progress in Ferroptosis Inducers for Cancer Therapy","volume":"31","author":"Liang","year":"2019","journal-title":"Adv. Mater. (Deerfield Beach Fla.)"},{"issue":"5","key":"10.1016\/j.intimp.2021.108156_b0060","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.intimp.2021.108156_b0065","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.celrep.2017.07.055","article-title":"The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity","volume":"20","author":"Xie","year":"2017","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.intimp.2021.108156_b0070","doi-asserted-by":"crossref","first-page":"517","DOI":"10.18632\/oncoscience.160","article-title":"Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells","volume":"2","author":"Eling","year":"2015","journal-title":"Oncoscience"},{"issue":"7755","key":"10.1016\/j.intimp.2021.108156_b0075","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.intimp.2021.108156_b0080","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41568-019-0149-1","article-title":"Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion","volume":"19","author":"Friedmann Angeli","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2021.108156_b0085","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molmed.2020.08.010","article-title":"Targeting Ferroptosis: New Hope for As-Yet-Incurable Diseases","volume":"27","author":"Conrad","year":"2021","journal-title":"Trends Mol. Med."},{"issue":"13","key":"10.1016\/j.intimp.2021.108156_b0090","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.7150\/ijbs.45050","article-title":"A Novel Ferroptosis-related Gene Signature for Overall Survival Prediction in Patients with Hepatocellular Carcinoma","volume":"16","author":"Liang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41420-021-00473-5","article-title":"The role of ferroptosis in breast cancer patients: a comprehensive analysis","volume":"7","author":"Wu","year":"2021","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.intimp.2021.108156_b0100","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/cns.13654","article-title":"Ferroptosis-related gene signature predicts prognosis and immunotherapy in glioma","volume":"27","author":"Wan","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2021.108156_b0105","doi-asserted-by":"crossref","first-page":"649347","DOI":"10.3389\/fonc.2021.649347","article-title":"Ferroptosis-Related Gene Signature Accurately Predicts Survival Outcomes in Patients With Clear-Cell Renal Cell Carcinoma","volume":"11","author":"Chang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2021.108156_b0110","doi-asserted-by":"crossref","first-page":"629868","DOI":"10.3389\/fonc.2021.629868","article-title":"Identification of Novel Prognostic Risk Signatures of Soft Tissue Sarcoma Based on Ferroptosis-Related Genes","volume":"11","author":"Huang","year":"2021","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0115","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1186\/s12885-021-08687-7","article-title":"A novel survival model based on a Ferroptosis-related gene signature for predicting overall survival in bladder cancer","volume":"21","author":"Liang","year":"2021","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0120","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1186\/s12885-021-08478-0","article-title":"Ferroptosis-related gene signature predicts the prognosis in Oral squamous cell carcinoma patients","volume":"21","author":"Li","year":"2021","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0125","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12890-021-01588-2","article-title":"A novel ferroptosis-related genes model for prognosis prediction of lung adenocarcinoma","volume":"21","author":"Li","year":"2021","journal-title":"BMC Pulmonary Med."},{"key":"10.1016\/j.intimp.2021.108156_b0130","doi-asserted-by":"crossref","first-page":"596679","DOI":"10.3389\/fcell.2020.596679","article-title":"Development and Validation of a Combined Ferroptosis and Immune Prognostic Classifier for Hepatocellular Carcinoma","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0135","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1080\/21655979.2021.1935400","article-title":"A new ferroptosis-related gene model for prognostic prediction of papillary thyroid carcinoma","volume":"12","author":"Qian","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.intimp.2021.108156_b0140","doi-asserted-by":"crossref","unstructured":"Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Oct;45(10):1113-20. doi: 10.1038\/ng.2764. PMID: 24071849; PMCID: PMC3919969.","DOI":"10.1038\/ng.2764"},{"issue":"D1","key":"10.1016\/j.intimp.2021.108156_b0145","doi-asserted-by":"crossref","first-page":"D853","DOI":"10.1093\/nar\/gky1095","article-title":"The UCSC Genome Browser database: 2019 update","volume":"47","author":"Haeussler","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2021.108156_b0150","doi-asserted-by":"crossref","unstructured":"Zhou N, Bao J. FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations. Database (Oxford). 2020 Jan 1;2020:baaa021. doi: 10.1093\/database\/baaa021. PMID: 32219413; PMCID: PMC7100629.","DOI":"10.1093\/database\/baaa021"},{"key":"10.1016\/j.intimp.2021.108156_b0155","doi-asserted-by":"crossref","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015 Apr 20;43(7):e47. doi: 10.1093\/nar\/gkv007. Epub 2015 Jan 20. PMID: 25605792; PMCID: PMC4402510.","DOI":"10.1093\/nar\/gkv007"},{"key":"10.1016\/j.intimp.2021.108156_b0160","doi-asserted-by":"crossref","unstructured":"D. Szklarczyk, A. Franceschini, M. Kuhn, M. Simonovic, A. Roth, P. Minguez, T. Doerks, M. Stark, J. Muller, P. Bork, L.J. Jensen, C. von Mering, The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored, Nucleic acids research 39(Database issue) (2011) D561-8.","DOI":"10.1093\/nar\/gkq973"},{"key":"10.1016\/j.intimp.2021.108156_b0165","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.12659\/MSM.902615","article-title":"Identification of a RNA-Seq Based 8-Long Non-Coding RNA Signature Predicting Survival in Esophageal Cancer","volume":"22","author":"Fan","year":"2016","journal-title":"Med. Sci. Monit. : Int. Med. J. Exp. Clin. Res."