{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:49:17Z","timestamp":1789447757520,"version":"build-2803163510"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.intimp.2022.109054","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T22:59:14Z","timestamp":1659308354000},"page":"109054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Effects of niacin on intestinal epithelial Barrier, intestinal Immunity, and microbial community in weaned piglets challenged by PDCoV"],"prefix":"10.1016","volume":"111","author":[{"given":"Yibo","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsen","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2022.109054_b0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1099\/0022-1317-36-3-531","article-title":"Biological properties of avian coronavirus RNA","volume":"36","author":"Lomniczi","year":"1977","journal-title":"J. Gen. Virol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109054_b0010","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0042-6822(91)90071-I","article-title":"The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase","volume":"180","author":"Lee","year":"1991","journal-title":"Virology"},{"key":"10.1016\/j.intimp.2022.109054_b0015","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3389\/fmicb.2018.00702","article-title":"Bats, coronaviruses, and deforestation: Toward the emergence of novel infectious diseases?","volume":"9","author":"Afelt","year":"2018","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109054_b0020","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1128\/MMBR.69.4.635-664.2005","article-title":"Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus","volume":"69","author":"Weiss","year":"2005","journal-title":"Microbiol Mol Biol Rev"},{"issue":"2","key":"10.1016\/j.intimp.2022.109054_b0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s12250-018-0003-8","article-title":"A highly pathogenic strain of porcine deltacoronavirus caused watery diarrhea in newborn piglets","volume":"33","author":"Xu","year":"2018","journal-title":"Virologica Sinica"},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0030","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00705-015-2627-4","article-title":"Porcine deltacoronavirus: Histological lesions and genetic characterization","volume":"161","author":"Wang","year":"2016","journal-title":"Arch. Virol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109054_b0035","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3201\/eid2104.141859","article-title":"Pathogenicity of 2 porcine deltacoronavirus strains in gnotobiotic pigs","volume":"21","author":"Jung","year":"2015","journal-title":"Emerg. Infect. Dis."},{"issue":"7","key":"10.1016\/j.intimp.2022.109054_b0040","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/JVI.06540-11","volume":"86","author":"Woo","year":"2012","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.intimp.2022.109054_b0045","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3201\/eid2007.140296","article-title":"Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA, 2014","volume":"20","author":"Wang","year":"2014","journal-title":"Emerg. Infect. Dis."},{"issue":"2","key":"10.1016\/j.intimp.2022.109054_b0050","first-page":"149","article-title":"The first case of porcine epidemic diarrhea in Canada","volume":"56","author":"Ojkic","year":"2015","journal-title":"Can. Vet. J."},{"issue":"5","key":"10.1016\/j.intimp.2022.109054_b0055","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/tbed.12690","article-title":"Prevalence, complete genome sequencing and phylogenetic analysis of porcine deltacoronavirus in South Korea, 2014\u20132016","volume":"64","author":"Jang","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0060","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s12917-019-2212-2","article-title":"Prevalence and phylogenetic analysis of porcine diarrhea associated viruses in southern China from 2012 to 2018","volume":"15","author":"Zhang","year":"2019","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.intimp.2022.109054_b0065","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.meegid.2018.03.030","article-title":"Genetic characterization and pathogenicity of Japanese porcine deltacoronavirus","volume":"61","author":"Suzuki","year":"2018","journal-title":"Infect. Genet. Evol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/tbed.12585","article-title":"Different lineage of porcine deltacoronavirus in thailand, vietnam and lao PDR in 2015","volume":"64","author":"Saeng-chuto","year":"2017","journal-title":"Transbound. Emerg. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0075","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/v12010079","article-title":"Isolation and identification of porcine deltacoronavirus and alteration of immunoglobulin transport receptors in the intestinal mucosa of PDCoV-Infected piglets","volume":"12","author":"Qian","year":"2020","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.intimp.2022.109054_b0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3201\/eid2602.190346","article-title":"Porcine deltacoronavirus infection and transmission in poultry, united states(1)","volume":"26","author":"Boley","year":"2020","journal-title":"Emerg. Infect. Dis."