{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:12:10Z","timestamp":1792419130523,"version":"4.5.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A0303100027"],"award-info":[{"award-number":["2018A0303100027"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010706"],"award-info":[{"award-number":["2021A1515010706"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20180228163401333"],"award-info":[{"award-number":["JCYJ20180228163401333"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20190806170612680"],"award-info":[{"award-number":["JCYJ20190806170612680"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201612086"],"award-info":[{"award-number":["SZSM201612086"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800785"],"award-info":[{"award-number":["81800785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972085"],"award-info":[{"award-number":["81972085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.intimp.2021.108179","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T23:44:29Z","timestamp":1633045469000},"page":"108179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"PA","title":["Crosstalk between immune cells and bone cells or chondrocytes"],"prefix":"10.1016","volume":"101","author":[{"given":"Zhiqin","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.intimp.2021.108179_b0005","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","article-title":"Osteoimmunology: evolving concepts in bone-immune interactions in health and disease","volume":"19","author":"Tsukasaki","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2021.108179_b0010","doi-asserted-by":"crossref","first-page":"C162","DOI":"10.1152\/ajpcell.00014.2017","article-title":"Estradiol activates chloride channels via estrogen receptor-alpha in the cell membranes of osteoblasts","volume":"313","author":"Deng","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.intimp.2021.108179_b0015","doi-asserted-by":"crossref","first-page":"3686749","DOI":"10.1155\/2020\/3686749","article-title":"The Interplay between Immune System and Microbiota in Osteoporosis","volume":"2020","author":"Locantore","year":"2020","journal-title":"Mediators Inflamm."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0020","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031245","article-title":"Osteoimmunology","volume":"9","author":"Okamoto","year":"2019","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"10.1016\/j.intimp.2021.108179_b0025","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fendo.2019.00236","article-title":"Updates on Osteoimmunology: What's New on the Cross-Talk Between Bone and Immune System","volume":"10","author":"Ponzetti","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00774-020-01162-6","article-title":"Osteoclast differentiation by RANKL and OPG signaling pathways","volume":"39","author":"Udagawa","year":"2021","journal-title":"J. Bone Miner. Metab."},{"issue":"18","key":"10.1016\/j.intimp.2021.108179_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184653","article-title":"Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis","volume":"20","author":"Kovacs","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2021.108179_b0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/03008207.2017.1290085","article-title":"Osteoblast-osteoclast interactions","volume":"59","author":"Chen","year":"2018","journal-title":"Connect. Tissue Res."},{"issue":"3","key":"10.1016\/j.intimp.2021.108179_b0045","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.bone.2010.06.011","article-title":"How B cells influence bone biology in health and disease","volume":"47","author":"Horowitz","year":"2010","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0050","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s00774-020-01178-y","article-title":"Regulation of T cell-associated tissues and T cell activation by RANKL-RANK-OPG","volume":"39","author":"Walsh","year":"2021","journal-title":"J. Bone Miner. Metab."},{"issue":"7","key":"10.1016\/j.intimp.2021.108179_b0055","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/odi.12189","article-title":"Reciprocal effects of Interferon-gamma and IL-4 on differentiation to osteoclast-like cells by RANKL or LPS","volume":"20","author":"Hu","year":"2014","journal-title":"Oral Dis."},{"issue":"8","key":"10.1016\/j.intimp.2021.108179_b0060","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.molmed.2014.06.001","article-title":"Osteoclasts: more than 'bone eaters'","volume":"20","author":"Charles","year":"2014","journal-title":"Trends Mol. Med."},{"issue":"7","key":"10.1016\/j.intimp.2021.108179_b0065","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/cr.2011.21","article-title":"Osteoclast activity modulates B-cell development in the bone marrow","volume":"21","author":"Mansour","year":"2011","journal-title":"Cell Res."},{"issue":"11","key":"10.1016\/j.intimp.2021.108179_b0070","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","article-title":"Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment","volume":"8","author":"Schett","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2021.108179_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00679","article-title":"Osteoimmunology of Bone Loss in Inflammatory Rheumatic Diseases","volume":"10","author":"Coury","year":"2019","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2021.108179_b0080","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.216267","article-title":"Common signalling pathways in macrophage and osteoclast multinucleation","volume":"131","author":"Pereira","year":"2018","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0085","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/art.39489","article-title":"Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis","volume":"68","author":"Meednu","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0090","doi-asserted-by":"crossref","DOI":"10.4110\/in.2019.19.e2","article-title":"Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis","volume":"19","author":"Jung","year":"2019","journal-title":"Immune Netw."