},{"issue":"5","key":"10.1016\/j.intimp.2021.108156_b0170","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2021.108156_b0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cell.2014.12.033","article-title":"Molecular and genetic properties of tumors associated with local immune cytolytic activity","volume":"160","author":"Rooney","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2021.108156_b0180","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/ncomms3612","article-title":"Inferring tumour purity and stromal and immune cell admixture from expression data","volume":"4","author":"Yoshihara","year":"2013","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.intimp.2021.108156_b0185","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gr.239244.118","article-title":"Maftools: efficient and comprehensive analysis of somatic variants in cancer","volume":"28","author":"Mayakonda","year":"2018","journal-title":"Genome Res."},{"issue":"3","key":"10.1016\/j.intimp.2021.108156_b0190","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"issue":"7146","key":"10.1016\/j.intimp.2021.108156_b0195","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2021.108156_b0200","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells","volume":"15","author":"Yang","year":"2008","journal-title":"Chem. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108156_b0205","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI124049","article-title":"Suppression of the SLC7A11\/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma","volume":"130","author":"Hu","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.intimp.2021.108156_b0210","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1089\/thy.2019.0065","article-title":"Characterization of Activating Mutations of the MEK1 Gene in Papillary Thyroid Carcinomas","volume":"29","author":"Borrelli","year":"2019","journal-title":"Thyroid : Off. J. Am. Thyroid Ass."},{"issue":"4","key":"10.1016\/j.intimp.2021.108156_b0215","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrc3701","article-title":"Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential","volume":"14","author":"Lee","year":"2014","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.intimp.2021.108156_b0220","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1158\/0008-5472.CAN-16-1979","article-title":"HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.intimp.2021.108156_b0225","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s12020-019-02021-9","article-title":"Identification of gene co-expression modules and hub genes associated with lymph node metastasis of papillary thyroid cancer","volume":"66","author":"Zhai","year":"2019","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0230","first-page":"331","article-title":"Metformin induces TPC-1 cell apoptosis through endoplasmic reticulum stress-associated pathways in vitro and in vivo","volume":"55","author":"Ye","year":"2019","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0235","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/cjp2.6","article-title":"Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers","volume":"1","author":"Aradottir","year":"2015","journal-title":"J. Pathol. Clin. Res."},{"issue":"25","key":"10.1016\/j.intimp.2021.108156_b0240","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1182\/blood-2009-12-259523","article-title":"A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma","volume":"115","author":"G\u00f6rg\u00fcn","year":"2010","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.intimp.2021.108156_b0245","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrc.2016.138","article-title":"Cell cycle proteins as promising targets in cancer therapy","volume":"17","author":"Otto","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"14","key":"10.1016\/j.intimp.2021.108156_b0250","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1158\/1078-0432.CCR-16-2141","article-title":"Activation of EIF4E by Aurora Kinase A Depicts a Novel Druggable Axis in Everolimus-Resistant Cancer Cells","volume":"23","author":"Katsha","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.intimp.2021.108156_b0255","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/1878-0261.12066","article-title":"Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib","volume":"11","author":"Wang","year":"2017","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.intimp.2021.108156_b0260","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12943-015-0375-4","article-title":"Aurora kinase A in gastrointestinal cancers: time to target","volume":"14","author":"Katsha","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2021.108156_b0265","doi-asserted-by":"crossref","first-page":"10180","DOI":"10.1038\/ncomms10180","article-title":"Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.intimp.2021.108156_b0270","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1093\/emboj\/17.11.3052","article-title":"A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers","volume":"17","author":"Bischoff","year":"1998","journal-title":"EMBO J."},{"issue":"7","key":"10.1016\/j.intimp.2021.108156_b0275","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nm.4107","article-title":"A MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer","volume":"22","author":"Dauch","year":"2016","journal-title":"Nat. Med."