{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:41:04Z","timestamp":1786387264284,"version":"build-2736575974"},"reference-count":151,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.intimp.2022.108712","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T17:14:42Z","timestamp":1649265282000},"page":"108712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Emerging roles of Sirtuins in alleviating alcoholic liver Disease: A comprehensive review"],"prefix":"10.1016","volume":"108","author":[{"given":"Xingtao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2022.108712_b0005","doi-asserted-by":"crossref","unstructured":"D. Shmulewitz, E. Aharonovich, K. Witkiewitz, R.F. Anton, H.R. Kranzler, J. Scodes, K.F. Mann, M.M. Wall, D. Hasin, The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001-2002 and 2012-2013, The American journal of psychiatry 178(6) (2021) 548-559.","DOI":"10.1176\/appi.ajp.2020.20050610"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0010","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5009\/gnl16477","article-title":"Pathophysiology and Management of Alcoholic Liver Disease: Update 2016","volume":"11","author":"Stickel","year":"2017","journal-title":"Gut and liver"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0015","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/acs.jproteome.0c00750","article-title":"Systematic Identification of Protein Phosphorylation-Mediated Interactions","volume":"20","author":"Floyd","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.intimp.2022.108712_b0020","doi-asserted-by":"crossref","unstructured":"M. Shvedunova, A. Akhtar, Modulation of cellular processes by histone and non-histone protein acetylation, Nature reviews. Molecular cell biology (2022).","DOI":"10.1038\/s41580-021-00441-y"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0025","doi-asserted-by":"crossref","first-page":"G373","DOI":"10.1152\/ajpgi.00026.2019","article-title":"Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets, American journal of physiology","volume":"317","author":"Groebner","year":"2019","journal-title":"Gastrointestinal and liver physiology"},{"issue":"6771","key":"10.1016\/j.intimp.2022.108712_b0030","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"Imai","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.108712_b0035","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pharmthera.2018.03.004","article-title":"Sirtuin activators and inhibitors: Promises, achievements, and challenges","volume":"188","author":"Dai","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2022.108712_b0040","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annual review of pathology"},{"key":"10.1016\/j.intimp.2022.108712_b0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejmech.2018.10.028","article-title":"An overview of Sirtuins as potential therapeutic target: Structure, function and modulators","volume":"161","author":"Wang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"7814","key":"10.1016\/j.intimp.2022.108712_b0050","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-020-2337-2","article-title":"Hepatic NADH reductive stress underlies common variation in metabolic traits","volume":"583","author":"Goodman","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.108712_b0055","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2021.01.061","article-title":"Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice","volume":"544","author":"Xin","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2022.108712_b0060","article-title":"Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity","volume":"11","author":"Raj","year":"2020","journal-title":"Diabetes and Neurodegenerative Disease, Frontiers in pharmacology"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0065","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cmet.2007.07.003","article-title":"SIRT2 regulates adipocyte differentiation through FoxO1 acetylation\/deacetylation","volume":"6","author":"Jing","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.intimp.2022.108712_b0070","doi-asserted-by":"crossref","first-page":"7293861","DOI":"10.1155\/2018\/7293861","article-title":"SIRT3: A New Regulator of Cardiovascular Diseases","volume":"2018","author":"Sun","year":"2018","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"21","key":"10.1016\/j.intimp.2022.108712_b0075","doi-asserted-by":"crossref","first-page":"13653","DOI":"10.1073\/pnas.222538099","article-title":"SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria","volume":"99","author":"Onyango","year":"2002","journal-title":"PNAS"},{"issue":"14","key":"10.1016\/j.intimp.2022.108712_b0080","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1016\/j.bmc.2018.07.031","article-title":"SIRT4 is the last puzzle of mitochondrial sirtuins","volume":"26","author":"Li","year":"2018","journal-title":"Bioorg. Med. Chem."