{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:50:53Z","timestamp":1768521053337,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.intimp.2022.108997","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T05:04:37Z","timestamp":1656219877000},"page":"108997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Protective effects of (R)-enantiomers but not (S)-enantiomers of \u03b22-adrenergic receptor agonists against acute colitis: The role of \u03b22AR"],"prefix":"10.1016","volume":"110","author":[{"given":"Liangjun","family":"Deng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingsong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2022.108997_b0005","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fmed.2018.00183","article-title":"A Systematic Review of Epidemiology and Risk Factors Associated With Chinese Inflammatory Bowel Disease","volume":"5","author":"Cui","year":"2018","journal-title":"Front. Med."},{"issue":"6","key":"10.1016\/j.intimp.2022.108997_b0010","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cgh.2016.10.039","article-title":"Incidence and Prevalence of Crohn's Disease and Ulcerative Colitis in Olmsted County, Minnesota From 1970 Through 2010","volume":"15","author":"Shivashankar","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"11","key":"10.1016\/j.intimp.2022.108997_b0015","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.mayocp.2014.07.002","article-title":"Ulcerative Colitis: Epidemiology, Diagnosis, and Management","volume":"89","author":"Feuerstein","year":"2014","journal-title":"Mayo Clin. Proc."},{"issue":"1","key":"10.1016\/j.intimp.2022.108997_b0020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4110\/in.2017.17.1.25","article-title":"Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies","volume":"17","author":"Kim","year":"2017","journal-title":"Immune Network"},{"key":"10.1016\/j.intimp.2022.108997_b0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.intimp.2019.05.013","article-title":"L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation","volume":"73","author":"He","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"6371","key":"10.1016\/j.intimp.2022.108997_b0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.aan3706","article-title":"Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors","volume":"359","author":"Routy","year":"2018","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.intimp.2022.108997_b0035","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1053\/j.gastro.2015.02.031","article-title":"Trough Concentrations of Infliximab Guide Dosing for Patients With Inflammatory Bowel Disease","volume":"148","author":"Vande Casteele","year":"2015","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.intimp.2022.108997_b0040","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1053\/j.gastro.2015.03.001","article-title":"Clinical Practice Guidelines for the Medical Management of Nonhospitalized Ulcerative Colitis: The Toronto Consensus","volume":"148","author":"Bressler","year":"2015","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.intimp.2022.108997_b0045","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/jcmm.14780","article-title":"Effect of (R)-salbutamol on the switch of phenotype and metabolic pattern in LPS-induced macrophage cells","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2022.108997_b0050","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3390\/cells9020511","article-title":"(R)-Salbutamol Improves Imiquimod-Induced Psoriasis-Like Skin Dermatitis by Regulating the Th17\/Tregs Balance and Glycerophospholipid Metabolism","volume":"9","author":"Liu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2022.108997_b0055","unstructured":"W. Tan, New use of R-enantiomer of adrenergic \u03b22 receptor agonists for treatment of inflammatory bowel disease and its extra intestinal manifestations, PCT Int. Appl NO. WO2020051568A1, 2018."},{"issue":"2","key":"10.1016\/j.intimp.2022.108997_b0060","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0091-6749(99)70276-9","article-title":"The asthma-like pharmacology and toxicology of (S)-isomers of beta agonists","volume":"104","author":"Handley","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2022.108997_b0065","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s12098-009-0245-4","article-title":"Levosalbutamol vs racemic salbutamol in the treatment of acute exacerbation of asthma","volume":"76","author":"Punj","year":"2009","journal-title":"Indian J. Pediatr."},{"issue":"3","key":"10.1016\/j.intimp.2022.108997_b0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00580-010-0979-4","article-title":"The dextran sulphate sodium (DSS) model of colitis: an overview","volume":"19","author":"Solomon","year":"2010","journal-title":"Comp. Clin. Pathol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108997_b0075","first-page":"238","article-title":"Clinicopathologic study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper","year":"1993","journal-title":"Lab. Invest."