{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:38:41Z","timestamp":1792633121007,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.intimp.2021.108396","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T21:28:56Z","timestamp":1638912536000},"page":"108396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Atlas of circulating immune cells in Kawasaki disease"],"prefix":"10.1016","volume":"102","author":[{"given":"Zhenyu","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinde","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.108396_b0005","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.intimp.2021.108396_b0010","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.autrev.2015.04.002","article-title":"Kawasaki disease: an evolving paradigm","volume":"14","author":"Greco","year":"2015","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2188\/jea.JE20110131","article-title":"Epidemiology of Kawasaki disease in Asia, Europe, and the United States","volume":"22","author":"Uehara","year":"2012","journal-title":"J. Epidemiol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108396_b0020","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0022-3476(75)80220-4","article-title":"Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome","volume":"86","author":"Kato","year":"1975","journal-title":"J. Pediatr."},{"issue":"14","key":"10.1016\/j.intimp.2021.108396_b0025","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.jacc.2015.12.073","article-title":"Kawasaki disease","volume":"67","author":"Newburger","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10176","key":"10.1016\/j.intimp.2021.108396_b0030","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0140-6736(18)33133-7","article-title":"Improving coronary artery outcomes for children with Kawasaki disease","volume":"393","author":"McCrindle","year":"2019","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.intimp.2021.108396_b0035","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41584-020-0426-0","article-title":"Kawasaki disease: pathophysiology and insights from mouse models","volume":"16","author":"Noval Rivas","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108396_b0040","doi-asserted-by":"crossref","first-page":"e38998","DOI":"10.1371\/journal.pone.0038998","article-title":"Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study","volume":"7","author":"Orenstein","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2021.108396_b0045","doi-asserted-by":"crossref","first-page":"108385","DOI":"10.1016\/j.clim.2020.108385","article-title":"A framework for understanding Kawasaki disease pathogenesis","volume":"214","author":"Lo","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0050","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fped.2018.00198","article-title":"Kawasaki disease","volume":"6","author":"Hedrich","year":"2018","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.intimp.2021.108396_b0055","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/cei.12832","article-title":"Kawasaki disease: a matter of innate immunity","volume":"186","author":"Hara","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0060","first-page":"1","article-title":"Changes in peripheral blood neutrophils, lymphocytes and IL-10 in children with Kawasaki disease from different age groups undergoing intravenous immunoglobulin: a retrospective study","volume":"2020","author":"Zhang","year":"2020","journal-title":"Mediators Inflamm."},{"issue":"4","key":"10.1016\/j.intimp.2021.108396_b0065","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.cell.2020.09.016","article-title":"The immunology of multisystem inflammatory syndrome in children with COVID-19","volume":"183","author":"Consiglio","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/clim.2002.5209","article-title":"Intravenous immunoglobulin therapy induces neutrophil apoptosis in Kawasaki disease","volume":"103","author":"Tsujimoto","year":"2002","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0075","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1186\/s13073-014-0102-6","article-title":"Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease","volume":"6","author":"Hoang","year":"2014","journal-title":"Genome Med."},{"issue":"6","key":"10.1016\/j.intimp.2021.108396_b0080","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/adc.67.6.706","article-title":"Mononuclear cell subsets and coronary artery lesions in Kawasaki disease","volume":"67","author":"Furukawa","year":"1992","journal-title":"Arch. Dis. Child."},{"issue":"3","key":"10.1016\/j.intimp.2021.108396_b0085","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2249.2005.02821.x","article-title":"Immunological profile of peripheral blood lymphocytes and monocytes\/macrophages in Kawasaki disease","volume":"141","author":"Matsubara","year":"2005","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0090","first-page":"410","article-title":"CD8+ T cells contribute to the development of coronary arteritis in the Lactobacillus casei cell wall extract-induced murine model of Kawasaki disease, Arthritis","volume":"69","author":"Noval Rivas","year":"2017","journal-title":"Rheumatol."