},{"issue":"5","key":"10.1016\/j.intimp.2022.108712_b0085","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2006.06.057","article-title":"SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells","volume":"126","author":"Haigis","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2022.108712_b0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ebiom.2018.09.037","article-title":"SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob\/ob mice","volume":"36","author":"Du","year":"2018","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0095","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.cell.2009.02.026","article-title":"SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle","volume":"137","author":"Nakagawa","year":"2009","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0100","doi-asserted-by":"crossref","first-page":"18367","DOI":"10.1038\/s41598-020-75615-3","article-title":"Impaired mitochondrial medium-chain fatty acid oxidation drives periportal macrovesicular steatosis in sirtuin-5 knockout mice","volume":"10","author":"Goetzman","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0105","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8030050","article-title":"Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease","volume":"8","author":"Jiang","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.intimp.2022.108712_b0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.redox.2014.11.004","article-title":"CYP2E1 autoantibodies in liver diseases","volume":"3","author":"Sutti","year":"2014","journal-title":"Redox Biol."},{"issue":"14","key":"10.1016\/j.intimp.2022.108712_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10143011","article-title":"Oxidative Stress-A Key Player in the Course of Alcohol-Related Liver Disease","volume":"10","author":"Michalak","year":"2021","journal-title":"Journal of clinical medicine"},{"issue":"7241","key":"10.1016\/j.intimp.2022.108712_b0120","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Cant\u00f3","year":"2009","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.intimp.2022.108712_b0125","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1242\/jcs.194480","article-title":"Acute stimulation of glucose influx upon mitoenergetic dysfunction requires LKB1, AMPK, Sirt2 and mTOR-RAPTOR","volume":"129","author":"Liemburg-Apers","year":"2016","journal-title":"J. Cell Sci."},{"issue":"38","key":"10.1016\/j.intimp.2022.108712_b0130","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1073\/pnas.0803790105","article-title":"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis","volume":"105","author":"Ahn","year":"2008","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0135","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.molmed.2017.02.005","article-title":"Mitochondrial Sirtuins and Molecular Mechanisms of Aging","volume":"23","author":"van de Ven","year":"2017","journal-title":"Trends Mol. Med."},{"issue":"16","key":"10.1016\/j.intimp.2022.108712_b0140","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.7150\/ijbs.49535","article-title":"Emerging Roles of SIRT1 in Alcoholic Liver Disease","volume":"16","author":"Ren","year":"2020","journal-title":"International journal of biological sciences"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010265","article-title":"Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK\/SIRT1 and Nrf2 Signaling Pathways","volume":"21","author":"Nagappan","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2022.108712_b0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13020-021-00528-w","article-title":"Honokiol attenuates lipotoxicity in hepatocytes via activating SIRT3-AMPK mediated lipophagy","volume":"16","author":"Liu","year":"2021","journal-title":"Chinese medicine"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0155","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cmet.2009.02.006","article-title":"Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation","volume":"9","author":"Purushotham","year":"2009","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0160","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.fct.2008.10.018","article-title":"Salvia miltiorrhiza Bunge and its active component cryptotanshinone protects primary cultured rat hepatocytes from acute ethanol-induced cytotoxicity and fatty infiltration","volume":"47","author":"Yin","year":"2009","journal-title":"Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41421-021-00326-6","article-title":"SIRT2-mediated deacetylation and deubiquitination of C\/EBP\u03b2 prevents ethanol-induced liver injury","volume":"7","author":"Zhang","year":"2021","journal-title":"Cell Discovery"},{"key":"10.1016\/j.intimp.2022.108712_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119997","article-title":"The role of Sirtuin 2 in sustaining functional integrity of the liver","volume":"285","author":"Park","year":"2021","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0175","first-page":"723","article-title":"Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4\u03b1, Hepatology (Baltimore","volume":"74","author":"Ren","year":"2021","journal-title":"Md.)"},{"issue":"9","key":"10.1016\/j.intimp.2022.108712_b0180","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1111\/jcmm.15148","article-title":"Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice","volume":"24","author":"Li","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"12","key":"10.1016\/j.intimp.2022.108712_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166249","article-title":"SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1","volume":"1867","author":"Zhu","year":"2021","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.intimp.2022.108712_b0190","doi-asserted-by":"crossref","unstructured":"S.H. Moon, C.H. Huang, S.L. Houlihan, K. Regunath, W.A. Freed-Pastor, J.P.t. Morris, D.F. Tschaharganeh, E.R. Kastenhuber, A.M. Barsotti, R. Culp-Hill, W. Xue, Y.J. Ho, T. Baslan, X. Li, A. Mayle, E. de Stanchina, L. Zender, D.R. Tong, A. D'Alessandro, S.W. Lowe, C. Prives, p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression, Cell 176(3) (2019) 