{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:35:07Z","timestamp":1790962507766,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.intimp.2022.109007","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:38:02Z","timestamp":1656524282000},"page":"109007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Andrographolide sodium bisulfite ameliorates dextran sulfate sodium-induced colitis and liver injury in mice via inhibiting macrophage proinflammatory polarization from the gut-liver axis"],"prefix":"10.1016","volume":"110","author":[{"given":"Fengkun","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziren","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10080","key":"10.1016\/j.intimp.2022.109007_b0005","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"The Lancet"},{"issue":"4","key":"10.1016\/j.intimp.2022.109007_b0010","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and Pathogenesis of Ulcerative Colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol Clin North Am"},{"issue":"12","key":"10.1016\/j.intimp.2022.109007_b0015","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1136\/gutjnl-2018-317571","article-title":"Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis","volume":"68","author":"van der Post","year":"2019","journal-title":"Gut"},{"issue":"10","key":"10.1016\/j.intimp.2022.109007_b0020","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/ibd\/izz149","article-title":"Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer","volume":"25","author":"Yao","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.intimp.2022.109007_b0025","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.intimp.2019.05.013","article-title":"L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation","volume":"73","author":"He","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2022.109007_b0030","article-title":"Wu-Mei-Wan Ameliorates Murine Ulcerative Colitis by Regulating Macrophage Polarization","volume":"13","author":"Yan","year":"2022","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.intimp.2022.109007_b0035","article-title":"Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis","volume":"2015","author":"Michielan","year":"2015","journal-title":"Clinical Evaluation, and Therapy of Leaky Gut, Mediators Inflamm"},{"issue":"5","key":"10.1016\/j.intimp.2022.109007_b0040","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2020.01.007","article-title":"AGA Technical Review on the Management of Moderate to Severe Ulcerative Colitis","volume":"158","author":"Singh","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2022.109007_b0045","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.15159.1","article-title":"Recent advances and emerging therapies in the non-surgical management of ulcerative colitis","volume":"7","author":"Wehkamp","year":"2018","journal-title":"F1000Res"},{"issue":"1","key":"10.1016\/j.intimp.2022.109007_b0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autrev.2013.06.004","article-title":"Innate and adaptive immunity in inflammatory bowel disease","volume":"13","author":"Geremia","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"3","key":"10.1016\/j.intimp.2022.109007_b0055","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s11605-021-05188-7","article-title":"The Role of Gut-Derived Lipopolysaccharides and the Intestinal Barrier in Fatty Liver Diseases","volume":"26","author":"An","year":"2022","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.intimp.2022.109007_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126707","article-title":"Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis","volume":"421","author":"Zhang","year":"2022","journal-title":"Journal of Hazardous Materials"},{"key":"10.1016\/j.intimp.2022.109007_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00322","article-title":"Hepatic Macrophages in Liver Injury","volume":"11","author":"Shan","year":"2020","journal-title":"Frontiers in Immunology"},{"issue":"3","key":"10.1016\/j.intimp.2022.109007_b0070","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/sji.12468","article-title":"Macrophage Phenotype in Liver Injury and Repair","volume":"85","author":"Sun","year":"2017","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.intimp.2022.109007_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114260","article-title":"beta-patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance","volume":"182","author":"Liu","year":"2020","journal-title":"Biochem Pharmacol"},{"issue":"sup1","key":"10.1016\/j.intimp.2022.109007_b0080","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1080\/10408398.2018.1501657","article-title":"Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide","volume":"59","author":"Dai","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"10.1016\/j.intimp.2022.109007_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26010005","article-title":"Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism","volume":"26","author":"Burgos","year":"2020","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.intimp.2022.109007_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/ph14111102","article-title":"Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System","volume":"14","author":"Adiguna","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"issue":"2","key":"10.1016\/j.intimp.2022.109007_b0095","first-page":"465","article-title":"Andrographolide presents therapeutic effect on ulcerative colitis through the inhibition of IL-23\/IL-17 axis","volume":"10","author":"Zhu","year":"2018","journal-title":"American Journal of Translational Research"},{"issue":"9","key":"10.1016\/j.intimp.2022.109007_b0100","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.drudis.2019.05.017","article-title":"Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents","volume":"24","author":"Soo","year":"2019","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.intimp.2022.109007_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103511","article-title":"Andrographolide: Chemical modification and its effect on biological activities","volume":"95","author":"Kumar","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.intimp.2022.109007_b0110","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jchromb.2012.09.013","article-title":"Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS\/MS