{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:01:07Z","timestamp":1790802067418,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2C1013664"],"award-info":[{"award-number":["2020R1A2C1013664"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.intimp.2022.108567","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T12:33:47Z","timestamp":1643718827000},"page":"108567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Sargahydroquinoic acid isolated from Sargassum serratifolium as inhibitor of cellular basophils activation and passive cutaneous anaphylaxis in mice"],"prefix":"10.1016","volume":"105","author":[{"given":"Kap","family":"Seong Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Sun","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginnae","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui","family":"Jeong Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Beom","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Hee","family":"Kho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae","family":"Heon Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Yup","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2022.108567_b0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11882-009-0082-6","article-title":"Does exposure to indoor allergens contribute to the development of asthma and allergy?","volume":"10","author":"Arshad","year":"2010","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.intimp.2022.108567_b0010","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0952-7915(05)80005-6","article-title":"Cytokine production by mast cells and basophils","volume":"3","author":"Galli","year":"1991","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0015","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/imr.12634","article-title":"Mast cells as sources of cytokines, chemokines, and growth factors","volume":"282","author":"Mukai","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2022.108567_b0020","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0006-2952(99)00226-9","article-title":"Molecular consequences of human mast cell activation following immunoglobulin E-high affinity immunoglobulin E receptor (IgE\u2013FcERI) interaction","volume":"58","author":"Reischl","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2022.108567_b0025","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/aps.2013.88","article-title":"Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis","volume":"34","author":"Shao-heng","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2022.108567_b0030","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1111\/all.13594","article-title":"Enhanced therapeutic effects of human mesenchymal stem cells transduced with superoxide dismutase 3 in a murine atopic dermatitis-like skin inflammation model","volume":"73","author":"Sah","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2022.108567_b0035","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1101\/gad.9.13.1586","article-title":"Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway","volume":"9","author":"Chen","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.intimp.2022.108567_b0040","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/365182a0","article-title":"Rapid proteolysis of i kappa B-alpha is necessary for activation of transcription factor NF-kappa B","volume":"365","author":"Henkel","year":"1993","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.intimp.2022.108567_b0045","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nri2634","article-title":"Transcriptional control of the inflammatory response","volume":"9","author":"Medzhitov","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0050","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1074\/jbc.270.25.14843","article-title":"How MAP kinase are regulated","volume":"270","author":"Cobb","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2022.108567_b0055","doi-asserted-by":"crossref","first-page":"22201","DOI":"10.1074\/jbc.273.35.22201","article-title":"Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor \u03baB-binding sites","volume":"273","author":"Marks-Konczalik","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2022.108567_b0060","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0952-7915(99)00052-7","article-title":"Reactive oxygen and nitrogen intermediates in innate and specific immunity","volume":"12","author":"Bogdan","year":"2000","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0065","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.4049\/jimmunol.169.10.5866","volume":"169","author":"Swindle","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0070","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/biof.5520170128","article-title":"Redox signaling and the Map kinase pathways","volume":"17","author":"Torres","year":"2003","journal-title":"BioFactors"},{"issue":"3","key":"10.1016\/j.intimp.2022.108567_b0075","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jep.2012.05.046","article-title":"Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: A phytochemical and pharmacological review","volume":"142","author":"Liu","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2022.108567_b0080","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.foodchem.2012.11.026","article-title":"In vitro antioxidant properties of crude extracts and compounds from brown algae","volume":"138","author":"Balboa","year":"2013","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.intimp.2022.108567_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900373","article-title":"Meroterpenoid-Rich Fraction of the Ethanol Extract of Sargassum Serratifolium Suppresses Collagen-Induced Rheumatoid Arthritis in DBA\/1J Mice Via Inhibition of Nuclear Factor \u03baB Activation","volume":"64","author":"Joung","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2022.108567_b0090","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10811-016-0954-9","article-title":"Anti-inflammatory action of the ethanolic extract from Sargassum serratifolium on lipopolysaccharide-stimulated mouse peritoneal macrophages and identification of active components","volume":"29","author":"Joung","year":"2017","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.intimp.2022.108567_b0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/a-1023-7385","article-title":"Effects of Sargaquinoic Acid in Sargassum Serratifolium on Inducing Brown Adipocyte-like Phenotype in Mouse Adipocytes In Vitro","volume":"86","author":"Kwon","year":"2020","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2022.108567_b0100","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.foodchem.2018.11.058","article-title":"Evaluation of Antioxidant Activities of Various Solvent Extract from Sargassum serratifolium and Its Major Antioxidant Components","volume":"278","author":"Lim","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.intimp.2022.108567_b0105","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3390\/md16100374","article-title":"Meroterpenoid-Rich Fraction of the Ethanolic Extract from Sargassum serratifolium Suppressed Oxidative Stress Induced by Tert-Butyl Hydroperoxide in HepG2 Cells","volume":"16","author":"Lim","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.intimp.2022.108567_b0110","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1089\/jmf.2016.3732","article-title":"Anti-inflammatory effect of ethanolic extract of Sargassum serratifolium in lipopolysaccharide-stimulated BV2 microglia cells","volume":"19","author":"Oh","year":"2016","journal-title":"J. Med. Food."