564-580.e19.","DOI":"10.1016\/j.cell.2018.11.011"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0195","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jhep.2012.11.042","article-title":"Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease","volume":"58","author":"Derdak","year":"2013","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0200","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s12192-017-0872-z","article-title":"Exendin-4 improves ER stress-induced lipid accumulation and regulates lipin-1 signaling in HepG2 cells","volume":"23","author":"Lee","year":"2018","journal-title":"Cell stress & chaperones"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0205","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12964-020-00640-8","article-title":"SIRT3 deficiency exacerbates fatty liver by attenuating the HIF1\u03b1-LIPIN 1 pathway and increasing CD36 through Nrf2","volume":"18","author":"Barroso","year":"2020","journal-title":"Cell communication and signaling : CCS"},{"issue":"7","key":"10.1016\/j.intimp.2022.108712_b0210","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1096\/fj.13-245241","article-title":"SIRT5 is under the control of PGC-1\u03b1 and AMPK and is involved in regulation of mitochondrial energy metabolism","volume":"28","author":"Buler","year":"2014","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"15","key":"10.1016\/j.intimp.2022.108712_b0215","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/pros.24208","article-title":"SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1\u03b1 axis in the development of benign prostatic hyperplasia","volume":"81","author":"Li","year":"2021","journal-title":"Prostate"},{"key":"10.1016\/j.intimp.2022.108712_b0220","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.freeradbiomed.2021.03.029","article-title":"Compartmentally scavenging hepatic oxidants through AMPK\/SIRT3-PGC1\u03b1 axis improves mitochondrial biogenesis and glucose catabolism","volume":"168","author":"Wu","year":"2021","journal-title":"Free Radical Biol. Med."},{"issue":"7029","key":"10.1016\/j.intimp.2022.108712_b0225","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0230","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbrc.2008.03.005","article-title":"Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats","volume":"370","author":"Lieber","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0235","first-page":"883","article-title":"The hepatic BMAL1\/AKT\/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPAR\u03b1 pathway, Hepatology (Baltimore","volume":"68","author":"Zhang","year":"2018","journal-title":"Md.)"},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0240","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/j.gastro.2013.11.008","article-title":"Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver","volume":"146","author":"Yin","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2022.108712_b0245","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.redox.2018.04.006","article-title":"Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1\/PGC-1\u03b1\/mitochondrial biosynthesis pathway","volume":"17","author":"Wang","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2022.108712_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101117","article-title":"PARPs in lipid metabolism and related diseases","volume":"84","author":"Sz\u00e1nt\u00f3","year":"2021","journal-title":"Prog. Lipid Res."},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0255","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2022.108712_b0260","doi-asserted-by":"crossref","unstructured":"D.V. Titov, V. Cracan, R.P. Goodman, J. Peng, Z. Grabarek, V.K. Mootha, Complementation of mitochondrial electron transport chain by manipulation of the NAD+\/NADH ratio, Science (New York, N.Y.) 352(6282) (2016) 231-5.","DOI":"10.1126\/science.aad4017"},{"issue":"8","key":"10.1016\/j.intimp.2022.108712_b0265","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","article-title":"The Role of Sirtuins in Antioxidant and Redox Signaling","volume":"28","author":"Singh","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"17","key":"10.1016\/j.intimp.2022.108712_b0270","doi-asserted-by":"crossref","first-page":"8120","DOI":"10.1039\/D1FO00978H","article-title":"Melanoidins, extracted from Chinese traditional vinegar powder, inhibit alcohol-induced inflammation and oxidative stress in macrophages via activation of SIRT1 and SIRT3","volume":"12","author":"Li","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2022.108712_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108477","article-title":"Astaxanthin inhibits alcohol-induced inflammation and oxidative stress in macrophages in a sirtuin 1-dependent manner","volume":"85","author":"Kang","year":"2020","journal-title":"The Journal of nutritional biochemistry"},{"issue":"9","key":"10.1016\/j.intimp.2022.108712_b0280","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41374-021-00599-1","article-title":"Nicotinamide riboside, an NAD(+) precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages","volume":"101","author":"Kang","year":"2021","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"issue":"10","key":"10.1016\/j.intimp.2022.108712_b0285","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.7150\/thno.55330","article-title":"SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux","volume":"11","author":"Zhou","year":"2021","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0290","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/gutjnl-2017-315123","article-title":"Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression","volume":"68","author":"Heo","year":"2019","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0295","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020372","article-title":"SIRT3 