},{"issue":"13","key":"10.1016\/j.intimp.2021.108179_b0095","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1182\/blood-2004-01-0041","article-title":"Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironment","volume":"104","author":"Rivollier","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2021.108179_b0100","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.bone.2016.01.010","article-title":"Proinflammatory T cells and IL-17 stimulate osteoblast differentiation","volume":"84","author":"Croes","year":"2016","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0105","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1359\/JBMR.051004","article-title":"Immunocompetent properties of human osteoblasts: interactions with T lymphocytes","volume":"21","author":"Stanley","year":"2006","journal-title":"J. Bone Min. Res. Off. J. Am. Soc. Bone Min. Res."},{"key":"10.1016\/j.intimp.2021.108179_b0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bone.2018.09.012","article-title":"TNF-alpha suppresses osteogenic differentiation of MSCs by accelerating P2Y(2) receptor in estrogen-deficiency induced osteoporosis","volume":"117","author":"Du","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.intimp.2021.108179_b0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fendo.2020.00465","article-title":"Osteoimmunology: The Regulatory Roles of T Lymphocytes in Osteoporosis","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.intimp.2021.108179_b0120","article-title":"Interaction between bone and immune cells: Implications for postmenopausal osteoporosis","author":"Fischer","year":"2021","journal-title":"Seminars Cell Develop. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108179_b0125","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"New Engl. J. Med."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0130","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.1945","article-title":"Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis","volume":"15","author":"Binder","year":"2009","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0135","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/jcp.22879","article-title":"Absence of MCP-1 leads to elevated bone mass via impaired actin ring formation","volume":"227","author":"Sul","year":"2012","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108179_b0140","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s11914-019-00545-7","article-title":"Monocyte Chemoattractant Protein-1 (MCP-1\/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis","volume":"17","author":"Mulholland","year":"2019","journal-title":"Curr. Osteoporosis Rep."},{"issue":"45","key":"10.1016\/j.intimp.2021.108179_b0145","doi-asserted-by":"crossref","first-page":"33098","DOI":"10.1074\/jbc.M611781200","article-title":"Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre\/osteoclasts","volume":"282","author":"Li","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2021.108179_b0150","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.3389\/fimmu.2019.02182","article-title":"Chemokines in Physiological and Pathological Bone Remodeling","volume":"10","author":"Brylka","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0155","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bone.2008.08.120","article-title":"Gene expression profile of the bone microenvironment in human fragility fracture bone","volume":"44","author":"Hopwood","year":"2009","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.intimp.2021.108179_b0160","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nrrheum.2017.213","article-title":"Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity","volume":"14","author":"Walsh","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0165","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1038\/s41467-018-07626-8","article-title":"B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation","volume":"9","author":"Sun","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0170","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13075-020-02290-0","article-title":"Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment","volume":"22","author":"Duan","year":"2020","journal-title":"Arthritis Res. Therapy"},{"key":"10.1016\/j.intimp.2021.108179_b0175","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fimmu.2016.00415","article-title":"Human Articular Chondrocytes Regulate Immune Response by Affecting Directly T Cell Proliferation and Indirectly Inhibiting Monocyte Differentiation to Professional Antigen-Presenting Cells","volume":"7","author":"Pereira","year":"2016","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2021.108179_b0180","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/stem.1636","article-title":"Macrophage-inducing FasL on chondrocytes forms immune privilege in cartilage tissue engineering, enhancing in vivo regeneration","volume":"32","author":"Fujihara","year":"2014","journal-title":"Stem Cells"},{"issue":"6","key":"10.1016\/j.intimp.2021.108179_b0185","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/sctm.17-0051","article-title":"Mesenchymal Stem Cells: Time to Change the Name!","volume":"6","author":"Caplan","year":"2017","journal-title":"Stem Cells Transl. Med."},{"issue":"8","key":"10.1016\/j.intimp.2021.108179_b0190","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41581-018-0023-5","article-title":"Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases","volume":"14","author":"Shi","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.intimp.2021.108179_b0195","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.exphem.2015.10.009","article-title":"Immunoregulatory effects on T lymphocytes by human mesenchymal stromal cells isolated from bone marrow, amniotic fluid, and placenta","volume":"44","author":"Mareschi","year":"2016","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.intimp.2021.108179_b0200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/scrt537","article-title":"Effect of human bone marrow mesenchymal stromal cells on cytokine production by peripheral blood naive, memory, and effector T cells","volume":"6","author":"Laranjeira","year":"2015","journal-title":"Stem Cell Res. Ther."