{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:08:47Z","timestamp":1791083327081,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.intimp.2022.109039","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T02:37:53Z","timestamp":1659148673000},"page":"109039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Secoisolariciresinol diglucoside-derived metabolite, enterolactone, attenuates atopic dermatitis by suppressing Th2 immune response"],"prefix":"10.1016","volume":"111","author":[{"given":"Lu","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qishan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ledong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-9474","authenticated-orcid":false,"given":"Daming","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.intimp.2022.109039_b0005","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/exd.13698","article-title":"Toll-like receptor 4 attenuates a murine model of atopic dermatitis through inhibition of langerin-positive DCs migration","volume":"27","author":"Lin","year":"2018","journal-title":"Exp. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109039_b0010","doi-asserted-by":"crossref","DOI":"10.4172\/2155-9899.1000110","article-title":"Th2 cytokines and atopic dermatitis","volume":"2","author":"Brandt","year":"2011","journal-title":"J. Clin Cell. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109039_b0015","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jsps.2017.04.035","article-title":"Polysaccharide extracted from Chinese white wax scale ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB\/c mice","volume":"25","author":"Lin","year":"2017","journal-title":"Saudi Pharm. J."},{"issue":"2","key":"10.1016\/j.intimp.2022.109039_b0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.intimp.2022.109039_b0025","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1038\/jid.2015.318","article-title":"TSLP directly interacts with skin-homing Th2 cells highly expressing its receptor to enhance IL-4 production in atopic dermatitis","volume":"135","author":"Tatsuno","year":"2015","journal-title":"J. Invest. Dermatol."},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2022.109039_b0030","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s40257-020-00538-8","article-title":"The role of the microbiome and microbiome-derived metabolites in atopic dermatitis and non-histaminergic itch","volume":"21","author":"Li","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109039_b0035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12020-018-1605-5","article-title":"Microbiota and metabolic diseases","volume":"61","author":"Pascale","year":"2018","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.intimp.2022.109039_b0040","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jaci.2017.02.007","article-title":"The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy Asthma & Immunology and the European Academy of Allergy and Clinical Immunology","volume":"139","author":"Huang","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2022.109039_b0045","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002699","article-title":"Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack","volume":"4","author":"Yin","year":"2015","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.intimp.2022.109039_b0050","first-page":"322","article-title":"Imbalance of gut streptococcus, clostridium, and akkermansia determines the natural course of atopic dermatitis in infant, allergy asthma","volume":"12","author":"Park","year":"2020","journal-title":"Immunol. Res."},{"issue":"6","key":"10.1016\/j.intimp.2022.109039_b0055","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/19490976.2019.1589281","article-title":"Lactobacillus fermentum species ameliorate dextran sulfate sodium-induced colitis by regulating the immune response and altering gut microbiota","volume":"10","author":"Jang","year":"2019","journal-title":"Gut Microbes"},{"key":"10.1016\/j.intimp.2022.109039_b0060","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fmolb.2019.00092","article-title":"Administration of lactobacillus fermentum KBL375 causes taxonomic and functional changes in gut microbiota leading to improvement of atopic dermatitis","volume":"6","author":"Kim","year":"2019","journal-title":"Front Mol. Biosci."},{"issue":"Suppl 3","key":"10.1016\/j.intimp.2022.109039_b0065","doi-asserted-by":"crossref","first-page":"S557","DOI":"10.21037\/tcr.2016.09.33","article-title":"Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered","volume":"5","author":"Miftahussurur","year":"2016","journal-title":"Transl. Can. Res."},{"issue":"6","key":"10.1016\/j.intimp.2022.109039_b0070","first-page":"61","article-title":"Phytoestrogenis properties of flaxseed lignans","volume":"81","author":"Martinchik","year":"2012","journal-title":"Vopr. Pitan."},{"issue":"16","key":"10.1016\/j.intimp.2022.109039_b0075","doi-asserted-by":"crossref","first-page":"e1801159","DOI":"10.1002\/mnfr.201801159","article-title":"Factors explaining interpersonal variation in plasma enterolactone concentrations in humans","volume":"63","author":"Halldin","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2022.109039_b0080","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.3389\/fphar.2020.01018","article-title":"Chijabyukpi-tang inhibits pro-inflammatory cytokines and chemokines via the Nrf2\/HO-1 signaling pathway in TNF-alpha\/IFN-gamma-stimulated HaCaT cells and ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice","volume":"11","author":"Lee","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2022.109039_b0085","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1111\/all.13801","article-title":"Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1beta","volume":"74","author":"Schwartz","year":"2019","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.intimp.2022.109039_b0090","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jaci.2015.06.045","article-title":"Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity","volume":"137","author":"Saunders","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"51","key":"10.1016\/j.intimp.2022.109039_b0095","doi-asserted-by":"crossref","first-page":"E12091","DOI":"10.1073\/pnas.1814132115","article-title":"Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch","volume":"115","author":"Emrick","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2022.109039_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106659","article-title":"2'-fucosyllactose inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response via the STAT3 signaling pathway","volume":"85","author":"Lei","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109039_b0105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00253-011-3338-8","article-title":"Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside","volume":"92","author":"Roncaglia","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109039_b0110","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1021\/acs.jnatprod.1c00335","article-title":"Oral pharmacokinetics of enriched secoisolariciresinol diglucoside and its polymer in rats","volume":"84","author":"Yang","year":"2021","journal-title":"J. Nat. Prod."