},{"issue":"8","key":"10.1016\/j.intimp.2022.109054_b0085","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1007\/s00705-017-3351-z","article-title":"Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus","volume":"162","author":"Jung","year":"2017","journal-title":"Arch. Virol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109054_b0090","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/v11060573","article-title":"Susceptibility of chickens to porcine deltacoronavirus infection","volume":"11","author":"Liang","year":"2019","journal-title":"Viruses"},{"issue":"7887","key":"10.1016\/j.intimp.2022.109054_b0095","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-021-04111-z","article-title":"Independent infections of porcine deltacoronavirus among Haitian children","volume":"600","author":"Lednicky","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.nutr.28.061807.155443","article-title":"Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD+ precursor vitamins in human nutrition","volume":"28","author":"Bogan","year":"2008","journal-title":"Annu. Rev. Nutr."},{"issue":"19","key":"10.1016\/j.intimp.2022.109054_b0105","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.jacc.2009.06.036","article-title":"Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: A randomized, placebo-controlled, magnetic resonance imaging study","volume":"54","author":"Lee","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109054_b0110","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1161\/ATVBAHA.111.241836","article-title":"Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms","volume":"32","author":"Digby","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0115","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2174\/1874192401307010090","article-title":"Niacin modulates pro-inflammatory cytokine secretion. A potential mechanism involved in its anti-atherosclerotic effect","volume":"7","author":"Lipszyc","year":"2013","journal-title":"Open Cardiovasc Med J"},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0120","doi-asserted-by":"crossref","first-page":"7139","DOI":"10.1038\/s41598-017-07280-y","article-title":"Effect of niacin on inflammation and angiogenesis in a murine model of ulcerative colitis","volume":"7","author":"Salem","year":"2017","journal-title":"Sci Rep"},{"issue":"7408","key":"10.1016\/j.intimp.2022.109054_b0125","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature11228","article-title":"ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation","volume":"487","author":"Hashimoto","year":"2012","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2022.109054_b0130","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013487","article-title":"Niacin ameliorates ulcerative colitis via prostaglandin D2 -mediated D prostanoid receptor 1 activation","volume":"12","author":"Li","year":"2020","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0135","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2527\/jas.2011-4035","article-title":"Effect of graded levels of niacin supplementation of a semipurified diet on energy and nitrogen balance, growth performance, diarrhea occurrence, and niacin metabolite excretion by growing swine","volume":"90","author":"Ivers","year":"2012","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.intimp.2022.109054_b0140","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.prevetmed.2015.11.001","article-title":"Characterization and evolution of porcine deltacoronavirus in the United States","volume":"123","author":"Homwong","year":"2016","journal-title":"Prev. Vet. Med."},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0145","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00705-017-3594-8","article-title":"A novel strain of porcine deltacoronavirus in Vietnam","volume":"163","author":"Le","year":"2018","journal-title":"Arch. Virol."},{"issue":"12","key":"10.1016\/j.intimp.2022.109054_b0150","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1007\/s00705-020-04796-z","article-title":"Prevalence and phylogenetic analysis of porcine deltacoronavirus in Sichuan province","volume":"165","author":"Feng","year":"2020","journal-title":"China. Arch. Virol."},{"key":"10.1016\/j.intimp.2022.109054_b0155","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.vetmic.2016.10.022","article-title":"Isolation, genomic characterization, and pathogenicity of a Chinese porcine deltacoronavirus strain CHN-HN-2014","volume":"196","author":"Dong","year":"2016","journal-title":"Vet. Microbiol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12917-019-1848-2","article-title":"Expression profile analysis of 5-day-old neonatal piglets infected with porcine Deltacoronavirus","volume":"15","author":"Wu","year":"2019","journal-title":"BMC Vet. Res."},{"issue":"7","key":"10.1016\/j.intimp.2022.109054_b0165","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s00705-020-04590-x","article-title":"Evaluation of the immune response in conventionally weaned pigs infected with porcine deltacoronavirus","volume":"165","author":"Zhao","year":"2020","journal-title":"Arch. Virol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109054_b0170","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.2527\/2004.8261764x","article-title":"Spray-dried plasma improves growth performance and reduces inflammatory status of weaned pigs challenged with enterotoxigenic Escherichia coli K88","volume":"82","author":"Bosi","year":"2004","journal-title":"J. Anim. Sci."},{"issue":"10","key":"10.1016\/j.intimp.2022.109054_b0175","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1017\/S0007114513001293","article-title":"Dietary fibre affects intestinal mucosal barrier function and regulates intestinal bacteria in weaning piglets","volume":"110","author":"Chen","year":"2013","journal-title":"Br J Nutr"},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0180","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.26321","article-title":"Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice","volume":"58","author":"Hartmann","year":"2013","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.intimp.2022.109054_b0185","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00109-017-1557-x","article-title":"Layered defense: How mucus and tight junctions seal the intestinal barrier","volume":"95","author":"Capaldo","year":"2017","journal-title":"J Mol Med (Berl)"},{"issue":"3","key":"10.1016\/j.intimp.2022.109054_b0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11259-019-09754-y","article-title":"RNA-Seq-based transcriptomic profiling of primary interstitial cells of Cajal in response to bovine viral diarrhea virus infection","volume":"43","author":"Li","year":"2019","journal-title":"Vet. Res. Commun."