},{"issue":"6","key":"10.1016\/j.intimp.2021.108396_b0095","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/03009742.2019.1604992","article-title":"Dynamics of immunocyte activation during intravenous immunoglobulin treatment in Kawasaki disease","volume":"48","author":"Matsuguma","year":"2019","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.intimp.2021.108396_b0100","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1365-2249.2010.04297.x","article-title":"Increased frequency of immunoglobulin (Ig)A-secreting cells following Toll-like receptor (TLR)-9 engagement in patients with Kawasaki disease","volume":"163","author":"Giordani","year":"2011","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"10.1016\/j.intimp.2021.108396_b0105","first-page":"493","article-title":"Immunoglobulin V(H) chain gene analysis of peripheral blood IgM-producing B cells in patients with Kawasaki disease, Yonsei","volume":"50","author":"Lee","year":"2009","journal-title":"Med. J."},{"key":"10.1016\/j.intimp.2021.108396_b0110","first-page":"357","article-title":"Effects of intravenous immune globulin on the peripheral lymphocyte phenotypes in Kawasaki disease, Yonsei","volume":"37","author":"Lee","year":"1996","journal-title":"Med. J."},{"key":"10.1016\/j.intimp.2021.108396_b0115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s12891-015-0744-6","article-title":"Profiles of responses of immunological factors to different subtypes of Kawasaki disease","volume":"16","author":"Ding","year":"2015","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.intimp.2021.108396_b0120","first-page":"617","article-title":"The effect of intravenous immunoglobulin on lymphocyte populations in children with Kawasaki syndrome","volume":"10","author":"Saulsbury","year":"1992","journal-title":"Clin. Exp. Rheumatol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108396_b0125","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1203\/00006450-200110000-00019","article-title":"Surface and cytoplasmic immunoglobulin expression in circulating B-lymphocytes in acute Kawasaki disease","volume":"50","author":"Shingadia","year":"2001","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.intimp.2021.108396_b0130","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/iid3.373","article-title":"Five immune-gene-signatures participate in the development and pathogenesis of Kawasaki disease","volume":"9","author":"Nie","year":"2020","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.intimp.2021.108396_b0135","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000024412","article-title":"Reduced frequencies of peripheral interferon-gamma-producing CD4+ and CD4- cells during acute Kawasaki disease","volume":"122","author":"Hahn","year":"2000","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0140","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/cei.13506","article-title":"Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens","volume":"202","author":"Burns","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0145","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2249.2007.03567.x","article-title":"T cell activation profiles in Kawasaki syndrome","volume":"151","author":"Brogan","year":"2008","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0150","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/cei.12418","article-title":"Regulatory T cell microRNA expression changes in children with acute Kawasaki disease","volume":"178","author":"Ni","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0155","first-page":"93","article-title":"Defective FOXP3 expression in patients with acute Kawasaki disease and restoration by intravenous immunoglobulin therapy","volume":"28","author":"Olivito","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0160","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2249.2010.04236.x","article-title":"The T helper type 17\/regulatory T cell imbalance in patients with acute Kawasaki disease","volume":"162","author":"Jia","year":"2010","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2021.108396_b0165","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/all.12558","article-title":"Th17- and Treg-related cytokine and mRNA expression are associated with acute and resolving Kawasaki disease","volume":"70","author":"Guo","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2021.108396_b0170","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"issue":"D1","key":"10.1016\/j.intimp.2021.108396_b0175","doi-asserted-by":"crossref","first-page":"D833","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pi\u00f1ero","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"43","key":"10.1016\/j.intimp.2021.108396_b0180","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.intimp.2021.108396_b0185","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"issue":"7","key":"10.1016\/j.intimp.2021.108396_b0190","first-page":"1902880","article-title":"ImmuCellAI: a unique method for comprehensive T-cell subsets abundance prediction and its application in cancer immunotherapy","volume":"7","author":"Miao","year":"2020","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"4","key":"10.1016\/j.intimp.2021.108396_b0195","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","article-title":"Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer","volume":"39","author":"Bindea","year":"2013","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.intimp.2021.108396_b0200","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.autrev.2009.12.004","article-title":"Kawasaki disease: aetiopathogenesis and therapeutic utility of intravenous immunoglobulin","volume":"9","author":"Galeotti","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.intimp.2021.108396_b0205","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3389\/fped.2018.00374","article-title":"The epidemiology and pathogenesis of Kawasaki disease","volume":"6","author":"Rowley","year":"2018","journal-title":"Front. Pediatr."},{"issue":"7","key":"10.1016\/j.intimp.2021.108396_b0210","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41588-020-0640-3","article-title":"Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases","volume":"52","author":"Ishigaki","year":"2020","journal-title":"Nat. Genet."},{"issue":"10239","key":"10.1016\/j.intimp.2021.108396_b0215","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study","volume":"395","author":"Verdoni","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2021.108396_b0220","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1001\/jama.2020.10370","article-title":"SARS-CoV-2-related inflammatory multisystem syndrome in children: different or shared etiology and pathophysiology as Kawasaki disease?","volume":"324","author":"McCrindle","year":"2020","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.intimp.2021.108396_b0225","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12016-020-08783-9","article-title":"Immunogenetics of Kawasaki disease","volume":"59","author":"Kumrah","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2021.108396_b0230","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1253\/circj.CJ-19-0206","article-title":"Global investigation of immune repertoire suggests Kawasaki disease has infectious cause","volume":"83","author":"Kuo","year":"2019","journal-title":"Circ. J."},{"key":"10.1016\/j.intimp.2021.108396_b0235","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12865-019-0299-7","article-title":"Distinct variations of antibody secreting cells and memory B cells during the course of Kawasaki disease","volume":"20","author":"Xu","year":"2019","journal-title":"BMC Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0240","doi-asserted-by":"crossref","first-page":"5946","DOI":"10.4049\/jimmunol.159.12.5946","article-title":"IgA plasma cells in vascular tissue of patients with Kawasaki syndrome","volume":"159","author":"Rowley","year":"1997","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2021.108396_b0245","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1086\/315832","article-title":"IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease","volume":"182","author":"Rowley","year":"2000","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0250","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.4049\/jimmunol.166.2.1334","article-title":"Oligoclonal IgA response in the vascular wall in acute Kawasaki disease","volume":"166","author":"Rowley","year":"2001","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2021.108396_b0255","doi-asserted-by":"crossref","first-page":"e72037","DOI":"10.1371\/journal.pone.0072037","article-title":"Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility","volume":"8","author":"Chang","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0260","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00109-005-0010-8","article-title":"Expression of CD180, a toll-like receptor homologue, is up-regulated in children with Kawasaki disease","volume":"84","author":"Imayoshi","year":"2006","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"1","key":"10.1016\/j.intimp.2021.108396_b0265","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/0090-1229(82)90075-7","article-title":"Immunoregulatory abnormalities in mucocutaneous lymph node syndrome","volume":"23","author":"Leung","year":"1982","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.intimp.2021.108396_b0270","first-page":"516","article-title":"T-helper cytokine profiles in patients with Kawasaki disease, Korean","volume":"45","author":"Lee","year":"2015","journal-title":"Circ. J."},{"key":"10.1016\/j.intimp.2021.108396_b0275","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4049\/jimmunol.159.1.481","article-title":"Clonal expansion of CD8+ T cells in Kawasaki disease","volume":"159","author":"Choi","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0280","first-page":"52","article-title":"Decreased CD5+ B cells during the acute phase of Kawasaki disease, Yonsei","volume":"37","author":"Kim","year":"1996","journal-title":"Med. J."