},{"issue":"17","key":"10.1016\/j.intimp.2022.108997_b0080","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.intimp.2022.108997_b0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.2276","article-title":"Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing","volume":"10","author":"Bokulich","year":"2013","journal-title":"Nat. Methods"},{"issue":"10","key":"10.1016\/j.intimp.2022.108997_b0090","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.intimp.2022.108997_b0095","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molimm.2019.12.008","article-title":"Effect of dehydroepiandrosterone on the immune response and gut microbiota in dextran sulfate sodium-induced colitis mice","volume":"118","author":"Cao","year":"2020","journal-title":"Mol. Immunol."},{"issue":"18","key":"10.1016\/j.intimp.2022.108997_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.aaz2630","article-title":"Graphene quantum dots as anti-inflammatory therapy for colitis","volume":"6","author":"Lee","year":"2020","journal-title":"Sci. Adv."},{"issue":"7","key":"10.1016\/j.intimp.2022.108997_b0105","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1517\/14656566.2011.571210","article-title":"(R)-salbutamol in the treatment of asthma and chronic obstructive airways disease","volume":"12","author":"Patel","year":"2011","journal-title":"Expert Opin. Pharmacother."},{"issue":"6","key":"10.1016\/j.intimp.2022.108997_b0110","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1365-2133.2009.09330.x","article-title":"A randomized controlled trial of R-salbutamol for topical treatment of discoid lupus erythematosus","volume":"161","author":"Jemec","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2022.108997_b0115","doi-asserted-by":"crossref","first-page":"9318721","DOI":"10.1155\/2022\/9318721","article-title":"The Attenuation of Chronic Ulcerative Colitis by (R)-salbutamol in Repeated DSS-Induced Mice","volume":"2022","author":"Deng","year":"2022","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"9","key":"10.1016\/j.intimp.2022.108997_b0120","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/ecco-jcc\/jjab048","article-title":"Results of the Seventh Scientific Workshop of ECCO: Precision medicine in IBD- prediction and prevention of inflammatory bowel disease","volume":"15","author":"Torres","year":"2021","journal-title":"J. Crohns. Colitis."},{"issue":"8","key":"10.1016\/j.intimp.2022.108997_b0125","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/carcin\/bgh146","article-title":"Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases","volume":"25","author":"Hagemann","year":"2004","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.intimp.2022.108997_b0130","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00580-017-2420-8","article-title":"Effect of salbutamol against the experimental acute colitis in rat model","volume":"26","author":"Hosseini","year":"2017","journal-title":"Comp. Clin. Pathol."},{"issue":"3","key":"10.1016\/j.intimp.2022.108997_b0135","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.chom.2019.01.007","article-title":"Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models","volume":"25","author":"Limon","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.intimp.2022.108997_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2017.00942","article-title":"Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2022.108997_b0145","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jiac.2015.07.010","article-title":"Intestinal microbiota and ulcerative colitis","volume":"21","author":"Ohkusa","year":"2015","journal-title":"J. Infect. Chemoth."},{"key":"10.1016\/j.intimp.2022.108997_b0150","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ebiom.2019.10.002","article-title":"A single faecal microbiota transplantation modulates the microbiome and improves clinical manifestations in a rat model of colitis","volume":"48","author":"Lleal","year":"2019","journal-title":"Ebiomedicine"},{"issue":"2","key":"10.1016\/j.intimp.2022.108997_b0155","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/cells8020193","article-title":"Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease-Focusing on Intestinal Barrier Function","volume":"8","author":"Schoultz","year":"2019","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.intimp.2022.108997_b0160","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1080\/19490976.2016.1190073","article-title":"Composition and function of the pediatric colonic mucosal microbiome in untreated patients with ulcerative colitis","volume":"7","author":"Shah","year":"2016","journal-title":"Gut Microbes"},{"issue":"5","key":"10.1016\/j.intimp.2022.108997_b0165","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1099\/jmm.0.46198-0","article-title":"Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis","volume":"55","author":"Lucke","year":"2006","journal-title":"J. Med. Microbiol."