{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:53:56Z","timestamp":1793130836431,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","award":["JLSCZT2019-019"],"award-info":[{"award-number":["JLSCZT2019-019"]}],"id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.intimp.2022.108710","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T12:30:04Z","timestamp":1649421004000},"page":"108710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Maackiain protects against sepsis via activating AMPK\/Nrf2\/HO-1 pathway"],"prefix":"10.1016","volume":"108","author":[{"given":"Xiaoxue","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.intimp.2022.108710_b0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"10219","key":"10.1016\/j.intimp.2022.108710_b0010","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5152\/eurasianjmed.2017.17062","article-title":"Sepsis and Septic Shock: Current Treatment Strategies and New Approaches","volume":"49","author":"Polat","year":"2017","journal-title":"Eurasian J. Med."},{"key":"10.1016\/j.intimp.2022.108710_b0020","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.phrs.2016.07.019","article-title":"Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression","volume":"111","author":"Patil","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0025","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-020-02950-2","article-title":"Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis","volume":"24","author":"Bauer","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.intimp.2022.108710_b0030","doi-asserted-by":"crossref","first-page":"8416763","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid Med Cell Longev"},{"issue":"2 Suppl 1","key":"10.1016\/j.intimp.2022.108710_b0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","article-title":"What is oxidative stress?","volume":"49","author":"Betteridge","year":"2000","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.intimp.2022.108710_b0040","doi-asserted-by":"crossref","first-page":"R290","DOI":"10.1186\/cc13155","article-title":"Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients","volume":"17","author":"Lorente","year":"2013","journal-title":"Crit. Care"},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053741","article-title":"Prognostic value of malondialdehyde serum levels in severe sepsis: a multicenter study","volume":"8","author":"Lorente","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.intimp.2022.108710_b0050","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12653","article-title":"Evaluation of oxidative stress and antioxidant status: Correlation with the severity of sepsis","volume":"87","author":"Kumar","year":"2018","journal-title":"Scand J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0055","doi-asserted-by":"crossref","DOI":"10.1186\/s13613-016-0198-5","article-title":"Erythrocyte superoxide dismutase as a biomarker of septic acute kidney injury","volume":"6","author":"Costa","year":"2016","journal-title":"Ann Intensive Care"},{"issue":"8","key":"10.1016\/j.intimp.2022.108710_b0060","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1086\/340042","article-title":"Glutathione protects mice from lethal sepsis by limiting inflammation and potentiating host defense","volume":"185","author":"Villa","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.intimp.2022.108710_b0065","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.redox.2018.09.019","article-title":"gamma-glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level","volume":"20","author":"Yang","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2022.108710_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119807","article-title":"Protective effects of Nrf2 against sepsis-induced hepatic injury","volume":"282","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2022.108710_b0075","doi-asserted-by":"crossref","first-page":"9459047","DOI":"10.1155\/2016\/9459047","article-title":"Natural Products for Infectious Diseases","volume":"2016","author":"Kim","year":"2016","journal-title":"Evid Based Complement Alternat Med."},{"key":"10.1016\/j.intimp.2022.108710_b0080","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s11658-019-0164-y","article-title":"Progress in research on paclitaxel and tumor immunotherapy","volume":"24","author":"Zhu","year":"2019","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"9","key":"10.1016\/j.intimp.2022.108710_b0085","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.3390\/ijms19092508","article-title":"Natural Products for the Treatment of Autoimmune Arthritis: Their Mechanisms of Action, Targeted Delivery, and Interplay with the Host Microbiome","volume":"19","author":"Dudics","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"17","key":"10.1016\/j.intimp.2022.108710_b0090","doi-asserted-by":"crossref","first-page":"6355","DOI":"10.1021\/jm100332n","article-title":"Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus","volume":"53","author":"Nomura","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.intimp.2022.108710_b0095","article-title":"Dehydrocorydaline Protects Against Sepsis-Induced Myocardial Injury Through Modulating the TRAF6\/NF-kappaB Pathway","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2022.108710_b0100","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1479-5876-12-32","article-title":"Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis","volume":"12","author":"Fowler","year":"2014","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.intimp.2022.108710_b0105","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.chest.2016.11.036","article-title":"Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study","volume":"151","author":"Marik","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.intimp.2022.108710_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174522","article-title":"Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2\/HO-1-dependent macrophage polarization","volume":"911","author":"Feng","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2022.108710_b0115","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1111\/jcmm.16604","article-title":"Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-kappaB signalling suppression","volume":"25","author":"Dai","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2022.108710_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106965","article-title":"Diosmetin alleviates acute kidney injury by promoting the TUG1\/Nrf2\/HO-1 pathway in sepsis rats","volume":"88","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2022.108710_b0125","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jep.2015.06.010","article-title":"Sophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine","volume":"172","author":"He","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2022.108710_b0130","first-page":"1","article-title":"Bioactivity-guided isolation of compounds from Sophora flavescens with antibacterial activity against Acinetobacter baumannii","author":"Li","year":"2021","journal-title":"Nat. Prod. Res."