Acts as a Positive Autophagy Regulator to Promote Lipid Mobilization in Adipocytes via Activating AMPK","volume":"21","author":"Zhang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2022.108712_b0300","doi-asserted-by":"crossref","first-page":"822","DOI":"10.3389\/fcell.2020.00822","article-title":"Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria","volume":"8","author":"Xu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0305","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1172\/JCI88574","article-title":"Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2","volume":"127","author":"Yang","year":"2017","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0310","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/CIRCRESAHA.118.313648","article-title":"Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol","volume":"124","author":"Spolitu","year":"2019","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.intimp.2022.108712_b0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0309-0","article-title":"Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis","volume":"51","author":"Bang","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2022.108712_b0320","doi-asserted-by":"crossref","first-page":"6694964","DOI":"10.1155\/2021\/6694964","article-title":"Promoting Nrf2\/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration","volume":"2021","author":"Hu","year":"2021","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"12","key":"10.1016\/j.intimp.2022.108712_b0325","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202000619","article-title":"Functional Food XingJiuTang Attenuates Alcohol-Induced Liver Injury by Regulating SIRT1\/Nrf-2 Signaling Pathway","volume":"17","author":"Hao","year":"2020","journal-title":"Chem. Biodivers."},{"issue":"5","key":"10.1016\/j.intimp.2022.108712_b0330","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.jhep.2019.06.019","article-title":"The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice","volume":"71","author":"Kim","year":"2019","journal-title":"J. Hepatol."},{"issue":"16","key":"10.1016\/j.intimp.2022.108712_b0335","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMra2022774","article-title":"Autophagy in Human Diseases","volume":"383","author":"Mizushima","year":"2020","journal-title":"The New England journal of medicine"},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0340","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/15548627.2018.1520548","article-title":"CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1","volume":"15","author":"Hu","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.intimp.2022.108712_b0345","doi-asserted-by":"crossref","unstructured":"Y. Zhou, R. Wu, X. Wang, Y. Jiang, W. Xu, Y. Shao, C. Yue, W. Shi, H. Jin, T. Ge, X. Bao, C. Lu, Activation of UQCRC2-dependent mitophagy by tetramethylpyrazine inhibits MLKL-mediated hepatocyte necroptosis in alcoholic liver disease, Free radical biology & medicine (2021).","DOI":"10.1016\/j.freeradbiomed.2021.11.008"},{"issue":"15","key":"10.1016\/j.intimp.2022.108712_b0350","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158149","article-title":"mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership","volume":"22","author":"Cayo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.intimp.2022.108712_b0355","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1002\/jcp.29727","article-title":"SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK\/mTOR pathway and promoting GPX4 levels","volume":"235","author":"Han","year":"2020","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.intimp.2022.108712_b0360","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR Signaling in Growth, Metabolism, and Disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0365","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.molcel.2019.07.023","article-title":"Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1","volume":"75","author":"Jung","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2022.108712_b0370","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3389\/fcell.2020.00702","article-title":"Dihydromyricetin Protects Against Gentamicin-Induced Ototoxicity via PGC-1\u03b1\/SIRT3 Signaling in vitro","volume":"8","author":"Han","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2022.108712_b0375","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.ijbiomac.2019.06.163","article-title":"PGC-1\u03b1 acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy","volume":"136","author":"Xu","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0380","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.febslet.2011.11.031","article-title":"Acetylation-dependent regulation of mitochondrial ALDH2 activation by SIRT3 mediates acute ethanol-induced eNOS activation","volume":"586","author":"Xue","year":"2012","journal-title":"FEBS Lett."},{"issue":"18","key":"10.1016\/j.intimp.2022.108712_b0385","first-page":"1389","article-title":"SIRT4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity","volume":"38","author":"Luo","year":"2017","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.intimp.2022.108712_b0390","doi-asserted-by":"crossref","first-page":"811","DOI":"10.15252\/embr.201541643","article-title":"SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense","volume":"17","author":"Zhou","year":"2016","journal-title":"EMBO Rep."