{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:59:39Z","timestamp":1773799179736,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"am","delay-in-days":282,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H03570"],"award-info":[{"award-number":["19H03570"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K22479"],"award-info":[{"award-number":["19K22479"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.intimp.2022.108672","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T17:54:08Z","timestamp":1646934848000},"page":"108672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Anti-prion activity of cellulose ether is impaired in mice lacking pre T-cell antigen receptor \u03b1, T-cell receptor \u03b4, or lytic granule function"],"prefix":"10.1016","volume":"107","author":[{"given":"Kenta","family":"Teruya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Oguma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Watanabe-Matsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiyo","family":"Tsuji-Kawahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Doh-ura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.intimp.2022.108672_b0005","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1128\/JVI.78.10.4999-5006.2004","article-title":"Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models","volume":"78","author":"Doh-ura","year":"2004","journal-title":"J. Virol."},{"issue":"23","key":"10.1016\/j.intimp.2022.108672_b0010","doi-asserted-by":"crossref","first-page":"12889","DOI":"10.1128\/JVI.01563-07","article-title":"Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner","volume":"81","author":"Kawasaki","year":"2007","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.intimp.2022.108672_b0015","doi-asserted-by":"crossref","first-page":"a024430","DOI":"10.1101\/cshperspect.a024430","article-title":"Insights from therapeutic studies for PrP prion disease","volume":"7","author":"Teruya","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"12","key":"10.1016\/j.intimp.2022.108672_b0020","doi-asserted-by":"crossref","first-page":"e1006045","DOI":"10.1371\/journal.ppat.1006045","article-title":"A single subcutaneous injection of cellulose ethers administered long before infection confers sustained protection against prion diseases in rodents","volume":"12","author":"Teruya","year":"2016","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.intimp.2022.108672_b0025","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/jnc.14877","article-title":"Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression","volume":"152","author":"Hannaoui","year":"2020","journal-title":"J. Neurochem."},{"issue":"9","key":"10.1016\/j.intimp.2022.108672_b0030","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1007\/s12035-021-02418-6","article-title":"Decrease in skin prion-seeding activity of prion-infected mice treated with a compound against human and animal prions: a first possible biomarker for prion therapeutics","volume":"58","author":"Ding","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"9","key":"10.1016\/j.intimp.2022.108672_b0035","doi-asserted-by":"crossref","first-page":"e0185357","DOI":"10.1371\/journal.pone.0185357","article-title":"Pyrene conjugation and spectroscopic analysis of hydroxypropyl methylcellulose compounds successfully demonstrated a local dielectric difference associated with in vivo anti-prion activity","volume":"12","author":"Teruya","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.intimp.2022.108672_b0040","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1016\/j.xphs.2019.03.025","article-title":"Preparation and characterization of cellulose ether liposomes for the inhibition of prion formation in prion-infected cells","volume":"108","author":"Nishizawa","year":"2019","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2022.108672_b0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/19336896.2019.1670928","article-title":"Combining autophagy stimulators and cellulose ethers for therapy against prion disease","volume":"13","author":"Abdulrahman","year":"2019","journal-title":"Prion"},{"key":"10.1016\/j.intimp.2022.108672_b0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2021.04.116","article-title":"Polymorphisms in glia maturation factor \u03b2 gene are markers of cellulose ether effectiveness in prion-infected mice","volume":"560","author":"Teruya","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.intimp.2022.108672_b0055","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.4049\/jimmunol.176.6.3490","article-title":"Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus","volume":"176","author":"Jouvin-Marche","year":"2006","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108672_b0060","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1365-2567.2008.02944.x","article-title":"Perturbation of T-cell development by insertional mutation of a PrP transgene","volume":"127","author":"Zabel","year":"2009","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.intimp.2022.108672_b0065","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1128\/JVI.74.2.828-833.2000","article-title":"Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: role of prion protein expression in peripheral nerves and spleen","volume":"74","author":"Race","year":"2000","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.intimp.2022.108672_b0070","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/j.1460-2075.1996.tb00467.x","article-title":"Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie","volume":"15","author":"Fischer","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2022.108672_b0075","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/375795a0","article-title":"Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells","volume":"375","author":"Fehling","year":"1995","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.intimp.2022.108672_b0080","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1084\/jem.20050456","article-title":"Characterization of the early stages of thymic NKT cell development","volume":"202","author":"Benlagha","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2022.108672_b0085","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri1636","article-title":"Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate","volume":"5","author":"von Boehmer","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"3-4","key":"10.1016\/j.intimp.2022.108672_b0090","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/08830189809042999","article-title":"Interleukin-7 (IL-7) knockout mice. Implications for lymphopoiesis and organ-specific immunity","volume":"16","author":"Maeurer","year":"1998","journal-title":"Int. Rev. Immunol."},{"issue":"5703","key":"10.1016\/j.intimp.2022.108672_b0095","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/278451a0","article-title":"The beige mutation in the mouse selectively impairs natural killer cell function","volume":"278","author":"Roder","year":"1979","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2022.108672_b0100","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41577-020-0345-y","article-title":"Thymic development of unconventional T cells: how NKT cells, MAIT cells and \u03b3\u03b4 T cells emerge","volume":"20","author":"Pellicci","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2022.108672_b0105","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/ni837","article-title":"Homeostasis of V alpha 14i NKT cells","volume":"3","author":"Matsuda","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2022.108672_b0110","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1743-422X-8-32","article-title":"Cross-talk between cd1d-restricted nkt cells and \u03b3\u03b4 cells in t regulatory cell response","volume":"8","author":"Liu","year":"2011","journal-title":"Virol. J."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922001564?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922001564?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:36:57Z","timestamp":1761586617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922001564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":22,"alternative-id":["S1567576922001564"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108672","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-prion activity of cellulose ether is impaired in mice lacking pre T-cell antigen receptor \u03b1, T-cell receptor \u03b4, or lytic granule function","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108672","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108672"}}