{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:34:20Z","timestamp":1789475660918,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472658"],"award-info":[{"award-number":["81472658"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772979"],"award-info":[{"award-number":["81772979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.intimp.2021.108430","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T16:12:33Z","timestamp":1639757553000},"page":"108430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["JAM2 predicts a good prognosis and inhibits invasion and migration by suppressing EMT pathway in breast cancer"],"prefix":"10.1016","volume":"103","author":[{"given":"Yang","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beige","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9933-3643","authenticated-orcid":false,"given":"Shengchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2021.108430_b0005","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2021.108430_b0010","first-page":"87","article-title":"Global cancer statistics, 2012: Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.intimp.2021.108430_b0015","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA A Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.intimp.2021.108430_b0020","first-page":"52","article-title":"Breast cancer statistics, 2013: Breast Cancer Statistics, 2013","volume":"64","author":"DeSantis","year":"2014","journal-title":"CA Cancer J. Clin."},{"issue":"18","key":"10.1016\/j.intimp.2021.108430_b0025","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/jnci\/djr257","article-title":"Incidence of breast cancer in the United States: current and future trends","volume":"103","author":"Anderson","year":"2011","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.intimp.2021.108430_b0030","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.1038\/ncomms6406","article-title":"BRMS1L suppresses breast cancer metastasis by inducing epigenetic silence of FZD10","volume":"5","author":"Gong","year":"2014","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.intimp.2021.108430_b0035","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/gim.2016.23","article-title":"Low risk of solid tumors in persons with down syndrome","volume":"18","author":"Hasle","year":"2016","journal-title":"Genetics Med.: Official J. Am. College Med. Genetics"},{"key":"10.1016\/j.intimp.2021.108430_b0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.canlet.2013.05.038","article-title":"Tight junction proteins: from barrier to tumorigenesis","volume":"337","author":"Runkle","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2021.108430_b0045","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1083\/jcb.142.1.117","article-title":"Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration","volume":"142","author":"Mart\u00ecn-Padura","year":"1998","journal-title":"J. Cell Biol."},{"issue":"Pt 13","key":"10.1016\/j.intimp.2021.108430_b0050","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1242\/jcs.113.13.2363","article-title":"Human junction adhesion molecule regulates tight junction resealing in epithelia","volume":"113","author":"Liu","year":"2000","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.intimp.2021.108430_b0055","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.addr.2005.01.005","article-title":"The JAM family of proteins","volume":"57","author":"Mandell","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.intimp.2021.108430_b0060","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00441-014-1820-1","article-title":"Tight junction dynamics: the role of junctional adhesion molecules (JAMs)","volume":"355","author":"Garrido-Urbani","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.intimp.2021.108430_b0065","unstructured":"P. Bradfield, C. Scheiermann, S. Nourshargh, C. Ody, and B.J.S.m.w.o.j.o.t.S.S.o.I.D. Imfof, the Swiss Society of Internal Medicine, the Swiss Society of Pneumology, JAM-C, a turnstile for monocyte transendothelial migration in inflammation. 137 (2007) 12S-12S."},{"key":"10.1016\/j.intimp.2021.108430_b0070","doi-asserted-by":"crossref","unstructured":"K. Ebnet, M. Aurrand-Lions, A. Kuhn, F. Kiefer, S. Butz, K. Zander, M.K. Meyer zu Brickwedde, A. Suzuki, B.A. Imhof, and D. Vestweber, The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity, J. Cell Sci. 116 (2003) 3879-91.","DOI":"10.1242\/jcs.00704"},{"issue":"8","key":"10.1016\/j.intimp.2021.108430_b0075","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1096\/fj.15-270223","article-title":"Junctional adhesion molecule B interferes with angiogenic VEGF\/VEGFR2 signaling","volume":"29","author":"Meguenani","year":"2015","journal-title":"FASEB J.: Official Publ. Federation Am. Soc. Exp. Biol."},{"key":"10.1016\/j.intimp.2021.108430_b0080","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s12032-012-0380-z","article-title":"Junctional adhesion molecules 2 and 3 may potentially be involved in progression of gastric adenocarcinoma tumors","volume":"30","author":"Hajjari","year":"2013","journal-title":"Med. Oncol. (Northwood, London, England)"},{"key":"10.1016\/j.intimp.2021.108430_b0085","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/glia.20941","article-title":"Cooperative expression of junctional adhesion molecule-C and -B supports growth and invasion of glioma","volume":"58","author":"Tenan","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2021.108430_b0090","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nature09106","article-title":"Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome","volume":"465","author":"Reynolds","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2021.108430_b0095","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/nprot.2011.366","article-title":"Metabolite extraction from suspension-cultured mammalian cells for global metabolite profiling","volume":"6","author":"Sellick","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.intimp.2021.108430_b0100","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.intimp.2021.108430_b0105","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/ncomms3612","article-title":"Inferring tumour purity and stromal and immune cell admixture from expression data","volume":"4","author":"Yoshihara","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2021.108430_b0110","doi-asserted-by":"crossref","unstructured":"Y.R. Miao, Q. Zhang, Q. Lei, M. Luo, G.Y. Xie, H. Wang, and A.Y. Guo, ImmuCellAI: A Unique Method for Comprehensive T-Cell Subsets Abundance Prediction and its Application in Cancer Immunotherapy. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 (2020) 1902880.","DOI":"10.1002\/advs.201902880"},{"key":"10.1016\/j.intimp.2021.108430_b0115","doi-asserted-by":"crossref","unstructured":"S. Lamouille, J. Xu, and R.J.N.R.M.C.B. Derynck, Molecular mechanisms of epithelial-mesenchymal transition 15 (2014) 178-196.","DOI":"10.1038\/nrm3758"},{"issue":"344","key":"10.1016\/j.intimp.2021.108430_b0120","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.intimp.2021.108430_b0125","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2021.108430_b0130","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00281-014-0421-0","article-title":"JAM-related proteins in mucosal homeostasis and inflammation","volume":"36","author":"Luissint","year":"2014","journal-title":"Sem. Immunopathology"},{"key":"10.1016\/j.intimp.2021.108430_b0135","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3892\/or.2015.3993","article-title":"Identification of diagnostic markers in colorectal cancer via integrative epigenomics and genomics data","volume":"34","author":"Kok-Sin","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.intimp.2021.108430_b0140","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1038\/bjc.2013.548","article-title":"Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oesophageal squamous cell carcinoma","volume":"109","author":"Li","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.intimp.2021.108430_b0145","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1016\/j.febslet.2012.10.005","article-title":"The junctional adhesion molecule-B regulates JAM-C-dependent melanoma cell metastasis","volume":"586","author":"Arcangeli","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2021.108430_b0150","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1039\/C4TB00954A","article-title":"Inhibition of glioma proliferation and migration by magnetic nanoparticle mediated JAM-2 silencing","volume":"2","author":"Qi","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.intimp.2021.108430_b0155","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13148-016-0184-7","article-title":"DNA methylation and hormone receptor status in breast cancer","volume":"8","author":"Benevolenskaya","year":"2016","journal-title":"Clinical Epigenetics"},{"key":"10.1016\/j.intimp.2021.108430_b0160","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1038\/sj.onc.1205651","article-title":"DNA methylation in cancer: too much, but also too little","volume":"21","author":"Ehrlich","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2021.108430_b0165","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jss.2014.06.025","article-title":"Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer","volume":"192","author":"Huang","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.intimp.2021.108430_b0170","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1039\/C2TB00027J","article-title":"JAM-2 siRNA intracellular delivery and real-time imaging by proton-sponge coated quantum dots","volume":"1","author":"Qi","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.intimp.2021.108430_b0175","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1016\/j.jmb.2013.01.022","article-title":"Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol","volume":"425","author":"Bhan","year":"2013","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.intimp.2021.108430_b0180","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.foodres.2017.03.028","article-title":"Characterization of white tea metabolome: Comparison against green and black tea by a nontargeted metabolomics approach","volume":"96","author":"Dai","year":"2017","journal-title":"Food Res. Int. (Ottawa, Ont.)"},{"key":"10.1016\/j.intimp.2021.108430_b0185","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2567.2009.03100.x","article-title":"Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin","volume":"128","author":"Ludwig","year":"2009","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.intimp.2021.108430_b0190","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3390\/jcm10020346","article-title":"Association of NAFLD and insulin resistance with non metastatic bladder cancer patients: a cross-sectional retrospective study","volume":"10","author":"Tarantino","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2021.108430_b0195","doi-asserted-by":"crossref","unstructured":"F. Vega, L.J. Medeiros, V. Leventaki, C. Atwell, J.H. Cho-Vega, L. Tian, F.X. Claret, G.Z. Rassidakis, Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma, Cancer Res. 2006, 66:6589-6597.","DOI":"10.1158\/0008-5472.CAN-05-3018"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921010663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576921010663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:35:28Z","timestamp":1761586528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576921010663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":39,"alternative-id":["S1567576921010663"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108430","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"JAM2 predicts a good prognosis and inhibits invasion and migration by suppressing EMT pathway in breast cancer","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2021.108430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108430"}}