{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:02:32Z","timestamp":1792252952100,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M683645XB"],"award-info":[{"award-number":["2020M683645XB"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFS0312"],"award-info":[{"award-number":["2020YFS0312"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104824"],"award-info":[{"award-number":["82104824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.intimp.2022.109186","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T21:46:13Z","timestamp":1663191973000},"page":"109186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":155,"special_numbering":"C","title":["Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2\/SLC7A11\/GPX4 axis to inhibit PM2.5-mediated lung injury in mice"],"prefix":"10.1016","volume":"112","author":[{"given":"Xiaoming","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zherui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2022.109186_b0005","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.scitotenv.2015.09.122","article-title":"Elemental characterization and source apportionment of PM10 and PM2.5 in the western coastal area of central Taiwan","volume":"541","author":"Hsu","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.intimp.2022.109186_b0010","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/bmb\/ldg022","article-title":"Air pollution and infection in respiratory illness","volume":"68","author":"Chauhan","year":"2003","journal-title":"Br. Med. Bull."},{"issue":"9","key":"10.1016\/j.intimp.2022.109186_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0305-4","article-title":"Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications","volume":"51","author":"Ryu","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"5","key":"10.1016\/j.intimp.2022.109186_b0020","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2022.109186_b0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15430\/JCP.2017.22.1.6","article-title":"Predictive and Prognostic Biomarkers of Respiratory Diseases due to Particulate Matter Exposure","volume":"22","author":"Kim","year":"2017","journal-title":"J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.intimp.2022.109186_b0030","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3892\/or.2020.7836","article-title":"Regulation of ferroptosis by non-coding RNAs in the development and treatment of cancer (Review)","volume":"45","author":"Luo","year":"2021","journal-title":"Oncol. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2022.109186_b0035","doi-asserted-by":"crossref","first-page":"517","DOI":"10.18632\/oncoscience.160","article-title":"Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells","volume":"2","author":"Eling","year":"2015","journal-title":"Oncoscience"},{"issue":"12","key":"10.1016\/j.intimp.2022.109186_b0040","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neo.2017.10.005","article-title":"Cysteine Dioxygenase 1 Mediates Erastin-Induced Ferroptosis in Human Gastric Cancer Cells","volume":"19","author":"Hao","year":"2017","journal-title":"Neoplasia"},{"issue":"7682","key":"10.1016\/j.intimp.2022.109186_b0045","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nature24637","article-title":"NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis","volume":"551","author":"Alvarez","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2022.109186_b0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/JAD-130209","article-title":"Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imaging","volume":"37","author":"Raven","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.intimp.2022.109186_b0055","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.freeradbiomed.2018.04.002","article-title":"Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically","volume":"120","author":"Agrawal","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.intimp.2022.109186_b0060","doi-asserted-by":"crossref","first-page":"F702","DOI":"10.1152\/ajprenal.00044.2017","article-title":"Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells","volume":"314","author":"Adedoyin","year":"2018","journal-title":"Am. J. Physiol. Renal. Physiol."},{"issue":"6","key":"10.1016\/j.intimp.2022.109186_b0065","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41419-018-0506-0","article-title":"Ferroptosis-inducing agents compromise in vitro human islet viability and function","volume":"9","author":"Bruni","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2022.109186_b0070","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11658-020-00205-0","article-title":"Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis","volume":"25","author":"Liu","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.intimp.2022.109186_b0075","doi-asserted-by":"crossref","unstructured":"Y. Wang, M. Tang, PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance, Environ. Pollut. 254(Pt A) (2019) 112937, https:\/\/doi.org:10.1016\/j.envpol.2019.07.105.","DOI":"10.1016\/j.envpol.2019.07.105"},{"issue":"9","key":"10.1016\/j.intimp.2022.109186_b0080","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/molecules23092167","article-title":"Polyphenols from Acorn Leaves (Quercus liaotungensis) Protect Pancreatic Beta Cells and Their Inhibitory Activity against \u03b1-Glucosidase and Protein Tyrosine Phosphatase 1B","volume":"23","author":"Xu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2022.109186_b0085","first-page":"7090534","article-title":"Role of Nrf2 and Its Activators in Respiratory Diseases","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.intimp.2022.109186_b0090","doi-asserted-by":"crossref","unstructured":"D. Kalpana Deepa Priya, R. Gayathri, D. Sakthisekaran, Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene, Biomed. Pharmacother. 