{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:32:17Z","timestamp":1768807937541,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971741"],"award-info":[{"award-number":["81971741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.intimp.2021.108352","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T16:32:59Z","timestamp":1637771579000},"page":"108352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"PB","title":["Mangiferin exert protective effects on joints of adjuvant-induced arthritis rats by regulating the MAPKs\/NF-\u03baB pathway of fibroblast-like synoviocytes"],"prefix":"10.1016","volume":"101","author":[{"given":"Ran","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhehuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyue","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-0101","authenticated-orcid":false,"given":"Xiaotian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2021.108352_b0005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.5114\/reum.2018.75523","article-title":"Cartilage and bone damage in rheumatoid arthritis","volume":"56","author":"Ostrowska","year":"2018","journal-title":"Reumatologia"},{"issue":"5","key":"10.1016\/j.intimp.2021.108352_b0010","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11926-010-0117-y","article-title":"Epidemiology of rheumatoid arthritis: rheumatoid arthritis and mortality","volume":"12","author":"Myasoedova","year":"2010","journal-title":"Curr. Rheumatol. Rep."},{"issue":"10","key":"10.1016\/j.intimp.2021.108352_b0015","doi-asserted-by":"crossref","first-page":"853","DOI":"10.5124\/jkma.2010.53.10.853","article-title":"Pathogenesis of rheumatoid arthritis","volume":"53","author":"Kim","year":"2010","journal-title":"J. Korean Medical Assoc."},{"issue":"1","key":"10.1016\/j.intimp.2021.108352_b0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol. Rev."},{"issue":"6","key":"10.1016\/j.intimp.2021.108352_b0025","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/rheumatology\/kel065","article-title":"Synovial fibroblasts: key players in rheumatoid arthritis","volume":"45","author":"Huber","year":"2006","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.intimp.2021.108352_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-017-1283-3","article-title":"Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"19","author":"Takahashi","year":"2017","journal-title":"Arthritis Res. Therapy"},{"issue":"1","key":"10.1016\/j.intimp.2021.108352_b0035","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrrheum.2012.190","article-title":"Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors","volume":"9","author":"Bottini","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108352_b0040","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.berh.2013.09.002","article-title":"Can rheumatoid arthritis be prevented?","volume":"27","author":"Deane","year":"2013","journal-title":"Best Practice Res. Clin. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108352_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res."},{"issue":"3","key":"10.1016\/j.intimp.2021.108352_b0050","first-page":"417","article-title":"Risk of serious adverse effects of biological and targeted drugs in patients with rheumatoid arthritis: a systematic review meta-analysis","volume":"56","author":"Tarp","year":"2017","journal-title":"Rheumatology"},{"issue":"Suppl_1","key":"10.1016\/j.intimp.2021.108352_b0055","article-title":"PS-008The effect of disease-modifying antirheumatic drugs on the suspension of biologic al treatment due to adverse effects","volume":"22","author":"Varela","year":"2015","journal-title":"European Journal of Hospital Pharmacy"},{"issue":"6","key":"10.1016\/j.intimp.2021.108352_b0060","first-page":"4775","article-title":"Mangiferin: An effective therapeutic agent against several disorders","volume":"18","author":"Du","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"8","key":"10.1016\/j.intimp.2021.108352_b0065","first-page":"1371","article-title":"Mangiferin suppresses CIA by suppressing the expression of TNF-\u03b1, IL-6, IL-1\u03b2, and RANKL through inhibiting the activation of NF-\u03baB and ERK1\/2","volume":"7","author":"Tsubaki","year":"2015","journal-title":"Am. J. Translat. Res."