{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:36:46Z","timestamp":1789843006678,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672042"],"award-info":[{"award-number":["81672042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.intimp.2022.108716","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T18:23:46Z","timestamp":1648232626000},"page":"108716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Dynamic changes of macrophage activation in mice infected with Trichinella spiralis"],"prefix":"10.1016","volume":"108","author":[{"given":"Qing","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2022.108716_b0005","doi-asserted-by":"crossref","unstructured":"The European Union One Health 2019 Zoonoses Report. EFSA J, 19(2) (2021) e06406.","DOI":"10.2903\/j.efsa.2021.6406"},{"key":"10.1016\/j.intimp.2022.108716_b0010","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.3389\/fmicb.2017.02674","article-title":"Comprehensive proteomic analysis of lysine acetylation in the foodborne pathogen Trichinella spiralis","volume":"8","author":"Yang","year":"2017","journal-title":"Front Microbiol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108716_b0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/zph.12761","article-title":"Second outbreak of Trichinella pseudospiralis in Europe: clinical patterns, epidemiological investigation and identification of the etiological agent based on the western blot patterns of the patients' serum","volume":"68","author":"G\u00f3mez\u2010Morales","year":"2021","journal-title":"Zoonoses Public Health"},{"issue":"6","key":"10.1016\/j.intimp.2022.108716_b0020","first-page":"938.e1","article-title":"Myocarditis and Raw Meat Consumption: Strange Bedfellows!","volume":"37","author":"Tso","year":"2021","journal-title":"Can. J. Cardiol."},{"issue":"10","key":"10.1016\/j.intimp.2022.108716_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009865","article-title":"Oral vaccination with recombinant Lactobacillus plantarum encoding Trichinella spiralis inorganic pyrophosphatase elicited a protective immunity in BALB\/c mice","volume":"15","author":"Hu","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.intimp.2022.108716_b0030","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ijbiomac.2021.10.021","article-title":"A metalloproteinase Tsdpy31 from Trichinella spiralis participates in larval molting and development","volume":"192","author":"Ren","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108716_b0035","doi-asserted-by":"crossref","DOI":"10.1186\/s13567-020-00791-z","article-title":"The cysteine protease ATG4B of Trichinella spiralis promotes larval invasion into the intestine of the host","volume":"51","author":"Li","year":"2020","journal-title":"Vet. Res."},{"issue":"4","key":"10.1016\/j.intimp.2022.108716_b0040","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.coi.2007.07.002","article-title":"Alternatively activated macrophages in helminth infections","volume":"19","author":"Kreider","year":"2007","journal-title":"Curr. Opin. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2022.108716_b0045","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3390\/ijms19061801","article-title":"Role of Human Macrophage Polarization in Inflammation during Infectious Diseases","volume":"19","author":"Atri","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.intimp.2022.108716_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112962","article-title":"ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-kappaB Acetylation","volume":"10","author":"Santarsiero","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.intimp.2022.108716_b0055","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/v12030356","article-title":"Transcriptomic Analysis Suggests the M1 Polarization and Launch of Diverse Programmed Cell Death Pathways in Japanese Encephalitis Virus-Infected Macrophages","volume":"12","author":"Wang","year":"2020","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.intimp.2022.108716_b0060","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12617","article-title":"Canine neutrophils cooperate with macrophages in the early stages of Leishmania infantum in vitro infection","volume":"41","author":"Pereira","year":"2019","journal-title":"Parasite Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2022.108716_b0065","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.3390\/cells10113181","article-title":"Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus","volume":"10","author":"Jhan","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.intimp.2022.108716_b0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-020-2314-6","article-title":"NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.intimp.2022.108716_b0075","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3390\/cells8121596","article-title":"GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice","volume":"8","author":"Yang","year":"2019","journal-title":"Cells"},{"issue":"16","key":"10.1016\/j.intimp.2022.108716_b0080","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144016","article-title":"TNFR2\/14-3-3epsilon signaling complex instructs macrophage plasticity in inflammation and autoimmunity","volume":"131","author":"Fu","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.intimp.2022.108716_b0085","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"issue":"20","key":"10.1016\/j.intimp.2022.108716_b0090","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.7150\/thno.65203","article-title":"Interleukin-4 and interleukin-13 induce different metabolic profiles in microglia and macrophages that relate with divergent outcomes after spinal cord injury","volume":"11","author":"Amo-Aparicio","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2022.108716_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113909","article-title":"IL-4 expressing cells are recruited to nerve after injury and promote