65(1) (2011) 9\u201316, https:\/\/doi.org:10.1016\/j.biopha.2010.08.009.","DOI":"10.1016\/j.biopha.2010.08.009"},{"issue":"6","key":"10.1016\/j.intimp.2022.109186_b0095","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1513\/pats.201001-014AW","article-title":"Cellular response to cigarette smoke and oxidants: adapting to survive","volume":"7","author":"Cantin","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.intimp.2022.109186_b0100","doi-asserted-by":"crossref","unstructured":"Retraction: Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1; Heightened Endoplasmic Reticulum Stress in the Lungs of Patients with Chronic Obstructive Pulmonary Disease: The Role of Nrf2-Regulated Proteasomal Activity, Am. J. Respir. Crit. Care Med. 193(3) (2016) 344, https:\/\/doi.org:10.1164\/rccm.1933retraction.","DOI":"10.1164\/rccm.1933retraction"},{"issue":"1","key":"10.1016\/j.intimp.2022.109186_b0105","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cyto.2013.09.021","article-title":"Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status","volume":"65","author":"McGrath-Morrow","year":"2014","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.intimp.2022.109186_b0110","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"11\u201312","key":"10.1016\/j.intimp.2022.109186_b0115","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/10715762.2019.1666983","article-title":"Ferroptosis caused by cysteine insufficiency and oxidative insult","volume":"54","author":"Fujii","year":"2020","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.intimp.2022.109186_b0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1476-5381.2011.01480.x","article-title":"System xc- cystine\/glutamate antiporter: an update on molecular pharmacology and roles within the CNS","volume":"165","author":"Bridges","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109186_b0125","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1089\/ars.2011.4391","article-title":"The cystine\/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities","volume":"18","author":"Lewerenz","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.intimp.2022.109186_b0130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.intimp.2022.109186_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101417","article-title":"Peroxiredoxin-1 regulates lipid peroxidation in corneal endothelial cells","volume":"30","author":"Lovatt","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2022.109186_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112588","article-title":"Melatonin protects against PM2.5-induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner","volume":"223","author":"Guohua","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.intimp.2022.109186_b0145","doi-asserted-by":"crossref","unstructured":"Y. Wang, Z. Shen, S. Zhao, D. Huang, X. Wang, Y. Wu, et al., Sipeimine ameliorates PM2.5-induced lung injury by inhibiting ferroptosis via the PI3K\/Akt\/Nrf2 pathway: A network pharmacology approach, Ecotoxicol. Environ. Saf. 239 (2022) 113615, https:\/\/doi.org:10.1016\/j.ecoenv.2022.113615.","DOI":"10.1016\/j.ecoenv.2022.113615"},{"key":"10.1016\/j.intimp.2022.109186_b0150","doi-asserted-by":"crossref","unstructured":"Q. Wang, B. Li, T. Benmarhnia, S. Hajat, M. Ren, T. Liu, et al., Independent and Combined Effects of Heatwaves and PM2.5 on Preterm Birth in Guangzhou, China: A Survival Analysis, Environ. Health Perspect. 128(1) (2020) 17006, https:\/\/doi.org:10.1289\/ehp5117.","DOI":"10.1289\/EHP5117"},{"issue":"8","key":"10.1016\/j.intimp.2022.109186_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23082032","article-title":"Astragaloside IV Attenuates Acetaminophen-Induced Liver Injuries in Mice by Activating the Nrf2 Signaling Pathway","volume":"23","author":"Li","year":"2018","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.intimp.2022.109186_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24091838","article-title":"The Role of Astragaloside IV against Cerebral Ischemia\/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy","volume":"24","author":"Zhang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2022.109186_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107290","article-title":"Astragaloside IV alleviates PM2.5-induced lung injury in rats by modulating TLR4\/MyD88\/NF-\u03baB signalling pathway","volume":"91","author":"Wu","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109186_b0170","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1007\/s10753-016-0420-5","article-title":"Inhibitory Effects of Astragaloside IV on Bleomycin-Induced Pulmonary Fibrosis in Rats Via Attenuation of Oxidative Stress and Inflammation","volume":"39","author":"Yu","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2022.109186_b0175","doi-asserted-by":"crossref","first-page":"5080843","DOI":"10.1155\/2019\/5080843","article-title":"Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"issue":"16","key":"10.1016\/j.intimp.2022.109186_b0180","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1007\/s00216-016-9519-7","article-title":"Development of two fine particulate matter standard reference materials (<4 \u03bcm and <10 \u03bcm) for the determination of organic and inorganic constituents","volume":"408","author":"Schantz","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.intimp.2022.109186_b0185","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.2147\/JIR.S312167","article-title":"Astragaloside IV Protects from PM2.5-Induced Lung Injury by Regulating Autophagy via Inhibition of PI3K\/Akt\/mTOR Signaling in vivo and in vitro","volume":"14","author":"Pei","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.intimp.2022.109186_b0190","doi-asserted-by":"crossref","unstructured":"Y. Xia, D.S, S. Jiang, R. Fan, Y. Wang, Y. Wang, et al., YiQiFuMai lyophilized injection attenuates particulate matter-induced acute lung injury in mice via TLR4-mTOR-autophagy pathway, Biomed. Pharmacother. 