{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:27:08Z","timestamp":1790364428101,"version":"4.1.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.intimp.2022.109032","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T05:48:33Z","timestamp":1657259313000},"page":"109032","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["The immunoregulatory effects of natural products on psoriasis via its action on Th17 cells versus regulatory T cells balance"],"prefix":"10.1016","volume":"110","author":[{"given":"Lingyuan","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingsheng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0005","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jdv.13854","article-title":"A systematic review of worldwide epidemiology of psoriasis","volume":"31","author":"Michalek","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0010","first-page":"187","article-title":"Prevalence of psoriasis in children and adolescents in the United States: a claims-based analysis","volume":"17","author":"Paller","year":"2018","journal-title":"J. Drugs Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0015","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/bjd.19169","article-title":"Systematic review examining changes over time and variation in the incidence and prevalence of psoriasis by age and gender","volume":"184","author":"Iskandar","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"10281","key":"10.1016\/j.intimp.2022.109032_b0020","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/abd1806-4841.20153038","article-title":"Psoriasis: classical and emerging comorbidities","volume":"90","author":"Oliveira","year":"2015","journal-title":"An. Bras. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0030","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/ijms19010058","article-title":"Cardiometabolic comorbidities in psoriasis and psoriatic arthritis","volume":"19","author":"Puig","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2022.109032_b0035","unstructured":"Organization WH, Global Report on Psoriasis, World Health Organization, 2016."},{"issue":"19","key":"10.1016\/j.intimp.2022.109032_b0040","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/bjd.19380","article-title":"Role of regulatory T cells in psoriasis pathogenesis and treatment","volume":"184","author":"Nussbaum","year":"2021","journal-title":"Br. J. Dermatol."},{"issue":"13","key":"10.1016\/j.intimp.2022.109032_b0050","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.celrep.2018.12.012","article-title":"Regulatory T cells restrain pathogenic T helper cells during skin inflammation","volume":"25","author":"Hartwig","year":"2018","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.intimp.2022.109032_b0055","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1084\/jem.20172094","article-title":"Foxp3(+) T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8(+) T cell response","volume":"215","author":"Stockenhuber","year":"2018","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0060","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jaad.2018.11.057","article-title":"Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics","volume":"80","author":"Menter","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/09546630802441234","article-title":"Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases","volume":"20","author":"Ko","year":"2009","journal-title":"J. Dermatolog. Treat."},{"issue":"6","key":"10.1016\/j.intimp.2022.109032_b0070","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1365-2133.2010.10005.x","article-title":"Onset of psoriasis following treatment with tocilizumab","volume":"163","author":"Laurent","year":"2010","journal-title":"Br. J. Dermatol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109032_b0075","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/14712598.2020.1727439","article-title":"Clinical and histopathological characterization of eczematous eruptions occurring in course of anti IL-17 treatment: a case series and review of the literature","volume":"20","author":"Caldarola","year":"2020","journal-title":"Expert Opin. Biol. Ther."},{"issue":"11","key":"10.1016\/j.intimp.2022.109032_b0080","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1001\/jamadermatol.2018.2972","article-title":"Complementary and alternative medicine therapies for psoriasis: a systematic review","volume":"154","author":"Gamret","year":"2018","journal-title":"JAMA Dermatol."},{"issue":"115","key":"10.1016\/j.intimp.2022.109032_b0085","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bcp.2016.06.001","article-title":"Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88","volume":"1","author":"Shao","year":"2016","journal-title":"Biochem Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0090","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ng.2827","article-title":"A large-scale screen for coding variants predisposing to psoriasis","volume":"46","author":"Tang","year":"2014","journal-title":"Nat Genet."},{"issue":"8","key":"10.1016\/j.intimp.2022.109032_b0095","doi-asserted-by":"crossref","first-page":"15382","DOI":"10.1038\/ncomms15382","article-title":"Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants","volume":"24","author":"Tsoi","year":"2017","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.intimp.2022.109032_b0100","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.clindermatol.2007.08.015","article-title":"Triggering psoriasis: the role of infections and medications","volume":"25","author":"Fry","year":"2007","journal-title":"Clin. Dermatol."