},{"issue":"26","key":"10.1016\/j.intimp.2021.108179_b0205","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.1182\/blood-2009-02-203943","article-title":"MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2","volume":"113","author":"Spaggiari","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2021.108179_b0210","doi-asserted-by":"crossref","first-page":"798","DOI":"10.3389\/fimmu.2019.00798","article-title":"Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response","volume":"10","author":"Luque-Campos","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0215","first-page":"65","article-title":"The Macrophage Polarization Regulates MSC Osteoblast Differentiation in vitro","volume":"46","author":"Gong","year":"2016","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2021.108179_b0220","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00441-017-2598-8","article-title":"Macrophage type modulates osteogenic differentiation of adipose tissue MSCs","volume":"369","author":"Zhang","year":"2017","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0225","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/annrheumdis-2015-208918","article-title":"Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib\/IIa clinical trial","volume":"76","author":"Alvaro-Gracia","year":"2017","journal-title":"Ann. Rheum. Dis."},{"issue":"24","key":"10.1016\/j.intimp.2021.108179_b0230","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1089\/scd.2013.0023","article-title":"Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy","volume":"22","author":"Wang","year":"2013","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/scrt392","article-title":"Inhibition of mesenchymal stromal cells by pre-activated lymphocytes and their culture media","volume":"5","author":"Valencic","year":"2014","journal-title":"Stem Cell Res. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0240","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/abbs\/gmab010","article-title":"Interleukin 1 beta-induced chloride currents are important in osteoarthritis onset: an in vitro study","volume":"53","author":"Deng","year":"2021","journal-title":"Acta Biochim. Biophy. Sin."},{"issue":"8","key":"10.1016\/j.intimp.2021.108179_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080936","article-title":"Physioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis","volume":"8","author":"Pattappa","year":"2019","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.intimp.2021.108179_b0250","doi-asserted-by":"crossref","first-page":"5024","DOI":"10.4049\/jimmunol.1500907","article-title":"IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice","volume":"196","author":"Kour","year":"2016","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0255","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/03008207.2016.1183667","article-title":"SOX9 and the many facets of its regulation in the chondrocyte lineage","volume":"58","author":"Lefebvre","year":"2017","journal-title":"Connect. Tissue Res."},{"issue":"10","key":"10.1016\/j.intimp.2021.108179_b0260","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1093\/rheumatology\/keaa248","article-title":"A roadmap to target interleukin-6 in osteoarthritis","volume":"59","author":"Wiegertjes","year":"2020","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0265","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.bbrc.2014.06.030","article-title":"Transforming growth factor-beta (TGF-beta) induces the expression of chondrogenesis-related genes through TGF-beta receptor II (TGFRII)-AKT-mTOR signaling in primary cultured mouse precartilaginous stem cells","volume":"450","author":"Li","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.intimp.2021.108179_b0270","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.joca.2019.04.014","article-title":"TGF-beta dampens IL-6 signaling in articular chondrocytes by decreasing IL-6 receptor expression","volume":"27","author":"Wiegertjes","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0275","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4049\/jimmunol.178.1.557","article-title":"B cell clonal expansion and somatic hypermutation of Ig variable heavy chain genes in the synovial membrane of patients with osteoarthritis","volume":"178","author":"Da","year":"2007","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2021.108179_b0280","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10067-019-04768-y","article-title":"Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis","volume":"39","author":"Zhu","year":"2020","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.intimp.2021.108179_b0285","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1749-6632.2011.06227.x","article-title":"Altered matrix at the chondro-osseous junction leads to defects in lymphopoiesis","volume":"1237","author":"Sweeney","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"19","key":"10.1016\/j.intimp.2021.108179_b0290","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1089\/scd.2012.0387","article-title":"Defective endochondral ossification-derived matrix and bone cells alter the lymphopoietic niche in collagen X mouse models","volume":"22","author":"Sweeney","year":"2013","journal-title":"Stem Cells Dev."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0295","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.humimm.2019.02.007","article-title":"IgM(+)CD27(+) B cells possessed regulatory function and represented the main source of B cell-derived IL-10 in the synovial fluid of osteoarthritis patients","volume":"80","author":"Sun","year":"2019","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.intimp.2021.108179_b0300","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jaut.2016.09.002","article-title":"Pathogenic conversion of regulatory B10 cells into osteoclast-priming cells in rheumatoid arthritis","volume":"76","author":"Hu","year":"2017","journal-title":"J. Autoimmun."},{"issue":"5","key":"10.1016\/j.intimp.2021.108179_b0305","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/annrheumdis-2014-206965","article-title":"Activated human B cells induce inflammatory fibroblasts with cartilage-destructive properties and become functionally suppressed in return","volume":"75","author":"Storch","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0310","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3899\/jrheum.161363","article-title":"Synoviocytes-derived Interleukin 35 Potentiates B Cell Response in Patients with Osteoarthritis and Rheumatoid Arthritis","volume":"45","author":"Kam","year":"2018","journal-title":"J. Rheumatol."