{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:16:25Z","timestamp":1772982985577,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.intimp.2022.109064","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T17:43:13Z","timestamp":1658338993000},"page":"109064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9"],"prefix":"10.1016","volume":"110","author":[{"given":"Jian-Lin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Song","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong-jie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10134","key":"10.1016\/j.intimp.2022.109064_b0005","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/S0140-6736(18)31064-X","article-title":"Osteoarthritis","volume":"391","author":"Barnett","year":"2018","journal-title":"Lancet (London, England)"},{"issue":"8","key":"10.1016\/j.intimp.2022.109064_b0010","doi-asserted-by":"crossref","first-page":"635","DOI":"10.7326\/0003-4819-133-8-200010170-00016","article-title":"Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors","volume":"133","author":"Felson","year":"2000","journal-title":"Ann. Intern. Med."},{"issue":"6","key":"10.1016\/j.intimp.2022.109064_b0015","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2105\/AJPH.74.6.574","article-title":"Epidemiology of musculoskeletal impairments and associated disability","volume":"74","author":"Cunningham","year":"1984","journal-title":"Am. J. Public Health"},{"issue":"4","key":"10.1016\/j.intimp.2022.109064_b0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/ard.48.4.271","article-title":"Epidemiology of osteoarthritis: Zoetermeer survey. Comparison of radiological osteoarthritis in a Dutch population with that in 10 other populations","volume":"48","author":"van Saase","year":"1989","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.intimp.2022.109064_b0025","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0021-9681(67)90009-4","article-title":"Estimates of the prevalence of rheumatic diseases in the population of Tecumseh, Michigan, 1959\u201360","volume":"20","author":"Mikkelsen","year":"1967","journal-title":"J. Chronic Diseases"},{"issue":"12","key":"10.1016\/j.intimp.2022.109064_b0030","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/art.1780361205","article-title":"Bone mineral density and knee osteoarthritis in elderly men and women. the framingham study","volume":"36","author":"Hannan","year":"1993","journal-title":"Arthritis Rheum."},{"issue":"7036","key":"10.1016\/j.intimp.2022.109064_b0035","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/bmj.312.7036.940","article-title":"Genetic influences on osteoarthritis in women: a twin study","volume":"312","author":"Spector","year":"1996","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.intimp.2022.109064_b0040","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/0002-9343(94)90292-5","article-title":"Reactive oxygen species and antioxidant vitamins: Mechanisms of action","volume":"97","author":"Frei","year":"1994","journal-title":"Am. J. Med."},{"key":"10.1016\/j.intimp.2022.109064_b0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.arr.2017.07.004","article-title":"Aging and osteoarthritis: Central role of the extracellular matrix","volume":"40","author":"Rahmati","year":"2017","journal-title":"Ageing Res. Rev."},{"issue":"7441","key":"10.1016\/j.intimp.2022.109064_b0050","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2022.109064_b0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.omtn.2017.04.004","article-title":"Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis","volume":"7","author":"Liu","year":"2017","journal-title":"Mol. Therapy Nucleic Acids"},{"issue":"11","key":"10.1016\/j.intimp.2022.109064_b0060","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1101\/gad.1939310","article-title":"MicroRNA-140 and the silencing of osteoarthritis","volume":"24","author":"Araldi","year":"2010","journal-title":"Genes Dev."},{"issue":"7441","key":"10.1016\/j.intimp.2022.109064_b0065","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2022.109064_b0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.21037\/tcr-20-2808","article-title":"Identification of a novel circRNA, hsa_circ_0065898, that regulates tumor growth in cervical squamous cell carcinoma","volume":"10","author":"Li","year":"2021","journal-title":"Trans. Cancer Res."},{"key":"10.1016\/j.intimp.2022.109064_b0075","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/s12885-021-08331-4","article-title":"Hsa_circ_0000301 facilitates the progression of cervical cancer by targeting miR-1228-3p\/IRF4 Axis","volume":"21","author":"Deng","year":"2021","journal-title":"BMC Cancer"},{"issue":"9","key":"10.1016\/j.intimp.2022.109064_b0080","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthrit. Cartilage"},{"issue":"1","key":"10.1016\/j.intimp.2022.109064_b0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/15476286.2015.1128065","article-title":"CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs","volume":"13","author":"Dudekula","year":"2016","journal-title":"RNA Biol."