},{"issue":"10","key":"10.1016\/j.intimp.2022.109032_b0105","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/jdv.12001","article-title":"Obesity, waist circumference, weight change and the risk of psoriasis in US women","volume":"27","author":"Kumar","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109032_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062979","article-title":"Psoriasis: pathogenesis, comorbidities, and therapy updated","volume":"22","author":"Kanda","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2022.109032_b0115","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nri2295","article-title":"TH17 cells in development: an updated view of their molecular identity and genetic programming","volume":"8","author":"Dong","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2022.109032_b0120","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and TH17 cells in chronic inflammation","volume":"11","author":"Miossec","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.intimp.2022.109032_b0125","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000330330","article-title":"Th1, Th2, Th17 and regulatory T cell pattern in psoriatic patients: modulation of cytokines and gene targets induced by etanercept treatment and correlation with clinical response","volume":"223","author":"Quaglino","year":"2011","journal-title":"Dermatology"},{"issue":"5","key":"10.1016\/j.intimp.2022.109032_b0135","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.intimp.2010.11.008","article-title":"FOXP3 and ROR\u03b3t: transcriptional regulation of Treg and Th17","volume":"11","author":"Chen","year":"2011","journal-title":"Int. Immunopharmacol."},{"issue":"7152","key":"10.1016\/j.intimp.2022.109032_b0140","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","article-title":"Essential autocrine regulation by IL-21 in the generation of inflammatory T cells","volume":"448","author":"Nurieva","year":"2007","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2022.109032_b0145","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.4049\/jimmunol.176.3.1908","article-title":"In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin","volume":"176","author":"Piskin","year":"2006","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109032_b0150","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12016-016-8535-x","article-title":"The inflammatory response in psoriasis: a comprehensive review","volume":"50","author":"Deng","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109032_b0155","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/jid.2009.59","article-title":"The IL-23\/Th17 axis in the immunopathogenesis of psoriasis","volume":"129","author":"Di Cesare","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.intimp.2022.109032_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.788940","article-title":"The role of helper T cells in psoriasis","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0165","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ni.2554","article-title":"Regulatory T cells: recommendations to simplify the nomenclature","volume":"14","author":"Abbas","year":"2013","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109032_b0170","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/imm.12791","article-title":"Regulatory T cells in skin","volume":"152","author":"Ali","year":"2017","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.intimp.2022.109032_b0175","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2022.109032_b0180","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2006.00427.x","article-title":"Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease","volume":"212","author":"Sakaguchi","year":"2006","journal-title":"Immunol. Rev."},{"issue":"7","key":"10.1016\/j.intimp.2022.109032_b0185","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nri2343","article-title":"How regulatory T cells work","volume":"8","author":"Vignali","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0190","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.autrev.2014.10.012","article-title":"Regulatory T-cells in autoimmune diseases: challenges, controversies and\u2013yet\u2013unanswered questions","volume":"14","author":"Grant","year":"2015","journal-title":"Autoimmun. Rev."},{"issue":"suppl_1","key":"10.1016\/j.intimp.2022.109032_b0195","doi-asserted-by":"crossref","first-page":"i55","DOI":"10.1093\/rheumatology\/kew427","article-title":"Pathways leading to an immunological disease: systemic lupus erythematosus","volume":"56","author":"Zharkova","year":"2017","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0200","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/jimmunol.174.1.164","article-title":"Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation","volume":"174","author":"Sugiyama","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0205","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.det.2014.09.002","article-title":"The immunopathogenesis of psoriasis","volume":"33","author":"Kim","year":"2015","journal-title":"Dermatol. Clin."},{"issue":"3","key":"10.1016\/j.intimp.2022.109032_b0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19030730","article-title":"The balance of Th17 versus treg cells in autoimmunity","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2022.109032_b0215","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1038\/jid.2011.139","article-title":"Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin","volume":"131","author":"Bovenschen","year":"2011","journal-title":"J Invest Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109032_b0220","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/sji.12404","article-title":"Characterization of Th17 and FoxP3(+) treg cells in paediatric psoriasis patients","volume":"83","author":"Zhang","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.intimp.2022.109032_b0225","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.biopha.2017.06.055","article-title":"MiR-200a expression in CD4+ T cells correlates with the expression of Th17\/Treg cells and relevant cytokines in psoriasis vulgaris: a case control study","volume":"93","author":"Wang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2022.109032_b0230","doi-asserted-by":"crossref","first-page":"3069521","DOI":"10.1155\/2018\/3069521","article-title":"Notch1 signaling regulates the Th17\/treg immune imbalance in patients with psoriasis vulgaris","volume":"2018","author":"Ma","year":"2018","journal-title":"Mediators Inflamm."