},{"issue":"12","key":"10.1016\/j.intimp.2021.108179_b0315","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1002\/art.25020","article-title":"Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances production of interleukin-6","volume":"60","author":"Take","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.intimp.2021.108179_b0320","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/rheumatology\/kep040","article-title":"A novel paradigm for dendritic cells as effectors of cartilage destruction","volume":"48","author":"Lakey","year":"2009","journal-title":"Rheumatology"},{"key":"10.1016\/j.intimp.2021.108179_b0325","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8390","article-title":"Identification of key biomarkers and immune infiltration in the synovial tissue of osteoarthritis by bioinformatics analysis","volume":"8","author":"Cai","year":"2020","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0330","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s40425-019-0580-6","article-title":"The clinical application of cancer immunotherapy based on naturally circulating dendritic cells","volume":"7","author":"Bol","year":"2019","journal-title":"J. ImmunoTher. Cancer"},{"issue":"6","key":"10.1016\/j.intimp.2021.108179_b0335","doi-asserted-by":"crossref","first-page":"664","DOI":"10.5009\/gnl18072","article-title":"Regulatory Dendritic Cells Induced by Mesenchymal Stem Cells Ameliorate Dextran Sodium Sulfate-Induced Chronic Colitis in Mice","volume":"12","author":"Jo","year":"2018","journal-title":"Gut Liver"},{"issue":"2","key":"10.1016\/j.intimp.2021.108179_b0340","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/rheumatology\/keaa745","article-title":"Potential efficacy of dendritic cell immunomodulation in the treatment of osteoarthritis","volume":"60","author":"Alahdal","year":"2021","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0345","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.immuni.2013.11.020","article-title":"Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation","volume":"40","author":"Campbell","year":"2014","journal-title":"Immunity"},{"issue":"13","key":"10.1016\/j.intimp.2021.108179_b0350","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1182\/blood-2008-02-139535","article-title":"A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis","volume":"112","author":"Eyles","year":"2008","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.intimp.2021.108179_b0355","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.4049\/jimmunol.1103551","article-title":"Neutrophil-mediated inhibition of proinflammatory cytokine responses","volume":"189","author":"Gresnigt","year":"2012","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2021.108179_b0360","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0889-857X(21)00463-4","article-title":"The neutrophil in rheumatoid arthritis","volume":"21","author":"Pillinger","year":"1995","journal-title":"Rheum. Dis. Clin. North Am."},{"issue":"178","key":"10.1016\/j.intimp.2021.108179_b0365","doi-asserted-by":"crossref","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"3","key":"10.1016\/j.intimp.2021.108179_b0370","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/ar4579","article-title":"Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility","volume":"16","author":"Sur Chowdhury","year":"2014","journal-title":"Arthritis Res. Therapy"},{"issue":"13","key":"10.1016\/j.intimp.2021.108179_b0375","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139388","article-title":"Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis","volume":"5","author":"Carmona-Rivera","year":"2020","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.intimp.2021.108179_b0380","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.joca.2017.01.017","article-title":"Corticoids synergize with IL-1 in the induction of LCN2","volume":"25","author":"Conde","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.intimp.2021.108179_b0385","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.joca.2016.07.009","article-title":"Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice","volume":"25","author":"Choi","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"315","key":"10.1016\/j.intimp.2021.108179_b0390","doi-asserted-by":"crossref","first-page":"315ra190","DOI":"10.1126\/scitranslmed.aac5608","article-title":"Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis","volume":"7","author":"Headland","year":"2015","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0395","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00223-017-0331-y","article-title":"Gut Microbiota, Immune System, and Bone","volume":"102","author":"D'Amelio","year":"2018","journal-title":"Calcif. Tissue Int."},{"issue":"7","key":"10.1016\/j.intimp.2021.108179_b0400","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1210\/jc.2012-4262","article-title":"Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial","volume":"98","author":"Jones","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2021.108179_b0405","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/971938","article-title":"Probiotics, nuclear receptor signaling, and anti-inflammatory pathways","volume":"2011","author":"Yoon","year":"2011","journal-title":"Gastroenterol. Res. Practice"},{"issue":"5","key":"10.1016\/j.intimp.2021.108179_b0410","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jaci.2011.02.015","article-title":"Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity?","volume":"127","author":"Ly","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2021.108179_b0415","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.cell.2008.09.059","article-title":"Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum","volume":"135","author":"Yadav","year":"2008","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.intimp.2021.108179_b0420","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1172\/JCI64906","article-title":"FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin","volume":"122","author":"Kode","year":"2012","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.intimp.2021.108179_b0425","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nm.2098","article-title":"Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis","volume":"16","author":"Yadav","year":"2010","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.intimp.2021.108179_b0430","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nm.2388","article-title":"Lrp5 