},{"issue":"12","key":"10.1016\/j.intimp.2022.108997_b0170","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s00109-015-1318-7","article-title":"Inhibition of TLR4 attenuates vascular dysfunction and oxidative stress in diabetic rats","volume":"93","author":"Carrillo-Sepulveda","year":"2015","journal-title":"J. Mol. Med.-Jmm"},{"key":"10.1016\/j.intimp.2022.108997_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-51878-3","article-title":"The abundance of Akkermansia muciniphila and its relationship with sulphated colonic mucins in health and ulcerative colitis","volume":"9","author":"Earley","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2022.108997_b0180","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1039\/C8FO02364F","article-title":"Anti-inflammation effects of fucosylated chondroitin sulphate from Acaudina molpadioides by altering gut microbiota in obese mice","volume":"10","author":"Hu","year":"2019","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.intimp.2022.108997_b0185","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cell.2015.12.023","article-title":"Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages","volume":"164","author":"Gabanyi","year":"2016","journal-title":"Cell"},{"issue":"6379","key":"10.1016\/j.intimp.2022.108997_b0190","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.aan4829","article-title":"beta(2)-adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses","volume":"359","author":"Moriyama","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.intimp.2022.108997_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.00736","article-title":"Adrenergic Signaling at the Interface of Allergic Asthma and Viral Infections","volume":"9","author":"Agac","year":"2018","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2022.108997_b0200","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1902\/jop.2017.160464","article-title":"Salmeterol, a Long-Acting beta 2-Adrenergic Receptor Agonist, Inhibits Macrophage Activation by Lipopolysaccharide From Porphyromonas gingivalis","volume":"88","author":"Sharma","year":"2017","journal-title":"J. Periodontol."},{"issue":"6","key":"10.1016\/j.intimp.2022.108997_b0205","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00281-020-00829-6","article-title":"Adrenergic regulation of immune cell function and inflammation","volume":"42","author":"Sharma","year":"2020","journal-title":"Semin. Immunopathol."},{"issue":"5","key":"10.1016\/j.intimp.2022.108997_b0210","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.immuni.2021.04.007","article-title":"Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation","volume":"54","author":"Schiller","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2022.108997_b0215","first-page":"1","article-title":"Excretory\/Secretory Products FromTrichinella spiralisAdult Worms Attenuated DSS-Induced Colitis in Mice by Driving PD-1-Mediated M2 Macrophage Polarization","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2022.108997_b0220","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108997_b0225","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/ppul.10027","article-title":"Levalbuterol hydrochloride","volume":"33","author":"Slattery","year":"2002","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.intimp.2022.108997_b0230","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.intimp.2019.04.036","article-title":"Differential effects of inhaled R- and S-terbutaline in ovalbumin-induced asthmatic mice","volume":"73","author":"Beng","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.108997_b0235","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/pharmaceutics12010035","article-title":"Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS","volume":"12","author":"Zhang","year":"2020","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.intimp.2022.108997_b0240","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/bph.14862","article-title":"Pharmacological targeting of beta2-adrenoceptors is neuroprotective in the LPS inflammatory rat model of Parkinson's disease","volume":"177","author":"O'Neill","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2022.108997_b0245","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/gutjnl-2020-322429","article-title":"Inflammatory bowel disease and Parkinson's disease: common pathophysiological links","volume":"70","author":"Lee","year":"2021","journal-title":"Gut"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922004817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922004817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:57:01Z","timestamp":1761587821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922004817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":49,"alternative-id":["S1567576922004817"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108997","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of (R)-enantiomers but not (S)-enantiomers of \u03b22-adrenergic receptor agonists against acute colitis: The role of \u03b22AR","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.108997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108997"}}