},{"issue":"5","key":"10.1016\/j.intimp.2022.108710_b0135","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.166","article-title":"Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes","volume":"3","author":"Mizuguchi","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"issue":"45","key":"10.1016\/j.intimp.2022.108710_b0140","doi-asserted-by":"crossref","first-page":"27393","DOI":"10.1074\/jbc.M115.657023","article-title":"Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cdelta (PKCdelta) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells","volume":"290","author":"Nariai","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.intimp.2022.108710_b0145","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.3390\/ijms21124455","article-title":"Maackiain Ameliorates 6-Hydroxydopamine and SNCA Pathologies by Modulating the PINK1\/Parkin Pathway in Models of Parkinson's Disease in Caenorhabditis elegans and the SH-SY5Y Cell Line","volume":"21","author":"Tsai","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2022.108710_b0150","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/iai.58.3.619-624.1990","article-title":"Mortality and bacteriology of sepsis following cecal ligation and puncture in aged mice","volume":"58","author":"Hyde","year":"1990","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0155","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/imr.12499","article-title":"The immune system's role in sepsis progression, resolution, and long-term outcome","volume":"274","author":"Delano","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2022.108710_b0160","doi-asserted-by":"crossref","first-page":"5985209","DOI":"10.1155\/2017\/5985209","article-title":"Role of Oxidative Stress and Mitochondrial Dysfunction in Sepsis and Potential Therapies","volume":"2017","author":"Mantzarlis","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"issue":"11","key":"10.1016\/j.intimp.2022.108710_b0165","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1101\/gad.7.11.2063","article-title":"Proposed NF-kappa B\/I kappa B family nomenclature","volume":"7","author":"Nabel","year":"1993","journal-title":"Genes Dev."},{"issue":"6","key":"10.1016\/j.intimp.2022.108710_b0170","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0092-8674(00)81698-0","article-title":"Structure of an IkappaBalpha\/NF-kappaB complex","volume":"95","author":"Jacobs","year":"1998","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.intimp.2022.108710_b0175","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-kappaB in immunobiology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell Res."},{"issue":"10","key":"10.1016\/j.intimp.2022.108710_b0180","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/jat.3309","article-title":"Let-7a modulates particulate matter (<\/= 2.5 mum)-induced oxidative stress and injury in human airway epithelial cells by targeting arginase 2","volume":"36","author":"Song","year":"2016","journal-title":"J. Appl. Toxicol."},{"issue":"7","key":"10.1016\/j.intimp.2022.108710_b0185","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1039\/D0FO01583K","article-title":"The protective role of Zingerone in a murine asthma model via activation of the AMPK\/Nrf2\/HO-1 pathway","volume":"12","author":"Zhu","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2022.108710_b0190","doi-asserted-by":"crossref","first-page":"8678267","DOI":"10.1155\/2018\/8678267","article-title":"6'-O-Galloylpaeoniflorin Attenuates Cerebral Ischemia Reperfusion-Induced Neuroinflammation and Oxidative Stress via PI3K\/Akt\/Nrf2 Activation","volume":"2018","author":"Wen","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.intimp.2022.108710_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111801","article-title":"Pterocarpus santalinus L. extract mitigates gamma radiation-inflicted derangements in BALB\/c mice by Nrf2 upregulation","volume":"141","author":"Hanuma Kumar","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.intimp.2022.108710_b0200","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2022.108710_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101393","article-title":"AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes","volume":"29","author":"Matzinger","year":"2020","journal-title":"Redox Biol."},{"issue":"14","key":"10.1016\/j.intimp.2022.108710_b0210","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1128\/MCB.00118-16","article-title":"AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550","volume":"36","author":"Joo","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.intimp.2022.108710_b0215","doi-asserted-by":"crossref","first-page":"7161592","DOI":"10.1155\/2018\/7161592","article-title":"Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2\/HO-1 Pathway","volume":"2018","author":"Liu","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"issue":"4","key":"10.1016\/j.intimp.2022.108710_b0220","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1248\/cpb.16.771","article-title":"The presence of L-maackiain and pterocarpin in callus tissue of Sophora angustifolia","volume":"16","author":"Furuya","year":"1968","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"2","key":"10.1016\/j.intimp.2022.108710_b0225","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/AAC.17.2.120","article-title":"Susceptibility of zoopathogenic fungi to phytoalexins","volume":"17","author":"Gordon","year":"1980","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.intimp.2022.108710_b0230","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1104\/pp.83.2.365","article-title":"Role of oxygenases in pisatin biosynthesis and in the fungal degradation of maackiain","volume":"83","author":"Matthews","year":"1987","journal-title":"Plant Physiol."