},{"issue":"11","key":"10.1016\/j.intimp.2022.108712_b0395","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/s41419-018-1112-x","article-title":"Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy\/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury","volume":"9","author":"Kim","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2022.108712_b0400","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.freeradbiomed.2019.12.004","article-title":"Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway","volume":"147","author":"Cao","year":"2020","journal-title":"Free Radical Biol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0405","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1053\/j.gastro.2018.05.027","article-title":"Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice","volume":"155","author":"Chao","year":"2018","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.intimp.2022.108712_b0410","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.18632\/aging.202566","article-title":"Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages","volume":"13","author":"Zheng","year":"2021","journal-title":"Aging"},{"issue":"8","key":"10.1016\/j.intimp.2022.108712_b0415","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1080\/15548627.2019.1582743","article-title":"SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions","volume":"15","author":"Kim","year":"2019","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0420","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12974-018-1345-8","article-title":"Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1","volume":"15","author":"Chen","year":"2018","journal-title":"Journal of neuroinflammation"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0425","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040731","article-title":"Sirtuin 2 Dysregulates Autophagy in High-Fat-Exposed Immune-Tolerant Macrophages","volume":"10","author":"Roychowdhury","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0430","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10565-020-09528-2","article-title":"Cytoplasmic sirtuin 6 translocation mediated by p62 polyubiquitination plays a critical role in cadmium-induced kidney toxicity","volume":"37","author":"So","year":"2021","journal-title":"Cell Biol. Toxicol."},{"issue":"10","key":"10.1016\/j.intimp.2022.108712_b0435","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.18632\/aging.101307","article-title":"SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy","volume":"9","author":"Lang","year":"2017","journal-title":"Aging"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0440","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41419-021-03666-z","article-title":"Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis","volume":"12","author":"Feng","year":"2021","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0445","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/15548627.2015.1009778","article-title":"SIRT5 regulation of ammonia-induced autophagy and mitophagy","volume":"11","author":"Polletta","year":"2015","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.intimp.2022.108712_b0450","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1111\/acer.14117","article-title":"5-ALA\/SFC Attenuated Binge Alcohol-Induced Gut Leakiness and Inflammatory Liver Disease in HIV Transgenic Rats","volume":"43","author":"Liu","year":"2019","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"8","key":"10.1016\/j.intimp.2022.108712_b0455","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.ajpath.2018.05.004","article-title":"Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice","volume":"188","author":"Wang","year":"2018","journal-title":"The American journal of pathology"},{"issue":"6","key":"10.1016\/j.intimp.2022.108712_b0460","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12667","article-title":"SIRT1 attenuates murine allergic rhinitis by downregulated HMGB 1\/TLR4 pathway","volume":"87","author":"Yuan","year":"2018","journal-title":"Scand. J. Immunol."},{"issue":"17","key":"10.1016\/j.intimp.2022.108712_b0465","first-page":"2067","article-title":"Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release, Cell cycle (Georgetown","volume":"18","author":"Li","year":"2019","journal-title":"Tex.)"},{"key":"10.1016\/j.intimp.2022.108712_b0470","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.freeradbiomed.2020.08.006","article-title":"Cyanidin-3-O-\u03b2-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1\/NF-\u03baB signaling pathway","volume":"160","author":"Zhou","year":"2020","journal-title":"Free Radical Biol. Med."