},{"issue":"48","key":"10.1016\/j.intimp.2021.108156_b0280","doi-asserted-by":"crossref","first-page":"13726","DOI":"10.1073\/pnas.1610626113","article-title":"Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors","volume":"113","author":"Richards","year":"2016","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0285","doi-asserted-by":"crossref","first-page":"16970","DOI":"10.1038\/s41598-019-53174-6","article-title":"Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers","volume":"9","author":"Gomaa","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2021.108156_b0290","doi-asserted-by":"crossref","first-page":"9421079","DOI":"10.1155\/2019\/9421079","article-title":"Novel Prognostic Factors Associated with Cell Cycle Control in Sporadic Medullary Thyroid Cancer Patients","volume":"2019","author":"Pezzani","year":"2019","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.intimp.2021.108156_b0295","doi-asserted-by":"crossref","first-page":"e5822","DOI":"10.7717\/peerj.5822","article-title":"Meta-analysis of microarray datasets identify several chromosome segregation-related cancer\/testis genes potentially contributing to anaplastic thyroid carcinoma","volume":"6","author":"Liu","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.intimp.2021.108156_b0300","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.12659\/MSM.910088","article-title":"Identification of Key Pathways and Genes in Anaplastic Thyroid Carcinoma via Integrated Bioinformatics Analysis","volume":"24","author":"Hu","year":"2018","journal-title":"Med. Sci. Moni. : Int. Med. J. Exp. Clin. Res."},{"issue":"12","key":"10.1016\/j.intimp.2021.108156_b0305","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1089\/thy.2018.0183","article-title":"c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer","volume":"28","author":"Li","year":"2018","journal-title":"Thyroid : Off. J. Am. Thyroid Ass."},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0310","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbrc.2016.03.081","article-title":"Aurora kinase A induces papillary thyroid cancer lymph node metastasis by promoting cofilin-1 activity","volume":"473","author":"Maimaiti","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2021.108156_b0315","doi-asserted-by":"crossref","first-page":"e0121514","DOI":"10.1371\/journal.pone.0121514","article-title":"Deregulated expression of Aurora kinases is not a prognostic biomarker in papillary thyroid cancer patients","volume":"10","author":"Baldini","year":"2015","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.intimp.2021.108156_b0320","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/s41591-019-0566-4","article-title":"Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity","volume":"25","author":"Yang","year":"2019","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2021.108156_b0325","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2018.03.023","article-title":"The Immune Landscape of Cancer","volume":"48","author":"Thorsson","year":"2018","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0330","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12943-018-0786-0","article-title":"Novel targeted therapies and immunotherapy for advanced thyroid cancers","volume":"17","author":"Naoum","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2021.108156_b0335","doi-asserted-by":"crossref","first-page":"570604","DOI":"10.3389\/fendo.2020.570604","article-title":"Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment","volume":"11","author":"Xie","year":"2020","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0340","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1309\/AJCPAKYDO56NKMYZ","article-title":"The role of s100-positive dendritic cells in the prognosis of papillary thyroid carcinoma","volume":"139","author":"Hilly","year":"2013","journal-title":"Am. J. Clin. Pathol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108156_b0345","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s12020-012-9853-2","article-title":"Regulatory T cells and plasmacytoid dendritic cells contribute to the immune escape of papillary thyroid cancer coexisting with multinodular non-toxic goiter","volume":"44","author":"Yu","year":"2013","journal-title":"Endocrine"},{"issue":"3","key":"10.1016\/j.intimp.2021.108156_b0350","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1586\/17446651.1.3.353","article-title":"Thyroid cancer and the immune system: a model for effective immune surveillance","volume":"1","author":"Scouten","year":"2006","journal-title":"Exp. Rev. Endocrinol. Metabol."},{"issue":"9","key":"10.1016\/j.intimp.2021.108156_b0355","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.prp.2015.05.009","article-title":"CD1a-positive dendritic cell density predicts disease-free survival in papillary thyroid carcinoma","volume":"211","author":"Hilly","year":"2015","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.intimp.2021.108156_b0360","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1038\/ncomms9971","article-title":"Systematic pan-cancer analysis of tumour purity","volume":"6","author":"Aran","year":"2015","journal-title":"Nat. Commun."},{"issue":"Pt B","key":"10.1016\/j.intimp.2021.108156_b0365","doi-asserted-by":"crossref","first-page":"107090","DOI":"10.1016\/j.intimp.2020.107090","article-title":"Papillary thyroid carcinoma with a high tumor mutation burden has a poor prognosis","volume":"89","author":"Xie","year":"2020","journal-title":"Int. Immunopharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692100792X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692100792X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:28:07Z","timestamp":1761586087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692100792X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":73,"alternative-id":["S156757692100792X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108156","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a ferroptosis-related prognostic model for the prediction of progression-free survival and immune microenvironment in patients with papillary thyroid carcinoma","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108156"}}