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00403-010-1080-1","article-title":"Definition of treatment goals for moderate to severe psoriasis: a European consensus","volume":"303","author":"Mrowietz","year":"2011","journal-title":"Arch. Dermatol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0240","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jaad.2017.10.051","article-title":"Change over time in the rates of adverse events in patients receiving systemic therapy for psoriasis: a cohort study","volume":"78","author":"Descalzo","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"issue":"20","key":"10.1016\/j.intimp.2022.109032_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207488","article-title":"New treatment addressing the pathogenesis of psoriasis","volume":"21","author":"Tokuyama","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0250","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jid.2017.09.044","article-title":"Differential drug survival of second-line biologic therapies in patients with psoriasis: observational cohort study from the British association of dermatologists biologic interventions register (BADBIR)","volume":"138","author":"Iskandar","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109032_b0255","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/bjd.16776","article-title":"Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study","volume":"180","author":"Warren","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0260","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1142\/S0192415X18500386","article-title":"The immunoregulatory effects of traditional Chinese medicine on psoriasis via its action on interleukin: advances and considerations","volume":"46","author":"Wu","year":"2018","journal-title":"Am. J. Chin. Med."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0265","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jaad.2018.06.057","article-title":"Psoriasis: Which therapy for which patient: psoriasis comorbidities and preferred systemic agents","volume":"80","author":"Kaushik","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.intimp.2022.109032_b0270","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/molecules21101321","article-title":"Anti-inflammatory activity of natural products","volume":"21","author":"Azab","year":"2016","journal-title":"Molecules"},{"issue":"285","key":"10.1016\/j.intimp.2022.109032_b0275","article-title":"Total withanolides ameliorates imiquimod-induced psoriasis-like skin inflammation","volume":"1","author":"Su","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2022.109032_b0280","doi-asserted-by":"crossref","unstructured":"Y. Su, Q. Wang, B. Yang, L. Wu, G. Cheng, H. Kuang, Withasteroid B from D. metel L. regulates immune responses by modulating the JAK\/STAT pathway and the IL-17(+) ROR\u03b3t(+) \/IL-10(+) FoxP3(+) ratio, Clin. Exp. Immunol. 190 (1) (2017) 40\u201353.","DOI":"10.1111\/cei.12998"},{"issue":"03","key":"10.1016\/j.intimp.2022.109032_b0285","first-page":"25","article-title":"Effect of Yangjinhua compounds on CD4+T cell subsets","volume":"31","author":"Yang","year":"2017","journal-title":"Modern Chin. Med. Res. Practice"},{"key":"10.1016\/j.intimp.2022.109032_b0290","unstructured":"S. Yang, R. Wenchen, L. Shanshan, W. lun, G. Jian, W. Qiuhong, et al., The effect of Datura metel L. on intestinal Th17\/Treg in psoriasis mice based on intestine-immune-skin axis, Modern Chin. Med. Res. Practice 32 (05) (2018) 27\u201330."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0295","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1055\/s-0043-123472","article-title":"New pharmacological opportunities for betulinic acid","volume":"84","author":"R\u00edos","year":"2018","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2022.109032_b0300","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.intimp.2019.05.030","article-title":"Betulinic acid suppresses Th17 response and ameliorates psoriasis-like murine skin inflammation","volume":"73","author":"Liu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2022.109032_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106070","article-title":"Effects of luteolin on treatment of psoriasis by repressing HSP90","volume":"79","author":"Lv","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0310","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0367-326X(99)00161-6","article-title":"Characterization of proanthocyanidins from grape seeds","volume":"71","author":"Gabetta","year":"2000","journal-title":"Fitoterapia"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2022.109032_b0315","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.imlet.2010.09.011","article-title":"Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3(+) regulatory and IL-17(+) pathogenic T cell in autoimmune arthritis","volume":"135","author":"Park","year":"2011","journal-title":"Immunol. Lett."