{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:14:08Z","timestamp":1793067248627,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072808"],"award-info":[{"award-number":["32072808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.intimp.2022.109171","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T11:12:54Z","timestamp":1660993974000},"page":"109171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Gondoic acid alleviates LPS\u2011induced Kupffer cells inflammation by inhibiting ROS production and PKC\u03b8\/ERK\/STAT3 signaling pathway"],"prefix":"10.1016","volume":"111","author":[{"given":"Guoqiang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2022.109171_b0005","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.coph.2009.06.018","article-title":"Inflammation, a silent killer in cancer is not so silent!","volume":"9","author":"Aggarwal","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"issue":"7203","key":"10.1016\/j.intimp.2022.109171_b0010","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Natur"},{"issue":"6116","key":"10.1016\/j.intimp.2022.109171_b0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1126\/science.339.6116.155","article-title":"Inflammation. Inflammation's yin-yang. Introduction","volume":"339","author":"Mueller","year":"2013","journal-title":"Sci."},{"issue":"14","key":"10.1016\/j.intimp.2022.109171_b0020","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.intimp.2022.109171_b0025","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jhep.2016.12.018","article-title":"HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1beta production via suppressing the NF-kappaB pathway and ROS production","volume":"66","author":"Yu","year":"2017","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109171_b0030","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1378\/chest.118.2.503","article-title":"Proinflammatory cytokines","volume":"118","author":"Dinarello","year":"2000","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0035","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190314","article-title":"Inflammasome signaling and regulation of interleukin-1 family cytokines","volume":"217","author":"Chan","year":"2020","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-0038-1676806","article-title":"Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets","volume":"39","author":"Yang","year":"2019","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.intimp.2022.109171_b0045","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bbi.2020.10.008","article-title":"Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central alpha2A adrenoceptor","volume":"91","author":"Mei","year":"2021","journal-title":"Brain. Behav. Immun."},{"issue":"3","key":"10.1016\/j.intimp.2022.109171_b0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.diabet.2011.11.006","article-title":"Inflammation and type 2 diabetes","volume":"38","author":"Calle","year":"2012","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.intimp.2022.109171_b0055","doi-asserted-by":"crossref","unstructured":"D. Sorriento, G. Iaccarino, Inflammation and Cardiovascular Diseases: The Most Recent Findings, Int. J. Mol. Sci. 20(16) (2019).","DOI":"10.3390\/ijms20163879"},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0060","doi-asserted-by":"crossref","first-page":"6493","DOI":"10.1038\/s41598-020-63491-w","article-title":"In-vitro analysis of free radical scavenging activities and suppression of LPS-induced ROS production in macrophage cells by Solanum sisymbriifolium extracts","volume":"10","author":"More","year":"2020","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.intimp.2022.109171_b0065","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/aps.2017.143","article-title":"Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK\/NF-kappaB signaling pathway and activating the PI3K\/Akt\/Nrf2 pathway","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0070","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13075-021-02512-z","article-title":"Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-kappaB pathways","volume":"23","author":"Lu","year":"2021","journal-title":"Arthritis Res. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2022.109171_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26092745","article-title":"Polyphenols Extracted from Shanxi-Aged Vinegar Inhibit Inflammation in LPS-Induced RAW264.7 Macrophages and ICR Mice via the Suppression of MAPK\/NF-kappaB Pathway Activation","volume":"26","author":"Du","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010092","article-title":"Targeting MAPK\/NF-kappaB Pathways in Anti-Inflammatory Potential of Rutaecarpine: Impact on Src\/FAK-Mediated Macrophage Migration","volume":"23","author":"Jayakumar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.intimp.2022.109171_b0085","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.4049\/jimmunol.165.10.5767","article-title":"Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages","volume":"165","author":"Matsuguchi","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2022.109171_b0090","doi-asserted-by":"crossref","first-page":"726931","DOI":"10.3389\/fcell.2021.726931","article-title":"A Novel Function of Mitochondrial Phosphoenolpyruvate Carboxykinase as a Regulator of Inflammatory Response in Kupffer Cells","volume":"9","author":"Dong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0095","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1038\/s41467-020-17881-3","article-title":"Triacylglycerol synthesis enhances macrophage inflammatory function","volume":"11","author":"Castoldi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2022.109171_b0100","doi-asserted-by":"crossref","unstructured":"W.Y. Hsieh, Q.D. Zhou, A.G. York, K.J. Williams, P.O. Scumpia, E.B. Kronenberger, X.P. Hoi, B. Su, X. Chi, V.L. Bui, E. Khialeeva, A. Kaplan, Y.M. Son, A.S. Divakaruni, J. Sun, S.T. Smale, R.A. Flavell, S.J. Bensinger, Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome, Cell Metab. 