108 (2018) 906\u2013913, https:\/\/doi.org:10.1016\/j.biopha.2018.09.088.","DOI":"10.1016\/j.biopha.2018.09.088"},{"key":"10.1016\/j.intimp.2022.109186_b0195","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2016.02.017","article-title":"Differences in allergic inflammatory responses between urban PM2.5 and fine particle derived from desert-dust in murine lungs","volume":"297","author":"He","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2022.109186_b0200","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.3390\/jcm8122210","article-title":"Erastin Inhibits Septic Shock and Inflammatory Gene Expression via Suppression of the NF-\u03baB Pathway","volume":"8","author":"Oh","year":"2019","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.intimp.2022.109186_b0205","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.intimp.2014.06.043","article-title":"Usnic acid protects LPS-induced acute lung injury in mice through attenuating inflammatory responses and oxidative stress","volume":"22","author":"Su","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2022.109186_b0210","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10565-010-9158-2","article-title":"Roles of oxidative stress in signaling and inflammation induced by particulate matter","volume":"26","author":"Mazzoli-Rocha","year":"2010","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.intimp.2022.109186_b0215","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.freeradbiomed.2018.11.016","article-title":"Prolonged PM2.5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia","volume":"130","author":"Xu","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.intimp.2022.109186_b0220","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/oemed-2013-101498","article-title":"Endotoxin in concentrated coarse and fine ambient particles induces acute systemic inflammation in controlled human exposures","volume":"70","author":"Behbod","year":"2013","journal-title":"Occup. Environ. Med."},{"issue":"11","key":"10.1016\/j.intimp.2022.109186_b0225","doi-asserted-by":"crossref","first-page":"H1423","DOI":"10.1152\/ajpheart.00369.2015","article-title":"Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis","volume":"310","author":"Haberzettl","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.intimp.2022.109186_b0230","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.intimp.2022.109186_b0235","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1289\/ehp\/1408092","article-title":"Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis","volume":"122","author":"Hamra","year":"2014","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.intimp.2022.109186_b0240","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ecoenv.2019.03.086","article-title":"PM2.5 induces EMT and promotes CSC properties by activating Notch pathway in vivo and vitro","volume":"178","author":"Wang","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.intimp.2022.109186_b0245","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/tox.20699","article-title":"In vitro toxicology of ambient particulate matter: correlation of cellular effects with particle size and components","volume":"28","author":"Kroll","year":"2013","journal-title":"Environ. Toxicol."},{"issue":"11","key":"10.1016\/j.intimp.2022.109186_b0250","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/s41419-019-2064-5","article-title":"ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2022.109186_b0255","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and Transferrin Regulate Ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.intimp.2022.109186_b0260","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12931-020-01500-2","article-title":"Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis","volume":"21","author":"Qiu","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2022.109186_b0265","doi-asserted-by":"crossref","unstructured":"M. He, T. Ichinose, S. Yoshida, T. Ito, C. He, Y. Yoshida, et al., PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells, J. Appl. Toxicol. 37(10) (2017) 1203\u20131218, https:\/\/doi.org:10.1002\/jat.3482.","DOI":"10.1002\/jat.3482"},{"key":"10.1016\/j.intimp.2022.109186_b0270","doi-asserted-by":"crossref","unstructured":"Y. Zhang, H. Zhang, Z. Mao, C. Gao, ROS-Responsive Nanoparticles for Suppressing the Cytotoxicity and Immunogenicity Caused by PM2.5 Particulates, Biomacromolecules 20(4) (2019) 1777\u20131788, https:\/\/doi.org:10.1021\/acs.biomac.9b00174.","DOI":"10.1021\/acs.biomac.9b00174"},{"key":"10.1016\/j.intimp.2022.109186_b0275","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2022.109186_b0280","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","article-title":"ATF3 promotes erastin-induced ferroptosis by suppressing system Xc","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"issue":"13","key":"10.1016\/j.intimp.2022.109186_b0285","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.18632\/aging.103378","article-title":"Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1","volume":"12","author":"Dong","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2022.109186_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153370","article-title":"Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2\/HO-1 axis in EGFR wild-type non-small-cell lung cancer","volume":"80","author":"Lou","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2022.109186_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.126236","article-title":"Identification of two novel prenylated flavonoids in mulberry leaf and their bioactivities","volume":"315","author":"Wen","year":"2020","journal-title":"Food Chem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922006701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576922006701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T17:50:28Z","timestamp":1761587428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576922006701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":59,"alternative-id":["S1567576922006701"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109186","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2\/SLC7A11\/GPX4 axis to inhibit PM2.5-mediated lung injury in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2022.109186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109186"}}