{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:45:09Z","timestamp":1784713509011,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.intimp.2022.108564","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T11:52:58Z","timestamp":1644580378000},"page":"108564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Berberine suppresses cecal ligation and puncture induced intestinal injury by enhancing Treg cell function"],"prefix":"10.1016","volume":"106","author":[{"given":"Dongze","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenju","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunke","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingfang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.intimp.2022.108564_b0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2022.108564_b0010","article-title":"Sepsis: pathophysiology and clinical management","volume":"353","author":"Gotts","year":"2016","journal-title":"BMJ (Clin. Res. Ed.)"},{"issue":"3","key":"10.1016\/j.intimp.2022.108564_b0015","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med."},{"issue":"10141","key":"10.1016\/j.intimp.2022.108564_b0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet (London, England)"},{"issue":"1","key":"10.1016\/j.intimp.2022.108564_b0025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/viru.27372","article-title":"Epidemiology of severe sepsis","volume":"5","author":"Mayr","year":"2014","journal-title":"Virulence"},{"issue":"23","key":"10.1016\/j.intimp.2022.108564_b0030","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMoa1703058","article-title":"Time to Treatment and Mortality during Mandated Emergency Care for Sepsis","volume":"376","author":"Seymour","year":"2017","journal-title":"New Engl. J. Med."},{"issue":"2","key":"10.1016\/j.intimp.2022.108564_b0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ccc.2015.11.004","article-title":"The Gut as the Motor of Multiple Organ Dysfunction in Critical Illness","volume":"32","author":"Klingensmith","year":"2016","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.intimp.2022.108564_b0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40560-019-0372-6","article-title":"Gut integrity in critical illness","volume":"7","author":"Otani","year":"2019","journal-title":"J. Intensive Care"},{"issue":"10","key":"10.1016\/j.intimp.2022.108564_b0045","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.bbadis.2017.03.005","article-title":"The intestinal microenvironment in sepsis","volume":"1863","author":"Fay","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Mol. Basis Dis."},{"issue":"6","key":"10.1016\/j.intimp.2022.108564_b0050","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s00063-018-0475-1","article-title":"Intestinal cross-talk : The gut as motor of multiple organ failure","volume":"113","author":"Druml","year":"2018","journal-title":"Medizinische Klinik, Intensivmedizin und Notfallmedizin"},{"key":"10.1016\/j.intimp.2022.108564_b0055","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.intimp.2018.12.036","article-title":"Protective effects of berberine hydrochloride on DSS-induced ulcerative colitis in rats","volume":"68","author":"Zhu","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2022.108564_b0060","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/cbf.1570","article-title":"Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET-1, TNF-alpha, and IL-1 alpha in LPS-induced rat intestinal microvascular endothelial cells","volume":"27","author":"Hu","year":"2009","journal-title":"Cell Biochem. Funct."},{"issue":"4","key":"10.1016\/j.intimp.2022.108564_b0065","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3109\/08923970902814129","article-title":"Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells","volume":"31","author":"Hu","year":"2009","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.intimp.2022.108564_b0070","first-page":"2092","article-title":"Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberine","volume":"19","author":"Tian","year":"2013","journal-title":"Mol. Vision"},{"issue":"6","key":"10.1016\/j.intimp.2022.108564_b0075","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/jdi.12516","article-title":"Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in Apoe(-\/-) mice with hyperhomocysteinemia","volume":"7","author":"Li","year":"2016","journal-title":"J. Diab. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2022.108564_b0080","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.ijcard.2012.03.090","article-title":"Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans","volume":"167","author":"Cheng","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.intimp.2022.108564_b0085","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2012.03.065","article-title":"Neuroprotection of early and short-time applying berberine in the acute phase of cerebral ischemia: up-regulated pAkt, pGSK and pCREB, down-regulated NF-\u03baB expression, ameliorated BBB permeability","volume":"1459","author":"Zhang","year":"2012","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.intimp.2022.108564_b0090","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4049\/jimmunol.1303064","article-title":"Regulatory T cells restrain CD4+ T cells from causing unregulated immune activation and hypersensitivity to lipopolysaccharide challenge","volume":"193","author":"Okeke","year":"2014","journal-title":"J. Immunol. (Baltimore, Md. 1950)"},{"issue":"7\u20138","key":"10.1016\/j.intimp.2022.108564_b0095","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s10495-019-01548-6","article-title":"Berberine mitigates IL-21\/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17\/Treg imbalance in rheumatoid arthritis","volume":"24","author":"Dinesh","year":"2019","journal-title":"Apoptosis: Int. J. Programmed Cell Death"},{"key":"10.1016\/j.intimp.2022.108564_b0100","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fphar.2018.00571","article-title":"Berberine Regulates Treg\/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon","volume":"9","author":"Cui","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2022.108564_b0105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/SHK.0b013e318296e65b","article-title":"CD4+CD25+ regulatory T cells attenuate lipopolysaccharide-induced systemic inflammatory responses and promotes survival in murine Escherichia coli infection","volume":"40","author":"Okeke","year":"2013","journal-title":"Shock (Augusta, Ga.)"