{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:00:00Z","timestamp":1790913600851,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.intimp.2022.109097","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T04:49:41Z","timestamp":1659934181000},"page":"109097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer"],"prefix":"10.1016","volume":"111","author":[{"given":"Hongyan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongling","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongming","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2022.109097_b0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.25122\/jml-2018-0075","article-title":"A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease","volume":"12","author":"Seyedian","year":"2019","journal-title":"J. Med. Life"},{"key":"10.1016\/j.intimp.2022.109097_b0010","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev-immunol-082019-081656","article-title":"Cruel to be kind: epithelial, microbial, and immune cell interactions in gastrointestinal cancers","volume":"38","author":"Shalapour","year":"2020","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109097_b0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1053\/j.gastro.2016.04.001","article-title":"Genomic alterations observed in colitis-associated cancers are distinct from those found in sporadic colorectal cancers and vary by type of inflammatory bowel disease","volume":"151","author":"Yaeger","year":"2016","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.intimp.2022.109097_b0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1024\/1661-8157\/a001548","article-title":"Das Kolitis-assoziierte kolorektale Karzinom: Epidemiologie, Pathogenese und Fr\u00fcherkennung","volume":"103","author":"Scharl","year":"2014","journal-title":"Praxis"},{"key":"10.1016\/j.intimp.2022.109097_b0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2017.04.003","article-title":"Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development","volume":"32","author":"Kang","year":"2017","journal-title":"Semin. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109097_b0030","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3748\/wjg.v22.i2.501","article-title":"Gut microbiota imbalance and colorectal cancer","volume":"22","author":"Gagni\u00e8re","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"10","key":"10.1016\/j.intimp.2022.109097_b0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11882-015-0562-9","article-title":"Immune responses to intestinal microbes in inflammatory bowel diseases","volume":"15","author":"Hansen","year":"2015","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"1","key":"10.1016\/j.intimp.2022.109097_b0040","doi-asserted-by":"crossref","first-page":"e53653","DOI":"10.1371\/journal.pone.0053653","article-title":"Fusobacterium is associated with colorectal adenomas","volume":"8","author":"McCoy","year":"2013","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.intimp.2022.109097_b0045","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1101\/gr.126573.111","article-title":"Genomic analysis identifies association of Fusobacterium with colorectal carcinoma","volume":"22","author":"Kostic","year":"2012","journal-title":"Genome Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109097_b0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/gast.2002.30294","article-title":"Mucosal flora in inflammatory bowel disease","volume":"122","author":"Swidsinski","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2022.109097_b0055","doi-asserted-by":"crossref","first-page":"e25801","DOI":"10.7554\/eLife.25801","article-title":"Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma","volume":"7","author":"Repass","year":"2018","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.intimp.2022.109097_b0060","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/j.gastro.2016.11.018","article-title":"Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor-\u03baB, and up-regulating expression of microRNA-21","volume":"152","author":"Yang","year":"2017","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.intimp.2022.109097_b0065","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/s41564-019-0541-3","article-title":"Peptostreptococcus anaerobius promotes colorectal carcinogenesis and modulates tumour immunity","volume":"4","author":"Long","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109097_b0070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.chom.2018.01.007","article-title":"Bacteroides fragilis toxin coordinates a pro-carcinogenic inflammatory cascade via targeting of colonic epithelial cells","volume":"23","author":"Chung","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.intimp.2022.109097_b0075","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.canlet.2019.04.033","article-title":"Shikonin derivatives for cancer prevention and therapy","volume":"459","author":"Boulos","year":"2019","journal-title":"Cancer Lett."