},{"key":"10.1016\/j.intimp.2022.108567_b0115","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.3390\/ijms19082308","article-title":"Sargassum serratifolium Extract Attenuates Interleukin-1\u03b2-Induced Oxidative Stress and Inflammatory Response in Chondrocytes by Suppressing the Activation of NF-\u03baB, p38 MAPK, and PI3K\/Akt","volume":"19","author":"Park","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2022.108567_b0120","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3390\/ijerph15061173","article-title":"Activation of the Nrf2\/HO-1 Signaling Pathway Contributes to the Protective Effects of Sargassum serratifolium Extract Against Oxidative Stress-Induced DNA Damage and Apoptosis in SW1353 Human Chondrocytes","volume":"15","author":"Park","year":"2018","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.intimp.2022.108567_b0125","doi-asserted-by":"crossref","first-page":"257","DOI":"10.5582\/bst.2018.01107","article-title":"Sargassum Serratifolium Attenuates RANKL-induced Osteoclast Differentiation and Oxidative Stress Through Inhibition of NF-\u03baB and Activation of the Nrf2\/HO-1 Signaling Pathway","volume":"12","author":"Kim","year":"2018","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.intimp.2022.108567_b0130","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/md15120368","article-title":"\u03b1-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitory Activity of Plastoquinones from Marine Brown Alga Sargassum serratifolium","volume":"15","author":"Ali","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.intimp.2022.108567_b0135","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.3892\/or.2015.4222","article-title":"Hexane Extract from Sargassum serratifolium Inhibits the Cell Proliferation and Metastatic Ability of Human Glioblastoma U87MG Cells","volume":"34","author":"Kang","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.intimp.2022.108567_b0140","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.biopha.2018.05.083","article-title":"Sargaquinoic Acid Ameliorates Hyperpigmentation Through cAMP and ERK-mediated Downregulation of MITF in \u03b1-MSH-stimulated B16F10 Cells","volume":"104","author":"Azam","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2022.108567_b0145","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1016\/j.bmc.2017.05.033","article-title":"BACE1 Inhibitory Activity and Molecular Docking Analysis of Meroterpenoids from Sargassum serratifolium","volume":"25","author":"Seong","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.intimp.2022.108567_b0150","doi-asserted-by":"crossref","first-page":"9053","DOI":"10.1021\/acs.jafc.5b04050","article-title":"Sargaquinoic Acid Inhibits TNF-\u03b1-Induced NF-\u03baB Signaling, Thereby Contributing to Decreased Monocyte Adhesion to Human Umbilical Vein Endothelial Cells (HUVECs)","volume":"63","author":"Gwon","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2022.108567_b0155","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/exd.12814","article-title":"Dieckol, a phlorotannin of Ecklonia cava, suppresses IgE-mediated mast cell activation and passive cutaneous anaphylactic reaction","volume":"24","author":"Ahn","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.intimp.2022.108567_b0160","article-title":"Measuring local anaphylaxis in mice","volume":"92","author":"Evans","year":"2014","journal-title":"J. Visualized Exp.: JoVE"},{"issue":"2","key":"10.1016\/j.intimp.2022.108567_b0165","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jaci.2009.11.017","article-title":"IgE, mast cells, basophils, and eosinophils","volume":"125","author":"Stone","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0170","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2017.06.007","article-title":"Mast cell activation syndromes","volume":"140","author":"Akim","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0175","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/339064a0","article-title":"Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores","volume":"339","author":"Plaut","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.108567_b0180","article-title":"In vitro and in vivo antiallergic effects of taurine on allergic rhinitis","volume":"1\u201313","author":"Zhou","year":"2019","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2022.108567_b0185","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000097357","article-title":"Role of cytokines in allergic airway inflammation","volume":"142","author":"Nakajima","year":"2007","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0190","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0610852103","article-title":"Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1","volume":"104","author":"Nigrovic","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2022.108567_b0195","article-title":"IL-1 \u03b2 promotes immunoregulatory responses in human blood basophils","author":"Lype","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2022.108567_b0200","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/intimm\/dxq030","article-title":"IL-6: from its discovery to clinical applications","volume":"22","author":"Kishimoto","year":"2010","journal-title":"Intl. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0205","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1074-7613(04)00026-3","article-title":"Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production","volume":"20","author":"Voehringer","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2022.108567_b0210","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.4049\/jimmunol.149.8.2662","article-title":"Activation of human basophils through the IL-8 receptor","volume":"149","author":"Krieger","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0215","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.4049\/jimmunol.2001354","article-title":"IgE-Binding Monocytes Have an Enhanced Ability to Produce IL-8 (CXCL8) in Animals with Naturally Occurring Allergy","volume":"206","author":"Larson","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2022.108567_b0220","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0014-5793(92)80909-Z","article-title":"Interleukin-8, a chemotactic and inflammatory cytokine","volume":"307","author":"Baggiolini","year":"1992","journal-title":"FEBS Lett."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922000510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922000510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T20:17:19Z","timestamp":1730837839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922000510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":44,"alternative-id":["S1567576922000510"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108567","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sargahydroquinoic acid isolated from Sargassum serratifolium as inhibitor of cellular basophils activation and passive cutaneous anaphylaxis in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108567"}}