},{"key":"10.1016\/j.intimp.2022.108710_b0235","article-title":"Induction of apoptosis by maackiain and trifolirhizin (maackiain glycoside) isolated from sanzukon (Sophora Subprostrate Chen et T. Chen) in human promyelotic leukemia HL-60 cells","author":"Aratanechemuge","year":"2004","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.intimp.2022.108710_b0240","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3389\/fphar.2018.00760","article-title":"Antidiabetic Activity of a Flavonoid-Rich Extract From Sophora davidii (Franch.) Skeels in KK-Ay Mice via Activation of AMP-Activated Protein Kinase","volume":"9","author":"Huang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2022.108710_b0245","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.2147\/DDDT.S326975","article-title":"Maackiain Protects the Kidneys of Type 2 Diabetic Rats via Modulating the Nrf2\/HO-1 and TLR4\/NF-kappaB\/Caspase-3 Pathways","volume":"15","author":"Guo","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2022.108710_b0250","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fcell.2019.00108","article-title":"Sepsis: Inflammation Is a Necessary Evil","volume":"7","author":"Nedeva","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2022.108710_b0255","first-page":"669","article-title":"Role of cytokines as a double-edged sword in sepsis","volume":"27","author":"Chaudhry","year":"2013","journal-title":"In Vivo"},{"issue":"5","key":"10.1016\/j.intimp.2022.108710_b0260","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00281-017-0639-8","article-title":"Cytokine storm and sepsis disease pathogenesis","volume":"39","author":"Chousterman","year":"2017","journal-title":"Semin Immunopathol."},{"issue":"21","key":"10.1016\/j.intimp.2022.108710_b0265","doi-asserted-by":"crossref","first-page":"12308","DOI":"10.1111\/jcmm.15647","article-title":"Maackiain dampens osteoclastogenesis via attenuating RANKL-stimulated NF-kappaB signalling pathway and NFATc1 activity","volume":"24","author":"Liu","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0270","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.2557","article-title":"ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression","volume":"18","author":"Hoetzenecker","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2022.108710_b0275","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biomaterials.2017.08.008","article-title":"Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice","volume":"144","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2022.108710_b0280","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3389\/fphys.2018.01487","article-title":"Mitochondria, Oxidative Stress and Innate Immunity","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2022.108710_b0285","doi-asserted-by":"crossref","first-page":"5698931","DOI":"10.1155\/2016\/5698931","article-title":"Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"issue":"6","key":"10.1016\/j.intimp.2022.108710_b0290","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1039\/C9NP00061E","article-title":"The role of natural products in revealing NRF2 function","volume":"37","author":"Zhang","year":"2020","journal-title":"Nat. Prod. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2022.108710_b0295","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"issue":"17","key":"10.1016\/j.intimp.2022.108710_b0300","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0305","doi-asserted-by":"crossref","first-page":"569","DOI":"10.4049\/jimmunol.0902315","article-title":"NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice","volume":"185","author":"Kong","year":"2010","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2022.108710_b0310","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI25790","article-title":"Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis","volume":"116","author":"Thimmulappa","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.intimp.2022.108710_b0315","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1164\/rccm.201102-0271OC","article-title":"Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis","volume":"184","author":"Kong","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0320","first-page":"55","article-title":"Systematic review and meta-analysis of the protective effect of resveratrol on multiple organ injury induced by sepsis in animal models","volume":"10","author":"Zhou","year":"2019","journal-title":"Biomed. Rep."},{"issue":"16","key":"10.1016\/j.intimp.2022.108710_b0325","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1111\/febs.13698","article-title":"AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours","volume":"283","author":"Ross","year":"2016","journal-title":"FEBS J."},{"issue":"14","key":"10.1016\/j.intimp.2022.108710_b0330","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.3390\/ijms21144875","article-title":"Activation of Nrf2 by Natural Bioactive Compounds: A Promising Approach for Stroke?","volume":"21","author":"Gugliandolo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2022.108710_b0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.apsb.2015.06.002","article-title":"Regulation of AMP-activated protein kinase by natural and synthetic activators","volume":"6","author":"Grahame Hardie","year":"2016","journal-title":"Acta Pharm. Sin B"},{"key":"10.1016\/j.intimp.2022.108710_b0340","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.etap.2017.02.011","article-title":"Exposure to PM2.5 induces aberrant activation of NF-kappaB in human airway epithelial cells by downregulating miR-331 expression","volume":"50","author":"Song","year":"2017","journal-title":"Environ. Toxicol. Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.intimp.2024.112877","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000}}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922001941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922001941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:50:03Z","timestamp":1761587403000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922001941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":68,"alternative-id":["S1567576922001941"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108710","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maackiain protects against sepsis via activating AMPK\/Nrf2\/HO-1 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108710"}}