{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:34:58Z","timestamp":1788910498214,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100386"],"award-info":[{"award-number":["81100386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400046"],"award-info":[{"award-number":["81400046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170077"],"award-info":[{"award-number":["82170077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.intimp.2022.108784","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T20:29:52Z","timestamp":1650486592000},"page":"108784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Serum amyloid A\/anti-CCL20 induced the rebalance of Th17\/regulatory T cells in SodA-induced sarcoidosis"],"prefix":"10.1016","volume":"109","author":[{"given":"Kaifang","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhua","family":"Gui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-4504","authenticated-orcid":false,"given":"Jingjing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.intimp.2022.108784_b0005","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1056\/NEJMra071714","article-title":"Sarcoidosis","volume":"357","author":"Iannuzzi","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2022.108784_b0010","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.intimp.2018.08.030","article-title":"Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis","volume":"64","author":"Zhang","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2022.108784_b0015","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.4049\/jimmunol.1202891","article-title":"Reversal of Global CD4 (+) Subset Dysfunction Is Associated with Spontaneous Clinical Resolution of Pulmonary Sarcoidosis","volume":"190","author":"Oswald-Richter","year":"2013","journal-title":"J. Immunol."},{"issue":"9923","key":"10.1016\/j.intimp.2022.108784_b0020","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(13)60680-7","article-title":"Sarcoidosis","volume":"383","author":"Valeyre","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2022.108784_b0025","doi-asserted-by":"crossref","unstructured":"S. Paramothayan, T.J. Lasserson, E.H. Walters, Immunosuppressive and cytotoxic therapy for pulmonary sarcoidosis, The Cochrane database of systematic reviews (3) (2006) CD003536.","DOI":"10.1002\/14651858.CD003536.pub2"},{"issue":"9","key":"10.1016\/j.intimp.2022.108784_b0030","first-page":"1702","article-title":"Corticosteroids for pulmonary sarcoidosis","volume":"72","author":"Ebell","year":"2005","journal-title":"Am. Fam. Physician"},{"issue":"3","key":"10.1016\/j.intimp.2022.108784_b0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-3083.1985.tb01431.x","article-title":"Transformation of amyloid precursor SAA to protein AA and incorporation in amyloid fibrils in vivo","volume":"21","author":"Husebekk","year":"1985","journal-title":"Scand. J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2022.108784_b0040","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.rmed.2010.12.010","article-title":"Analysis of serum amyloid A in sarcoidosis patients","volume":"105","author":"Bargagli","year":"2011","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.intimp.2022.108784_b0045","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.intimp.2015.01.015","article-title":"Conventional markers in determination of activity of sarcoidosis","volume":"25","author":"Gungor","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2022.108784_b0050","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1164\/rccm.200905-0696OC","article-title":"Serum Amyloid A Regulates Granulomatous Inflammation in Sarcoidosis through Toll-like Receptor-2","volume":"181","author":"Chen","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"11","key":"10.1016\/j.intimp.2022.108784_b0055","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.7150\/ijms.18838","article-title":"Extensively disturbance of regulatory T cells - Th17 cells balance in stage II pulmonary sarcoidosis","volume":"14","author":"Ding","year":"2017","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.intimp.2022.108784_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rmed.2017.03.009","article-title":"The role of serum amyloid A staining of granulomatous tissues for the diagnosis of sarcoidosis","volume":"126","author":"Huho","year":"2017","journal-title":"Respir. Med."},{"key":"10.1016\/j.intimp.2022.108784_b0065","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fimmu.2018.01516","article-title":"In Situ Humoral Immunity to Vimentin in HLA-DrB1*03(+) Patients With Pulmonary Sarcoidosis","volume":"9","author":"Kinloch","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2022.108784_b0070","first-page":"462","article-title":"Selected molecular events in the pathogenesis of sarcoidosis - recent advances","volume":"83","author":"Kiszalkiewicz","year":"2015","journal-title":"Pneumonol. Alergol. Pol."