},{"issue":"10","key":"10.1016\/j.intimp.2022.109054_b0195","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00202-17","article-title":"Tight junction protein occludin is a porcine epidemic diarrhea virus entry factor","volume":"91","author":"Luo","year":"2017","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109054_b0200","doi-asserted-by":"crossref","first-page":"345","DOI":"10.24425\/pjvs.2019.129226","article-title":"Effects of porcine epidemic diarrhea virus infection on tight junction protein gene expression and morphology of the intestinal mucosa in pigs","volume":"22","author":"Zong","year":"2019","journal-title":"Pol. J. Vet. Sci."},{"issue":"7\u20138","key":"10.1016\/j.intimp.2022.109054_b0205","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s00018-007-6475-6","article-title":"Cationic host defence peptides: Innate immune regulatory peptides as a novel approach for treating infections","volume":"64","author":"Mookherjee","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"issue":"12","key":"10.1016\/j.intimp.2022.109054_b0210","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1007\/s00253-014-5560-7","article-title":"High-level expression, purification and characterisation of porcine beta-defensin 2 in Pichia pastoris and its potential as a cost-efficient growth promoter in porcine feed","volume":"98","author":"Peng","year":"2014","journal-title":"Appl Microbiol Biotechnol"},{"issue":"2","key":"10.1016\/j.intimp.2022.109054_b0215","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.molimm.2007.06.001","article-title":"Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria","volume":"45","author":"Veldhuizen","year":"2008","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109054_b0220","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/mnfr.201500992","article-title":"Green tea polyphenol epigallocatechin-3-gallate improves epithelial barrier function by inducing the production of antimicrobial peptide pBD-1 and pBD-2 in monolayers of porcine intestinal epithelial IPEC-J2 cells","volume":"60","author":"Wan","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"4","key":"10.1016\/j.intimp.2022.109054_b0225","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1017\/S0007114515004997","article-title":"The piglet as a model for studying dietary components in infant diets: Effects of galacto-oligosaccharides on intestinal functions","volume":"115","author":"Alizadeh","year":"2016","journal-title":"Br J Nutr"},{"issue":"7","key":"10.1016\/j.intimp.2022.109054_b0230","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1128\/AEM.03277-12","article-title":"Modulation of porcine beta-defensins 1 and 2 upon individual and combined Fusarium toxin exposure in a swine jejunal epithelial cell line","volume":"79","author":"Wan","year":"2013","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0235","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13567-021-00955-5","article-title":"Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestine","volume":"52","author":"Duan","year":"2021","journal-title":"Vet. Res."},{"issue":"6","key":"10.1016\/j.intimp.2022.109054_b0240","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/MOG.0000000000000315","article-title":"Cytokines and intestinal inflammation","volume":"32","author":"Bamias","year":"2016","journal-title":"Curr Opin Gastroenterol"},{"issue":"3","key":"10.1016\/j.intimp.2022.109054_b0245","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.molmed.2018.01.004","article-title":"Inflammasome, inflammation, and tissue homeostasis","volume":"24","author":"Rathinam","year":"2018","journal-title":"Trends Mol. Med."},{"issue":"6","key":"10.1016\/j.intimp.2022.109054_b0250","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.immuni.2014.12.010","article-title":"NOD1 and NOD2: Signaling, host defense, and inflammatory disease","volume":"41","author":"Caruso","year":"2014","journal-title":"Immunity"},{"issue":"44","key":"10.1016\/j.intimp.2022.109054_b0255","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1038\/sj.onc.1204787","article-title":"The NOD: A signaling module that regulates apoptosis and host defense against pathogens","volume":"20","author":"Inohara","year":"2001","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0260","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1600-065X.2008.00737.x","article-title":"Innate immunity to virus infection","volume":"227","author":"Takeuchi","year":"2009","journal-title":"Immunol. Rev."},{"issue":"6857","key":"10.1016\/j.intimp.2022.109054_b0265","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.109054_b0270","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fimmu.2020.00211","article-title":"NLRP3 Inflammasome-A key player in antiviral responses","volume":"11","author":"Zhao","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.intimp.2022.109054_b0275","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.vetmic.2018.12.012","article-title":"Porcine deltacoronavirus induces TLR3, IL-12, IFN-alpha, IFN-beta and PKR mRNA expression in infected Peyer's patches in vivo","volume":"228","author":"Xu","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.intimp.2022.109054_b0280","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.virusres.2016.05.016","article-title":"Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts","volume":"226","author":"Langel","year":"2016","journal-title":"Virus Res."