},{"issue":"18","key":"10.1016\/j.intimp.2022.108712_b0475","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184607","article-title":"PKC\u03b4 Mediates NF-\u03baB Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis","volume":"20","author":"Lee","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0480","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1007\/s12035-017-0520-8","article-title":"17\u03b2-Estradiol via SIRT1\/Acetyl-p53\/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication","volume":"55","author":"Khan","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.intimp.2022.108712_b0485","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113858","article-title":"Relevance of SIRT1-NF-\u03baB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease","volume":"21","author":"de Gregorio","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0490","doi-asserted-by":"crossref","first-page":"19232","DOI":"10.1038\/s41598-020-75301-4","article-title":"Activation of toll like receptor 4 (TLR4) promotes cardiomyocyte apoptosis through SIRT2 dependent p53 deacetylation","volume":"10","author":"Katare","year":"2020","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.intimp.2022.108712_b0495","doi-asserted-by":"crossref","first-page":"9141","DOI":"10.1002\/jcb.27176","article-title":"Sirtuin6 inhibits c-triggered inflammation through TLR4 abrogation regulated by ROS and TRPV1\/CGRP","volume":"119","author":"Zhang","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2022.108712_b0500","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.freeradbiomed.2013.06.005","article-title":"PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages","volume":"63","author":"Kim","year":"2013","journal-title":"Free Radical Biol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0505","doi-asserted-by":"crossref","DOI":"10.1080\/23723556.2018.1445942","article-title":"Complex role of SIRT6 in NF-\u03baB pathway regulation","volume":"5","author":"Santos-Barriopedro","year":"2018","journal-title":"Molecular & cellular oncology"},{"issue":"22","key":"10.1016\/j.intimp.2022.108712_b0510","article-title":"An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation, Molecules (Basel","volume":"25","author":"Saha","year":"2020","journal-title":"Switzerland)"},{"key":"10.1016\/j.intimp.2022.108712_b0515","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2017.06.027","article-title":"Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1\/TXNIP complex in cerebral ischemia reperfusion injury","volume":"336","author":"Hou","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.intimp.2022.108712_b0520","article-title":"Ainsliadimer C, a disesquiterpenoid isolated from Ainsliaea macrocephala, ameliorates inflammatory responses in adipose tissue via Sirtuin 1-NLRP3 inflammasome axis","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0525","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1096\/fj.201700602R","article-title":"Silybin inhibits NLRP3 inflammasome assembly through the NAD(+)\/SIRT2 pathway in mice with nonalcoholic fatty liver disease","volume":"32","author":"Zhang","year":"2018","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0530","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cmet.2020.01.009","article-title":"An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance","volume":"31","author":"He","year":"2020","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0535","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-021-02089-z","article-title":"Sirtuin 3 protects against anesthesia\/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation","volume":"18","author":"Liu","year":"2021","journal-title":"Journal of neuroinflammation"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0540","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41401-020-0490-7","article-title":"Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation","volume":"42","author":"Song","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"20","key":"10.1016\/j.intimp.2022.108712_b0545","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1111\/bph.15215","article-title":"Small molecule-driven SIRT3-autophagy-mediated NLRP3 inflammasome inhibition ameliorates inflammatory crosstalk between macrophages and adipocytes","volume":"177","author":"Zhang","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0550","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/jcmm.14805","article-title":"Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2022.108712_b0555","doi-asserted-by":"crossref","first-page":"2452848","DOI":"10.1155\/2020\/2452848","article-title":"Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner","volume":"2020","author":"Gu","year":"2020","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"9","key":"10.1016\/j.intimp.2022.108712_b0560","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/bph.14145","article-title":"Liver kinase B1\/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis","volume":"175","author":"Li","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"19","key":"10.1016\/j.intimp.2022.108712_b0565","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1021\/acs.jafc.8b00944","article-title":"Amelioration of Alcoholic Liver Steatosis by Dihydroquercetin through the Modulation of AMPK-Dependent Lipogenesis Mediated by P2X7R-NLRP3-Inflammasome Activation","volume":"66","author":"Zhang","year":"2018","journal-title":"J. Agric. Food. Chem."},{"issue":"7534","key":"10.1016\/j.intimp.2022.108712_b0570","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.108712_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107717","article-title":"A decade of cell death studies: Breathing new life into necroptosis","volume":"220","author":"Khan","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2022.108712_b0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152923","article-title":"Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation","volume":"461","author":"Shao","year":"2021","journal-title":"Toxicology"},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0585","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1872-034X.2011.00776.x","article-title":"Evolution of hepatic fibrosis research, Hepatology research : the official journal of the Japan Society