},{"issue":"11","key":"10.1016\/j.intimp.2022.109039_b0115","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1002\/eji.201242433","article-title":"STAT6-dependent and -independent mechanisms in Th2 polarization","volume":"42","author":"Maier","year":"2012","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109039_b0120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40257-018-0413-2","article-title":"JAK Inhibitors for Atopic Dermatitis: An Update","volume":"20","author":"He","year":"2019","journal-title":"Am. J. Clin. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109039_b0125","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4168\/aair.2018.10.4.354","article-title":"Microbiome in the Gut-Skin Axis in Atopic Dermatitis","volume":"10","author":"Lee","year":"2018","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.intimp.2022.109039_b0130","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-981-15-2385-4_10","article-title":"Gut microbiota and immune responses","volume":"1238","author":"Dong","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109039_b0135","first-page":"190","article-title":"Inhibitory effects of Aristotelia chilensis water extract on 2,4-Dinitrochlorobenzene induced atopic-like dermatitis in BALB\/c Mice","volume":"38","author":"Moon","year":"2020","journal-title":"Asian Pac. J. Allergy Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2022.109039_b0140","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1080\/10408398.2013.789823","article-title":"Bioactivation of phytoestrogens: intestinal bacteria and health","volume":"56","author":"Landete","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.intimp.2022.109039_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2021.110488","article-title":"Metabolism of flavonoids and lignans by lactobacilli and bifidobacteria strains improves the nutritional properties of flaxseed-enriched beverages","volume":"147","author":"Ruiz de la Bastida","year":"2021","journal-title":"Food Res. Int."},{"issue":"1","key":"10.1016\/j.intimp.2022.109039_b0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11011-012-9371-1","article-title":"Antidepressant-like effect of flaxseed secoisolariciresinol diglycoside in ovariectomized mice subjected to unpredictable chronic stress","volume":"28","author":"Ma","year":"2013","journal-title":"Metab. Brain Dis."},{"issue":"11","key":"10.1016\/j.intimp.2022.109039_b0155","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1002\/ijc.31647","article-title":"Circulating enterolactone concentrations and prognosis of postmenopausal breast cancer: assessment of mediation by inflammatory markers","volume":"143","author":"Jaskulski","year":"2018","journal-title":"Int. J. Can."},{"issue":"8","key":"10.1016\/j.intimp.2022.109039_b0160","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0167-5699(98)01285-7","article-title":"A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis","volume":"19","author":"Grewe","year":"1998","journal-title":"Immunol. Today"},{"issue":"15","key":"10.1016\/j.intimp.2022.109039_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26154409","article-title":"Gomisin M2 ameliorates atopic dermatitis-like skin lesions via inhibition of STAT1 and NF-kappaB activation in 2,4-dinitrochlorobenzene\/dermatophagoides farinae extract-induced BALB\/c mice","volume":"26","author":"Kang","year":"2021","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.intimp.2022.109039_b0170","doi-asserted-by":"crossref","first-page":"6678","DOI":"10.1021\/jf100471n","article-title":"Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB (NF-kappaB) signaling","volume":"58","author":"Corsini","year":"2010","journal-title":"J. Agric. Food Chem."},{"issue":"10","key":"10.1016\/j.intimp.2022.109039_b0175","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.4049\/jimmunol.165.10.5472","article-title":"IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL-4-induced IL-4 receptor gene expression","volume":"165","author":"So","year":"2000","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109039_b0180","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1067\/mai.2001.114883","article-title":"TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression","volume":"107","author":"Christodoulopoulos","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2022.109039_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105931","article-title":"Secoisolariciresinol diglucoside suppresses Dextran sulfate sodium salt-induced colitis through inhibiting NLRP1 inflammasome","volume":"78","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2022.109039_b0190","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3389\/fgene.2018.00641","article-title":"Secoisolariciresinol diglucoside of flaxseed and its metabolites: biosynthesis and potential for nutraceuticals","volume":"9","author":"Kezimana","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.intimp.2022.109039_b0195","doi-asserted-by":"crossref","first-page":"3621261","DOI":"10.1155\/2020\/3621261","article-title":"Secoisolariciresinol diglucoside exerts anti-inflammatory and antiapoptotic effects through inhibiting the Akt\/IkappaB\/NF-kappaB pathway on human umbilical vein endothelial cells","volume":"2020","author":"Zhang","year":"2020","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2022.109039_b0200","doi-asserted-by":"crossref","first-page":"7395238","DOI":"10.1155\/2017\/7395238","article-title":"The synthetic lignan secoisolariciresinol diglucoside prevents asbestos-induced NLRP3 inflammasome activation in murine macrophages","volume":"2017","author":"Pietrofesa","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.intimp.2022.109039_b0205","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/942375","article-title":"Role of macrophages in the pathogenesis of atopic dermatitis","volume":"2013","author":"Kasraie","year":"2013","journal-title":"Mediators Inflamm."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:43:04Z","timestamp":1761586984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922005239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":41,"alternative-id":["S1567576922005239"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109039","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secoisolariciresinol diglucoside-derived metabolite, enterolactone, attenuates atopic dermatitis by suppressing Th2 immune response","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109039"}}