32(1) (2020) 128\u2013143 e5.","DOI":"10.1016\/j.cmet.2020.05.003"},{"issue":"2","key":"10.1016\/j.intimp.2022.109171_b0105","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cmet.2016.11.009","article-title":"SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism","volume":"25","author":"Oishi","year":"2017","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010330","article-title":"Monounsaturated Fatty Acids in Obesity-Related Inflammation","volume":"22","author":"Ravaut","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2022.109171_b0115","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/jam.12725","article-title":"Production of cis-11-eicosenoic acid by Mortierella fungi","volume":"118","author":"Kikukawa","year":"2015","journal-title":"J. Appl. Microbiol."},{"issue":"2","key":"10.1016\/j.intimp.2022.109171_b0120","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00425-021-03682-5","article-title":"Ectopic expression of cDNAs from larkspur (Consolida ajacis) for increased synthesis of gondoic acid (cis-11 eicosenoic acid) and its positional redistribution in seed triacylglycerol of Camelina sativa","volume":"254","author":"Sarvas","year":"2021","journal-title":"Planta"},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0125","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/pbi.12379","article-title":"Synthesis of oleyl oleate wax esters in Arabidopsis thaliana and Camelina sativa seed oil","volume":"14","author":"Iven","year":"2016","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.intimp.2022.109171_b0130","doi-asserted-by":"crossref","unstructured":"G.E. Delgado, B.K. Kramer, S. Lorkowski, W. Marz, C. von Schacky, M.E. Kleber, Individual omega-9 monounsaturated fatty acids and mortality-The Ludwigshafen Risk and Cardiovascular Health Study, J. Clin. Lipidol. 11(1) (2017) 126\u2013135 e5.","DOI":"10.1016\/j.jacl.2016.10.015"},{"issue":"6","key":"10.1016\/j.intimp.2022.109171_b0135","doi-asserted-by":"crossref","DOI":"10.3390\/nu12061895","article-title":"Serum Phospholipid Fatty Acids Levels, Anthropometric Variables and Adiposity in Spanish Premenopausal Women","volume":"12","author":"Del Pozo","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2022.109171_b0140","doi-asserted-by":"crossref","first-page":"9510305","DOI":"10.1155\/2020\/9510305","article-title":"Camelina sativa Methanolic and Ethanolic Extract Potential in Alleviating Oxidative Stress, Memory Deficits, and Affective Impairments in Stress Exposure-Based Irritable Bowel Syndrome Mouse Models","volume":"2020","author":"Cojocariu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.intimp.2022.109171_b0145","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1017\/S0007114520002044","article-title":"Dietary supplementation with seed oil from transgenic Camelina sativa induces similar increments in plasma and erythrocyte DHA and EPA to fish oil in healthy humans","volume":"124","author":"West","year":"2020","journal-title":"Br. J. Nutr."},{"issue":"9","key":"10.1016\/j.intimp.2022.109171_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/nu13093116","article-title":"Dietary Supplementation with Transgenic Camelina sativa Oil Containing 20:5n\u20133 and 22:6n\u20133 or Fish Oil Induces Differential Changes in the Transcriptome of CD3(+) T Lymphocytes","volume":"13","author":"West","year":"2021","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0155","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41419-020-03347-3","article-title":"DHA\/AA alleviates LPS-induced Kupffer cells pyroptosis via GPR120 interaction with NLRP3 to inhibit inflammasome complexes assembly","volume":"12","author":"Fan","year":"2021","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.intimp.2022.109171_b0160","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1124\/jpet.112.194613","article-title":"Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-kappaB pathways and protects mice from lethal endotoxin shock","volume":"342","author":"Rim","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.intimp.2022.109171_b0165","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0170","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s42003-022-03369-x","article-title":"beta-elemene regulates M1\u2013M2 macrophage balance through the ERK\/JNK\/P38 MAPK signaling pathway","volume":"5","author":"Zhou","year":"2022","journal-title":"Commun. Biol."},{"issue":"19","key":"10.1016\/j.intimp.2022.109171_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910637","article-title":"Donepezil Regulates LPS and Abeta-Stimulated Neuroinflammation through MAPK\/NLRP3 Inflammasome\/STAT3 Signaling","volume":"22","author":"Kim","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.intimp.2022.109171_b0180","doi-asserted-by":"crossref","first-page":"15149","DOI":"10.1074\/jbc.M110.105429","article-title":"p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9","volume":"285","author":"Loesch","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2022.109171_b0185","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2009.03.008","article-title":"Kupffer cells in non-alcoholic fatty liver disease: the emerging view","volume":"51","author":"Baffy","year":"2009","journal-title":"J. Hepatol."