},{"key":"10.1016\/j.intimp.2021.108396_b0285","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000235446","article-title":"Increased expression of Fc epsilon R2\/CD23 on peripheral blood B lymphocytes and serum IgE levels in Kawasaki disease","volume":"95","author":"Furukawa","year":"1991","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0290","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI112835","article-title":"Reversal of lymphocyte activation in vivo in the Kawasaki syndrome by intravenous gammaglobulin","volume":"79","author":"Leung","year":"1987","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2021.108396_b0295","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/cei.12182","article-title":"Immune-monitoring in Kawasaki disease patients treated with infliximab and intravenous immunoglobulin","volume":"174","author":"Burns","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0300","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12887-019-1412-z","article-title":"Distribution of distinct subsets of circulating T follicular helper cells in Kawasaki disease","volume":"19","author":"Xu","year":"2019","journal-title":"BMC Pediatr."},{"issue":"1","key":"10.1016\/j.intimp.2021.108396_b0305","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cellimm.2010.07.003","article-title":"Early activation does not translate into effector differentiation of peripheral CD8T cells during the acute phase of Kawasaki disease","volume":"265","author":"Ehara","year":"2010","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0310","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2249.2009.04073.x","article-title":"Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease","volume":"160","author":"Ikeda","year":"2010","journal-title":"Clin. Exp. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2021.108396_b0315","doi-asserted-by":"crossref","first-page":"R261","DOI":"10.1186\/gb-2007-8-12-r261","article-title":"Gene-expression patterns reveal underlying biological processes in Kawasaki disease","volume":"8","author":"Popper","year":"2007","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.intimp.2021.108396_b0320","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/sji.12022","article-title":"Aberrantly decreased levels of NKG2D expression in children with Kawasaki disease","volume":"77","author":"Ge","year":"2013","journal-title":"Scand. J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0325","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/infdis\/163.2.416","article-title":"Comparison of Kawasaki disease and infectious mononucleosis in terms of natural killer cell and CD8+ T cell subsets","volume":"163","author":"Furukawa","year":"1991","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2021.108396_b0330","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0090-1229(88)90088-8","article-title":"Peripheral blood monocyte\/macrophages and serum tumor necrosis factor in Kawasaki disease","volume":"48","author":"Furukawa","year":"1988","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.intimp.2021.108396_b0335","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1046\/j.1365-2249.2000.01321.x","article-title":"CD14+CD16+ monocyte subpopulation in Kawasaki disease","volume":"121","author":"Katayama","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2021.108396_b0340","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1440-1827.1998.tb03942.x","article-title":"Activation of peripheral blood monocytes and macrophages in Kawasaki disease: ultrastructural and immunocytochemical investigation","volume":"48","author":"Koga","year":"1998","journal-title":"Pathol. Int."},{"issue":"4","key":"10.1016\/j.intimp.2021.108396_b0345","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1440-1827.2001.01202.x","article-title":"Maturation of macrophages from peripheral blood monocytes in Kawasaki disease: immunocytochemical and immunoelectron microscopic study","volume":"51","author":"Ariga","year":"2001","journal-title":"Pathol. Int."},{"issue":"1","key":"10.1016\/j.intimp.2021.108396_b0350","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2177\/jsci.36.27","article-title":"Biomarkers associated with unresponsiveness to IVIG in children with Kawasaki disease\u5ddd\u5d0e\u75c5\u306b\u304a\u3051\u308b\u6cbb\u7642\u53cd\u5fdc\u6027\u3068\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc","volume":"36","author":"Abe","year":"2013","journal-title":"Nihon Rinsho Meneki Gakkai Kaishi"},{"issue":"10","key":"10.1016\/j.intimp.2021.108396_b0355","doi-asserted-by":"crossref","first-page":"e182293","DOI":"10.1001\/jamapediatrics.2018.2293","article-title":"Diagnosis of Kawasaki disease using a minimal whole-blood gene expression signature","volume":"172","author":"Wright","year":"2018","journal-title":"JAMA Pediatr."