},{"key":"10.1016\/j.intimp.2021.108352_b0070","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.intimp.2017.05.034","article-title":"Naturally occurring xanthone and benzophenone derivatives exert significant anti-proliferative and proapoptotic effects in vitro on synovial fibroblasts and macrophages from rheumatoid arthritis patients","volume":"49","author":"Henc","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2021.108352_b0075","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/biof.1292","article-title":"Mangiferin: A xanthonoid with multipotent anti-inflammatory potential","volume":"42","author":"Saha","year":"2016","journal-title":"BioFactors"},{"key":"10.1016\/j.intimp.2021.108352_b0080","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cbi.2015.04.021","article-title":"Protective effect of apigenin on Freund\u2019s complete adjuvant-induced arthritis in rats via inhibiting P2X7\/NF-\u03baB pathway","volume":"236","author":"Chang","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.intimp.2021.108352_b0085","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10787-018-0507-8","article-title":"Pharmacological and biochemical studies on protective effects of mangiferin and its interaction with nitric oxide (NO) modulators in adjuvant-induced changes in arthritic parameters, inflammatory, and oxidative biomarkers in rats","volume":"27","author":"Pal","year":"2019","journal-title":"Inflammopharmacology"},{"issue":"11","key":"10.1016\/j.intimp.2021.108352_b0090","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1007\/s10495-017-1420-0","article-title":"Protodioscin ameliorates oxidative stress, inflammation and histology outcome in Complete Freund\u2019s adjuvant induced arthritis rats","volume":"22","author":"Liu","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.intimp.2021.108352_b0095","doi-asserted-by":"crossref","first-page":"152876","DOI":"10.1016\/j.phymed.2019.152876","article-title":"Kadsura heteroclita stem suppresses the onset and progression of adjuvant-induced arthritis in rats","volume":"58","author":"Yu","year":"2019","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.intimp.2021.108352_b0100","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3390\/ijms19051514","article-title":"Jatrorrhizine Hydrochloride Suppresses Proliferation, Migration, and Secretion of Synoviocytes In Vitro and Ameliorates Rat Models of Rheumatoid Arthritis In Vivo","volume":"19","author":"Qiu","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2021.108352_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152925","article-title":"Increased reactive oxygen species formation and oxidative stress in rheumatoid arthritis","volume":"11","author":"Mateen","year":"2016","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.intimp.2021.108352_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40064-016-1671-1","article-title":"Oxidative changes in the blood and serum albumin differentiate rats with monoarthritis and polyarthritis","volume":"5","author":"Bracht","year":"2016","journal-title":"SpringerPlus"},{"issue":"14","key":"10.1016\/j.intimp.2021.108352_b0115","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1021\/jf800738r","article-title":"Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.)","volume":"56","author":"Barreto","year":"2008","journal-title":"J. Agric. Food. Chem."},{"issue":"7","key":"10.1016\/j.intimp.2021.108352_b0120","doi-asserted-by":"crossref","first-page":"582","DOI":"10.2174\/1389557515666150401111410","article-title":"Medicinal properties of mangiferin, structural features, derivative synthesis, pharmacokinetics and biological activities","volume":"15","author":"Benard","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2021.108352_b0125","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3109\/10799893.2014.931431","article-title":"Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets","volume":"35","author":"Rajendran","year":"2015","journal-title":"J. Recept. Signal Transduction"},{"issue":"2","key":"10.1016\/j.intimp.2021.108352_b0130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.phrs.2003.12.003","article-title":"In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG\u00ae)","volume":"50","author":"Garrido","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2021.108352_b0135","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fitote.2013.07.020","article-title":"Isolation of xanthone and benzophenone derivatives from Cyclopia genistoides (L.) Vent. (honeybush) and their pro-apoptotic activity on synoviocytes from patients with rheumatoid arthritis","volume":"90","author":"Kokotkiewicz","year":"2013","journal-title":"Fitoterapia"},{"issue":"6","key":"10.1016\/j.intimp.2021.108352_b0140","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2094","article-title":"Cytokines in the pathogenesis of rheumatoid arthritis","volume":"7","author":"McInnes","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108352_b0145","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00281-017-0619-z","article-title":"Selected cytokine pathways in rheumatoid