},{"issue":"6","key":"10.1016\/j.intimp.2022.108784_b0075","first-page":"487","article-title":"Intracellular cytokine repertoire in different T cell subsets from patients with sarcoidosis","volume":"56","author":"Mollers","year":"2001","journal-title":"Thorax"},{"issue":"11","key":"10.1016\/j.intimp.2022.108784_b0080","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1164\/rccm.201507-1499OC","article-title":"IFN-gamma-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells","volume":"193","author":"Ramstein","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"8","key":"10.1016\/j.intimp.2022.108784_b0085","doi-asserted-by":"crossref","DOI":"10.1038\/s41584-021-00663-6","article-title":"Targeting the CCR6-CCL20 axis improves experimental PsA","volume":"17","author":"Onuora","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"23","key":"10.1016\/j.intimp.2022.108784_b0090","doi-asserted-by":"crossref","first-page":"14893","DOI":"10.1074\/jbc.272.23.14893","article-title":"Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC","volume":"272","author":"Baba","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.intimp.2022.108784_b0095","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/rheumatology\/kep089","article-title":"Serum amyloid A protein stimulates CCL20 production in rheumatoid synoviocytes","volume":"48","author":"Migita","year":"2009","journal-title":"Rheumatology"},{"issue":"7","key":"10.1016\/j.intimp.2022.108784_b0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181486","article-title":"Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis","volume":"12","author":"Couderc","year":"2017","journal-title":"PLoS ONE"},{"issue":"14","key":"10.1016\/j.intimp.2022.108784_b0105","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1182\/blood-2010-11-318832","article-title":"Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways","volume":"117","author":"Nguyen","year":"2011","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.intimp.2022.108784_b0110","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1165\/rcmb.2009-0350OC","article-title":"Development of a Sarcoidosis Murine Lung Granuloma Model Using Mycobacterium Superoxide Dismutase A Peptide","volume":"44","author":"Swaisgood","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.intimp.2022.108784_b0115","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jaut.2017.12.012","article-title":"Th17-lineage cells in pulmonary sarcoidosis and Lofgren's syndrome: Friend or foe?","volume":"87","author":"Miedema","year":"2018","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.intimp.2022.108784_b0120","first-page":"334","article-title":"The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis","volume":"15","author":"Mortaz","year":"2016","journal-title":"Iranian J. Allergy Asthma Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2022.108784_b0125","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.7150\/ijms.18838","article-title":"Extensively disturbance of regulatory T cells-Th17 cells balance in stage II pulmonary sarcoidosis","volume":"14","author":"Ding","year":"2017","journal-title":"Int. J. Med. Sci."},{"issue":"11","key":"10.1016\/j.intimp.2022.108784_b0130","doi-asserted-by":"crossref","first-page":"21463","DOI":"10.3390\/ijms141121463","article-title":"Imbalance between Th17 and Regulatory T-Cells in Sarcoidosis","volume":"14","author":"Huang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2022.108784_b0135","first-page":"765","article-title":"Frequency of Th1, Th2 and Th17 producing T lymphocytes in bronchoalveolar lavage of patients with systemic sclerosis","volume":"27","author":"Meloni","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108784_b0140","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/thx.2010.140319","article-title":"Sarcoidosis is a Th1\/Th17 multisystem disorder","volume":"66","author":"Facco","year":"2011","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.intimp.2022.108784_b0145","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2353\/ajpath.2009.080580","article-title":"FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions","volume":"174","author":"Taflin","year":"2009","journal-title":"The Am. J. Pathology"},{"issue":"1","key":"10.1016\/j.intimp.2022.108784_b0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.clim.2011.03.015","article-title":"Regulatory T cells with reduced repressor capacities are extensively amplified in pulmonary sarcoid lesions and sustain granuloma formation","volume":"140","author":"Rappl","year":"2011","journal-title":"Clin. Immunology"},{"issue":"5","key":"10.1016\/j.intimp.2022.108784_b0155","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1164\/rccm.201006-0865CI","article-title":"A concise review