and its application to pharmacokinetics","volume":"907","author":"Zhang","year":"2012","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"1","key":"10.1016\/j.intimp.2022.109007_b0115","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jchromb.2011.11.006","article-title":"Quantification of andrographolide sodium bisulphite in urine after intravenous injection to rats by LC-MS\/MS","volume":"880","author":"Zhang","year":"2012","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"2","key":"10.1016\/j.intimp.2022.109007_b0120","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.intimp.2015.04.025","article-title":"Gastroprotective effect of andrographolide sodium bisulfite against indomethacin-induced gastric ulceration in rats","volume":"26","author":"Liu","year":"2015","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2022.109007_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113646","article-title":"Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK","volume":"170","author":"Kim","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2022.109007_b0130","article-title":"Comparative Transcriptomic Analysis Reveals the Immunosuppressive Targets of Mesalazine in Dextran Sulfate Sodium-Induced Ulcerative Colitis","volume":"12","author":"Li","year":"2021","journal-title":"Frontiers in Genetics"},{"issue":"4","key":"10.1016\/j.intimp.2022.109007_b0135","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/acs.jnatprod.5b01071","article-title":"Anti-inflammatory Actions of (+)-3'alpha-Angeloxy-4'-keto-3',4'-dihydroseselin (Pd-Ib) against Dextran Sulfate Sodium-Induced Colitis in C57BL\/6 Mice","volume":"79","author":"Mu","year":"2016","journal-title":"J Nat Prod"},{"issue":"8","key":"10.1016\/j.intimp.2022.109007_b0140","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.metabol.2015.11.008","article-title":"Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"65","author":"Brown","year":"2016","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.intimp.2022.109007_b0145","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2982.2012.01921.x","article-title":"Intestinal barrier function in health and gastrointestinal disease","volume":"24","author":"Camilleri","year":"2012","journal-title":"Neurogastroenterol Motil"},{"issue":"1","key":"10.1016\/j.intimp.2022.109007_b0150","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mayocp.2018.09.013","article-title":"Mechanisms of Disease: Inflammatory Bowel Diseases","volume":"94","author":"Ramos","year":"2019","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"10.1016\/j.intimp.2022.109007_b0155","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029181","article-title":"Cell-Cell Junctions Organize Structural and Signaling Networks","volume":"10","author":"Garcia","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"10.1016\/j.intimp.2022.109007_b0160","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bbamem.2007.07.012","article-title":"Adherens and tight junctions: structure, function and connections to the actin cytoskeleton","volume":"1778","author":"Hartsock","year":"2008","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.intimp.2022.109007_b0165","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12673","article-title":"Inhibition of CREB-mediated ZO-1 and activation of NF-kappaB-induced IL-6 by colonic epithelial MCT4 destroys intestinal barrier function","volume":"52","author":"Zhang","year":"2019","journal-title":"Cell Prolif"},{"issue":"6","key":"10.1016\/j.intimp.2022.109007_b0170","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002899","article-title":"Adherens junction: molecular architecture and regulation","volume":"1","author":"Meng","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"10.1016\/j.intimp.2022.109007_b0175","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00441-014-1994-6","article-title":"Defects in the adherens junction complex (E-cadherin\/ beta-catenin) in inflammatory bowel disease","volume":"360","author":"Mehta","year":"2015","journal-title":"Cell Tissue Res"},{"issue":"8","key":"10.1016\/j.intimp.2022.109007_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008766","article-title":"YAP in epithelium senses gut barrier loss to deploy defenses against pathogens","volume":"16","author":"Ma","year":"2020","journal-title":"PLoS Pathog"},{"issue":"7","key":"10.1016\/j.intimp.2022.109007_b0185","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1002\/cbin.11345","article-title":"YAP nuclear-cytoplasmic translocation is regulated by mechanical signaling, protein modification, and metabolism","volume":"44","author":"Zou","year":"2020","journal-title":"Cell Biol Int"},{"issue":"4","key":"10.1016\/j.intimp.2022.109007_b0190","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.devcel.2020.07.009","article-title":"Intestinal Regeneration: Regulation by the Microenvironment","volume":"54","author":"Hageman","year":"2020","journal-title":"Dev Cell"},{"issue":"9","key":"10.1016\/j.intimp.2022.109007_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9091264","article-title":"Yes-Associated Protein Is Required for ZO-1-Mediated Tight-Junction Integrity and Cell Migration in E-Cadherin-Restored AGS Gastric Cancer Cells","volume":"9","author":"Kim","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.intimp.2022.109007_b0200","doi-asserted-by":"crossref","unstructured":"X. Zhou, W. Li, S. Wang, P. Zhang, Q. Wang, J. Xiao, C. Zhang, X. Zheng, X. Xu, S. Xue, L. Hui, H. Ji, B. Wei, H. Wang, YAP Aggravates Inflammatory Bowel Disease by Regulating M1\/M2 Macrophage Polarization and Gut Microbial Homeostasis, Cell Rep 27(4) (2019) 1176-1189 e5.","DOI":"10.1016\/j.celrep.2019.03.028"},{"issue":"49","key":"10.1016\/j.intimp.2022.109007_b0205","volume":"6","author":"Meli","year":"2020","journal-title":"YAP-mediated mechanotransduction tunes the macrophage inflammatory response"},{"issue":"3","key":"10.1016\/j.intimp.2022.109007_b0210","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/08830185.2015.1087518","article-title":"The Characteristics and Function of Bacterial Lipopolysaccharides and Their Endotoxic Potential in