},{"issue":"7","key":"10.1016\/j.intimp.2022.108564_b0110","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/bph.14150","article-title":"Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function","volume":"175","author":"Lu","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108564_b0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"issue":"4","key":"10.1016\/j.intimp.2022.108564_b0120","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1001\/archsurg.1970.01340280036010","article-title":"Intestinal mucosal lesion in low-flow states. II. The protective effect of intraluminal glucose as energy substrate","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch. Surg. (Chicago, Ill.: 1960)"},{"issue":"6","key":"10.1016\/j.intimp.2022.108564_b0125","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.174.6.3344","article-title":"Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities","volume":"174","author":"Haeryfar","year":"2005","journal-title":"J. Immunol. (Baltimore, Md. : 1950)"},{"issue":"3","key":"10.1016\/j.intimp.2022.108564_b0130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41419-019-1462-z","article-title":"Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice","volume":"10","author":"Qiu","year":"2019","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.intimp.2022.108564_b0135","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/shk.0b013e31805569df","article-title":"Intestinal crosstalk: a new paradigm for understanding the gut as the \u201cmotor\u201d of critical illness","volume":"28","author":"Clark","year":"2007","journal-title":"Shock (Augusta, Ga.)"},{"issue":"2","key":"10.1016\/j.intimp.2022.108564_b0140","first-page":"143","article-title":"New insights into the gut as the driver of critical illness and organ failure","volume":"23","author":"Meng","year":"2017","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.intimp.2022.108564_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174349","article-title":"Berberine administrated with different routes attenuates inhaled LPS-induced acute respiratory distress syndrome through TLR4\/NF-\u03baB and JAK2\/STAT3 inhibition","volume":"908","author":"Xu","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108564_b0150","first-page":"1","volume":"19","author":"Li","year":"2015","journal-title":"Pharmacology"},{"issue":"10","key":"10.1016\/j.intimp.2022.108564_b0155","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/ni.2683","article-title":"Regulatory T cells in nonlymphoid tissues","volume":"14","author":"Burzyn","year":"2013","journal-title":"Nat. Immunol."},{"issue":"49","key":"10.1016\/j.intimp.2022.108564_b0160","doi-asserted-by":"crossref","first-page":"19446","DOI":"10.1073\/pnas.0706832104","article-title":"CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes\/macrophages","volume":"104","author":"Tiemessen","year":"2007","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.intimp.2022.108564_b0165","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/icb.2010.70","article-title":"Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice","volume":"89","author":"Liu","year":"2011","journal-title":"Immunol. Cell Biol."},{"issue":"23","key":"10.1016\/j.intimp.2022.108564_b0170","doi-asserted-by":"crossref","first-page":"13573","DOI":"10.1111\/jcmm.16049","article-title":"Anti-inflammatory and immune-modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation","volume":"24","author":"Ehteshamfar","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2022.108564_b0175","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4193\/Rhino15.028","article-title":"Berberine reduce allergic inflammation in a house dust mite allergic rhinitis mouse model","volume":"53","author":"KIm","year":"2015","journal-title":"Rhinology"},{"key":"10.1016\/j.intimp.2022.108564_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107683","article-title":"Juglone regulates gut microbiota and Th17\/Treg balance in DSS-induced ulcerative colitis","volume":"97","author":"Hua","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108564_b0185","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.20021345","article-title":"CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms","volume":"197","author":"Maloy","year":"2003","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.intimp.2022.108564_b0190","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/cmi.2012.47","article-title":"Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4(+)CD25(+) regulatory T cells","volume":"9","author":"Hu","year":"2012","journal-title":"Cell. Mol. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2022.108564_b0195","first-page":"64","article-title":"Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony","volume":"14","author":"Monneret","year":"2008","journal-title":"Mol. Med. (Cambridge Mass.)"},{"issue":"4","key":"10.1016\/j.intimp.2022.108564_b0200","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/MOT.0000000000000212","article-title":"New insights into the mechanisms of Treg function","volume":"20","author":"Rothstein","year":"2015","journal-title":"Curr. Opin. Organ Transplant."},{"key":"10.1016\/j.intimp.2022.108564_b0205","doi-asserted-by":"crossref","first-page":"7854389","DOI":"10.1155\/2019\/7854389","article-title":"Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1\/Sirt1\/FoxO3a Signaling Pathway","volume":"2019","author":"Zou","year":"2019","journal-title":"Mediators Inflamm."},{"issue":"2","key":"10.1016\/j.intimp.2022.108564_b0210","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00024382-199902000-00008","article-title":"Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model","volume":"11","author":"ter Steege","year":"1999","journal-title":"Shock (Augusta, Ga.)"},{"key":"10.1016\/j.intimp.2022.108564_b0215","doi-asserted-by":"crossref","first-page":"5985209","DOI":"10.1155\/2017\/5985209","article-title":"Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies","volume":"2017","author":"Mantzarlis","year":"2017","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"10.1016\/j.intimp.2022.108564_b0220","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejphar.2015.05.068","article-title":"Dhull, Current knowledge and pharmacological profile of berberine: An update","volume":"761","author":"Kumar","year":"2015","journal-title":"Eur. J. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922000480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922000480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:40:31Z","timestamp":1761586831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922000480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":44,"alternative-id":["S1567576922000480"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108564","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine suppresses cecal ligation and puncture induced intestinal injury by enhancing Treg cell function","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108564","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108564"}}