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0320","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","article-title":"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma","volume":"28","author":"Yang","year":"2008","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0325","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/mnfr.200700389","article-title":"Ursolic acid: an anti- and pro-inflammatory triterpenoid","volume":"52","author":"Ikeda","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"issue":"26","key":"10.1016\/j.intimp.2022.109032_b0330","doi-asserted-by":"crossref","first-page":"22707","DOI":"10.1074\/jbc.C111.250407","article-title":"Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein","volume":"286","author":"Xu","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.intimp.2022.109032_b0335","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1080\/14786419.2015.1010084","article-title":"Study of quantitative and qualitative variations in essential oils of Sicilian Rosmarinus officinalis L","volume":"29","author":"Tuttolomondo","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.intimp.2022.109032_b0340","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.intimp.2018.12.021","article-title":"Thymol as a reciprocal regulator of T cell differentiation: promotion of regulatory T cells and suppression of Th1\/Th17 cells","volume":"67","author":"Namdari","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0345","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.intimp.2014.01.027","article-title":"Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2\/STAT3 pathway","volume":"19","author":"Xu","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0350","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s10753-019-00982-7","article-title":"Shikonin controls the differentiation of CD4(+)CD25(+) regulatory T cells by inhibiting AKT\/mTOR pathway","volume":"42","author":"Zhang","year":"2019","journal-title":"Inflammation"},{"issue":"1\u20133","key":"10.1016\/j.intimp.2022.109032_b0355","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2012.03.035","article-title":"Dihydroquercetin: more than just an impurity?","volume":"684","author":"Weidmann","year":"2012","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2022.109032_b0360","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/ptr.3084","article-title":"Effect of taxifolin glycoside on atopic dermatitis-like skin lesions in NC\/Nga mice","volume":"24","author":"Ahn","year":"2010","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0365","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.taap.2015.06.002","article-title":"Taxifolin protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload","volume":"287","author":"Guo","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109032_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109747","article-title":"Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2\/STAT3 signal pathways","volume":"123","author":"Yuan","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.intimp.2022.109032_b0375","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22030387","article-title":"Pharmacological activities and synthesis of esculetin and its derivatives: a mini-review","volume":"22","author":"Liang","year":"2017","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.intimp.2022.109032_b0380","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2174\/0929867053507315","article-title":"Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity","volume":"12","author":"Borges","year":"2005","journal-title":"Curr. Med. Chem."},{"issue":"814","key":"10.1016\/j.intimp.2022.109032_b0385","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejphar.2017.08.025","article-title":"Esculetin exerts antitumor effect on human gastric cancer cells through IGF-1\/PI3K\/Akt signaling pathway","volume":"5","author":"Wang","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109032_b0390","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbrc.2018.04.195","article-title":"Esculetin inhibits oxidative stress and apoptosis in H9c2 cardiomyocytes following hypoxia\/reoxygenation injury","volume":"501","author":"He","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2022.109032_b0395","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.3389\/fimmu.2018.02092","article-title":"Esculetin ameliorates psoriasis-like skin disease in mice by inducing CD4(+)Foxp3(+) regulatory T cells","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Immunol."},{"issue":"772","key":"10.1016\/j.intimp.2022.109032_b0400","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejphar.2015.12.040","article-title":"Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion","volume":"5","author":"Zhao","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109032_b0405","series-title":"Study on the Effect and Molecular Mechanism of Paeoniflor in Inhibiting the Expression of Keratin 17 in the Treatment of Psoriasis Air Force","author":"Chen","year":"2019"},{"issue":"27","key":"10.1016\/j.intimp.2022.109032_b0410","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.1021\/jf401191q","article-title":"Identification and quantification of phytochemical composition and anti-inflammatory, cellular antioxidant, and radical scavenging activities of 12 Plantago species","volume":"61","author":"Zhou","year":"2013","journal-title":"J. Agric. Food Chem."},{"issue":"34","key":"10.1016\/j.intimp.2022.109032_b0415","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.1021\/jf501963a","article-title":"Utility of hesperidinase for food function research: enzymatic digestion of botanical extracts alters cellular antioxidant capacities and anti-inflammatory properties","volume":"62","author":"Yu","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2022.109032_b0420","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.intimp.2015.12.035","article-title":"Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB\/c mice via Jak3\/Stat3 signaling pathway","volume":"32","author":"Di","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109032_b0425","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1021\/jf000892m","article-title":"Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants","volume":"49","author":"Miean","year":"2001","journal-title":"J. Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0430","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.foodchem.2012.11.139","article-title":"A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention","volume":"138","author":"Chen","year":"2013","journal-title":"Food Chem."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0435","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ptr.6227","article-title":"Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: a comprehensive review","volume":"33","author":"Imran","year":"2019","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.intimp.2022.109032_b0440","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/cei.13363","article-title":"Kaempferol attenuates imiquimod-induced psoriatic skin inflammation in a mouse model","volume":"198","author":"Liu","year":"2019","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109032_b0445","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.intimp.2015.03.044","article-title":"Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation","volume":"28","author":"Lin","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"03","key":"10.1016\/j.intimp.2022.109032_b0450","first-page":"20","article-title":"Effect of Rumex L. on the expression of transforming growth factor\u2013\u03b21 neuropilin-1 in the skin tissue of mice with psoriasis","volume":"29","author":"Rabigul","year":"2020","journal-title":"China Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.intimp.2022.109032_b0455","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1742-7843.2010.00653.x","article-title":"In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait","volume":"108","author":"Lin","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109032_b0460","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3892\/ijmm.2014.1718","article-title":"Aloperine induces G2\/M phase cell cycle arrest and apoptosis in HCT116 human colon cancer cells","volume":"33","author":"Zhang","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"8","key":"10.1016\/j.intimp.2022.109032_b0465","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13045-015-0120-x","article-title":"Aloperine executes antitumor effects against multiple myeloma through dual apoptotic mechanisms","volume":"15","author":"Wang","year":"2015","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2022.109032_b0470","series-title":"Aloperine Attenuates IMQ-induced Psoriasis in Mice by Regulating IL-23\/Th17 Axis and Treg Cell Stability","author":"Zhou","year":"2019"},{"key":"10.1016\/j.intimp.2022.109032_b0475","unstructured":"X. Li, Study on the Mechanism of Rosin in the Treatment of Psoriatic Dermatitis and Related Substances, Nanjing University of Traditional Chinese Medicine, 2020."},{"issue":"272","key":"10.1016\/j.intimp.2022.109032_b0480","article-title":"Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice","volume":"23","author":"Li","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"761","key":"10.1016\/j.intimp.2022.109032_b0485","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejphar.2015.05.068","article-title":"Current knowledge and pharmacological profile of berberine: an update","volume":"15","author":"Kumar","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0490","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41419-019-1510-8","article-title":"Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes","volume":"10","author":"Sun","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2022.109032_b0495","unstructured":"X. Yin, Study on the mechanism of \u201cBuShengPeiYuan\u201d method based on intervention of medicinalindianmulberry root polysaccharid (MOP) on immune regulation function of adipose mesenchymal stem cellsin in psoriasis patients, China Acad. Chin. Med. Sci. (2017)."},{"key":"10.1016\/j.intimp.2022.109032_b0500","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.biochi.2015.02.004","article-title":"The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus","volume":"111","author":"Cen","year":"2015","journal-title":"Biochimie"},{"issue":"9","key":"10.1016\/j.intimp.2022.109032_b0505","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1016\/j.fct.2012.06.003","article-title":"Anti-skin cancer properties of phenolic-rich extract from the pericarp of mangosteen (Garcinia mangostana Linn.)","volume":"50","author":"Wang","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109032_b0510","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1021\/acs.jafc.6b05207","article-title":"Isogarcinol extracted from Garcinia mangostana L. Ameliorates imiquimod-induced psoriasis-like skin lesions in mice","volume":"65","author":"Chen","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2022.109032_b0515","article-title":"C26H26N4O10 suppressed Th17 differentiation and the pathogenesis of imiquimod-induced psoriasis","volume":"4","author":"Li","year":"2017","journal-title":"Int. J. Sci."},{"key":"10.1016\/j.intimp.2022.109032_b0520","doi-asserted-by":"crossref","unstructured":"M. Wang, T. Li, Z. Ouyang, K. Tang, Y. Zhu, C. Song, et al., SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23\/Th17 axis, iScience 25 (4) (2022) 104009.","DOI":"10.1016\/j.isci.2022.104009"},{"issue":"3","key":"10.1016\/j.intimp.2022.109032_b0525","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114455","article-title":"Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis","volume":"14","author":"Zhu","year":"2022","journal-title":"EMBO Mol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:51:27Z","timestamp":1778820687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922005161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":105,"alternative-id":["S1567576922005161"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109032","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The immunoregulatory effects of natural products on psoriasis via its action on Th17 cells versus regulatory T cells balance","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109032"}}