of pulmonary sarcoidosis","volume":"183","author":"Baughman","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"4","key":"10.1016\/j.intimp.2022.108784_b0160","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1164\/rccm.200909-1451OC","article-title":"Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis","volume":"182","author":"Prasse","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2022.108784_b0165","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3389\/fimmu.2013.00437","article-title":"Granuloma formation in pulmonary sarcoidosis","volume":"4","author":"Broos","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2022.108784_b0170","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1042\/bj2910701","article-title":"Biosynthesis of human acute-phase serum amyloid A protein (A-SAA) in vitro: the roles of mRNA accumulation, poly(A) tail shortening and translational efficiency","volume":"291","author":"Steel","year":"1993","journal-title":"Biochem. J."},{"issue":"8","key":"10.1016\/j.intimp.2022.108784_b0175","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.4049\/jimmunol.155.8.4004","article-title":"Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway","volume":"155","author":"Badolato","year":"1995","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2022.108784_b0180","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1373\/49.9.1510","article-title":"Potential usefulness of inflammatory markers to monitor respiratory functional impairment in sarcoidosis","volume":"49","author":"Rothkrantz-Kos","year":"2003","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.intimp.2022.108784_b0185","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1189\/jlb.0307133","article-title":"Expression and role of CCR6\/CCL20 chemokine axis in pulmonary sarcoidosis","volume":"82","author":"Facco","year":"2007","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108784_b0190","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.imlet.2008.07.013","article-title":"Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK (p38 and ERK1\/2) signaling pathways","volume":"121","author":"Sandri","year":"2008","journal-title":"Immunol. Lett."},{"issue":"7","key":"10.1016\/j.intimp.2022.108784_b0195","doi-asserted-by":"crossref","first-page":"102846","DOI":"10.1016\/j.autrev.2021.102846","article-title":"CCR6-CCL20 axis as a therapeutic target for autoimmune diseases","volume":"20","author":"Meitei","year":"2021","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"10.1016\/j.intimp.2022.108784_b0200","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00403-014-1493-3","article-title":"Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17\/Th2 imbalance of psoriasis","volume":"306","author":"Campanati","year":"2014","journal-title":"Arch. Dermatol. Res."},{"issue":"3","key":"10.1016\/j.intimp.2022.108784_b0205","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.4049\/jimmunol.1101647","article-title":"Difference in Th1 and Th17 lymphocyte adhesion to endothelium","volume":"188","author":"Alcaide","year":"2012","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108784_b0210","first-page":"485","article-title":"Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar","volume":"152","author":"Schmid","year":"1998","journal-title":"The Am. J. Pathology"},{"issue":"4","key":"10.1016\/j.intimp.2022.108784_b0215","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1183\/09031936.98.12040913","article-title":"Transforming growth factor-beta(1) in sarcoidosis","volume":"12","author":"Salez","year":"1998","journal-title":"Eur. Resp. J."},{"key":"10.1016\/j.intimp.2022.108784_b0220","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/5584_2014_106","article-title":"TGF-beta and SMADs mRNA Expression in Pulmonary Sarcoidosis","volume":"852","author":"Piotrowski","year":"2015","journal-title":"Respiratory Carcinogenesis"},{"key":"10.1016\/j.intimp.2022.108784_b0225","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12865-015-0123-y","article-title":"Immunoexpression of TGF-beta\/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients","volume":"16","author":"Piotrowski","year":"2015","journal-title":"BMC Immunology"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922002685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922002685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:40:06Z","timestamp":1761586806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922002685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":45,"alternative-id":["S1567576922002685"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108784","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum amyloid A\/anti-CCL20 induced the rebalance of Th17\/regulatory T cells in SodA-induced sarcoidosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108784"}}