},{"issue":"4","key":"10.1016\/j.intimp.2021.108396_b0360","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1086\/603538","article-title":"Gene transcript abundance profiles distinguish Kawasaki disease from adenovirus infection","volume":"200","author":"Popper","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.intimp.2021.108396_b0365","first-page":"681","article-title":"General pathology of Kawasaki disease. On the morphological alterations corresponding to the clinical manifestations","volume":"30","author":"Amano","year":"1980","journal-title":"Acta Pathol. Jpn."},{"issue":"3","key":"10.1016\/j.intimp.2021.108396_b0370","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cyto.2012.08.006","article-title":"Inflammatory cytokine profiles during Cyclosporin treatment for immunoglobulin-resistant Kawasaki disease","volume":"60","author":"Hamada","year":"2012","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.intimp.2021.108396_b0375","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jpeds.2012.02.048","article-title":"Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease","volume":"161","author":"Tremoulet","year":"2012","journal-title":"J. Pediatr."},{"key":"10.1016\/j.intimp.2021.108396_b0380","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3390\/ijms20081834","article-title":"B cells and antibodies in Kawasaki disease","volume":"20","author":"Lindquist","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.intimp.2021.108396_b0385","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/adc.2010.184101","article-title":"Assessment of intravenous immunoglobulin non-responders in Kawasaki disease","volume":"96","author":"Hwang","year":"2011","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.intimp.2021.108396_b0390","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13052-018-0475-z","article-title":"A comparison of efficacy of six prediction models for intravenous immunoglobulin resistance in Kawasaki disease","volume":"44","author":"Qian","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.intimp.2021.108396_b0395","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/ped.13240","article-title":"High neutrophil: lymphocyte ratio is associated with refractory Kawasaki disease","volume":"59","author":"Cho","year":"2017","journal-title":"Pediatr. Int."},{"key":"10.1016\/j.intimp.2021.108396_b0400","article-title":"Neutrophil-to-lymphocyte ratio as a biomarker for predicting the intravenous immunoglobulin-resistant Kawasaki disease","volume":"99","author":"Wu","year":"2020","journal-title":"Medicine"},{"issue":"10","key":"10.1016\/j.intimp.2021.108396_b0405","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1177\/0009922818759320","article-title":"Vital signs as predictor factors of intravenous immunoglobulin resistance in patients with Kawasaki disease","volume":"57","author":"G\u00e1mez-Gonz\u00e1lez","year":"2018","journal-title":"Clin. Pediatr."},{"issue":"12","key":"10.1016\/j.intimp.2021.108396_b0410","doi-asserted-by":"crossref","first-page":"e0167434","DOI":"10.1371\/journal.pone.0167434","article-title":"Unique molecular patterns uncovered in Kawasaki disease patients with elevated serum gamma glutamyl transferase levels: implications for intravenous immunoglobulin responsiveness","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2021.108396_b0415","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.clim.2016.08.012","article-title":"Intravenous immunoglobulin treatment responsiveness depends on the degree of CD8+ T cell activation in Kawasaki disease","volume":"171","author":"Ye","year":"2016","journal-title":"Clin. Immunol."},{"issue":"14","key":"10.1016\/j.intimp.2021.108396_b0420","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/CIRCULATIONAHA.120.046528","article-title":"Single-cell transcriptome analysis reveals dynamic cell populations and differential gene expression patterns in control and aneurysmal human aortic tissue","volume":"142","author":"Li","year":"2020","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.intimp.2021.108396_b0425","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/CIRCULATIONAHA.119.041460","article-title":"Critical role of cytosolic DNA and its sensing adaptor STING in aortic degeneration, dissection, and rupture","volume":"141","author":"Luo","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2021.108396_b0430","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1038\/s41467-021-25771-5","article-title":"Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921010328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921010328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:29:50Z","timestamp":1761586190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921010328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":86,"alternative-id":["S1567576921010328"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108396","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Atlas of circulating immune cells in Kawasaki disease","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108396"}}