},{"key":"10.1016\/j.intimp.2022.109064_b0090","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"issue":"13","key":"10.1016\/j.intimp.2022.109064_b0095","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1080\/15384101.2020.1772545","article-title":"CircRNA-UBE2G1 regulates LPS-induced osteoarthritis through miR-373\/HIF-1a axis","volume":"19","author":"Chen","year":"2020","journal-title":"Cell Cycle (Georgetown, Tex)"},{"key":"10.1016\/j.intimp.2022.109064_b0100","doi-asserted-by":"crossref","first-page":"22572","DOI":"10.1038\/srep22572","article-title":"Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2022.109064_b0105","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.omtm.2020.05.027","article-title":"Circular RNAs: Promising Molecular Biomarkers of Human Aging-Related Diseases via Functioning as an miRNA Sponge","volume":"18","author":"Ren","year":"2020","journal-title":"Mol. Therapy Methods Clin. Dev."},{"key":"10.1016\/j.intimp.2022.109064_b0110","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkp294","article-title":"MicroRNA and mRNA integrated analysis (MMIA): a web tool for examining biological functions of microRNA expression","volume":"37","author":"Nam","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109064_b0115","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jor.23010","article-title":"OARSI osteoarthritis cartilage histopathology assessment system: A biomechanical evaluation in the human knee","volume":"34","author":"Waldstein","year":"2016","journal-title":"J. Orthop. Res."},{"issue":"12","key":"10.1016\/j.intimp.2022.109064_b0120","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.drudis.2016.08.011","article-title":"Osteoarthritis: from pathogenic mechanisms and recent clinical developments to novel prospective therapeutic options","volume":"21","author":"Vinatier","year":"2016","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.intimp.2022.109064_b0125","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/1529-0131(200009)43:9<1916::AID-ANR2>3.0.CO;2-I","article-title":"The role of the chondrocyte in osteoarthritis","volume":"43","author":"Goldring","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2022.109064_b0130","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13059-015-0801-3","article-title":"Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development","volume":"16","author":"Ven\u00f8","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.intimp.2022.109064_b0135","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12943-018-0917-7","article-title":"CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells","volume":"17","author":"Liu","year":"2018","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.intimp.2022.109064_b0140","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1136\/annrheumdis-2018-214786","article-title":"CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene","volume":"78","author":"Shen","year":"2019","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2022.109064_b0145","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ymthe.2020.09.002","article-title":"Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18","volume":"29","author":"Wu","year":"2021","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2022.109064_b0150","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ymthe.2019.01.006","article-title":"circRNA.33186 Contributes to the Pathogenesis of Osteoarthritis by Sponging miR-127-5p","volume":"27","author":"Zhou","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.intimp.2022.109064_b0155","first-page":"1080","article-title":"MicroRNA-370-3p inhibits human vascular smooth muscle cell proliferation via targeting KDR\/AKT signaling pathway in cerebral aneurysm","volume":"21","author":"Hou","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2022.109064_b0160","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1080\/15384047.2018.1480888","article-title":"Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway","volume":"19","author":"Chen","year":"2018","journal-title":"Cancer Biol. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2022.109064_b0165","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1007\/s13577-021-00585-1","article-title":"Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells","volume":"34","author":"Xiong","year":"2021","journal-title":"Hum. Cell"},{"key":"10.1016\/j.intimp.2022.109064_b0170","article-title":"LncRNA HCG11 Facilitates Nasopharyngeal Carcinoma Progression Through Regulating miRNA-490-3p\/MAP3K9 Axis","volume":"12","author":"Zheng","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2022.109064_b0175","doi-asserted-by":"crossref","DOI":"10.1038\/s41401-022-00893-8","article-title":"Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9","author":"Liang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"10","key":"10.1016\/j.intimp.2022.109064_b0180","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.joca.2013.06.021","article-title":"Osteoarthritis year 2013 in review: clinical","volume":"21","author":"Arden","year":"2013","journal-title":"Osteoarthrit. Cartilage"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005483?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005483?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:41:23Z","timestamp":1761586883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922005483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":36,"alternative-id":["S1567576922005483"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109064","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109064"}}