},{"key":"10.1016\/j.intimp.2022.109054_b0285","article-title":"Essential role of IFN-gamma in regulating gut antimicrobial peptides and microbiota to protect against Alcohol-Induced bacterial translocation and hepatic inflammation in mice","volume":"11","author":"Yue","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.intimp.2022.109054_b0290","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.vetmic.2018.05.019","article-title":"Susceptibility of porcine IPEC-J2 intestinal epithelial cells to infection with porcine deltacoronavirus (PDCoV) and serum cytokine responses of gnotobiotic pigs to acute infection with IPEC-J2 cell culture-passaged PDCoV","volume":"221","author":"Jung","year":"2018","journal-title":"Vet. Microbiol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109054_b0295","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/ndt\/gft446","article-title":"Toll-like receptors: Sensing and reacting to diabetic injury in the kidney","volume":"29","author":"Lin","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"6","key":"10.1016\/j.intimp.2022.109054_b0300","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.coph.2013.08.006","article-title":"Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host","volume":"13","author":"Ganapathy","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0305","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity"},{"issue":"6145","key":"10.1016\/j.intimp.2022.109054_b0310","doi-asserted-by":"crossref","first-page":"1238858","DOI":"10.1126\/science.1238858","article-title":"A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection","volume":"341","author":"Eskandarian","year":"2013","journal-title":"Science"},{"issue":"21","key":"10.1016\/j.intimp.2022.109054_b0315","doi-asserted-by":"crossref","first-page":"E2993","DOI":"10.1073\/pnas.1605997113","article-title":"Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge","volume":"113","author":"Fischer","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.intimp.2022.109054_b0320","doi-asserted-by":"crossref","first-page":"e113341","DOI":"10.1371\/journal.pone.0113341","article-title":"Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy","volume":"9","author":"Lu","year":"2014","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.intimp.2022.109054_b0325","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.it.2011.04.001","article-title":"Histone deacetylases as regulators of inflammation and immunity","volume":"32","author":"Shakespear","year":"2011","journal-title":"Trends Immunol."},{"issue":"18","key":"10.1016\/j.intimp.2022.109054_b0330","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1007\/s00018-017-2527-8","article-title":"Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells","volume":"74","author":"Hwang","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2022.109054_b0335","doi-asserted-by":"crossref","first-page":"107584","DOI":"10.1016\/j.intimp.2021.107584","article-title":"Effects of niacin on intestinal immunity, microbial community and intestinal barrier in weaned piglets during starvation","volume":"95","author":"Feng","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2022.109054_b0340","first-page":"257","article-title":"Microbial contributions to chronic inflammation and metabolic disease","volume":"19","author":"Shanahan","year":"2016","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"8","key":"10.1016\/j.intimp.2022.109054_b0345","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.3390\/ani11082186","article-title":"Effect of niacin on growth performance, intestinal morphology, mucosal immunity and microbiota composition in weaned piglets","volume":"11","author":"Liu","year":"2021","journal-title":"Animals (Basel)"},{"issue":"2","key":"10.1016\/j.intimp.2022.109054_b0350","doi-asserted-by":"crossref","first-page":"e0192992","DOI":"10.1371\/journal.pone.0192992","article-title":"Differences in the intestinal microbiota between uninfected piglets and piglets infected with porcine epidemic diarrhea virus","volume":"13","author":"Huang","year":"2018","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.intimp.2022.109054_b0355","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/00071668.2019.1673318","article-title":"Xylanase and xylo- oligosaccharide prebiotic improve the growth performance and concentration of potentially prebiotic oligosaccharides in the ileum of broiler chickens","volume":"61","author":"Craig","year":"2020","journal-title":"Br Poult Sci"},{"issue":"9","key":"10.1016\/j.intimp.2022.109054_b0360","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: Microbial signature of dysbiosis in gut microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.intimp.2022.109054_b0365","first-page":"1","article-title":"Probiotic species in the modulation of gut microbiota: An overview","volume":"2018","author":"Azad","year":"2018","journal-title":"Biomed Res. Int."},{"issue":"7","key":"10.1016\/j.intimp.2022.109054_b0370","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.1036","article-title":"Porcine deltacoronavirus infection alters bacterial communities in the colon and feces of neonatal piglets","volume":"9","author":"Li","year":"2020","journal-title":"Microbiologyopen"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:45:32Z","timestamp":1761587132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922005380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":74,"alternative-id":["S1567576922005380"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109054","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of niacin on intestinal epithelial Barrier, intestinal Immunity, and microbial community in weaned piglets challenged by PDCoV","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109054"}}