},{"issue":"09\/10","key":"10.1016\/j.intimp.2022.109097_b0080","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1055\/a-0599-1145","article-title":"Shikonin prevents early phase inflammation associated with azoxymethane\/dextran sulfate sodium-induced colon cancer and induces apoptosis in human colon cancer cells","volume":"84","author":"And\u00fajar","year":"2018","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2022.109097_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.01.008","article-title":"SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer","volume":"797","author":"Zhang","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109097_b0090","doi-asserted-by":"crossref","unstructured":"I. And\u00fajar, J.L. R\u00edos, R.M. Giner, et al., Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in BALB\/c mice, Evid. Based Complement Alternat. Med. 2012 (2012) 271606. doi:10.1155\/2012\/271606.","DOI":"10.1155\/2012\/271606"},{"key":"10.1016\/j.intimp.2022.109097_b0095","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.10675","article-title":"Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis","volume":"9","author":"Han","year":"2021","journal-title":"PeerJ"},{"issue":"3","key":"10.1016\/j.intimp.2022.109097_b0100","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nprot.2007.41","article-title":"Chemically induced mouse models of intestinal inflammation","volume":"2","author":"Wirtz","year":"2007","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.intimp.2022.109097_b0105","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-021-01071-4","article-title":"A synthetic probiotic engineered for colorectal cancer therapy modulates gut microbiota","volume":"9","author":"Chung","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.intimp.2022.109097_b0110","doi-asserted-by":"crossref","first-page":"606490","DOI":"10.3389\/fcimb.2021.606490","article-title":"A comparison study of age and colorectal cancer-related gut bacteria","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2022.109097_b0115","doi-asserted-by":"crossref","first-page":"111237","DOI":"10.1016\/j.fct.2020.111237","article-title":"Long-term hexavalent chromium exposure facilitates colorectal cancer in mice associated with changes in gut microbiota composition","volume":"138","author":"Zhang","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"18","key":"10.1016\/j.intimp.2022.109097_b0120","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3748\/wjg.v24.i18.1995","article-title":"Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice","volume":"24","author":"Mendes","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2022.109097_b0125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nmni.2016.11.022","article-title":"'Ileibacterium massiliense' gen. nov., sp. nov., a new bacterial species isolated from human ileum of a patient with Crohn disease","volume":"17","author":"Mailhe","year":"2017","journal-title":"New Microbes New Infect."},{"issue":"10","key":"10.1016\/j.intimp.2022.109097_b0130","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1099\/ijsem.0.002339","volume":"67","author":"Cox","year":"2017","journal-title":"Int. J. Syst. Evol. Microbiol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109097_b0135","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.chom.2015.07.003","article-title":"Inhibition of dectin-1 signaling ameliorates colitis by inducing Lactobacillus-mediated regulatory T cell expansion in the intestine","volume":"18","author":"Tang","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.intimp.2022.109097_b0140","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2021.01.017","article-title":"Sleeping Beauty insertional mutagenesis screen identifies the pro-metastatic roles of CNPY2 and ACTN2 in hepatocellular carcinoma tumor progression","volume":"541","author":"Lo","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2022.109097_b0145","first-page":"939","article-title":"Ligustrazine reverts anthracycline chemotherapy resistance of human breast cancer by inhibiting JAK2\/STAT3 signaling and decreasing fibrinogen gamma chain (FGG) expression","volume":"10","author":"Liu","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.intimp.2022.109097_b0150","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biochi.2020.08.013","article-title":"Discovery of small extracellular vesicle proteins from human serum for liver cirrhosis and liver cancer","volume":"177","author":"Uzzaman","year":"2020","journal-title":"Biochimie"},{"issue":"7","key":"10.1016\/j.intimp.2022.109097_b0155","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1158\/1541-7786.MCR-19-1033","article-title":"Fibrinogen alpha chain knockout promotes tumor growth and metastasis through integrin\u2013AKT signaling pathway in lung cancer","volume":"18","author":"Wang","year":"2020","journal-title":"Mol. Cancer Res."},{"issue":"14","key":"10.1016\/j.intimp.2022.109097_b0160","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.2217\/fon-2018-0555","article-title":"A breast one\u2013patient panel of heterogeneous genomes reveals genetic alterations driving DCIS into invasive lesions","volume":"15","author":"Yang","year":"2019","journal-title":"Future Oncol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109097_b0165","doi-asserted-by":"crossref","first-page":"e0121648","DOI":"10.1371\/journal.pone.0121648","article-title":"ALDH1B1 is crucial for colon tumorigenesis by modulating Wnt\/\u03b2-Catenin, Notch and PI3K\/Akt signaling pathways","volume":"10","author":"Singh","year":"2015","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.intimp.2022.109097_b0170","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ejps.2013.05.018","article-title":"Shikonin promotes intestinal wound healing in vitro via induction of TGF-\u03b2 release in IEC-18 cells","volume":"49","author":"And\u00fajar","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"issue":"23","key":"10.1016\/j.intimp.2022.109097_b0175","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.2174\/09298673113209990008","article-title":"Traditional Chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy","volume":"20","author":"And\u00fajar","year":"2013","journal-title":"Curr. Med. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2022.109097_b0180","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00692-13","article-title":"The gut microbiome modulates colon tumorigenesis","volume":"4","author":"Zackular","year":"2013","journal-title":"mBio"},{"issue":"5","key":"10.1016\/j.intimp.2022.109097_b0185","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.3168\/jds.2021-21345","article-title":"Camel milk modulates the gut microbiota and has anti-inflammatory effects in a mouse model of colitis","volume":"105","author":"He","year":"2022","journal-title":"J. Dairy Sci."},{"issue":"2","key":"10.1016\/j.intimp.2022.109097_b0190","doi-asserted-by":"crossref","first-page":"e0010521","DOI":"10.1128\/Spectrum.00105-21","article-title":"Dietary supplementation of inulin ameliorates subclinical mastitis via regulation of rumen microbial community and metabolites in dairy cows","volume":"9","author":"Wang","year":"2021","journal-title":"Microbiol. Spectr."},{"issue":"20","key":"10.1016\/j.intimp.2022.109097_b0195","doi-asserted-by":"crossref","first-page":"9793","DOI":"10.1039\/D1FO01468D","article-title":"Gut microbiota-dependent catabolites of tryptophan play a predominant role in the protective effects of turmeric polysaccharides against DSS-induced ulcerative colitis","volume":"12","author":"Yang","year":"2021","journal-title":"Food Funct."},{"issue":"7","key":"10.1016\/j.intimp.2022.109097_b0200","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.3390\/ijms23073832","article-title":"Crocetin prolongs recovery period of DSS-induced colitis via altering intestinal microbiome and increasing intestinal permeability","volume":"23","author":"Feng","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2022.109097_b0205","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/jn\/nxy011","article-title":"Obese mice losing weight due to trans-10, cis-12 conjugated linoleic acid supplementation or food restriction harbor distinct gut microbiota","volume":"148","author":"den Hartigh","year":"2018","journal-title":"J. Nutr."},{"issue":"4","key":"10.1016\/j.intimp.2022.109097_b0210","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1039\/D0FO02632H","article-title":"Effect of different phosphatidylcholines on high fat diet-induced insulin resistance in mice","volume":"12","author":"Gao","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2022.109097_b0215","doi-asserted-by":"crossref","first-page":"585066","DOI":"10.3389\/fmicb.2020.585066","article-title":"Naringin attenuates high fat diet induced non-alcoholic fatty liver disease and gut bacterial dysbiosis in mice","volume":"11","author":"Mu","year":"2020","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109097_b0220","article-title":"Gut microbiota in early pregnancy among women with Hyperglycaemia vs Normal blood glucose","volume":"20","author":"Gao","year":"2020","journal-title":"BMC Pregnancy Childb."},{"issue":"1","key":"10.1016\/j.intimp.2022.109097_b0225","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7150\/ijbs.36955","article-title":"Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1\/JNK signaling axis","volume":"16","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2022.109097_b0230","article-title":"Integrated proteomics and metabolomics reveals the comprehensive characterization of antitumor mechanism underlying Shikonin on colon cancer patient-derived xenograft model","volume":"10","author":"Chen","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2022.109097_b0235","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1007\/s11095-014-1564-3","article-title":"Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde\u2013in vitro studies and computational modeling","volume":"32","author":"Jackson","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.intimp.2022.109097_b0240","doi-asserted-by":"crossref","first-page":"231","DOI":"10.7150\/jca.4542","article-title":"A pilot study assessing the potential role of non-CD133 colorectal cancer stem cells as biomarkers","volume":"3","author":"Langan","year":"2012","journal-title":"J. Cancer"},{"issue":"10","key":"10.1016\/j.intimp.2022.109097_b0245","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/bjc.2017.304","article-title":"Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer","volume":"117","author":"Matsumoto","year":"2017","journal-title":"Brit. J. Cancer"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922005811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:46:01Z","timestamp":1761587161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922005811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":49,"alternative-id":["S1567576922005811"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109097","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109097"}}