of","volume":"41","author":"Kawada","year":"2011","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.intimp.2022.108712_b0590","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7150\/ijbs.19370","article-title":"Emerging roles of SIRT1 in fatty liver diseases","volume":"13","author":"Ding","year":"2017","journal-title":"International journal of biological sciences"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0595","first-page":"500","article-title":"SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice, FASEB journal : official publication of the Federation of American Societies for","volume":"32","author":"Li","year":"2018","journal-title":"Experimental Biology"},{"issue":"11","key":"10.1016\/j.intimp.2022.108712_b0600","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1111\/bph.14573","article-title":"Pterostilbene prevents hepatocyte epithelial-mesenchymal transition in fructose-induced liver fibrosis through suppressing miR-34a\/Sirt1\/p53 and TGF-\u03b21\/Smads signalling","volume":"176","author":"Song","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2022.108712_b0605","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.taap.2018.11.011","article-title":"\u03b3-Mangostin alleviates liver fibrosis through Sirtuin 3-superoxide-high mobility group box 1 signaling axis","volume":"363","author":"Wang","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2022.108712_b0610","first-page":"1140","article-title":"Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells, Hepatology (Baltimore","volume":"73","author":"Zhang","year":"2021","journal-title":"Md.)"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0615","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1074\/jbc.RA118.007212","article-title":"Sirtuin 6 deficiency transcriptionally up-regulates TGF-\u03b2 signaling and induces fibrosis in mice","volume":"295","author":"Maity","year":"2020","journal-title":"The Journal of biological chemistry"},{"key":"10.1016\/j.intimp.2022.108712_b0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173667","article-title":"CD73 regulates hepatic stellate cells activation and proliferation through Wnt\/\u03b2-catenin signaling pathway","volume":"890","author":"Jia","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0625","doi-asserted-by":"crossref","first-page":"G262","DOI":"10.1152\/ajpgi.00129.2021","article-title":"PPAR\u03b1 agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and \u03b2-catenin signaling, American journal of physiology","volume":"321","author":"Mandala","year":"2021","journal-title":"Gastrointestinal and liver physiology"},{"key":"10.1016\/j.intimp.2022.108712_b0630","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2019.07.021","article-title":"Deacetylation of \u03b2-catenin by SIRT1 regulates self-renewal and oncogenesis of liver cancer stem cells","volume":"463","author":"Chen","year":"2019","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0635","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22625","article-title":"Modulation of antioxidant enzymes, SIRT1 and NF-\u03baB by resveratrol and nicotinamide in alcohol-aflatoxin B1-induced hepatocellular carcinoma","volume":"35","author":"Rawat","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0640","doi-asserted-by":"crossref","DOI":"10.3390\/nu8010027","article-title":"Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy","volume":"8","author":"Yu","year":"2016","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.intimp.2022.108712_b0645","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183541","article-title":"Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats","volume":"12","author":"Ding","year":"2017","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0650","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jep.2004.06.032","article-title":"Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice culture in vitro","volume":"95","author":"Naik","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2022.108712_b0655","article-title":"Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway","volume":"85","author":"Zhang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2022.108712_b0660","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.intimp.2017.08.032","article-title":"Berberine suppresses LPS-induced inflammation through modulating Sirt1\/NF-\u03baB signaling pathway in RAW264.7 cells","volume":"52","author":"Zhang","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"20","key":"10.1016\/j.intimp.2022.108712_b0665","article-title":"Inhibitory Role of Berberine, an Isoquinoline Alkaloid, on NLRP3 Inflammasome Activation for the Treatment of Inflammatory Diseases, Molecules (Basel","volume":"26","author":"Sarbadhikary","year":"2021","journal-title":"Switzerland)"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0670","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s11010-020-03933-1","article-title":"Resveratrol increases the activation markers and changes the release of inflammatory cytokines of hepatic stellate cells","volume":"476","author":"de Oliveira","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.intimp.2022.108712_b0675","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.intimp.2017.03.029","article-title":"Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-\u043aB\/I\u043aB\u03b1, p38 MAPK, and Bcl-2\/Bax signaling","volume":"47","author":"Wang","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2022.108712_b0680","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biopha.2018.05.110","article-title":"Berberine alleviates adipose tissue fibrosis by