regeneration","volume":"347","author":"Pan","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2022.108716_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101526","article-title":"Macrophage regulation & function in helminth infection","author":"Lechner","year":"2021","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.intimp.2022.108716_b0105","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.617461","article-title":"Schistosoma japonicum Cystatin Alleviates Sepsis Through Activating Regulatory Macrophages","volume":"11","author":"Xie","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.intimp.2022.108716_b0110","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3389\/fimmu.2020.02015","article-title":"Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages","volume":"11","author":"Jin","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108716_b0115","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00436-020-07000-y","article-title":"Regulation of human THP-1 macrophage polarization by Trichinella spiralis","volume":"120","author":"Zawistowska-Deniziak","year":"2021","journal-title":"Parasitol. Res."},{"issue":"3-4","key":"10.1016\/j.intimp.2022.108716_b0120","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0304-4017(00)00354-X","article-title":"International Commission on Trichinellosis: recommendations on methods for the control of Trichinella in domestic and wild animals intended for human consumption","volume":"93","author":"Gamble","year":"2000","journal-title":"Vet. Parasitol."},{"issue":"10","key":"10.1016\/j.intimp.2022.108716_b0125","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1017\/S0031182007002855","article-title":"Identification of stage-specifically expressed genes of Trichinella spiralis by suppression subtractive hybridization","volume":"134","author":"Liu","year":"2007","journal-title":"Parasitology"},{"issue":"5","key":"10.1016\/j.intimp.2022.108716_b0130","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules","volume":"49","author":"Maizels","year":"2018","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.intimp.2022.108716_b0135","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/all.13944","article-title":"Regulation of immunity and allergy by helminth parasites","volume":"75","author":"Maizels","year":"2020","journal-title":"Allergy"},{"issue":"7","key":"10.1016\/j.intimp.2022.108716_b0140","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12717","article-title":"Interactions between macrophages and helminths","volume":"42","author":"Coakley","year":"2020","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.intimp.2022.108716_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2021.109556","article-title":"Immunoprotective effects of invasive Lactobacillus plantarum delivered nucleic acid vaccine coexpressing Trichinella spiralis CPF1 and murine interleukin-4","volume":"298","author":"Xue","year":"2021","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.intimp.2022.108716_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103594","article-title":"Interplay of interferon-gamma and macrophage polarization during Talaromyces marneffei infection","volume":"134","author":"Lu","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.intimp.2022.108716_b0155","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molimm.2020.09.001","article-title":"TRAF6 promotes IL-4-induced M2 macrophage activation by stabilizing STAT6","volume":"127","author":"Zhou","year":"2020","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2022.108716_b0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006502","article-title":"Ts-Hsp70 induces protective immunity against Trichinella spiralis infection in mouse by activating dendritic cells through TLR2 and TLR4","volume":"12","author":"Zhang","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2022.108716_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111404","article-title":"Trichinella spiralis Excretory-Secretory Products Stimulate Host Regulatory T Cell Differentiation through Activating Dendritic Cells","volume":"8","author":"Sun","year":"2019","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.intimp.2022.108716_b0170","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3390\/metabo10110429","article-title":"Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight","volume":"10","author":"Palmieri","year":"2020","journal-title":"Metabolites"},{"issue":"6","key":"10.1016\/j.intimp.2022.108716_b0175","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.it.2020.04.006","article-title":"Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!","volume":"41","author":"Chazaud","year":"2020","journal-title":"Trends Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2022.108716_b0180","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1128\/IAI.72.6.3129-3137.2004","article-title":"Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis","volume":"72","author":"Beiting","year":"2004","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2022.108716_b0185","doi-asserted-by":"crossref","first-page":"34","DOI":"10.33160\/yam.2020.02.005","article-title":"Alternative Activation of Macrophages in Mice Peritoneal Cavities and Diaphragms by Newborn Larvae of Trichinella spiralis","volume":"63","author":"Itami","year":"2020","journal-title":"Yonago Acta Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922002004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922002004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:39:31Z","timestamp":1761586771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922002004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":37,"alternative-id":["S1567576922002004"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108716","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic changes of macrophage activation in mice infected with Trichinella spiralis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108716","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108716"}}