arthritis","volume":"39","author":"Noack","year":"2017","journal-title":"Semin. Immunopathol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108352_b0150","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/annrheumdis-2015-208093","article-title":"Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss","volume":"75","author":"Krishnamurthy","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2021.108352_b0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cei.13167","article-title":"NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis","volume":"194","author":"Guo","year":"2018","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2021.108352_b0160","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1084\/jem.170.3.865","article-title":"Cytokines in chronic inflammatory arthritis. IV. Granulocyte\/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis","author":"Alvaro-Gracia","year":"1989","journal-title":"J. Exp. Med.170"},{"issue":"4","key":"10.1016\/j.intimp.2021.108352_b0165","doi-asserted-by":"crossref","DOI":"10.2478\/v10054-008-0059-8","article-title":"Collagen-induced arthritis and pro-\/antioxidant status in Wistar and Lewis rats","author":"Leonavi\u010dien\u0117","year":"2008","journal-title":"Biologija"},{"issue":"2","key":"10.1016\/j.intimp.2021.108352_b0170","first-page":"145","article-title":"Free radicals, antioxidants, and the immune system","volume":"30","author":"Knight","year":"2000","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2021.108352_b0175","first-page":"230","article-title":"Increased nitric oxide levels in patients with rheumatoid arthritis","volume":"23","author":"Ueki","year":"1996","journal-title":"J. Rheumatol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108352_b0180","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1742-7843.2009.00526.x","article-title":"Effects of kaempferol and myricetin on inducible nitric oxide synthase expression and nitric oxide production in rats","volume":"106","author":"Rostoka","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108352_b0185","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.rbr.2014.07.003","article-title":"Higher nitric oxide levels are associated with disease activity in Egyptian rheumatoid arthritis patients","volume":"54","author":"Ali","year":"2014","journal-title":"Revista brasileira de reumatologia"},{"key":"10.1016\/j.intimp.2021.108352_b0190","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/B978-0-323-31696-5.00069-3","article-title":"Etiology and pathogenesis of rheumatoid arthritis","volume":"2","author":"Firestein","year":"2017","journal-title":"Kelley and Firestein's Textbook Rheumatol. (Tenth Edition)"},{"key":"10.1016\/j.intimp.2021.108352_b0195","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fphar.2019.00094","article-title":"Astragalin suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis and in human fibroblast-like synoviocytes","volume":"10","author":"Jia","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108352_b0200","doi-asserted-by":"crossref","first-page":"398","DOI":"10.23736\/S0391-1977.18.02725-6","article-title":"Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis","volume":"43","author":"Nagasaki","year":"2018","journal-title":"Minerva Endocrinol."},{"issue":"2","key":"10.1016\/j.intimp.2021.108352_b0205","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jbspin.2011.03.018","article-title":"Tacrolimus (FK506) inhibits interleukin-1\u03b2-induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes","volume":"79","author":"Choe","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"8","key":"10.1016\/j.intimp.2021.108352_b0210","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/rheumatology\/kex142","article-title":"Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis","volume":"56","author":"Li","year":"2017","journal-title":"Rheumatology"},{"key":"10.1016\/j.intimp.2021.108352_b0215","first-page":"185","article-title":"Expression of TREM-2 and its inhibitory effects on TNF-\u03b1 induced inflammation in fibroblast-like synoviocytes via inhibiting p38 pathway activation","volume":"36","author":"Huang","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2021.108352_b0220","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbrc.2008.11.002","article-title":"Inhibition of IL-1\u03b2-mediated inflammatory responses by the I\u03baB\u03b1 super-repressor in human fibroblast-like synoviocytes","volume":"378","author":"Lee","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921009887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921009887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:31:38Z","timestamp":1761586298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921009887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":44,"alternative-id":["S1567576921009887"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108352","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mangiferin exert protective effects on joints of adjuvant-induced arthritis rats by regulating the MAPKs\/NF-\u03baB pathway of fibroblast-like synoviocytes","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108352","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108352"}}