inducing AMP-activated kinase signaling in high-fat diet-induced obese mice","volume":"105","author":"Wang","year":"2018","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"key":"10.1016\/j.intimp.2022.108712_b0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173424","article-title":"Curcumin reduces methionine adenosyltransferase 2B expression by interrupting phosphorylation of p38 MAPK in hepatic stellate cells","volume":"886","author":"Hu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0690","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.bmcl.2018.01.021","article-title":"Novel SIRT1 activator MHY2233 improves glucose tolerance and reduces hepatic lipid accumulation in db\/db mice","volume":"28","author":"Kim","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"9\u201310","key":"10.1016\/j.intimp.2022.108712_b0695","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s10495-018-1483-6","article-title":"Novel 1,4-dihydropyridine induces apoptosis in human cancer cells through overexpression of Sirtuin1","volume":"23","author":"Manna","year":"2018","journal-title":"Apoptosis : an international journal on programmed cell death"},{"key":"10.1016\/j.intimp.2022.108712_b0700","article-title":"1,4-Dihydropyridine (DHP) suppresses against oxidative stress in nucleus pulposus via activating sirtuin-1","volume":"121","author":"Song","year":"2020","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie"},{"issue":"16","key":"10.1016\/j.intimp.2022.108712_b0705","doi-asserted-by":"crossref","first-page":"11004","DOI":"10.1074\/jbc.M112.441816","article-title":"A nitric oxide-dependent cross-talk between class I and III histone deacetylases accelerates skin repair","volume":"288","author":"Spallotta","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"5","key":"10.1016\/j.intimp.2022.108712_b0710","first-page":"E1179","article-title":"Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice, American journal of physiology","volume":"297","author":"Yamazaki","year":"2009","journal-title":"Endocrinology and metabolism"},{"issue":"2","key":"10.1016\/j.intimp.2022.108712_b0715","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/toxsci\/kfz095","article-title":"Acetaminophen Responsive miR-19b Modulates SIRT1\/Nrf2 Signaling Pathway in Drug-Induced Hepatotoxicity","volume":"170","author":"Liu","year":"2019","journal-title":"Toxicological sciences : an official journal of the Society of Toxicology"},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0720","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2125.2012.04340.x","article-title":"Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man","volume":"75","author":"Hoffmann","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.intimp.2022.108712_b0725","doi-asserted-by":"crossref","unstructured":"W. You, D. Rotili, T.M. Li, C. Kambach, M. Meleshin, M. Schutkowski, K.F. Chua, A. Mai, C. Steegborn, Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules, Angewandte Chemie (International ed. in English) 56(4) (2017) 1007-1011.","DOI":"10.1002\/anie.201610082"},{"issue":"12","key":"10.1016\/j.intimp.2022.108712_b0730","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/s41589-018-0150-0","article-title":"Identification of a cellularly active SIRT6 allosteric activator","volume":"14","author":"Huang","year":"2018","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108712_b0735","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.intimp.2022.108712_b0740","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug metabolism and disposition: the biological fate of chemicals"},{"issue":"4","key":"10.1016\/j.intimp.2022.108712_b0745","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3109\/00365521.2015.1107620","article-title":"Placebo-controlled, randomised clinical trial: high-dose resveratrol treatment for non-alcoholic fatty liver disease","volume":"51","author":"Heeb\u00f8ll","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.intimp.2022.108712_b0750","doi-asserted-by":"crossref","unstructured":"F. Faghihzadeh, P. Adibi, R. Rafiei, A. Hekmatdoost, Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease, Nutrition research (New York, N.Y.) 34(10) (2014) 837-43.","DOI":"10.1016\/j.nutres.2014.09.005"},{"key":"10.1016\/j.intimp.2022.108712_b0755","doi-asserted-by":"crossref","unstructured":"V.S. Chachay, G.A. Macdonald, J.H. Martin, J.P. Whitehead, T.M. O'Moore-Sullivan, P. Lee, M. Franklin, K. Klein, P.J. Taylor, M. Ferguson, J.S. Coombes, G.P. Thomas, G.J. Cowin, C.M. Kirkpatrick, J.B. Prins, I.J. Hickman, Resveratrol does not benefit patients with nonalcoholic fatty liver disease, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 12(12) (2014) 2092-103.e1-6.","DOI":"10.1016\/j.cgh.2014.02.024"}],"updated-by":[{"DOI":"10.1016\/j.intimp.2023.110248","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000}}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922001965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922001965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T18:20:11Z","timestamp":1726942811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922001965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":151,"alternative-id":["S1567576922001965"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108712","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging roles of Sirtuins in alleviating alcoholic liver Disease: A comprehensive review","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108712","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108712"}}