},{"issue":"19","key":"10.1016\/j.intimp.2022.109171_b0190","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.4254\/wjh.v7.i19.2184","article-title":"Targeting Kupffer cells in non-alcoholic fatty liver disease\/non-alcoholic steatohepatitis: Why and how?","volume":"7","author":"Lanthier","year":"2015","journal-title":"World J. Hepatol."},{"issue":"13","key":"10.1016\/j.intimp.2022.109171_b0195","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.7150\/ijbs.47143","article-title":"Kupffer Cells in Non-alcoholic Fatty Liver Disease: Friend or Foe?","volume":"16","author":"Chen","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2022.109171_b0200","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12986-017-0188-0","article-title":"Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice","volume":"14","author":"Yamada","year":"2017","journal-title":"Nutr. Metab. (Lond.)"},{"issue":"2","key":"10.1016\/j.intimp.2022.109171_b0205","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1023\/A:1020347818725","article-title":"Mammary gland immunity and mastitis susceptibility","volume":"7","author":"Sordillo","year":"2002","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"8","key":"10.1016\/j.intimp.2022.109171_b0210","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"13","key":"10.1016\/j.intimp.2022.109171_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2022.109171_b0220","doi-asserted-by":"crossref","first-page":"107823","DOI":"10.1016\/j.intimp.2021.107823","article-title":"Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes","volume":"97","author":"Arabpour","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2022.109171_b0225","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-0-387-46401-5_3","article-title":"Antioxidant and anti-inflammatory properties of curcumin","volume":"595","author":"Menon","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.intimp.2022.109171_b0230","doi-asserted-by":"crossref","first-page":"4350965","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-Mediated Cellular Signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.intimp.2022.109171_b0235","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.4049\/jimmunol.1201809","article-title":"NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-kappaB activity","volume":"190","author":"Han","year":"2013","journal-title":"J. Immunol."},{"issue":"14","key":"10.1016\/j.intimp.2022.109171_b0240","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3748\/wjg.15.1702","article-title":"Reactive oxygen species: a double-edged sword in oncogenesis","volume":"15","author":"Pan","year":"2009","journal-title":"World J. Gastroenterol."},{"issue":"10","key":"10.1016\/j.intimp.2022.109171_b0245","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41419-019-1998-y","article-title":"Inhibition of gap junction composed of Cx43 prevents against acute kidney injury following liver transplantation","volume":"10","author":"Yuan","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2022.109171_b0250","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2017.02.021","article-title":"PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages","volume":"259","author":"Zuniga","year":"2017","journal-title":"Atherosclerosis"},{"issue":"5","key":"10.1016\/j.intimp.2022.109171_b0255","doi-asserted-by":"crossref","first-page":"165684","DOI":"10.1016\/j.bbadis.2020.165684","article-title":"IL-20 promotes hypoxia\/reoxygenation-induced mitochondrial dysfunction and apoptosis in cardiomyocytes by upregulating oxidative stress by activating the PKC\/NADPH oxidase pathway","volume":"1866","author":"Tsai","year":"2020","journal-title":"Biochim. Biophys. Acta Mol Basis Dis"},{"issue":"1\u20133","key":"10.1016\/j.intimp.2022.109171_b0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.04.044","article-title":"Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1\/2, p38 and JNK pathways","volume":"542","author":"Jang","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2022.109171_b0265","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jep.2015.11.020","article-title":"Xanthii fructus inhibits inflammatory responses in LPS-stimulated RAW 264.7 macrophages through suppressing NF-kappaB and JNK\/p38 MAPK","volume":"176","author":"Yeom","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2022.109171_b0270","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2017.02.041","article-title":"Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS\/ERK\/Nrf2 signaling pathways in human Osteoarthritis chondrocytes","volume":"106","author":"Khan","year":"2017","journal-title":"Free Radic. Biol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922006555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922006555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:53:09Z","timestamp":1761587589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922006555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":54,"alternative-id":["S1567576922006555"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109171","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gondoic acid alleviates LPS\u2011induced Kupffer cells inflammation by inhibiting ROS production and PKC\u03b8\/ERK\/STAT3 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109171"}}