functions in bone to regulate bone mass","volume":"17","author":"Cui","year":"2011","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.intimp.2021.108179_b0435","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/jbmr.1588","article-title":"The gut microbiota regulates bone mass in mice","volume":"27","author":"Sjogren","year":"2012","journal-title":"J. Bone Min. Res. Off. J. Am. Soc. Bone Min. Res."},{"issue":"10","key":"10.1016\/j.intimp.2021.108179_b0440","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1210\/jc.2017-00513","article-title":"Association Between Gut Microbiota and Bone Health: Potential Mechanisms and Prospective","volume":"102","author":"Chen","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"49","key":"10.1016\/j.intimp.2021.108179_b0445","doi-asserted-by":"crossref","first-page":"18586","DOI":"10.1074\/jbc.RA119.010950","article-title":"Gut microbial beta-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens","volume":"294","author":"Ervin","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2021.108179_b0450","article-title":"ClC-3 chloride channels are involved in estradiol regulation of bone formation by MC3T3-E1 osteoblasts","author":"Deng","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0455","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41598-020-65324-2","article-title":"Colorectal cancer is associated with increased circulating lipopolysaccharide, inflammation and hypercoagulability","volume":"10","author":"de Waal","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2021.108179_b0460","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fimmu.2017.00598","article-title":"Leaky Gut As a Danger Signal for Autoimmune Diseases","volume":"8","author":"Mu","year":"2017","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2021.108179_b0465","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2021.108179_b0470","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12929-018-0493-6","article-title":"Probiotics, prebiotics and amelioration of diseases","volume":"26","author":"Tsai","year":"2019","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0475","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12934-020-1289-4","article-title":"Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier","volume":"19","author":"Liu","year":"2020","journal-title":"Microb. Cell Fact."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0480","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12937-019-0475-x","volume":"18","author":"Karakula-Juchnowicz","year":"2019","journal-title":"Nutr. J."},{"issue":"7610","key":"10.1016\/j.intimp.2021.108179_b0485","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"Baumler","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2021.108179_b0490","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fmicb.2021.675492","article-title":"Lactobacillus casei Zhang Counteracts Blood-Milk Barrier Disruption and Moderates the Inflammatory Response in Escherichia coli-Induced Mastitis","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.intimp.2021.108179_b0495","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/19490976.2019.1662712","article-title":"Additional Candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by Lactobacillus rhamnosus L34","volume":"11","author":"Panpetch","year":"2020","journal-title":"Gut Microbes"},{"issue":"3","key":"10.1016\/j.intimp.2021.108179_b0500","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.semarthrit.2019.05.007","article-title":"A cross talk between dysbiosis and gut-associated immune system governs the development of inflammatory arthropathies","volume":"49","author":"Kalinkovich","year":"2019","journal-title":"Semin. Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0505","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/BOR.0b013e3283477b7b","article-title":"Infection and rheumatoid arthritis: still an open question","volume":"23","author":"Hitchon","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108179_b0510","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1021\/acs.jproteome.6b00598","article-title":"Proteome Analysis of Rheumatoid Arthritis Gut Mucosa","volume":"16","author":"Bennike","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.intimp.2021.108179_b0515","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2017\/4835189","article-title":"Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis","volume":"2017","author":"Horta-Baas","year":"2017","journal-title":"J Immunol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0520","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.4049\/jimmunol.1501904","article-title":"Gut Microbiota Regulates K\/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells","volume":"196","author":"Block","year":"2016","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108179_b0525","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2016.03.013","article-title":"Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells","volume":"44","author":"Teng","year":"2016","journal-title":"Immunity"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921008158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921008158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:33:05Z","timestamp":1761586385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921008158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":105,"alternative-id":["S1567576921008158"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108179","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk between immune cells and bone cells or chondrocytes","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108179"}}