Humans","volume":"35","author":"Gnauck","year":"2016","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.intimp.2022.109007_b0215","doi-asserted-by":"crossref","first-page":"2617881","DOI":"10.1155\/2021\/2617881","article-title":"Ficus pandurata Hance Inhibits Ulcerative Colitis and Colitis-Associated Secondary Liver Damage of Mice by Enhancing Antioxidation Activity","volume":"2021","author":"Dai","year":"2021","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"10.1016\/j.intimp.2022.109007_b0220","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/jhg.2011.105","article-title":"Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels","volume":"56","author":"Shen","year":"2011","journal-title":"J Hum Genet"},{"key":"10.1016\/j.intimp.2022.109007_b0225","series-title":"Small Animal Clinical Diagnosis by Laboratory Methods (Fifth Edition)","first-page":"191","article-title":"9 - Gastrointestinal, Pancreatic, and Hepatic Disorders","author":"Willard","year":"2012"},{"issue":"2","key":"10.1016\/j.intimp.2022.109007_b0230","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/hep.31056","article-title":"Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD","volume":"72","author":"Carpino","year":"2020","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.intimp.2022.109007_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020379","article-title":"Recent Advances in Lipopolysaccharide Recognition Systems","volume":"21","author":"Mazgaeen","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"10.1016\/j.intimp.2022.109007_b0240","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00018-020-03656-y","article-title":"TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling","volume":"78","author":"Ciesielska","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.intimp.2022.109007_b0245","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S140188","article-title":"Mechanisms of NF-kappaB p65 and strategies for therapeutic manipulation","volume":"11","author":"Giridharan","year":"2018","journal-title":"J Inflamm Res"},{"issue":"6","key":"10.1016\/j.intimp.2022.109007_b0250","first-page":"476","article-title":"immunotoxicology","volume":"40","author":"Wang","year":"2018","journal-title":"Curcumin as a therapeutic agent for blocking NF-\u03baB activation in ulcerative colitis"},{"issue":"5","key":"10.1016\/j.intimp.2022.109007_b0255","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7150\/ijbs.8879","article-title":"Macrophage polarization in inflammatory diseases","volume":"10","author":"Liu","year":"2014","journal-title":"Int J Biol Sci"},{"issue":"6","key":"10.1016\/j.intimp.2022.109007_b0260","first-page":"1297","article-title":"Monocyte and M1 Macrophage-induced Barrier Defect Contributes to Chronic Intestinal Inflammation in IBD","volume":"21","author":"Lissner","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.intimp.2022.109007_b0265","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bcp.2017.08.013","article-title":"Chromofungin (CHR: CHGA47-66) is downregulated in persons with active ulcerative colitis and suppresses pro-inflammatory macrophage function through the inhibition of NF-kappaB signaling","volume":"145","author":"Eissa","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.intimp.2022.109007_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-380995-7.00001-X","article-title":"Macrophage proinflammatory activation and deactivation: a question of balance","volume":"108","author":"Valledor","year":"2010","journal-title":"Adv Immunol"},{"issue":"3","key":"10.1016\/j.intimp.2022.109007_b0275","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","article-title":"The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"16","author":"Kazankov","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.intimp.2022.109007_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113517","article-title":"Chemical profile of Xian-He-Cao-Chang-Yan formula and its effects on ulcerative colitis","volume":"267","author":"Li","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.intimp.2022.109007_b0285","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.intimp.2015.11.031","article-title":"The pentacyclic triterpene Lupeol switches M1 macrophages to M2 and ameliorates experimental inflammatory bowel disease","volume":"30","author":"Zhu","year":"2016","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.intimp.2022.109007_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107591","article-title":"BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-\u03baB dependent macrophage polarization","volume":"96","author":"Jiang","year":"2021","journal-title":"International Immunopharmacology"},{"issue":"2","key":"10.1016\/j.intimp.2022.109007_b0295","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/0960327115579429","article-title":"Metabolic changes in the urine of andrographolide sodium bisulfite-treated rats","volume":"35","author":"Xu","year":"2016","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.intimp.2022.109007_b0300","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-017-0124-2","article-title":"Non-alcoholic fatty liver disease phenotypes in patients with inflammatory bowel disease","volume":"9","author":"Sartini","year":"2018","journal-title":"Cell Death & Disease"},{"issue":"7","key":"10.1016\/j.intimp.2022.109007_b0305","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.crohns.2013.12.006","article-title":"Detection of liver injury in IBD using transient elastography","volume":"8","author":"Thin","year":"2014","journal-title":"Journal of Crohns & Colitis"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692200491X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692200491X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:59:41Z","timestamp":1761587981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692200491X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":61,"alternative-id":["S156757692200491X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109007","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Andrographolide sodium bisulfite ameliorates dextran sulfate sodium-induced colitis and liver injury in mice via inhibiting macrophage proinflammatory polarization from the gut-liver axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109007"}}