{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:14:07Z","timestamp":1783163647860,"version":"3.54.6"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017585","name":"First Hospital of Jilin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.intimp.2022.108942","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T09:51:35Z","timestamp":1657187495000},"page":"108942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitro"],"prefix":"10.1016","volume":"110","author":[{"given":"Jiarui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruipeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2022.108942_b0005","article-title":"Education and training improve quality of life and decrease depression score in elderly population","volume":"13","author":"Nyandra","year":"2018","journal-title":"Eurasian J. Anal. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2022.108942_b0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.mpmed.2018.11.007","article-title":"Diabetes in the elderly","volume":"47","author":"Abdelhafiz","year":"2019","journal-title":"Medicine"},{"key":"10.1016\/j.intimp.2022.108942_b0015","first-page":"487","article-title":"The research progress on comprehensive treatment of primary liver cancer in the elderly","author":"Li","year":"2018","journal-title":"Chin. J. Hepatobil. Surg."},{"issue":"5","key":"10.1016\/j.intimp.2022.108942_b0020","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/cid\/ciy530","article-title":"Sepsis and risk of cancer among elderly adults in the United States","volume":"68","author":"Liu","year":"2019","journal-title":"Clin. Infect. Dis."},{"issue":"4","key":"10.1016\/j.intimp.2022.108942_b0025","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.cld.2008.07.007","article-title":"The global impact of hepatic fibrosis and end-stage liver disease","volume":"12","author":"Lim","year":"2008","journal-title":"Clin. Liver Dis."},{"issue":"3","key":"10.1016\/j.intimp.2022.108942_b0030","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/MOG.0000000000000176","article-title":"Aging and liver disease","volume":"31","author":"Kim","year":"2015","journal-title":"Curr. Opin. Gastroen."},{"issue":"6","key":"10.1016\/j.intimp.2022.108942_b0035","doi-asserted-by":"crossref","first-page":"1600469","DOI":"10.1002\/mnfr.201600469","article-title":"Canthaxanthin: From molecule to function","volume":"61","author":"Esatbeyoglu","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"issue":"4","key":"10.1016\/j.intimp.2022.108942_b0040","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1080\/00071660310001616200","article-title":"Effect of canthaxanthin content of the maternal diet on the antioxidant system of the developing chick","volume":"44","author":"Surai","year":"2003","journal-title":"Brit. Poultry. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2022.108942_b0045","doi-asserted-by":"crossref","first-page":"H225","DOI":"10.1111\/j.1750-3841.2009.01274.x","article-title":"Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells","volume":"74","author":"Chan","year":"2009","journal-title":"J. Food Sci."},{"issue":"9","key":"10.1016\/j.intimp.2022.108942_b0050","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrm2240","article-title":"Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?","volume":"8","author":"Giorgio","year":"2007","journal-title":"Nat. Rev. Mol. Cell Bio."},{"issue":"23\u201324","key":"10.1016\/j.intimp.2022.108942_b0055","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1101\/gad.343129.120","article-title":"Senescence and the SASP: many therapeutic avenues","volume":"34","author":"Birch","year":"2020","journal-title":"Gene Dev."},{"issue":"5","key":"10.1016\/j.intimp.2022.108942_b0060","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nsmb.3202","article-title":"SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence","volume":"23","author":"Tasselli","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"7179","key":"10.1016\/j.intimp.2022.108942_b0065","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nature06516","article-title":"The coming acceleration of global population ageing","volume":"451","author":"Lutz","year":"2008","journal-title":"Nature"},{"issue":"27","key":"10.1016\/j.intimp.2022.108942_b0070","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.3748\/wjg.14.4300","article-title":"Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis","volume":"14","author":"Gomaa","year":"2008","journal-title":"World J. Gastroentero: WJG"},{"issue":"3","key":"10.1016\/j.intimp.2022.108942_b0075","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/MOG.0000000000000176","article-title":"Aging and liver disease","volume":"31","author":"Kim","year":"2015","journal-title":"Curr. Opin. Gastroen."},{"issue":"2","key":"10.1016\/j.intimp.2022.108942_b0080","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1535370219898141","article-title":"Mechanisms of liver fibrosis and its role in liver cancer","volume":"245","author":"Dhar","year":"2020","journal-title":"Exp. Biol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2022.108942_b0085","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/35036093","article-title":"Hayflick, his limit, and cellular ageing","volume":"1","author":"Shay","year":"2000","journal-title":"Nat. Rev. Mol. Cell Bio."},{"issue":"5","key":"10.1016\/j.intimp.2022.108942_b0090","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/acel.12242","article-title":"Cellular senescence and aging: the role of B-MYB","volume":"13","author":"Mowla","year":"2014","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.intimp.2022.108942_b0095","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/cas.13184","article-title":"Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases","volume":"108","author":"Watanabe","year":"2017","journal-title":"Cancer Sci."},{"key":"10.1016\/j.intimp.2022.108942_b0100","article-title":"Aging, cell senescence, the pathogenesis and targeted therapies of osteoarthritis","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2022.108942_b0105","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2741\/reeves","article-title":"Activation of hepatic stellate cells\u2014a key issue in liver fibrosis","volume":"7","author":"Reeves","year":"2002","journal-title":"Front. Biosci."},{"issue":"1","key":"10.1016\/j.intimp.2022.108942_b0110","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/0471141755.ph1430s66","article-title":"The DEN and CCl4-induced mouse model of fibrosis and inflammation-associated hepatocellular carcinoma","volume":"66","author":"Uehara","year":"2014","journal-title":"Curr. Protocol. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108942_b0115","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.22034","article-title":"Liver: an organ with predominant innate immunity","volume":"47","author":"Gao","year":"2008","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.intimp.2022.108942_b0120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol.: J. Pathol. Soc. Great Brit. Ireland"},{"issue":"10","key":"10.1016\/j.intimp.2022.108942_b0125","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.bbadis.2013.06.001","article-title":"Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis","volume":"1832","author":"Nevzorova","year":"2013","journal-title":"BBA-Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.intimp.2022.108942_b0130","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1002\/hep.23594","article-title":"Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection","volume":"51","author":"Starley","year":"2010","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.intimp.2022.108942_b0135","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1053\/j.gastro.2004.09.011","article-title":"Primary liver cancer: worldwide incidence and trends","volume":"127","author":"Bosch","year":"2004","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.intimp.2022.108942_b0140","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","article-title":"The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: results from the global burden of disease study 2015","volume":"3","author":"Akinyemiju","year":"2017","journal-title":"JAMA Oncol."}],"updated-by":[{"DOI":"10.1016\/j.intimp.2022.109189","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000}}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692200426X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692200426X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T15:12:04Z","timestamp":1684595524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692200426X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":28,"alternative-id":["S156757692200426X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108942","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.intimp.2022.109189","asserted-by":"object"}]},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108942"}}